公开(公告)号：WO1998026841A1

公开(公告)日：1998-06-25

申请号：PCT/US1997023400

申请日：1997-12-16

Applicant: ZMD CORPORATION

Inventor： ZMD CORPORATION ,  AYATI, Shervin ,  LOPIN, Michael, L.

IPC: A61N01/39

CPC classification number: A61N1/39 ,  A61N1/3906 ,  A61N1/3912 ,  A61N1/3925 ,  A61N1/3937 ,  A61N1/3943 ,  A61N1/3956

Abstract: The invention provides a method and circuit for forming an electrotherapy current wave form. A charge storage device located externally of a patient's body is charged, and is discharged through the patient's body (24) through at least two discharge electrodes (21, 23) connected by electrical circuitry to opposite poles of the charge storage device. A continuous discharge of the charge storage device through the electrodes is controlled so as to produce at least one phase of a current wave form that includes a ripple (14). The ripple has a height less than one third of the height of the peak current of the phase. The current wave form has a sensing pulse portion (10) that is integral with the therapeutic discharge portion of the current wave form.

Abstract translation: 本发明提供了一种形成电疗电流波形的方法和电路。 位于患者身体外部的电荷存储装置被充电，并且通过由电路连接到电荷存储装置的相对极的至少两个放电电极（21,23）通过患者身体（24）排出。 控制通过电极的电荷存储装置的连续放电，以便产生包括纹波（14）的电流波形的至少一个相位。 波纹的高度小于相位峰值电流高度的三分之一。 当前波形具有与当前波形的治疗放电部分成一体的感测脉冲部分（10）。

公开(公告)号：WO1997038754A1

公开(公告)日：1997-10-23

申请号：PCT/US1997006003

申请日：1997-04-11

Applicant: SURVIVALINK CORPORATION

Inventor： SURVIVALINK CORPORATION ,  BREWER, James, E. ,  SWERDLOW, Charles, D.

IPC: A61N01/39

CPC classification number: A61N1/39 ,  A61N1/3906 ,  A61N1/3912

Abstract: A method and apparatus for delivering a truncated damped sinusoidal external defibrillation waveform, which when applied through aplurality of electrodes positioned on a patient's torso will produce a desired response in the patient's cardiac cell membranes, is provided. The external defibrillator is utilized for applying a damped sinusoidal waveform having a first waveform phase, and a second waveform phase to a pair of electrodes. The external defibrillator has a first capacitive component (C1), a first inductive component (L1), a first truncating switch, and waveform control circuitry. The waveform control circuitry of the defibrillator controls the first and second truncating switches, such that the duration of the second phase waveform delivered by the second charge storage component, is greater than the duration of the first phase waveform delivered by the first charge storage component.

Abstract translation: 提供截断的阻尼正弦外部除颤波形的方法和装置，其在通过位于患者躯干上的多个电极施加时将产生在患者的心脏细胞膜中的期望的响应。 外部除颤器用于向一对电极施加具有第一波形相位的阻尼正弦波形和第二波形相位。 外部除颤器具有第一电容分量（C1），第一电感分量（L1），第一截断开关和波形控制电路。 除颤器的波形控制电路控制第一和第二截断开关，使得由第二电荷存储部件传送的第二相位波形的持续时间大于由第一电荷存储部件传送的第一相位波形的持续时间。

公开(公告)号：WO2016058004A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/055330

申请日：2015-10-13

Applicant: RUSE TECHNOLOGIES, LLC ,  IDEKER, Raymond, E. ,  RUSE, Richard, B. ,  BOHANAN, Scott

Inventor： IDEKER, Raymond, E. ,  RUSE, Richard, B. ,  BOHANAN, Scott

IPC: A61H31/00

CPC classification number: A61N1/3906 ,  A61N1/046 ,  A61N1/0492 ,  A61N1/3625 ,  A61N1/39

Abstract: A method and apparatus for treating a cardiac condition in a human or animal patient comprises contacting an area of skin spanning the chest area of the patient with at least two patches or electrode paddles that apply low voltages and currents in a rotational manner to pre- stimulate that area, followed by applying a high voltage shock in rapid succession through the patient's heart through at least two electrode pad patches or paddles, wherein an amplifier-based external defibrillation cardioversion system is used. Also, an external pacing system is employed using ascending ramp or any arbitrary ascending or level waveform for transcutaneous pacing which employ a constant current delivery mode. Treatable conditions include atrial fibrillation (AF), atrial tachycardia (AT), ventricular fibrillation (VF), and ventricular tachycardia (VT).

Abstract translation: 用于治疗人或动物患者的心脏病症的方法和装置包括使穿过患者胸部区域的皮肤区域与至少两个以旋转方式施加低电压和电流的贴片或电极片接触以预刺激 然后通过患者的心脏通过至少两个电极垫片或桨片快速连续施加高电压冲击，其中使用基于放大器的外部除颤心脏复律系统。 此外，采用使用恒定电流传送模式的经皮起搏的上升斜坡或任意上升或电平波形使用外部起搏系统。 可治疗的病症包括心房颤动（房颤），房性心动过速（AT），室颤（VF）和室性心动过速（VT）。

公开(公告)号：WO2016058002A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/055314

申请日：2015-10-13

Applicant: RUSE TECHNOLOGIES, LLC

Inventor： IDEKER, Raymond, E. ,  RUSE, Richard, B. ,  BOHANAN, Scott

IPC: A61N1/362 ,  A61N1/368

CPC classification number: A61N1/3962 ,  A61N1/3906 ,  A61N1/3937 ,  A61N1/395 ,  A61N1/3987

Abstract: Cardiac defibrillation or cardioversion waveform energy control systems employ transvenous ICDs or subcutaneous SICDs for treating cardiac arrhythmias. The systems comprise differentially driven amplifier circuit operational modes to control the delivery of defibrillation or cardioversion electrical shocks, wherein the shock waveforms are constant current, constant voltage, or constant energy. Biphasic arbitrary shock waveforms deliver increasing and or level energy with increasing time as represented by phase 1 ascending ramp, ascending exponential, ascending chopped, ascending stepped, ascending curved, square, rectilinear or level and or any combination of geometric shaped ascending or level waveforms.

Abstract translation: 心脏除颤或心脏复律波形能量控制系统采用经静脉ICD或皮下SICD治疗心律失常。 该系统包括差分驱动的放大器电路操作模式以控制除颤或心脏复律电击的传递，其中冲击波形是恒定电流，恒定电压或恒定能量。 双相任意的冲击波形通过增加时间增加和/或增加能量，如第1阶段上升斜坡，上升指数，上升斩波，上升阶梯，上升曲线，平方，直线或水平以及或几何形状上升或电平波形的任何组合所表示的。

公开(公告)号：WO2015112893A1

公开(公告)日：2015-07-30

申请号：PCT/US2015/012743

申请日：2015-01-23

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： TANDRI, Harikrishna ,  BERGER, Ronald, David ,  WEINBERG, Seth ,  TUNG, Leslie ,  HALPERIN, Henry ,  HUNTER, David

IPC: A61N1/39

CPC classification number: A61N1/3962 ,  A61N1/06 ,  A61N1/3621 ,  A61N1/3624 ,  A61N1/3625 ,  A61N1/36514 ,  A61N1/3906 ,  A61N1/395 ,  A61N1/3956 ,  A61N1/3987

Abstract: The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.

Abstract translation: 本发明提供了用于终止心律失常的方法和装置，例如心室或心房快速性心律失常。 该装置和方法包括将交替电流（AC）在选定的治疗频率通过心脏组织施用于经历心律失常的受试者的临床显着持续时间。 还提供了减少或消除除颤期间的疼痛的方法。

公开(公告)号：WO2014160930A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/032163

申请日：2014-03-28

Applicant: GALVANI, LTD.

Inventor： KROLL, Mark, William

IPC: A61N1/39 ,  A61N1/362 ,  A61N1/365

CPC classification number: A61N1/3987 ,  A61N1/3906

Abstract: A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (MVT) adapted to reduce the side effects of MVT. The electrotherapy apparatus is configured to selectively deliver MVT to vectors not involving the ventricles and defibrillation therapy to vectors involving the ventricles. The apparatus can use biphasic waveforms configured to avoid capture of cardiac cells during MVT. The electrotherapy apparatus can minimize the risk of applying MVT at inappropriate times, such as during atrial fibrillation or where conventional ventricular tachycardia or ventricular fibrillation therapy is more appropriate.

Abstract translation: 一种多模式电疗装置，包括用于施用除颤治疗和用于施用适于减少MVT的副作用的中压治疗（MVT）的电路。 电疗设备被配置为选择性地将MVT递送到不涉及心室的矢量和除颤疗法到涉及心室的矢量。 该装置可以使用配置为避免在MVT期间捕获心脏细胞的双相波形。 电疗装置可以在不适当的时间（例如在心房颤动期间或在常规的室性心动过速或心室颤动疗法更合适的情况下）最小化应用MVT的风险。

公开(公告)号：WO2011163339A1

公开(公告)日：2011-12-29

申请号：PCT/US2011/041411

申请日：2011-06-22

Applicant: RAFAEL DEVELOPMENT CORPORATION LTD. ,  AZAR, Lazaro, Salomon ,  LIVNAT, Avi, Allon

Inventor： AZAR, Lazaro, Salomon ,  LIVNAT, Avi, Allon

IPC: A61N1/39

CPC classification number: A61N1/3925 ,  A61N1/39 ,  A61N1/3906 ,  A61N1/3918 ,  A61N1/3937 ,  A61N1/3956

Abstract: Devices, systems and methods relating to defibrillation and, more specifically, pulse parameters and electrode configurations for reducing patient discomfort are disclosed. Embodiments provide for an implantable defibrillator having an electrode lead system, at least one sensor for sensing a heart condition and emitting a condition signal, a controller in communication with the at least one sensor and configured to determine from the condition signal whether the heart is fibrillating and emitting a command signal if fibrillation is detected and a voltage generator communicating with the controller and the electrode system to communicate at least one defibrillation pulse to the electrode system, wherein the at least one defibrillation pulse includes at least one pulse having a voltage greater than 80 volts and a time duration up to 1000 microseconds.

Abstract translation: 公开了与除颤相关的装置，系统和方法，更具体地，公开了用于减少患者不适的脉冲参数和电极构造。 实施例提供了一种可植入除颤器，其具有电极引导系统，用于感测心脏状况和发出状况信号的至少一个传感器，与所述至少一个传感器通信的控制器，并且被配置为根据所述条件确定心脏是否原纤维化 并且如果检测到原纤维，则发出命令信号;以及电压发生器，其与所述控制器和所述电极系统通信以将至少一个除颤脉冲传送到所述电极系统，其中所述至少一个除颤脉冲包括至少一个电压大于 80伏特，持续时间长达1000微秒。

公开(公告)号：WO2009126642A8

公开(公告)日：2010-01-07

申请号：PCT/US2009039798

申请日：2009-04-07

Applicant: CARDIAC PACEMAKERS INC ,  SHUROS ALLAN CHARLES ,  ARCOT-KRISHNAMURTHY SHANTHA ,  LI DAN

Inventor： SHUROS ALLAN CHARLES ,  ARCOT-KRISHNAMURTHY SHANTHA ,  LI DAN

IPC: A61N1/39 ,  A61N1/365

CPC classification number: A61N1/3621 ,  A61N1/3906

Abstract: Embodiments of the invention are related to medical devices and methods for delivery high-energy anti-tachycardia therapy to a subject, amongst other things. In an embodiment, the invention includes a medical device including a controller module configured to administer a plurality of electrical pulses to a patient in response to a detected tachycardia, the electrical pulses comprising an amplitude of greater than 3 Volts and less than 40 Volts, the controller configured to modulate the amplitude of the electrical pulses. In an embodiment, the invention includes a method of treating a tachyarrhythmia including administering a first series of electrical pulses to a patient with an implantable medical device, the electrical pulses including an amplitude of greater than 8 Volts and less than 40 Volts, the first series of electrical pulses having an interval of less than about 600 ms in between individual pulses. Other embodiments are also included herein.

Abstract translation: 本发明的实施例涉及用于向对象递送高能抗心动过速疗法的医疗装置和方法。 在一个实施例中，本发明包括医疗装置，其包括控制器模块，其被配置为响应于检测到的心动过速向患者施加多个电脉冲，所述电脉冲包括大于3伏且小于40伏的振幅， 控制器被配置为调制电脉冲的幅度。 在一个实施方案中，本发明包括治疗快速性心律失常的方法，包括用可植入医疗装置向患者施用第一系列电脉冲，所述电脉冲包括大于8伏且小于40伏特的振幅，第一系列 在各个脉冲之间具有小于约600ms的间隔的电脉冲。 本文还包括其它实施例。

公开(公告)号：WO2009126642A2

公开(公告)日：2009-10-15

申请号：PCT/US2009/039798

申请日：2009-04-07

Applicant: CARDIAC PACEMAKERS, INC ,  SHUROS, Allan, Charles ,  ARCOT-KRISHNAMURTHY, Shantha ,  LI, Dan

Inventor： SHUROS, Allan, Charles ,  ARCOT-KRISHNAMURTHY, Shantha ,  LI, Dan

IPC: A61N1/39 ,  A61N1/365

CPC classification number: A61N1/3621 ,  A61N1/3906

Abstract: A solution for performing a data correction on a hierarchical integrated circuit layout is provided. A method includes: receiving a CD compensation map for the long range critical dimension variation prior to the data correction; grouping compensation amounts of the CD compensation into multiple compensation ranges; generating multiple target layers corresponding to the multiple compensation ranges; super-imposing a region of the CD compensation map having a compensation amount falling into a compensation range over a respective target layer to generate a target shape; performing the data correction on the layout to generate a data corrected layout; performing the data correction on the target shape separately to generate a data corrected target shape; and combining the data corrected layout and the data corrected target shape based on the CD compensation map.

Abstract translation: 提供了一种用于在分层集成电路布局上执行数据校正的解决方案。 一种方法包括：在数据校正之前接收用于长距离临界尺寸变化的CD补偿图; 将CD补偿的补偿量分组为多个补偿范围; 产生对应于多个补偿范围的多个目标层; 超级CD补偿图的区域具有落在相应目标层上的补偿范围内的补偿量以产生目标形状; 在布局上执行数据校正以生成数据校正布局; 分别对目标形状进行数据校正，生成数据校正对象形状; 并且基于CD补偿图组合数据校正布局和数据校正目标形状。

公开(公告)号：WO2007109076A1

公开(公告)日：2007-09-27

申请号：PCT/US2007/006489

申请日：2007-03-14

Applicant: BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

IPC: A61N1/08 ,  A61N1/36 ,  A61N1/362

CPC classification number: A61N1/3615 ,  A61N1/36167 ,  A61N1/362 ,  A61N1/3787 ,  A61N1/3906

Abstract: A medical apparatus, for artificially stimulating internal tissue of an animal, applies a composite voltage pulse to a pair of electrodes implanted in the animal. The composite voltage pulse is formed by a first segment and a second segment contiguous with the first segment, both of which have generally rectangular shapes. The amplitude of the first segment is significantly greater than, e.g. at least three times, the amplitude of the second segment. However, the second segment has a significantly longer duration than the first segment, e.g. at least three times longer. Preferably the integrals of the first and second segments are substantially equal.

Abstract translation: 用于人造刺激动物的内部组织的医疗装置将复合电压脉冲施加到植入动物体内的一对电极。 复合电压脉冲由第一段和与第一段邻接的第二段形成，它们都具有大致矩形形状。 第一段的幅度显着大于例如 至少三次，第二段的幅度。 然而，第二段具有比第一段显着更长的持续时间，例如。 至少三倍以上。 优选地，第一和第二段的积分基本相等。