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    SYSTEMS AND METHODS FOR ASSESSING THE EFFICACY OF NEUROMODULATION THERAPY
    1.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING THE EFFICACY OF NEUROMODULATION THERAPY 审中-公开

    公开(公告)号：WO2019147506A1

    公开(公告)日：2019-08-01

    申请号：PCT/US2019/014360

    申请日：2019-01-18

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. ,  NEIDERT, Michael

    Inventor： NEIDERT, Michael ,  COATES, Paul ,  MELDER, Robert, L.

    IPC: A61B18/14 ,  A61B1/313 ,  A61B18/00 ,  A61B5/02 ,  A61B5/00 ,  A61B5/107

    Abstract: Systems and methods for performing and assessing neuromodulation therapy are disclosed herein. One method for assessing the efficacy of neuromodulation therapy includes positioning a neuromodulation catheter at a target site within a renal blood vessel of a human patient and delivering neuromodulation energy at the target site with the neuromodulation catheter. The method can further include obtaining a measurement related to a dimension of the renal blood vessel via a sensing element of the neuromodulation catheter. The measurement can be compared to a baseline measurement related to the dimension of the renal blood vessel to assess the efficacy of the neuromodulation therapy. In some embodiments, the baseline measurement is obtained via the sensing element of the neuromodulation catheter prior to delivering the neuromodulation energy.

    SYSTEMS AND METHODS FOR MONITORING AND EVALUATING NEUROMODULATION THERAPY
    2.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING AND EVALUATING NEUROMODULATION THERAPY 审中-公开
    用于监测和评估神经调节疗法的系统和方法

    公开(公告)号：WO2017136362A1

    公开(公告)日：2017-08-10

    申请号：PCT/US2017/015887

    申请日：2017-01-31

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

    Inventor： TRUDEL, Julia ,  HETTRICK, Douglas

    IPC: A61B5/00 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/053 ,  A61B5/01 ,  A61B5/20 ,  G06F19/00 ,  A61N1/36

    CPC classification number: A61B5/4848 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0285 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/6851 ,  A61B5/7232 ,  A61B18/1492 ,  A61B2018/00577 ,  A61M25/0026 ,  A61N1/3606 ,  A61N1/36114 ,  A61N5/045 ,  A61N5/0622 ,  A61N7/02 ,  A61N2007/0026 ,  G06F19/00 ,  G06F19/34

    Abstract: Systems and methods for informing and evaluating neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a guidewire having a proximal portion, a distal portion configured to be positioned at a target site in a blood vessel of a human patient, and a sensing element positioned along the distal portion. The sensing element can be a pressure sensing element, a flow sensing element, an impedance sensing element, and/or a temperature sensing element. The system can further include a controller configured to obtain one or more measurements related to a physiological parameter of the patient via the sensing element. Based on the measurements, the controller can determine the physiological parameter and compare the parameter to a predetermined threshold. Based on the comparison, the controller and/or the operator can assess the likelihood of the patient benefitting from neuromodulation therapy.

    Abstract translation: 本文公开了用于通知和评估神经调节疗法的系统和方法。 根据本技术的实施例配置的系统可以包括例如导丝，该导丝具有近侧部分，被配置为定位在人类患者的血管中的目标位置处的远侧部分以及沿着 远端部分。 感测元件可以是压力感测元件，流量感测元件，阻抗感测元件和/或温度感测元件。 该系统还可以包括控制器，该控制器被配置为经由感测元件获得与患者的生理参数有关的一个或多个测量值。 基于测量结果，控制器可以确定生理参数并将该参数与预定阈值进行比较。 基于比较，控制器和/或操作员可以评估患者从神经调节疗法中受益的可能性。

    CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS
    4.
    发明申请
    CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 审中-公开
    具有增强灵活性的导管及相关装置，系统和方法

    公开(公告)号：WO2015113027A3

    公开(公告)日：2015-07-30

    申请号：PCT/US2015/013029

    申请日：2015-01-27

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

    Inventor： BEASLEY, Rudy ,  DHAMODHARASAMY, Rajesh ,  GOSHGARIAN, Justin ,  KU, Vincent ,  NASIT, Bhavin

    IPC: A61B18/14 ,  A61M25/00

    Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

    Abstract translation: 神经调节导管包括细长轴和神经调节元件。 所述轴包括沿着围绕所述轴的纵向轴线延伸的螺旋路径的两个或更多个第一切割形状和两个或更多个第二切割形状。 第一切割形状被构造成至少部分地抵抗响应于轴上的纵向压缩和张力以及轴上的第一圆周方向上的扭转而产生的变形。 第二切割形状构造成至少部分地抵抗响应于轴上的纵向压缩和轴上的第一和第二相反周向方向上的扭转而产生的变形。

    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS
    5.
    发明申请
    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    用于调节与脉冲系统和相关系统和方法的通信中的神经网络的导管装置

    公开(公告)号：WO2015061624A1

    公开(公告)日：2015-04-30

    申请号：PCT/US2014/062060

    申请日：2014-10-23

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

    Inventor： ROTHMAN, Martin ,  GOSHGARIAN, Justin ,  CHANG, William

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1495

    Abstract: Devices, systems, and methods for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

    Abstract translation: 本文公开了用于选择性定位血管内神经调节装置的装置，系统和方法。 这样的系统可以包括例如由细长轴的远端部分承载的细长轴和治疗组件。 治疗组件被配置为在血管内输送。 治疗组件可以包括预成形的形状，并且可以在基本上直的输送构型之间变形; 以及具有预先形成的螺旋形状以将治疗组件定位成与身体血管的壁稳定接触的治疗构型。 治疗组件还可以包括可操作地连接到治疗组件的机械解耦器，其被构造成通过轴吸收施加在治疗组件上的力的至少一部分，使得治疗组件相对于目标部位保持大致静止的位置 。

    ENDOVASCULAR CATHETERS WITH TUNED CONTROL MEMBERS AND ASSOCIATED SYSTEMS AND METHODS
    7.
    发明申请
    ENDOVASCULAR CATHETERS WITH TUNED CONTROL MEMBERS AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    具有调节控制成员和相关系统和方法的内腔导管

    公开(公告)号：WO2015038418A1

    公开(公告)日：2015-03-19

    申请号：PCT/US2014/054200

    申请日：2014-09-05

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

    Inventor： KU, Vincent ,  WU, Andrew

    IPC: A61B18/14 ,  A61M25/00

    CPC classification number: A61N1/28 ,  A61B18/1492 ,  A61B2017/00309 ,  A61B2017/00323 ,  A61B2017/00831 ,  A61B2017/00867 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0054

    Abstract: Endovascular catheters and control wires for operating the catheters and associated systems, apparatuses, and methods are disclosed include a catheter apparatus having an elongated shaft, a therapeutic assembly at a distal portion of the shaft, and a handle at a proximal portion of the shaft. An actuator is located at the handle and operably coupled to the therapeutic assembly via a tuned control member extending through the shaft. The tuned control member includes a control wire and a tuning component attached to one another within the shaft. The tuned control member is configured to achieve a desired tuned force-displacement response by modifying the stress-strain response that a non-tuned control wire would ordinarily provide without the intervening tuning component.

    Abstract translation: 公开了用于操作导管和相关系统，装置和方法的血管内导管和控制线，包括具有细长轴，在轴的远端部分处的治疗组件和在轴的近端部分处的手柄的导管装置。 致动器位于手柄处，并且经由经由轴延伸的调节控制构件可操作地联接到治疗组件。 调谐控制构件包括在轴内彼此附接的控制线和调谐部件。 调谐控制构件被配置为通过修改非调谐控制线通常在没有中间调谐组件的情况下提供的应力 - 应变响应来实现期望的调谐力 - 位移响应。

    CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS
    9.
    发明申请
    CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    具有用于肾神经调节的多电极阵列的导管设备及相关系统和方法

    公开(公告)号：WO2012061159A1

    公开(公告)日：2012-05-10

    申请号：PCT/US2011/057754

    申请日：2011-10-25

    Applicant: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. ,  KU, Vincent ,  BEETEL, Robert J. ,  WU, Andrew ,  ZARINS, Denise ,  ABOYTES, Maria G.

    Inventor： KU, Vincent ,  BEETEL, Robert J. ,  WU, Andrew ,  ZARINS, Denise ,  ABOYTES, Maria G.

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

    Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

    Abstract translation: 本文公开了用于通过血管内通路实现肾神经调节的导管设备，系统和方法。 例如，本技术的一个方面针对一种具有被配置为递送到肾血管的多电极阵列的治疗装置。 阵列在递送状态或低轮廓状态（例如，大致笔直的形状）与展开状态（例如径向扩张的，大致螺旋形状）之间可选择性地变形。 多电极阵列的尺寸和形状被设计成使得当阵列处于展开（例如，螺旋状态）时电极或能量输送元件接触肾血管的内壁。 电极或能量输送元件被配置用于直接和/或间接地施加热能和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或供给或灌注神经纤维的血管结构。

    NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS
    10.
    发明申请
    NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    神经修复性结缔组织及相关系统及方法

    公开(公告)号：WO2012058158A1

    公开(公告)日：2012-05-03

    申请号：PCT/US2011/057497

    申请日：2011-10-24

    Applicant: RYBA, Eric ,  ZARINS, Denise ,  MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

    Inventor： RYBA, Eric ,  ZARINS, Denise

    IPC: A61B18/02

    CPC classification number: A61B18/02 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00023 ,  A61B2018/00166 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/0025 ,  A61B2018/00261 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

    Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

    Abstract translation: 本文公开了神经调节冷冻治疗装置及相关系统和方法。 根据本技术的特定实施例配置的冷冻治疗装置可以包括细长轴，其具有沿轴的至少一部分的远侧部分和供应内腔。 轴可以被配置为将远端部分血管内定位在肾动脉或肾口附近的治疗部位。 供应内腔可被配置为接收液体制冷剂。 冷冻治疗装置还可以包括在轴的远端处的冷却组件。 冷却组件可以包括与供应内腔流体连通的施加器，并且构造成当冷却组件处于展开状态时，将冷冻治疗冷却递送到靠近目标部位的神经。

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