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    METHOD FOR PRODUCING NITROGUANIDINE
    93.
    发明申请
    METHOD FOR PRODUCING NITROGUANIDINE 审中-公开
    用于生产硝基胍

    公开(公告)号：WO0146129A3

    公开(公告)日：2002-01-10

    申请号：PCT/EP0013009

    申请日：2000-12-20

    Applicant: DYNAMIT NOBEL AG ,  PABST WINFRIED ,  BUSCH ANDREAS ,  SCHIRRA RAINER

    Inventor： PABST WINFRIED ,  BUSCH ANDREAS ,  SCHIRRA RAINER

    IPC: C07C277/08 ,  C07C279/34

    CPC classification number: C07C277/08 ,  C07C279/34

    Abstract: The invention relates to a method for producing nitroguanidine. According to the inventive method, guanidine nitrate or guanidine carbonate a dehydrated in a first step with high concentration nitric acid (> 85 %). The nitroguanidine nitrate formed is hydrolyzed in a second step with water to give nitroguanidine and nitric acid. The concentration of the nitric acid produced in the hydrolysis must not exceed 25 %.

    Abstract translation: 本发明涉及一种生产硝基胍，其特征在于，在第一阶段中，硝酸胍或与HOKO硝酸（> 85％）的碳酸胍脱水并以与水的第二阶段中形成硝基胍硝酸盐，得到胍和硝酸水解与 在水解形成硝酸的浓度必须不超过25％。

    METHOD FOR PRODUCING 1-METHYL-3-NITROGUANIDINE
    94.
    发明申请
    METHOD FOR PRODUCING 1-METHYL-3-NITROGUANIDINE 审中-公开
    用于生产1-甲基-3-硝基胍

    公开(公告)号：WO01055099A1

    公开(公告)日：2001-08-02

    申请号：PCT/EP2001/000351

    申请日：2001-01-12

    IPC: C07C279/36 ,  C07C277/08

    CPC classification number: C07C277/08 ,  C07C279/36

    Abstract: The invention relates to a method for producing 1-methyl-3-nitroguanidine. According to said method, nitroguanidine is reacted with methylamine and/or a methylammonium salt in an aqueous solution, at temperatures of 30 to 60 DEG C and at a pH value of 9.5 to 12.3. In this way, yields of 1-methyl-3-nitroguanidine of at least 80 % and degrees of purity > 99 % can be obtained in a particularly environmentally friendly and technically simple way.

    Abstract translation: 提供了一种用于制备1-甲基-3-硝基胍有描述，其中硝基胍用甲胺和/或在30的温度下在水溶液中的甲基铵盐至60℃，在pH为9.5至 12.3转换。 是1-甲基-3-硝基胍以这种方式可以在至少80％的收率和纯度来获得> 99％在一个特别环保且技术上简单的方式。

    METHOD FOR PRODUCING NITROGUANIDINE
    95.
    发明申请
    METHOD FOR PRODUCING NITROGUANIDINE 审中-公开
    用于生产硝基胍

    公开(公告)号：WO01046129A2

    公开(公告)日：2001-06-28

    申请号：PCT/EP2000/013009

    申请日：2000-12-20

    IPC: C07C277/08 ,  C07C279/34 ,  C07C277/00

    CPC classification number: C07C277/08 ,  C07C279/34

    Abstract: The invention relates to a method for producing nitroguanidine. According to the inventive method, guanidine nitrate or guanidine carbonate a dehydrated in a first step with high concentration nitric acid (> 85 %). The nitroguanidine nitrate formed is hydrolyzed in a second step with water to give nitroguanidine and nitric acid. The concentration of the nitric acid produced in the hydrolysis must not exceed 25 %.

    Abstract translation: 本发明涉及一种生产硝基胍，其特征在于，在第一阶段中，硝酸胍或与HOKO硝酸（> 85％）的碳酸胍脱水并以与水的第二阶段中形成硝基胍硝酸盐，得到胍和硝酸水解与 在水解形成硝酸的浓度必须不超过25％。

    ACYL ISOTHIOCYANATE RESINS AND THEIR USE IN SOLID-SUPPORTED SYNTHESIS OF GUANIDINES
    96.
    发明申请
    ACYL ISOTHIOCYANATE RESINS AND THEIR USE IN SOLID-SUPPORTED SYNTHESIS OF GUANIDINES 审中-公开
    ACYL异氰酸酯树脂及其在固体支持合成胍的应用

    公开(公告)号：WO0035860A3

    公开(公告)日：2000-10-26

    申请号：PCT/US9929771

    申请日：1999-12-15

    Applicant: PROCTER & GAMBLE ,  WILSON LAWRENCE JOSEPH

    Inventor： WILSON LAWRENCE JOSEPH

    IPC: C07D295/12 ,  C07C277/08 ,  C07C279/06 ,  C07C279/18 ,  C07C331/32 ,  C07D211/58 ,  C07D217/06 ,  C08F8/34 ,  C07C279/10 ,  C07C279/14 ,  C07C279/16 ,  C07C331/24

    CPC classification number: C07C277/08 ,  C07C331/32

    Abstract: The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, followed by treatment with tetraalkylammonium thiocyanate or an alkali metal salt thereof, to provide the acyl isothiocyanate resin. The subject invention also involves processes for making guanidine compounds and related cyclized compounds using an acyl isothiocyanate resin, comprising the following steps: (b) reacting the acyl isothiocyanate resin with a primary amine; (c) reacting the product from Step (b) with a sulfur activating agent and ammonia or a primary or secondary amine; (d) treating the product from Step (c) with a strong base or medium strength acid to cleave product from the resin, providing the guanidine compound or/and the related cyclized compound.

    Abstract translation: 本发明涉及式（I）的新型酰基异硫氰酸酯树脂及其制备方法：（a）从苯基羧基树脂开始，用任何将羧基转化为酰基卤的试剂处理树脂，然后用硫氰酸四烷基铵 或其碱金属盐，以提供酰基异硫氰酸酯树脂。 本发明还涉及使用酰基异硫氰酸酯树脂制备胍化合物和相关的环化化合物的方法，包括以下步骤：（b）使酰基异硫氰酸酯树脂与伯胺反应; （c）使来自步骤（b）的产物与硫活化剂和氨或伯胺或仲胺反应; （d）用强碱或中等强度酸处理来自步骤（c）的产物以从树脂上裂解产物，提供胍化合物或/和相关的环化化合物。

    ACYL ISOTHIOCYANATE RESINS AND THEIR USE IN SOLID-SUPPORTED SYNTHESIS OF GUANIDINES
    97.
    发明申请
    ACYL ISOTHIOCYANATE RESINS AND THEIR USE IN SOLID-SUPPORTED SYNTHESIS OF GUANIDINES 审中-公开
    ACYL异硫氰酸酯树脂及其在固体支持的合成中的应用

    公开(公告)号：WO00035860A2

    公开(公告)日：2000-06-22

    申请号：PCT/US1999/029771

    申请日：1999-12-15

    IPC: C07D295/12 ,  C07C277/08 ,  C07C279/06 ,  C07C279/18 ,  C07C331/32 ,  C07D211/58 ,  C07D217/06 ,  C08F8/34 ,  C07C279/10 ,  C07C279/14 ,  C07C279/16 ,  C07C331/24

    CPC classification number: C07C277/08 ,  C07C331/32

    Abstract: The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that converts the carboxy to an acyl halide, followed by treatment with tetraalkylammonium thiocyanate or an alkali metal salt thereof, to provide the acyl isothiocyanate resin. The subject invention also involves processes for making guanidine compounds and related cyclized compounds using an acyl isothiocyanate resin, comprising the following steps: (b) reacting the acyl isothiocyanate resin with a primary amine; (c) reacting the product from Step (b) with a sulfur activating agent and ammonia or a primary or secondary amine; (d) treating the product from Step (c) with a strong base or medium strength acid to cleave product from the resin, providing the guanidine compound or/and the related cyclized compound.

    Abstract translation: 本发明涉及式（I）的新型酰基异硫氰酸酯树脂及其制备方法：（a）由苯基羧基树脂开始，用任意将羧基转化为酰卤的试剂处理树脂，然后用硫氰酸四烷基铵 或其碱金属盐，以提供酰基异硫氰酸酯树脂。 本发明还涉及使用酰基异硫氰酸酯树脂制备胍化合物和相关环化化合物的方法，包括以下步骤：（b）使酰基异硫氰酸酯树脂与伯胺反应; （c）使来自步骤（b）的产物与硫活化剂和氨或伯胺或仲胺反应; （d）用强碱或中强酸处理步骤（c）的产物以从树脂中切割产物，提供胍化合物或/和相关的环化化合物。

    AQUEOUS CREATINE SOLUTION AND PROCESS OF PRODUCING A STABLE, BIOAVAILABLE AQUEOUS CREATINE SOLUTION
    98.
    发明申请
    AQUEOUS CREATINE SOLUTION AND PROCESS OF PRODUCING A STABLE, BIOAVAILABLE AQUEOUS CREATINE SOLUTION 审中-公开
    AQUEOUS CREATINE解决方案和生产稳定的生物可溶性水性溶液的方法

    公开(公告)号：WO99043312A1

    公开(公告)日：1999-09-02

    申请号：PCT/US1999/004240

    申请日：1999-02-26

    IPC: C07C277/08 ,  C07C279/14 ,  A61K31/195

    CPC classification number: C07C277/08 ,  C07C279/14

    Abstract: A stable aqueous solution of creatine acid sulfate provides a source of creatine to an animal when taken orally. The aqueous solution of creatine acid sulfate (after neutralization and buffering) has a pH of about 7.2 to about 7.8 and is stable for at least six months at room temperature. The creatine acid sulfate is produced by adding creatine monohydrate to a sulfuric acid solution in a stoichiometric amount to result in creatine acid sulfate having a pH initially of 2.0 - 3.0. The resulting creatine acid sulfate is diluted with water and neutralized to raise the pH and avoid the formation of creatinine. The resulting creatine acid sulfate solution preferably contains a buffering and neutralizing agent such as tribasic potassium phosphate which forms mono- and dibasic potassium phosphates by interaction with the hydrogen ions liberated from the acid sulfate. The aqueous solution can be combined with a sweetener, electrolyte and carbohydrate source to produce a stable drink for providing a source of creatine to an animal in need thereof. An effective amount of glycerol is preferably added to enhance absorption of the creatine through the intestinal wall into the bloodstream and eventually to the needy skeletal muscles.

    Abstract translation: 肌酸酸式硫酸酯的稳定水溶液在口服时为动物提供肌酸来源。 肌酸酸式硫酸酯水溶液（中和缓冲后）的pH值约为7.2〜7.8，在室温下稳定至少6个月。 肌酸酸性硫酸盐是通过以化学计量的量向硫酸溶液中加入肌酸一水合产生的，以产生最初pH为2.0-3.0的pH的肌酸硫酸盐。 所得肌酸酸性硫酸盐用水稀释并中和以提高pH并避免肌酸酐的形成。 所得到的酸式酸酐溶液优选含有缓冲和中和剂，例如通过与从酸式硫酸盐释放的氢离子相互作用而形成磷酸氢二钾和磷酸三钾。 水溶液可以与甜味剂，电解质和碳水化合物源组合以产生稳定的饮料，以向有需要的动物提供肌酸源。 优选添加有效量的甘油以增强肌酸通过肠壁进入血液并最终到有需要的骨骼肌的吸收。

    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES
    99.
    发明申请
    PREPARATION OF RADIOLABELLED HALOAROMATICS VIA POLYMER-BOUND INTERMEDIATES 审中-公开
    通过聚合物中间体制备无定形血红蛋白

    公开(公告)号：WO99018053A1

    公开(公告)日：1999-04-15

    申请号：PCT/CA1998/000933

    申请日：1998-10-02

    IPC: C07B59/00 ,  C07C277/08 ,  C07C279/06 ,  C08F8/30 ,  C08F8/42 ,  C08F30/04

    CPC classification number: C08F8/30 ,  C07B59/001 ,  C07C277/08 ,  C08F8/42 ,  C07C279/06

    Abstract: According to a first aspect of the invention, a process is disclosed for the preparation of radiolabelled haloaromatic compounds. According to a second aspect of the invention, intermediate precursor insoluble polymer compounds used in the preparation of the radiolabelled haloaromatics are disclosed, as well as processes for the preparation of the intermediate precursor insoluble polymer compounds.

    Abstract translation: 根据本发明的第一方面，公开了制备放射性标记的卤代芳族化合物的方法。 根据本发明的第二方面，公开了用于制备放射性标记的卤代芳烃的中间体前体不溶性聚合物化合物，以及制备中间体前体不溶性聚合物化合物的方法。

    METHOD FOR PRODUCING N-ALKYL-N'-NITROGUANIDINES
    100.
    发明申请
    METHOD FOR PRODUCING N-ALKYL-N'-NITROGUANIDINES 审中-公开
    PROCESS FOR的N-烷基-N'-硝基胍的制备

    公开(公告)号：WO98043951A1

    公开(公告)日：1998-10-08

    申请号：PCT/EP1998/001428

    申请日：1998-03-12

    IPC: C07C277/08 ,  C07C279/36

    CPC classification number: C07C277/08 ,  C07C279/36

    Abstract: The invention relates to a novel method for producing n-alkyl-n'-nitroguanidines of formula (I), wherein R stands for C1-C4-alkyl, alkylamine is neutralized with nitric acid, subsequently reacted with cyanamide and the alkylguanidine nitrate thus obtained is dehydrated.

    Abstract translation: 本发明涉及一种新的制备方法，其中R表示C1-C4烷基的式（I）的N-烷基-N'--胍，通过中和硝酸与烷基胺，然后与氨腈和烷基胍形成脱水 ，

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