公开(公告)号：WO2016093804A1

公开(公告)日：2016-06-16

申请号：PCT/US2014/069299

申请日：2014-12-09

Applicant: SHAPIRO, Ronald, S. ,  SUTTON, David, B.

Inventor： SHAPIRO, Ronald, S. ,  SUTTON, David, B.

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61B2018/00642 ,  A61B2018/00815 ,  A61B2018/00839 ,  A61F7/007 ,  A61F2007/0071 ,  A61N7/00 ,  A61N2005/0626 ,  A61N2005/0629 ,  A61N2005/0643 ,  A61N2005/0644 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2007/0026

Abstract: An apparatus includes a housing having a treatment surface, a light source disposed adjacent the treatment surface and configured to emit dynamic photonic energy, a thermal element disposed adjacent the treatment surface and configured to emit dynamic thermal kinetic energy, and a controller disposed in the housing, the controller in communication with the light source and the thermal element to vary a plurality of parameters of the light source and the thermal element to control the characteristics of the dynamic photonic energy and the dynamic thermal kinetic energy emitted thereby. The treatment surface can house a variety of sensors that can capture a variety of physical and chemical data. The apparatus can also in include a positioning element to assist a user in positioning the apparatus on a subject. The apparatus can also include a security element to manage the use and accessibility of the apparatus.

Abstract translation: 一种装置包括具有处理表面的壳体，邻近处理表面设置并被配置为发射动态光子能的光源，邻近处理表面设置并被配置为发射动态热动能的热元件，以及设置在壳体中的控制器 控制器与光源和热元件通信以改变光源和热元件的多个参数，以控制动态光子能量的特性和由此发射的动态光动能。 处理表面可容纳可以捕获各种物理和化学数据的各种传感器。 该装置还可以包括定位元件以帮助用户将该装置定位在被摄体上。 该设备还可以包括用于管理设备的使用和可访问性的安全元​​件。

公开(公告)号：WO2016075544A2

公开(公告)日：2016-05-19

申请号：PCT/IB2015/002313

申请日：2015-11-14

Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

Inventor： ROTHMAN, Martin ,  COATES, Paul

IPC: A61B18/14 ,  A61B18/02 ,  G01R5/26

CPC classification number: A61B18/1492 ,  A61B18/0206 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/0025 ,  A61B2018/00255 ,  A61B2018/00267 ,  A61B2018/00279 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/1407 ,  A61B2090/3966 ,  A61B2218/002 ,  A61N2007/0026 ,  G01R5/26

Abstract: Devices, systems, and methods for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

Abstract translation: 本文公开了用于选择性定位血管内神经调节装置的装置，系统和方法。 这样的系统可以包括例如由细长轴的远端部分承载的细长轴和治疗组件。 治疗组件被配置为在血管内输送。 治疗组件可以包括预成形的形状，并且可以在基本上直的输送构型之间变形; 以及具有预先形成的螺旋形状以将治疗组件定位成与身体血管的壁稳定接触的治疗构型。 治疗组件还可以包括可操作地连接到治疗组件的机械解耦器，其被构造成通过轴吸收施加在治疗组件上的力的至少一部分，使得治疗组件相对于目标部位保持大致静止的位置 。

公开(公告)号：WO2016069178A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/053142

申请日：2015-09-30

Applicant: HIGHLAND INSTRUMENTS, INC. ,  WAGNER, Timothy Andrew ,  EDELMAN, William ,  DIPIETRO, Laura ,  MULHAUSER, Paul James ,  LEE, Kyungmin, Andy

Inventor： WAGNER, Timothy Andrew ,  EDELMAN, William ,  DIPIETRO, Laura ,  MULHAUSER, Paul James ,  LEE, Kyungmin, Andy

IPC: A61N2/00 ,  A61N7/00 ,  A61B18/00

CPC classification number: A61B90/39 ,  A61B2090/3937 ,  A61B2090/502 ,  A61N1/0456 ,  A61N1/0472 ,  A61N1/0484 ,  A61N7/00 ,  A61N2007/0021 ,  A61N2007/0026 ,  F16M13/04

Abstract: The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.

Abstract translation: 本发明总体上涉及一种具有解剖标记的可调头盔及其使用方法。 在某些实施例中，本发明提供了一种装置，其包括构造成佩戴在使用者的头部上的头盔。 头盔包括至少第一插座，其被配置为接收和保持第一能量源，并且头戴装置可在至少一个方向上调节。 至少有一个解剖标记物连接在头盔上。 以这种方式，基于至少一个解剖标志物与其指定的解剖结构的对准，容器的位置可以可调节地对准头部中的神经组织的区域。

公开(公告)号：WO2015149170A1

公开(公告)日：2015-10-08

申请号：PCT/CA2015/050249

申请日：2015-03-31

Applicant: FUNCTIONAL NEUROMODULATION, INC.

Inventor： REYMERS, Donald E. ,  RISE, Mark ,  O'CONNELL, Daniel J. ,  FLAHERTY, R. Maxwell ,  FLAHERTY, J. Christopher

IPC: A61N1/372 ,  A61B19/00 ,  A61B5/00 ,  A61N1/36 ,  A61N2/00

CPC classification number: A61N1/36082 ,  A61B5/0008 ,  A61B5/021 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/4064 ,  A61B6/032 ,  A61B6/037 ,  A61B8/4245 ,  A61B2576/026 ,  A61M5/14276 ,  A61N1/0534 ,  A61N1/36017 ,  A61N2/006 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/00 ,  A61N2005/0612 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2007/0026

Abstract: Systems and methods for treating a cognitive disease or disorder are provided. A treatment method comprises: selecting a target volume of brain tissue to be stimulated; identifying at least one avoidance volume of brain tissue; selecting a first stimulation lead comprising at least one stimulation element; identifying at least one proposed trajectory for placement of the first stimulation lead based on the target volume and the at least one avoidance volume; placing the first stimulation lead along a placement trajectory selected from the at least one proposed trajectory; attaching the first stimulation lead to a stimulator; and stimulating the target volume with the first stimulation lead at least one stimulation element to treat at least one of a cognitive disease or a cognitive disorder. Systems include a stimulator with one or more stimulation leads and an image analyzer for identifying a proposed trajectory for placing the stimulation leads.

Abstract translation: 提供了用于治疗认知疾病或病症的系统和方法。 治疗方法包括：选择要刺激的脑组织的靶体积; 鉴定至少一个避免体积的脑组织; 选择包括至少一个刺激元件的第一刺激引线; 基于所述目标体积和所述至少一个回避体积识别用于放置所述第一刺激引线的至少一个所提出的轨迹; 将第一刺激引线沿着从至少一个所提出的轨迹中选择的放置轨迹放置; 将第一刺激引线附接到刺激器; 并且用第一刺激引线刺激目标体积至少一个刺激元件以治疗认知疾病或认知障碍中的至少一种。 系统包括具有一个或多个刺激引线的刺激器和用于识别用于放置刺激引线的所提出的轨迹的图像分析器。

公开(公告)号：WO2015138410A1

公开(公告)日：2015-09-17

申请号：PCT/US2015/019638

申请日：2015-03-10

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： REZAI, Ali, R. ,  DEOGAONKAR, Milind

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/34

CPC classification number: A61N1/36071 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/36021 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/403 ,  A61N7/00 ,  A61N2007/0026

Abstract: One aspect of the present disclosure relates to a method for treating fibromyalgia. One step of the method can include placing a therapy delivery device into electrical communication with a parasympathetic nervous system (PNS) nerve target, other than the vagus nerve, which is associated with the fibromyalgia. Next, the therapy delivery device can be activated to deliver a therapy signal to the PNS nerve target in an amount and for a time sufficient to effect a change in parasympathetic activity in the subject and thereby treat the fibromyalgia.

Abstract translation: 本公开的一个方面涉及治疗纤维肌痛的方法。 该方法的一个步骤可以包括将治疗递送装置置于与与纤维肌痛有关的迷走神经以外的副交感神经系统（PNS）神经靶电气通信。 接下来，可以激活治疗递送装置以将治疗信号传递给PNS神经靶标，其量足以使受试者中副交感神经活动发生变化，从而治疗纤维肌痛。

公开(公告)号：WO2015130124A1

公开(公告)日：2015-09-03

申请号：PCT/KR2015/001918

申请日：2015-02-27

Applicant: 주식회사 엠에스피

Inventor： 박문서

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0042 ,  A61B5/0077 ,  A61B5/055 ,  A61B5/6803 ,  A61B6/032 ,  A61B6/501 ,  A61B8/4209 ,  A61B90/39 ,  A61B2034/2055 ,  A61B2090/3937 ,  A61N2007/0026 ,  A61N2007/0091

Abstract: 본 발명에 따른 헬멧형 저강도 초음파 집속 자극장치는 호형으로 형성되고, 종방향으로 구비되는 제1 가이드부; 호형으로 형성되고, 상기 제1 가이드부와 직교하도록 횡방향으로 연결되는 제2 가이드부; 상기 제2 가이드부에 연결되고, 내측방향으로 진행하는 초음파를 생성하는 트랜스 듀서를 포함하는 초음파 모듈; 및 이용자의 두부에 착용되고, 상기 제1 가이드부가 고정되며, 상기 제2 가이드부의 양단부가 회동가능하도록 고정되는 지지부;를 포함하고, 상기 제2 가이드부는 일 지점이 상기 제1 가이드부를 따라 가이드되어 종방향으로 회동하고, 상기 트랜스 듀서는 상기 제2 가이드부를 따라 횡방향으로 이동가능하다.

Abstract translation: 根据本发明的头盔式低强度聚焦超声波刺激装置包括：形成为弧形并沿纵向设置的第一引导部分; 第二引导部，其形成为弧形，并且在横向方向上与第一引导部垂直; 超声模块，其连接到所述第二引导部，并且包括用于产生朝向内侧方向移动的超声波的换能器; 以及支撑部，其被佩戴在使用者的头部上，并且所述第一引导部被固定并且所述第二引导部的两端部旋转地固定到所述支撑部，所述第二引导部通过允许一个点 其沿着第一引导部被引导，并且换能器能够沿着第二引导部在横向方向上移动。

公开(公告)号：WO2015057411A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/059174

申请日：2014-10-03

Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

Inventor： MCCAFFREY, Gerry ,  O'CONNELL, Barry

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B2017/22055 ,  A61B2017/22068 ,  A61B2017/22071 ,  A61B2018/00029 ,  A61B2018/00166 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00648 ,  A61B2018/00666 ,  A61B2018/00791 ,  A61B2018/00827 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2090/064 ,  A61N7/022 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0043 ,  A61N2007/0065 ,  A61N2007/0073

Abstract: Devices, systems, and methods for the selective positioning of an intravascular ultrasound neuromodulation device are disclosed herein. One aspect of the present technology is directed to positioning systems for focused ultrasound devices. Some embodiments, for example, are directed to dual-balloon positioning systems. Such systems can include, for example, an elongated shaft and a therapeutic assembly and a balloon assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The balloon assembly can include a first balloon and a second balloon circumferentially offset from the first balloon about the elongated shaft. The first and second balloons can be selectively inflated to position an ultrasound transducer of the therapeutic assembly at a precise location within the blood vessel.

Abstract translation: 本文公开了用于选择性定位血管内超声神经调节装置的装置，系统和方法。 本技术的一个方面涉及用于聚焦超声装置的定位系统。 例如，一些实施例涉及双气囊定位系统。 这样的系统可以包括例如细长轴和治疗组件以及由细长轴的远端部分承载的球囊组件。 治疗组件被配置为在血管内输送。 球囊组件可以包括第一球囊和第二球囊，其围绕细长轴从第一球囊周向偏移。 第一和第二气囊可以选择性地膨胀以将治疗组件的超声换能器定位在血管内的精确位置。

公开(公告)号：WO2014163740A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/014208

申请日：2014-01-31

Applicant: PASSY-MUIR, INC.

Inventor： LUDLOW, Christy, Leslie ,  HOOD, Larry, Lee

IPC: A61H23/00

CPC classification number: A61H23/00 ,  A61B5/0205 ,  A61H9/0078 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/10 ,  A61H2201/102 ,  A61H2201/1609 ,  A61H2201/165 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5041 ,  A61H2201/5043 ,  A61H2201/5084 ,  A61H2201/5097 ,  A61H2205/04 ,  A61H2230/065 ,  A61H2230/201 ,  A61H2230/208 ,  A61H2230/305 ,  A61H2230/405 ,  A61N1/36014 ,  A61N5/0622 ,  A61N2005/067 ,  A61N2007/0026

Abstract: A device includes a first vibrational transducer and a second vibrational transducer. The first vibrational transducer has a first vibrating property. The second vibrotactile stimulator has a second vibrating property different than the first vibrating property. A collar may be configured to position the first vibrational transducer and the second vibrational transducer over a neck of a subject. A method for stimulating swallowing in a subject includes applying a first vibrotactile stimulation and applying a second vibrotactile stimulation to a throat area of the subject. The first vibrotactile stimulation has a first vibrating property and the second vibrotactile stimulation has a second vibrating property different than the first vibrating property. Example vibrating properties include vibrating frequency, vibrating frequency range, wave shape, continuousness, frequency phase, and direction of mechanical force.

Abstract translation: 一种装置包括第一振动换能器和第二振动换能器。 第一振动传感器具有第一振动特性。 第二振动触觉刺激器具有与第一振动特性不同的第二振动特性。 套环可以被配置成将第一振动换能器和第二振动换能器定位在受试者的颈部上。 用于刺激受试者吞咽的方法包括施加第一振动刺激刺激并对受试者的喉部区域施加第二振动刺激刺激。 第一振动触觉刺激具有第一振动特性，第二振动触觉刺激具有与第一振动特性不同的第二振动特性。 振动特性包括振动频率，振动频率范围，波形，连续性，频率相位和机械力方向。

公开(公告)号：WO2014130960A1

公开(公告)日：2014-08-28

申请号：PCT/US2014/018061

申请日：2014-02-24

Applicant: THYNC, INC.

Inventor： WETMORE, Daniel, Z. ,  GOLDWASSER, Isy ,  CHARLESWORTH, Jonathan ,  PAL, Sumon, K. ,  TYLER, William, J. ,  SATO, Tomokazu

IPC: H04L29/12 ,  A61N1/00

CPC classification number: A61N1/36014 ,  A61B5/0006 ,  A61B5/4058 ,  A61N1/36025 ,  A61N7/00 ,  A61N2007/0026 ,  A61N2007/0078 ,  H04L61/2015 ,  H04L61/6022

Abstract: Networkable transcranial neuromodulation apparatuses adapted for safely and effectively applying neuromodulation, including apparatuses adapted for coordination with a group of other individuals, as well as methods for securely and effectively applying neuromodulation, including coordinated neuromodulation.

Abstract translation: 适用于安全有效地应用神经调节的可网络经颅神经调节装置，包括适于与一组其他个体协调的装置，以及安全有效地应用神经调节的方法，包括协调的神经调节。

公开(公告)号：WO2014071386A1

公开(公告)日：2014-05-08

申请号：PCT/US2013/068538

申请日：2013-11-05

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  CABRERA, Jesus Arturo ,  BALLARD, John R. ,  KROCAK, James C. ,  PAUL, Saurav

Inventor： CABRERA, Jesus Arturo ,  BALLARD, John R. ,  KROCAK, James C. ,  PAUL, Saurav

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B8/4281 ,  A61B2018/00839 ,  A61H31/00 ,  A61H2031/002 ,  A61H2230/405 ,  A61N2007/0026 ,  A61N2007/0078 ,  A61N2007/0095

Abstract: A system for diaphragmatic pacing includes an ultrasonic transducer and a control module. The ultrasonic transducer has an emitting surface. The emitting surface is configured to couple with a tissue of a patient. The transducer is configured to transdermally emit ultrasonic energy and induce movement in a thoracic diaphragm of the patient in response thereto. The control module is coupled to the transducer and has a processor. The processor is configured to execute an algorithm to control operation of the transducer.

Abstract translation: 用于膈肌起搏的系统包括超声换能器和控制模块。 超声波换能器具有发射表面。 发射表面被配置为与患者的组织联接。 换能器被配置为经皮发射超声波能量并且响应于该能量诱导患者的胸膜中的运动。 控制模块耦合到换能器并具有处理器。 处理器被配置为执行算法来控制换能器的操作。