公开(公告)号：WO0174431A3

公开(公告)日：2002-05-30

申请号：PCT/GB0101529

申请日：2001-04-03

Applicant: BATTELLE MEMORIAL INST LTD ,  DAVIES LEE ADRIAN ,  DAVIES DAVID NEVILLE ,  WAN MARGARET ,  COFFEE RONALD ALAN

Inventor： DAVIES LEE ADRIAN ,  DAVIES DAVID NEVILLE ,  WAN MARGARET ,  COFFEE RONALD ALAN

IPC: A61K9/72 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61M11/00 ,  A61M13/00 ,  A61M15/00 ,  A61M15/02 ,  A61M15/08 ,  B05B5/025 ,  B05B5/16 ,  A61K9/00 ,  A61K48/00

CPC classification number: A61M15/00 ,  A61M11/00 ,  A61M11/001 ,  A61M15/02 ,  A61M15/08 ,  B05B5/0255 ,  B05B5/1691

Abstract: Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts form a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.

Abstract translation: 描述了递送生物材料的方法，该方法包括以下步骤：提供含有生物材料的液体制剂，将液体制剂供应到出口并使从出口发出的液体经受电场，从而引起液体的电流动力学处理而不变性 生物材料。 在一个实例中，通过从含有在醇中不变性的生物材料的制剂除去盐，然后在将液体制剂供应到出口之前向制剂中加入醇来提供液体制剂。 在将液体制剂供应到出口之前，可以向液体制剂中加入酸。

公开(公告)号：WO02011711A2

公开(公告)日：2002-02-14

申请号：PCT/US2001/024093

申请日：2001-08-01

IPC: A61K9/00 ,  A61K31/00 ,  A61K31/57 ,  A61K31/58 ,  A61K45/06 ,  A61M15/00 ,  A61P11/06 ,  A61P11/08

CPC classification number: A61K9/0075 ,  A61K9/008 ,  A61K31/57 ,  A61K31/58 ,  A61K45/06 ,  A61M11/001 ,  A61M15/0028 ,  A61M15/0033 ,  A61M2202/064 ,  A61K31/135 ,  A61K31/215 ,  A61K31/165 ,  A61K31/44 ,  A61K31/47 ,  A61K31/52 ,  A61K31/445 ,  A61K2300/00

Abstract: A pharmaceutical formulation is provided for pulmonary drug administration of a bronchodilator, a corticosteroid and an optional pharmaceutically acceptable carrier. In addition, methods for using the formulation to treat bronchodilator/corticosteroid-reponsive conditions, diseases or disorders are provided, as are drug delivery devices and dosage forms for housing and/or dispensing the formulations.

Abstract translation: 提供药物制剂用于支气管扩张剂，皮质类固醇和任选的药学上可接受的载体的肺部药物施用。 此外，提供了使用制剂治疗支气管扩张剂/皮质类固醇反应性疾病或疾病或病症的方法，以及用于容纳和/或分配制剂的药物递送装置和剂型。

公开(公告)号：WO99047199A1

公开(公告)日：1999-09-23

申请号：PCT/US1999/005797

申请日：1999-03-17

IPC: A61M13/00 ,  A61M15/00 ,  A61M16/00

CPC classification number: A61M15/0028 ,  A61M11/001 ,  A61M11/002 ,  A61M15/003 ,  A61M15/0033 ,  A61M15/0065 ,  A61M15/0091 ,  A61M15/0093 ,  A61M2202/064

Abstract: The present invention is an inhalation activated inhaler (10) having a primary inhalation passage (60), a secondary inhalation passage (90) disposed in communication with the primary inhalation passage, and a source of medicament. The primary inhalation passage has inflow inhibiting mechanism connected to a blocking plate (84) positioned to selectively block fluid flow in the secondary inhalation passage. As the user's inhalation reaches a defined rate, the flow inhibiting mechanism restricts flow through the primary inhalation passage, and moves the blocking plate to enable airflow through the secondary passage. Thus, as the user achieves a desired inhalation rate, the medicament is provided through the secondary inhalation passage, thereby optimizing the delivery of medicament to the lungs.

Abstract translation: 本发明是具有主要吸入通道（60），与主要吸入通道连通的第二吸入通道（90）和药物源的吸入式活化吸入器（10）。 主吸入通道具有连接到阻挡板（84）的流入阻止机构，该阻挡板定位成选择性地阻挡二次吸入通道中的流体流动。 当用户的吸入达到限定的速率时，流动抑制机构限制通过主要吸入通道的流动，并移动阻挡板以使气流通过次级通道。 因此，当使用者达到期望的吸入速率时，通过二次吸入通道提供药物，从而优化药物向肺的递送。

公开(公告)号：WO99031019A1

公开(公告)日：1999-06-24

申请号：PCT/IB1998/002052

申请日：1998-12-17

IPC: C02F3/20 ,  A61M15/00 ,  B01F3/04 ,  B01F3/08 ,  B01F5/04 ,  B05B1/02 ,  B05B7/04 ,  B05B7/06 ,  B05B7/08 ,  B81C1/00 ,  C40B60/14 ,  F02M43/04 ,  F02M67/10 ,  F02M69/04 ,  F02M69/08 ,  F23D11/10 ,  G01N15/14 ,  G01N21/01

CPC classification number: B82Y30/00 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0065 ,  A61M15/025 ,  A61M2202/064 ,  B01F3/0446 ,  B01F5/04 ,  B01J2219/00378 ,  B05B1/02 ,  B05B7/0475 ,  B05B7/061 ,  B05B7/065 ,  B05B7/066 ,  B05B7/0884 ,  C40B60/14 ,  F02M43/04 ,  F02M67/10 ,  F02M69/047 ,  F02M69/08 ,  F23D11/106 ,  G01N21/01 ,  G01N2015/1406 ,  G01N2015/1409

Abstract: Spherical particles having a size on the order of 0.1 to 100 microns in size are created by systems and devices of several types. The device includes a source of a stream of gas which is forced through a liquid held under pressure in a pressure chamber with an exit opening therein. The stream of gas surrounded by the liquid in the pressure chamber flows out of an exit orifice of the chamber into a liquid thereby creating a monodispersion of bubbles with substantially uniform diameter. The bubbles are small in size and produced with a relatively small amount of energy relative to comparable systems. Small particles of liquid may also be produced. Applications of the technology range from oxygenating sewage with monodispersions of bubbles to inhalation therapy with monodisperse aerosol dispersions of pharmaceutically active drugs.

Abstract translation: 尺寸为0.1至100微米尺寸的球形颗粒由几种类型的系统和装置产生。 该装置包括气流源，其被迫通过压力保持在液体中的液体，其中具有出口。 由压力室中的液体包围的气体流从腔室的出口流出到液体中，从而产生具有基本均匀直径的气泡的单分散体。 气泡尺寸小，相对于可比较的系统产生的能量相对较少。 也可以生产小颗粒的液体。 技术范围从氧化污水与单分散气泡到药物活性药物的单分散气溶胶分散剂的吸入治疗。

公开(公告)号：WO99030832A1

公开(公告)日：1999-06-24

申请号：PCT/IB1998/002053

申请日：1998-12-16

IPC: A61M15/00 ,  B01F3/04 ,  B01F5/04 ,  B05B1/02 ,  B05B7/04 ,  B05B7/06 ,  B05B7/08 ,  B81C1/00 ,  C40B60/14 ,  F02M43/04 ,  F02M67/10 ,  F02M69/04 ,  F02M69/08 ,  F23D11/10 ,  G01N15/14 ,  G01N21/01

CPC classification number: B82Y30/00 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0065 ,  A61M15/025 ,  A61M2202/064 ,  B01F3/0446 ,  B01F5/04 ,  B01F13/0062 ,  B01J2219/00378 ,  B05B1/02 ,  B05B7/0475 ,  B05B7/061 ,  B05B7/065 ,  B05B7/066 ,  B05B7/0884 ,  B82Y10/00 ,  C40B60/14 ,  F02M43/04 ,  F02M67/10 ,  F02M69/047 ,  F02M69/08 ,  F23D11/106 ,  G01N21/01 ,  G01N2015/1406 ,  G01N2015/1409 ,  Y10S977/773 ,  Y10S977/888 ,  Y10S977/89 ,  Y10S977/896

Abstract: The invention is directed to a stable capillary microjet and a monodisperse aerosol formed when the microjet dissociates. A variety of devices and methods are disclosed which allow for the formation of a stream of a first fluid (e.g. a liquid) characterized by forming a stable capillary microjet over a portion of the stream wherein the microjet portion of the stream is formed by a second fluid (e.g. a gas). The second fluid is preferably in a different state from the first fluid-liquid-gas or gas-liquid combinations. However, the first and second fluids may be two different fluids in miscible in each other. The stable capillary microjet comprises a diameter dj at a given point A in the stream characterized by formula (I): wherein dj is the diameter of the stable microjet, ≅ indicates approximately equally to where an acceptable margin of error is +/- 10 %, rho 1 is the density of the liquid and DELTA Pg is change in second fluid pressure from the second fluid pressure at a low velocity region (feeding region) upstream of point A to the second fluid pressure at point A.

Abstract translation: 本发明涉及一种稳定的毛细管微喷射和当微喷射离解时形成的单分散气溶胶。 公开了各种装置和方法，其允许形成第一流体（例如液体）的流，其特征在于在流的一部分上形成稳定的毛细管微喷射，其中流的微喷射部分由第二流体 流体（例如气体）。 第二流体优选地处于与第一流体 - 液体气体或气液组合不同的状态。 然而，第一和第二流体可以是彼此混溶的两种不同的流体。 稳定的毛细管微喷射包括在由式（I）表征的流中的给定点A处的直径dj：其中dj是稳定的微喷射器的直径，≅大致相等地表示可接受的误差幅度为+/- 10％ rho 1是液体的密度，DELTA Pg是在点A上游的低速区域（进料区域）处的第二流体压力与点A处的第二流体压力的第二流体压力的变化。

公开(公告)号：WO99027920A2

公开(公告)日：1999-06-10

申请号：PCT/GB1998/003543

申请日：1998-11-26

IPC: A61M11/02 ,  A61M15/00 ,  A61P11/06 ,  A61K31/00

CPC classification number: A61M11/02 ,  A61M11/001 ,  A61M11/002 ,  A61M15/00 ,  A61M2205/8225 ,  Y10S514/826 ,  Y10S514/958 ,  Y10S514/959

Abstract: A method and apparatus is disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and administered to the lungs in a gas stream. A preferred SAPL is a solid blend of dipalmitoyl phosphatidyl choline (DPPC) and phosphatidyl glycerol (PG).

Abstract translation: 公开了用于治疗哮喘和其它呼吸状况的方法和装置。 以细粉末的形式制备包含表面活性磷脂（SAPL）的药物，并以气流的形式给予肺。 优选的SAPL是二棕榈酰磷脂酰胆碱（DPPC）和磷脂酰甘油（PG）的固体共混物。

公开(公告)号：WO98048873A1

公开(公告)日：1998-11-05

申请号：PCT/US1998/008238

申请日：1998-04-23

IPC: A61M11/02 ,  A61J7/04 ,  A61K9/00 ,  A61K38/28 ,  A61M15/00 ,  A61M16/00 ,  A61M16/14 ,  A61M11/00 ,  A62B7/00

CPC classification number: A61K9/007 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/0073 ,  A61K38/28 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206 ,  Y10S514/866

Abstract: Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device (40) comprises a means (11, 29) for measuring inhaled volume and for halting inhalation at a predetermined point. The device also comprises an adjustable means (9) for applying various amounts of force to a container (1) of formulation (5) to expel different amounts of drugs from the container based on the force applied.

Abstract translation: 通过控制患者吸入的空气的总体积，将吸入胰岛素的剂量控制在狭窄的范围内。 通过以相同的总吸入体积的空气重复递送雾化胰岛素，每次输送给患者的胰岛素量是一致的。 装置（40）包括用于测量吸入体积并在预定点停止吸入的装置（11,29）。 该装置还包括可调节装置（9），用于向制剂（5）的容器（1）施加各种量的力以基于施加的力将不同量的药物从容器中排出。

公开(公告)号：WO98036651A1

公开(公告)日：1998-08-27

申请号：PCT/US1998/003108

申请日：1998-02-19

IPC: A24F47/00 ,  A61M15/00 ,  A24D1/00 ,  A61M15/06

CPC classification number: A24F47/002 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M2205/6081

Abstract: This invention is a device (1) for generating an inhaler aerosol by collapsing a wall portion (2) of a liquid (5) reservoir to force the liquid through a prefilter (301), and then through a porous nozzle (302). The porous nozzle has smaller pores than the prefilter.

Abstract translation: 本发明是一种用于通过塌陷液体（5）储存器的壁部分（2）产生吸入器气溶胶的装置（1），以迫使液体通过预过滤器（301），然后通过多孔喷嘴（302）。 多孔喷嘴具有比预过滤器小的孔。

公开(公告)号：WO1998032479A1

公开(公告)日：1998-07-30

申请号：PCT/US1997008904

申请日：1997-05-28

Applicant: ABRAMS, Andrew, L. ,  GUMASTE, Anand, V.

IPC: A61M15/00

CPC classification number: A61M15/0028 ,  A61M11/001 ,  A61M11/005 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0085 ,  A61M15/02 ,  A61M2016/0039 ,  A61M2202/064 ,  A61M2205/8206

Abstract: An inhaler (220) that utilizes vibration to facilitate suspension of powder into an air stream is provided. One embodiment of the inhaler includes a piezoelectric vibrator (254) for vibrating the powder. A controller is provided for controlling supply of actuating electricity to the vibrator so as to cause the powder to vibrate in such a way as to deaggregate the powder and separate the powder by size. The powder particles of interest are then suspended in the air stream by electrostatic means (232).

Abstract translation: 提供了利用振动促进粉末悬浮在空气流中的吸入器（220）。 吸入器的一个实施例包括用于使粉末振动的压电振动器（254）。 提供控制器用于控制对振动器的致动电力的供应，从而使粉末以使粉末解聚并按照大小分离粉末的方式振动。 然后将感兴趣的粉末颗粒通过静电装置（232）悬浮在空气流中。

公开(公告)号：WO1998004308A1

公开(公告)日：1998-02-05

申请号：PCT/EP1997004128

申请日：1997-07-30

Applicant: GLAXO GROUP LIMITED ,  VAN OORT, Michiel ,  SACCHETTI, Mark, Joseph

Inventor： GLAXO GROUP LIMITED

IPC: A61M15/00

CPC classification number: A61M15/0045 ,  A61M11/001 ,  A61M11/002 ,  A61M15/0048 ,  A61M15/005 ,  A61M15/0051

Abstract: A medicament carrier (10) having a first and a second spaced apart screen (12, 14) each of which has surfaces (12B, 14B) defining a plurality of interstices (12A, 14A). The carrier (10) contains powdered agglomerated medicament particles (SM) loaded onto the first screen surface (12B) such that the interstices (12A) of the first screen (12) are at least partially open and free of the agglomerated medicament particles (SM). When an air stream is provided to the carrier to entrain the agglomerated powdered medicament particles (SM) and move them from the first screen (12) through the interstices (14A) of the second screen (14), the agglomerated powdered medicament particles (SM) are sheared by air flow gradients created by the first and second screens (12, 14) and by contact with the surface (14B) of the second screen (14) to create particles of respirable particle size range. The carrier (10) can be used in a dry powder inhalator device.

Abstract translation: 一种具有第一和第二间隔开的筛网（12,14）的药物载体（10），每个筛网具有限定多个间隙（12A，14A）的表面（12B，14B）。 载体（10）包含装载到第一筛网表面（12B）上的粉末状聚集的药物颗粒（SM），使得第一筛网（12）的间隙（12A）至少部分地开放并且没有附聚的药物颗粒（SM ）。 当将空气流提供到载体以夹带聚集的粉末状药物颗粒（SM）并将它们从第一筛网（12）移动通过第二筛网（14）的间隙（14A）时，附聚的粉末状药物颗粒（SM ）由第一和第二筛网（12,14）产生的气流梯度和与第二筛网（14）的表面（14B）接触以产生可吸入粒度范围的颗粒。 载体（10）可用于干粉吸入装置。