公开(公告)号：WO0060120A3

公开(公告)日：2001-09-13

申请号：PCT/US0008773

申请日：2000-03-31

Applicant: MOSAIC TECHNOLOGIES ,  BOLES T CHRISTIAN

Inventor： BOLES T CHRISTIAN

IPC: G01N21/64 ,  C12N1/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N21/21 ,  G01N21/27 ,  G01N21/41 ,  G01N21/59 ,  G01N27/06 ,  G01N27/447 ,  G01N33/483 ,  G01N33/53 ,  G01N33/566 ,  G01N33/58 ,  G01N33/50

CPC classification number: C12Q1/689 ,  C12Q1/6837 ,  C12Q2600/156

Abstract: Methods of detecting the presence or absence of a microorganism comprising detecting the presence or absence of microbiological target molecules in a test sample employing electrophoresis comprising immobilized capture probes are described. Methods for detecting mutation sites within a putative mutant target molecule are also disclosed.

Abstract translation: 描述了检测微生物存在或不存在的方法，包括使用包含固定化捕获探针的电泳在检测样品中检测微生物靶分子的存在或不存在。 还公开了在推定的突变靶分子内检测突变位点的方法。

公开(公告)号：WO0013002A3

公开(公告)日：2001-02-22

申请号：PCT/US9919532

申请日：1999-08-27

Applicant: ABBOTT LAB

Inventor： JENG TZYY-WEN ,  MC DOWELL LARRY L ,  PEZZANITI JOSEPH L ,  OOSTA GARY M ,  SHAIN ERIC B

IPC: G01N21/64 ,  G01N21/05 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/41 ,  G01N21/65 ,  G01N33/483 ,  G01N33/493 ,  B01L3/14

CPC classification number: G01N21/4133 ,  G01N21/05 ,  G01N21/274 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/171538 ,  Y10T436/200833

Abstract: Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.

Abstract translation: 用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

公开(公告)号：WO01006234A1

公开(公告)日：2001-01-25

申请号：PCT/EP2000/005660

申请日：2000-06-20

IPC: G01N21/43 ,  G01N21/41

CPC classification number: G01N21/431

Abstract: A method and apparatus are provided for the determination of levels of components of coolants and heat exchange fluids, particularly monoethylene - and monopropylene - glycol content. Refractometric and gravimetric values are taken and the volume fraction of the individual components obtained by inverting a system of linear equations. A microprocessor controlled field test apparatus can compute the various values to be determined.

Abstract translation: 提供了一种用于确定冷却剂和热交换流体，特别是单亚乙基和单丙二醇含量的组分水平的方法和装置。 采用折射率和重量值，并通过反演线性方程组系统获得的各个分量的体积分数。 微处理器控制的现场测试装置可以计算待确定的各种值。

公开(公告)号：WO0045150B1

公开(公告)日：2000-12-28

申请号：PCT/US0002304

申请日：2000-01-28

Applicant: LEICA MICROSYSTEMS INC ,  COTTON CHRISTOPHER T ,  SABIN JEFFREY M ,  RYAN THOMAS E

Inventor： COTTON CHRISTOPHER T ,  SABIN JEFFREY M ,  RYAN THOMAS E

IPC: F16D66/00 ,  G01N21/43 ,  G01N21/41

CPC classification number: G01N21/43

Abstract: A refractometric apparatus and method for monitoring the percentage of water in hydraulic fluids employ a temperature sensitive device allowing a user to obtain accurate and correct readings of various measured properties. In particular, the temperature sensitive member comprises a prism-wedge-mirror combination in conjunction with a bimetallic strip. The combination ensures the proper angular displacement of a light beam inside the refractometric apparatus and, therefore, the correct reading of a parameter to be measured.

Abstract translation: 用于监测液压流体中的水的百分比的折射测量装置和方法采用温度敏感装置，其允许用户获得各种测量特性的准确和正确的读数。 特别地，温度敏感构件包括与双金属片结合的棱镜 - 楔形镜组合。 该组合确保了折射测量装置内光束的适当角位移，并因此确保了待测参数的正确读数。

公开(公告)号：WO00050861A1

公开(公告)日：2000-08-31

申请号：PCT/US2000/005044

申请日：2000-02-25

IPC: G01N21/41 ,  G01J3/30

CPC classification number: G01N21/4133

Abstract: A differential refractometry apparatus that maintains optimal optical alignment of components while accurately providing differential refractometry measurement at elevated temperatures. The differential refractometry apparatus has a first thermal zone (10), a thermal isolation zone and a second thermal zone (14). The first thermal zone (10) is configured to be located in an oven and exposed to higher temperatures. The thermal isolation zone is located adjacent to the first thermal zone (10) and acts as a barrier to the conduction of heat from the first thermal zone (10) into the second thermal zone (14). The second thermal zone (14) is at a relatively lower temperature than the first thermal zone (10) and its temperature is regulated using a thermal electric cooler located at its base. A flow cell (22), a mirror (24) which reflects the incoming light beam, and an imaging lens are located in the first thermal zone. An LED and a photodiode detector are located in the second thermal zone and are encased in thermally stable blocks with low coefficients of thermal expansion.

Abstract translation: 一种差分折射测量装置，可在高温下准确地提供差示折射测量，保持部件的最佳光学对准。 差示折射测定装置具有第一热区（10），热隔离区和第二热区（14）。 第一热区（10）构造成位于烘箱中并暴露于更高的温度。 热隔离区位于第一热区（10）附近，并且用作阻挡从第一热区（10）进入第二热区（14）的热传导。 第二热区（14）处于比第一热区（10）相对较低的温度，并且使用位于其底部的热电冷却器调节其温度。 流动池（22），反射入射光束的反射镜（24）和成像透镜位于第一热区中。 LED和光电二极管检测器位于第二热区，并被封装在具有低热膨胀系数的热稳定块中。

公开(公告)号：WO00023789A1

公开(公告)日：2000-04-27

申请号：PCT/IL1999/000435

申请日：1999-08-05

IPC: G01M11/02 ,  G01N21/41

CPC classification number: G01M11/0228 ,  G01N21/41

Abstract: A refractometer and a method for measuring the refractive index of a lens (80), wherein a thin insert (86) in the form of a pad of a flexible transparent material attached to a rigid transparent sheet (82), is lightly pressed onto a surface of the lens (80) under test, such that the pad surface effectively acquires the same profile as the lens surface. The focal length or power of the lens (80) is first measured without the insert, and the measurement is then repeated with the insert positioned first in contact with one surface of the lens (80), and then in contact with the other surface. The use of equations derived from the classical lens formula then enables the refractive index of the lens (80) to be easily and quickly determined. The apparatus and method also enables the measurement of the refractive index of lenses of low power.

Abstract translation: 折射计和用于测量透镜（80）的折射率的方法，其中将附着在刚性透明片（82）上的柔性透明材料的垫片形式的薄插入件（86）轻轻按压到 被检测的透镜（80）的表面，使得焊盘表面有效地获得与透镜表面相同的轮廓。 首先在没有插入物的情况下测量透镜（80）的焦距或功率，然后重复测量，其中插入件首先与透镜（80）的一个表面接触，然后与另一个表面接触。 使用从经典透镜公式得到的方程式使得能够容易且快速地确定透镜（80）的折射率。 该装置和方法还能够测量低功率透镜的折射率。

公开(公告)号：WO00013809A1

公开(公告)日：2000-03-16

申请号：PCT/NZ1999/000151

申请日：1999-09-07

IPC: B07C5/34 ,  G01N33/02 ,  B07C5/344 ,  G01N21/39 ,  G01N21/41 ,  G01N21/59

CPC classification number: B07C5/3416 ,  G01N33/02

Abstract: A method/an apparatus for sorting products includes a flexible concertina-like shield (3) sealingly engaging a portion of the surface of the product (2) at one end to receive electromagnetic radiation transmitted through the product, at the other end of the shield electromagnetic radiation receiving means (4) is positioned and a control means to selectively position the shielding means at or about the product selected (fig.3).

Abstract translation: 用于分拣产品的方法/设备包括柔性的三角截面状屏蔽（3），其一端密封地接合产品（2）的表面的一部分，以在屏蔽的另一端接收透过产品的电磁辐射 定位电磁辐射接收装置（4）和控制装置，以选择性地将屏蔽装置定位在所选择的产品处或周围（图3）。

公开(公告)号：WO00013808A1

公开(公告)日：2000-03-16

申请号：PCT/NZ1999/000150

申请日：1999-09-07

IPC: B07C5/342 ,  G01N33/02 ,  B07C5/344 ,  G01N21/39 ,  G01N21/41 ,  G01N21/59 ,  G01N21/33 ,  G01N21/35

CPC classification number: B07C5/342 ,  G01N33/025

Abstract: The present invention consists of a method and apparatus for identifying articles, particularly fruit or vegetables. The technique involves analysing either the reflected or transmitted electromagnetic energy (preferably electromagnetic energy corresponding to the optical spectrum). The reflected or transmitted energy may be diffracted using a diffraction grating whereby the diffracted spectrum is compared with a number of pre-determined spectra. The electromagnetic energy source may be stepped laser, sequentially switched light emitting diodes or other suitable radiation source. Instead of using a particular frequency of electromagnetic energy for the energy source, the source may provide a relatively narrow band of electromagnetic energy with the detection means being sensitive to a wide band. Identification of the characteristics of the reflection or transmission could be by way of wavelength shift. The present invention may find application in fruit sorting (at the growing location and the retail location) or similar process control type situations involving articles such as fruit or vegetables.

Abstract translation: 本发明包括用于识别物品，特别是水果或蔬菜的方法和装置。 该技术涉及分析反射或传输的电磁能（优选对应于光谱的电磁能）。 可以使用衍射光栅衍射出反射或透射的能量，从而将衍射光谱与许多预定光谱进行比较。 电磁能源可以是阶梯式激光，顺序切换发光二极管或其它合适的辐射源。 代替使用电磁能量的特定频率作为能量源，源可以提供相对窄的电磁能带，检测装置对宽带敏感。 识别反射或透射的特性可以通过波长偏移。 本发明可以在水果分拣（在生长位置和零售地点）或涉及诸如水果或蔬菜的物品的类似过程控制类型情况下使用。

公开(公告)号：WO9906818A9

公开(公告)日：1999-04-29

申请号：PCT/US9815084

申请日：1998-07-21

Applicant: LEICA MICROSYSTEMS INC

Inventor： COTTON CHRISTOPHER T ,  SABIN JEFFREY M ,  RYAN THOMAS E

IPC: G01N21/41 ,  G01N21/43

CPC classification number: G01N21/43

Abstract: A refractometric apparatus (10) and method for monitoring the percentage of water in hydraulic fluids employs a temperature sensitive device allowing a user to obtain accurate and correct readings of various measured properties on the reticle (92) of the apparatus (10). In particular, the temperature sensitive member comprises a prism-wedge-mirror combination (38, 58) in conjunction with a bimetallic strip (60). The combination ensures the proper angular displacement of a light beam inside the refractometric apparatus (10) and, therefore, the correct reading on the reticle (92).

Abstract translation: 用于监测液压流体中水的百分比的折射测量装置（10）和方法采用温度敏感装置，其允许用户获得装置（10）的标线（92）上的各种测量特性的准确和正确的读数。 特别地，温度敏感元件包括与双金属片（60）结合的棱镜 - 楔形镜组合（38,58）。 该组合确保了折射测量装置（10）内的光束的适当角位移，并因此确保了标线片（92）上的正确读数。

公开(公告)号：WO9733147A3

公开(公告)日：1997-10-30

申请号：PCT/DE9700361

申请日：1997-02-28

Applicant: FORSCHUNGSZENTRUM JUELICH GMBH ,  KRUEGER MICHAEL ,  BERGER MICHAEL ,  THOENISSEN MARKUS ,  ARENS FISCHER RUEDIGER ,  LUETH HANS

Inventor： KRUEGER MICHAEL ,  BERGER MICHAEL ,  THOENISSEN MARKUS ,  ARENS-FISCHER RUEDIGER ,  LUETH HANS

IPC: G01N21/01 ,  G01N21/41 ,  G01N21/45 ,  G01N

CPC classification number: G01N21/41

Abstract: In an analytic process using porous silicon, a substance is detected or its concentration in a fluid is determined, based on the change in optical properties of porous silicon as a function of the index of refraction of the substance or of the fluid containing the substance present in the pores of the porous silicon. An analytic device using porous silicon to detect a substance or determe the concentration of a substance in a fluid consists of a component which is at least partly made of porous silicon, the optical property of which is dependent on the index of refraction of the substance or of the fluid containing the substance, where a change in the optical property of porous silicon can be measured to indicate detection of the substance or to determine the concentration in the pores of the porous silicon.