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    PROCESS FOR THE MANUFACTURE OF SPIROKETALS
    11.
    发明申请
    PROCESS FOR THE MANUFACTURE OF SPIROKETALS 审中-公开
    制造SPIROKETALS的方法

    公开(公告)号：WO1993002084A1

    公开(公告)日：1993-02-04

    申请号：PCT/EP1992001601

    申请日：1992-07-15

    Applicant: GIVAUDAN-ROURE (INTERNATIONAL) S.A. ,  GONÇALVES DA COSTA, Maria do Céu ,  VIDAL DE OLIVEIRA BAPTISTA MARCELO CURTO, Maria, ... ,  DE LOUREIRO DA SILVA TAVARES DA ROSA, Maria, ... ,  MOTHERWELL, William, Branks

    Inventor： GIVAUDAN-ROURE (INTERNATIONAL) S.A.

    IPC: C07D493/10

    CPC classification number: C07D493/10 ,  C07C45/28 ,  C07C45/298 ,  C07C49/21 ,  C07D301/14 ,  C07D303/32 ,  C07D497/10

    Abstract: A process for the production of ambergris-type labdane spiroketals of general formulae (I) and (II), where R represents oxygen or sulphur, useful in the perfumery industry, the said process being characterized by the intramolecular cyclisation of the epoxyketone or its thio analog of general formula (III), where R1 represents COCH3 and R2 oxygen or sulphur. The starting materials are obtained by an oxidation step of labdane diterpenes of general formula (IV), where R is a tertiary allyl alcohol or vinyl acid, optionally esterified with an alkyl group, to form an intermediate methyl ketone of formula (V), where R = COCH3, with yields higher than 60 %, followed by an epoxidation step with peracid, with yields of the so-obtained epoxyketone III not below 80 %, and, finally, by treatment of III with various catalysts, in homogeneous or heterogeneous medium, the choice of catalyst depending on the desired selectivity, which can reach 100 % of I or 100 % of II, or lead to mixtures enriched in the odoriferous spiroketal II.

    Abstract translation: 一种制备通式（I）和（II）的琥珀酰型labdane螺缩酮的方法，其中R表示氧或硫，可用于香料工业，所述方法的特征在于环氧酮或其硫代的分子内环化 通式（III）的类似物，其中R 1表示COCH 3和R 2的氧或硫。 起始原料是通过通式（Ⅳ）的实心二萜的氧化步骤获得的，其中R是任选被烷基酯化的叔烯丙基醇或乙烯基酸，形成式（Ⅴ）的中间体甲基酮，其中 R = COCH 3，产率高于60％，随后用过酸进行环氧化步骤，所得到的环氧酮III的产率不低于80％，最后通过各种催化剂在均相或异相培养基中处理III ，催化剂的选择取决于所需的选择性，其可以达到I的100％或II的100％，或者导致富含有味的螺旋酮II的混合物。

    A TOY BUILDING ELEMENT COMPRISING A NUMBER OF PARTS
    13.
    发明申请
    A TOY BUILDING ELEMENT COMPRISING A NUMBER OF PARTS 审中-公开
    包含零件数量的玩具建筑元件

    公开(公告)号：WO2005007261A1

    公开(公告)日：2005-01-27

    申请号：PCT/DK2004/000510

    申请日：2004-07-22

    Applicant: LEGO A/S ,  INTERLEGO AG ,  HOLSHEIMER, Henk, Hendrik, Bernard ,  COSTA, Maria, Rosario, Pereira ,  GRINSELL, Peter, John

    Inventor： HOLSHEIMER, Henk, Hendrik, Bernard ,  COSTA, Maria, Rosario, Pereira ,  GRINSELL, Peter, John

    IPC: A63H33/08

    CPC classification number: A63H33/086 ,  A63F2009/0012 ,  A63H33/106

    Abstract: A toy building element with coupling studs (6) and/or coupling skirts (7) that are complementary therewith for being interconnected with other toy building elements provided with corresponding coupling studs and/or coupling skirts, said interconnection taking place in an axial direction of the coupling studs and/or the coupling skirts. The toy building element comprises a top element (1) and a bottom element (2) that can be interconnected by means of coupling means that are releasable exclusively by rotation about an axis (A) in parallel with the axial direction of the coupling studs (6) and/or the coupling skirts (7). Besides, the toy building comprises at least one intermediate element (8), said top element (1) being interconnectable with an upper end of the intermediate element (8), while the bottom element (2) can be interconnected with a lower end of the intermediate element (8).

    Abstract translation: 一种玩具构建元件，其具有与其互补的联接柱（6）和/或联接裙（7），以与设置有对应的联接柱和/或联接裙的其他玩具构建元件互连，所述互连沿轴向方向 联接螺柱和/或联接裙。 所述玩具构建元件包括顶部元件（1）和底部元件（2），所述顶部元件（1）和底部元件（2）可以通过联接装置相互连接，所述联接装置仅通过围绕所述轴线（A）绕所述联接柱的轴向方向 6）和/或联接裙（7）。 此外，玩具建筑物包括至少一个中间元件（8），所述顶部元件（1）可与中间元件（8）的上端互连，而底部元件（2）可以与下部元件 中间元件（8）。

    IMMUNOMODULATING AGENTS, A METHOD FOR THEIR PREPARATION AND THEIR USE FOR VACCINES
    14.
    发明申请
    IMMUNOMODULATING AGENTS, A METHOD FOR THEIR PREPARATION AND THEIR USE FOR VACCINES 审中-公开
    免疫调节剂，其制备方法及其用于疫苗的方法

    公开(公告)号：WO2003040163A2

    公开(公告)日：2003-05-15

    申请号：PCT/PT2002/000016

    申请日：2002-11-07

    Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA INDUSTRIAL ,  CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  CARDOSO, Fernando ,  COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

    Inventor： COSTA, Maria ,  GREEN, Luke ,  SCHMIDT, Richard ,  LEY, Steve ,  ELEUTÉRIO, Maria ,  ALVES, Susana ,  RUBALCAVA, Concepcion

    IPC: C07J69/00

    CPC classification number: C07J69/00

    Abstract: The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.

    Abstract translation: 本发明涉及用于增加哺乳动物免疫应答的新皂苷，并且在免疫学领域中得到应用，特别是从萜烯源开始通过半合成获得的新佐剂。 它还包括使用新皂甙作为佐剂以增加对哺乳动物抗原的免疫应答的方法。 本发明的皂苷适用于兽药和人类药物组合物，其包括一种或多种抗原，特别是合成来源的抗原，以及一种或多种稀释剂在药学上可接受的载体中。 这些组合物可用作动物和人类的免疫调节剂和/或免疫调节剂。 本发明还构成疫苗接种方法，其包括施用本发明的一种或多种抗原和一种或任选的多于一种的半合成皂苷。

    ASSAY FOR AUTOANTIBODIES TO FOLATE RECEPTORS
    16.
    发明申请
    ASSAY FOR AUTOANTIBODIES TO FOLATE RECEPTORS 审中-公开
    测定抑制受体的自身抗体

    公开(公告)号：WO2004043233A3

    公开(公告)日：2005-03-31

    申请号：PCT/US0335690

    申请日：2003-11-07

    Applicant: ROTHENBERG SHELDON P ,  DA COSTA MARIA ,  SEQUEIRA JEFFREY

    Inventor： ROTHENBERG SHELDON P ,  DA COSTA MARIA ,  SEQUEIRA JEFFREY

    IPC: A61B20060101 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  G01N33/536 ,  G01N33/564 ,  G01N33/567 ,  G01N33/82

    CPC classification number: G01N33/564 ,  G01N33/82 ,  G01N2500/00 ,  G01N2800/24

    Abstract: The present invention identifies autoantibodies to folate receptors. Methods to identify these autoantibodies to the human folate receptors are also provided. The present invention also contemplates diagnostic methods and test kits to be used in a clinical setting for identifying a subject at risk of folate-sensitive abnormalities or disorders as observed in neural tube defect complicatedpregnancies. In addition, infertility, spontaneous abortion, male sterility, unsuccessful in vitro fertilization,neurologic disorders and impaired folate absorption may also be associated with these autoantibodiesto folate receptors.

    Abstract translation: 本发明鉴定了叶酸受体的自身抗体。 还提供了鉴定人叶酸受体的这些自身抗体的方法。 本发明还考虑用于临床设置中用于鉴定在神经管缺陷复杂妊娠中观察到的具有叶酸敏感性异常或障碍风险的受试者的诊断方法和测试试剂盒。 此外，不孕不育，自然流产，雄性不育，体外受精失败，神经系统疾病和叶酸受体受损也可能与这些自身抗体对叶酸受体有关。

    SOLVENT EXTRACTION PROCESS
    19.
    发明申请
    SOLVENT EXTRACTION PROCESS 审中-公开
    溶剂萃取工艺

    公开(公告)号：WO1995027085A1

    公开(公告)日：1995-10-12

    申请号：PCT/GB1995000578

    申请日：1995-03-17

    Applicant: ZENECA LIMITED ,  DALTON, Raymond, Frederick ,  COSTA, Maria-Clara

    Inventor： ZENECA LIMITED

    IPC: C22B03/36

    CPC classification number: C22B3/0035 ,  C22B11/04 ,  Y02P10/234

    Abstract: A process for the extraction of palladium from an aqueous medium containing palladium and halide or pseudo-halide ions using as extractant a nitrogen-containing heterocyclic carbonamide or ester characterised in that the total concentration of free halide and pseudo-halide in the aqueous medium is less than 1 molar.

    Abstract translation: 一种从含有钯和卤化物或假卤离子的水性介质中提取钯的方法，使用含氮杂环碳酰胺或酯作为提取剂，其特征在于，水性介质中的游离卤化物和假卤化物的总浓度较小 超过1摩尔。

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