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    APPARATUS FOR APPLYING ELECTRIC PULSES TO LIVING MYOCARDIAL TISSUE
    3.
    发明申请
    APPARATUS FOR APPLYING ELECTRIC PULSES TO LIVING MYOCARDIAL TISSUE 审中-公开
    将电脉冲应用于活体心肌组织的装置

    公开(公告)号：WO2017157954A1

    公开(公告)日：2017-09-21

    申请号：PCT/EP2017/056021

    申请日：2017-03-14

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

    Inventor： SCHLEMMER, Alexander ,  LILIENKAMP, Thomas ,  BERG, Sebastian ,  PARLITZ, Ulrich ,  LUTHER, Stefan

    IPC: A61N1/05 ,  A61N1/365 ,  A61B5/0402 ,  A61B5/04 ,  A61B5/0464 ,  A61N1/362

    CPC classification number: A61N1/3621 ,  A61B5/04012 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/056 ,  A61N1/365 ,  A61N1/3704

    Abstract: An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input receiving an electric signal representing a present electric activity of the myocardial tissue; a signal processor (11) processing the electric signal to determine a measure of the present complexity of the electric signal in the state space and to output a control signal (13) when the complexity measure is lower than a predetermined complexity threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.

    Abstract translation: 用于向活体心肌组织施加至少一个电脉冲的设备包括：接收表示心肌组织的当前电活动的电信号的输入; 信号处理器（11），其处理电信号以确定状态空间中电信号的当前复杂度的量度并且当复杂度量度低于预定复杂度阈值时输出控制信号（13）; 脉冲发生器，被配置为响应于所述控制信号而生成所述至少一个电脉冲; 以及被配置为将所述至少一个电脉冲输出到心肌组织的输出。

    EXTRA-CARDIOVASCULAR PACING BY AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR
    4.
    发明申请
    EXTRA-CARDIOVASCULAR PACING BY AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR 审中-公开
    可植入式心脏除颤器的心脏外血管起搏

    公开(公告)号：WO2017096143A1

    公开(公告)日：2017-06-08

    申请号：PCT/US2016/064582

    申请日：2016-12-02

    Applicant: MEDTRONIC, INC.

    Inventor： ANDERSON, David A. ,  MARSHALL, Mark T. ,  NIKOLSKI, Vladimir P. ,  SAWCHUK, Robert T. ,  THOMPSON-NAUMAN, Amy E. ,  WAHLSTRAND, John D. ,  YOUNKER, Gregory A.

    IPC: A61N1/39 ,  A61N1/37 ,  A61N1/05

    CPC classification number: A61N1/3962 ,  A61N1/0587 ,  A61N1/3621 ,  A61N1/3706 ,  A61N1/371 ,  A61N1/3712 ,  A61N1/3758 ,  A61N1/3925 ,  A61N1/3987

    Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) having a low voltage therapy module and a high voltage therapy module is configured to select, by a control module of the ICD, a pacing output configuration from at least a low-voltage pacing output configuration of the low voltage therapy module and a high-voltage pacing output configuration of the high voltage therapy module. The high voltage therapy module includes a high voltage capacitor having a first capacitance and the low voltage therapy module includes a plurality of low voltage capacitors each having up to a second capacitance that is less than the first capacitance. The ICD control module controls a respective one of the low voltage therapy module or the high voltage therapy module to deliver extra-cardiovascular pacing pulses in the selected pacing output configuration via extra-cardiovascular electrodes coupled to the ICD.

    Abstract translation: 具有低电压治疗模块和高电压治疗模块的额外心血管植入式心脏复律除颤器（ICD）被配置为由ICD的控制模块选择至少一个起搏输出配置 低电压治疗模块的低电压起搏输出配置和高电压治疗模块的高电压起搏输出配置。 高电压治疗模块包括具有第一电容的高电压电容器，并且低电压治疗模块包括多个低电压电容器，每个低电压电容器具有小于第一电容的第二电容。 ICD控制模块控制低电压治疗模块或高电压治疗模块中的相应一个以经由耦合到ICD的额外心血管电极以选定的起搏输出配置传递心外心跳起搏脉冲。

    SYSTEMS AND METHODS FOR TREATING CARDIAC ARRHYTHMIAS
    5.
    发明申请
    SYSTEMS AND METHODS FOR TREATING CARDIAC ARRHYTHMIAS 审中-公开
    用于治疗心脏病的系统和方法

    公开(公告)号：WO2015191886A3

    公开(公告)日：2016-04-07

    申请号：PCT/US2015035378

    申请日：2015-06-11

    Applicant: CARDIAC PACEMAKERS INC

    Inventor： STAHMANN JEFFREY E ,  MAILE KEITH R ,  KANE MICHAEL J ,  LINDER WILLIAM J ,  SIMMS HOWARD D

    IPC: A61N1/372 ,  A61B5/00 ,  A61B5/0464 ,  A61N1/375 ,  A61N1/39

    CPC classification number: A61N1/3962 ,  A61B5/0464 ,  A61B5/4836 ,  A61N1/3621 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/3756 ,  A61N1/3987

    Abstract: Systems and methods for coordinating treatment of abnormal heart activity using multiple implanted devices within a patient. In one example, a leadless cardiac pacemaker (LCP) may receive signals related to one or more physiological conditions of a patient, wherein the LCP may be configured to deliver ATP therapy to a heart. The LCP may also be configured, based at least in part on the received signals, to detect an arrhythmia. In response to detecting an arrhythmia, the LCP may determine whether to deliver ATP therapy to the heart. If the LCP determines to deliver ATP therapy, the LCP may deliver ATP therapy to the heart.

    Abstract translation: 使用患者内的多个植入装置协调异常心脏活动治疗的系统和方法。 在一个示例中，无引线心脏起搏器（LCP）可以接收与患者的一个或多个生理状况相关的信号，其中所述LCP可被配置为向心脏递送ATP治疗。 至少部分地基于所接收的信号也可以配置LCP以检测心律失常。 响应于检测心律失常，LCP可以确定是否向心脏递送ATP治疗。 如果LCP决定提供ATP治疗，LCP可以向心脏递送ATP治疗。

    AUTOMATED ANALYSIS OF MULTI-LEAD ELECTROCARDIOGRAM DATA TO IDENTIFY THE EXIT SITES OF PHYSIOLOGICAL CONDITIONS
    7.
    发明申请
    AUTOMATED ANALYSIS OF MULTI-LEAD ELECTROCARDIOGRAM DATA TO IDENTIFY THE EXIT SITES OF PHYSIOLOGICAL CONDITIONS 审中-公开
    自动分析多领导电子数据以识别生理条件的出境地点

    公开(公告)号：WO2014055980A1

    公开(公告)日：2014-04-10

    申请号：PCT/US2013/063700

    申请日：2013-10-07

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： BOGUN, Frank ,  SCOTT, Clayton ,  HERO, Alfred ,  LIU, Tzu-yu

    IPC: A61B5/0402 ,  A61B5/0452

    CPC classification number: A61B5/0464 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/7485 ,  A61N1/3621

    Abstract: Techniques identify origins of ventricular arrhythmias (e.g., ventricular tachycardia or premature ventricular complexes) including exit sites or other sites using a single or multi- lead electrocardiogram (ECG) assembly. The ECG assembly is used to map an organ into a series of different three-dimensional (3D) regions. Pace maps or ventricular arrhythmia signals are used in form of ECG signals along with a supervised learning methods to pinpoint the potential origin of VT, i.e., exit sites, in the various regions.

    Abstract translation: 技术使用单导联或多导联心电图（ECG）组件来识别包括出口部位或其他部位的室性心律失常（例如室性心动过速或早发性心室复合体）的起源。 ECG组件用于将器官映射成一系列不同的三维（3D）区域。 心律图或心室心律失常信号以心电图信号的形式和监督学习方法一起使用，以确定各种区域中VT的潜在起源，即出口部位。

    MULTI-MODAL ELECTROTHERAPY METHOD AND APPARATUS
    9.
    发明申请
    MULTI-MODAL ELECTROTHERAPY METHOD AND APPARATUS 审中-公开
    多模式电疗方法和装置

    公开(公告)号：WO2013020135A1

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/049765

    申请日：2012-08-06

    Applicant: GALVANI LTD. ,  KROLL, Mark, William

    Inventor： KROLL, Mark, William

    IPC: A61N1/39 ,  A61N1/362 ,  A61N1/378

    CPC classification number: A61N1/3975 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3782 ,  A61N1/3962 ,  A61N1/3981

    Abstract: A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (MVT). A combined-use capacitor bank of at least one capacitor stores energy to be administered as defibrillation therapy and MVT. Combined-use discharge circuitry electrically is coupled between the combined-use capacitor bank and patient terminals for selectively administering energy from the capacitor bank according to a plurality of controllable waveforms as either defibrillation therapy or MVT. A controller is configured to cause the discharge circuitry to apply the MVT from the capacitor bank while the capacitor bank undergoes charging in preparation for administration of the defibrillation therapy.

    Abstract translation: 一种多模式电疗装置，包括用于施用除颤疗法和用于中压治疗（MVT）的电路。 至少一个电容器的组合使用的电容器组存储作为除颤疗法和MVT施用的能量。 组合使用的放电电路电耦合在组合使用的电容器组和患者端子之间，用于根据作为除颤治疗或MVT的多个可控波形从电容器组选择性地施加能量。 控制器被配置为使得放电电路从电容器组施加MVT，同时电容器组进行充电以准备施用除颤疗法。

    TECHNIQUES FOR DETERMINING MORPHOLOGICAL STABILITY OF CARDIAC CYCLES
    10.
    发明申请
    TECHNIQUES FOR DETERMINING MORPHOLOGICAL STABILITY OF CARDIAC CYCLES 审中-公开
    用于确定心脏循环的形态稳定性的技术

    公开(公告)号：WO2012154489A1

    公开(公告)日：2012-11-15

    申请号：PCT/US2012/036285

    申请日：2012-05-03

    Applicant: MEDTRONIC, INC. ,  GHOSH, Subham ,  GILLBERG, Jeffrey M.

    Inventor： GHOSH, Subham ,  GILLBERG, Jeffrey M.

    IPC: A61B5/04 ,  A61B5/0452 ,  A61N1/362

    CPC classification number: A61B5/686 ,  A61B5/04012 ,  A61B5/0452 ,  A61N1/3621

    Abstract: A medical device, comprising: a memory; and a processing module configured to retrieve electrogram (EGM) data for N cardiac cycles from the memory, wherein N is an integer greater than 1, categorize each of the N cardiac cycles into one of a plurality of categories based on a morphology of the N cardiac cycles, perform comparisons be¬ tween pairs of the N cardiac cycles, each of the comparisons between two cardiac cycles comprising: detecting a mismatch between the two cardiac cycles when the two cardiac cycles are in different categories; and detecting a match between the two cardiac cycles when the two cardiac cycles are in the same category, wherein the processing module is further configured to classify the rhythm of the N cardiac cycles based on a number of detected matches and detected mismatches.

    Abstract translation: 一种医疗装置，包括：存储器; 以及处理模块，被配置为从存储器中检索N个心动周期的电描记图（EGM）数据，其中N是大于1的整数，基于N的形态将N个心动周期中的每一个分类为多个类别 心动周期，执行N个心动周期对之间的比较，两个心动周期之间的每个比较包括：当两个心动周期处于不同类别时，检测两个心动周期之间的失配; 以及当所述两个心动周期处于相同类别时，检测所述两个心动周期之间的匹配，其中所述处理模块还被配置为基于检测到的匹配的数量和检测到的错配来对所述N个心动周期的节律进行分类。

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