公开(公告)号：WO2010142750A1

公开(公告)日：2010-12-16

申请号：PCT/EP2010/058124

申请日：2010-06-10

Applicant: DSM IP Assets B.V. ,  FRIEDEL, Angelika ,  KURATLI, Karin ,  WEHRLI, Christof ,  WERTZ, Karin ,  WOLFRAM, Swen ,  WANG-SCHMIDT, Ying

Inventor： FRIEDEL, Angelika ,  KURATLI, Karin ,  WEHRLI, Christof ,  WERTZ, Karin ,  WOLFRAM, Swen ,  WANG-SCHMIDT, Ying

IPC: A61K31/455 ,  A61K36/48 ,  A23L1/30

CPC classification number: A61K31/455 ,  A23L33/105 ,  A23L33/15 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/46 ,  A61K36/00 ,  A61K36/74 ,  A61K45/06 ,  A23V2200/316 ,  A23V2250/7046 ,  A23V2250/21

Abstract: This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.

Abstract translation: 本发明涉及烟酸和/或葫芦宁化合物在活动期间增加肌肉重量或在不活动期间抑制肌肉损失的用途。

公开(公告)号：WO2010118789A1

公开(公告)日：2010-10-21

申请号：PCT/EP2009/063492

申请日：2009-10-15

Applicant: DSM IP Assets B.V. ,  FOWLER, Ann ,  FRIEDEL, Angelika ,  KNUTTI, Darko ,  KURATLI, Karin ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

Inventor： FOWLER, Ann ,  FRIEDEL, Angelika ,  KNUTTI, Darko ,  KURATLI, Karin ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

IPC: A23L1/00 ,  A23L1/29 ,  A61K31/05 ,  A61K31/197 ,  A61K31/205 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/522 ,  A61K31/525 ,  A61K31/714 ,  A61K45/06 ,  A61K36/63 ,  A61K36/254

CPC classification number: A61K31/05 ,  A23K20/111 ,  A23K20/121 ,  A23K20/147 ,  A23K20/174 ,  A23L2/52 ,  A23L33/10 ,  A23L33/105 ,  A23L33/11 ,  A23L33/15 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/145 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/205 ,  A61K31/34 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/522 ,  A61K31/525 ,  A61K31/714 ,  A61K36/63 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/33 ,  A23V2250/2108 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/705 ,  A23V2250/706 ,  A23V2250/72

Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

Abstract translation: 含有羟基酪醇的羟基酪醇或橄榄油与选自肌酸，辅酶Q10，白藜芦醇，咖啡因，肉碱，B族维生素（B1，B2，B3，B5，B6和/或B12）中的至少一种化合物组合 ）和人参（优选：根）提取物可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

公开(公告)号：WO2007042271A3

公开(公告)日：2008-02-14

申请号：PCT/EP2006009814

申请日：2006-10-11

Applicant: DSM IP ASSETS BV ,  RAEDERSTORFF DANIEL ,  WANG-SCHMIDT YING ,  WOLFRAM SWEN

Inventor： RAEDERSTORFF DANIEL ,  WANG-SCHMIDT YING ,  WOLFRAM SWEN

IPC: A61K31/05 ,  A23L1/30 ,  A61K31/353 ,  A61P21/00

CPC classification number: A61K31/353 ,  A23L33/10 ,  A61K31/05

Abstract: The use of at least one component selected from the group consisting of EGCG, hydroxytyrosol, resveratrol and derivatives, metabolites or analogues thereof in the manufacture of a nutraceutical composition for the prevention and treatment of muscle wasting leading to muscle loss, atrophy and other associated muscle disorders in animals, in particular mammals including humans.

Abstract translation: 选自EGCG，羟基酪醇，白藜芦醇及其衍生物，代谢物或其类似物的至少一种组分在制备用于预防和治疗肌肉萎缩导致肌肉萎缩，萎缩和其他相关肌肉的营养组合物中的用途 动物疾病，特别是包括人类在内的哺乳动物。

公开(公告)号：WO2007096078A1

公开(公告)日：2007-08-30

申请号：PCT/EP2007/001256

申请日：2007-02-14

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  SCHEHLMANN, Volker ,  WANG-SCHMIDT, Ying ,  WEBER, Gilbert

Inventor： RAEDERSTORFF, Daniel ,  SCHEHLMANN, Volker ,  WANG-SCHMIDT, Ying ,  WEBER, Gilbert

IPC: A61K31/05 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00 ,  A61P39/00

CPC classification number: A61K31/05

Abstract: The invention relates to the use of resveratrol, a derivative, metabolite or analogue thereof for promoting the wellness state of a mammal or for changing gene expression profiles in older adult mammals towards conformity with expression profiles found in younger adult mammals as well as to their use for the manufacture of corresponding nutraceutical compositions.

Abstract translation: 本发明涉及白藜芦醇，其衍生物，代谢物或类似物用于促进哺乳动物的健康状态或改变老年成年哺乳动物中的基因表达谱以符合年轻成年哺乳动物中发现的表达谱以及其使用 用于制造相应的营养组合物。

公开(公告)号：WO2007042272A3

公开(公告)日：2007-04-19

申请号：PCT/EP2006/009815

申请日：2006-10-11

Applicant: DSM IP ASSETS B.V. ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WOLFRAM, Swen

Inventor： RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WOLFRAM, Swen

IPC: A61K31/05 ,  A61K31/353 ,  A23L1/30 ,  A61P43/00 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00

Abstract: The use of resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from EGCG, coenzyme Q-IO, genistein, lycopene, hydroxytyrosol and polyunsaturated fatty acids in the manufacture of a nutraceutical composition for delaying aging and/or for the treatment or prevention of age-related diseases in animals, in particular in mammals including humans.

公开(公告)号：WO2006136423A3

公开(公告)日：2007-03-01

申请号：PCT/EP2006006038

申请日：2006-06-23

Applicant: DSM IP ASSETS BV ,  D ORAZIO DANIEL ,  DE SAIZIEU ANTOINE ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WEHRLI CHRISTOF ,  WOLFRAM SWEN

Inventor： D ORAZIO DANIEL ,  DE SAIZIEU ANTOINE ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WEHRLI CHRISTOF ,  WOLFRAM SWEN

IPC: A61K31/12 ,  A23L1/307

CPC classification number: A61K31/12 ,  A23K20/111 ,  A23K50/20 ,  A23K50/40 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328

Abstract: The present invention relares to compounds of the formula (I) wherein R 3 is C 1-6 -alkyloxy, C 1-6 -acyloxy or aroyloxy; R 6 is hydrogen or C 1-6 -alkyloxy; R 7 is C 1-6 -alkyloxy, C 1-6 -acyloxy, aroyloxy or arylacyloxy; R 8 is hydrogen or C 1-6 -alkyloxy; or R 7 and R 8 form together a group O-L-O with L being (CR 1 R 2 ) n , with R 1 and R 2 being independently from each other hydrogen or C 1-5 -alkyl and n being an interger from 1 to 3; R 10 is hydrogen or N-C 1-4 -acyl, N- C 1-5 -alkyl-x-C x -alkyl with x being an interger from 1 to 5, for use as medicament for the treatment of a disorder connected to impaired glucose metabolism and impaired insulin action such as syndrome X and diabetes type 1,apd 2, especially for the treatment of (non-autoimmune) diabetes type 2. The invention also relates to food and pharmaceutical compositions containing these compounds.

Abstract translation: 本发明涉及式（I）化合物，其中R 3是C 1-6 - 烷氧基，C 1-6 - 酰氧基 或芳酰基; R 6是氢或C 1-6 - 烷氧基; R 7是C 1-6 - 烷氧基，C 1-6 - 酰氧基，芳氧基或芳基酰氧基; R 8是氢或C 1-6 - 烷氧基; 或R 7和R 8形成在一起的基团OLO，其中L为（CR 1，R 2）2 其中R 1和R 2彼此独立地为氢或C 1-5烷基，n为 1到3的整数; R 10是氢或NC 1-4 - 酰基，N-C 1-5 - 烷基-XC

公开(公告)号：WO2009144093A1

公开(公告)日：2009-12-03

申请号：PCT/EP2009/054585

申请日：2009-04-17

Applicant: DSM IP Assets B.V. ,  LIU, Jiankang ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

Inventor： LIU, Jiankang ,  RAEDERSTORFF, Daniel ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

IPC: A61K31/05 ,  A61K36/63 ,  A61P1/16 ,  A61P7/00 ,  A61P9/00 ,  A61P21/00 ,  A23L1/00

CPC classification number: A61K31/05 ,  A61K36/63

Abstract: Hydroxytyrosol or olive juice containing hydroxytyrosol can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

Abstract translation: 含有羟基酪醇的羟基酪醇或橄榄汁可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

公开(公告)号：WO2009103754A3

公开(公告)日：2009-11-12

申请号：PCT/EP2009051958

申请日：2009-02-19

Applicant: DSM IP ASSETS BV ,  HUG HUBERT ,  MUSSELR BERND ,  RAEDERSTORFF DANIEL ,  WANG-SCHMIDT YING

Inventor： HUG HUBERT ,  MUSSELR BERND ,  RAEDERSTORFF DANIEL ,  WANG-SCHMIDT YING

IPC: A23L1/30 ,  A61K31/404 ,  A61P17/00 ,  A61P43/00

CPC classification number: A61K31/404 ,  A23L33/10 ,  A23L33/105

Abstract: The present invention relates to a novel use of 3,3'-diindolylmethane (CAS1968-05-4) and/or its derivatives in the form of a pharmaceutical and/or nutritional composition to retard or delay typical signs of aging and/or age-related pathological changes.

Abstract translation: 本发明涉及以药物和/或营养组合物形式的3,3'-二吲哚基甲烷（CAS1968-05-4）和/或其衍生物的新用途，以延缓或延缓老化和/或老化的典型迹象 相关病理变化。

公开(公告)号：WO2009103755A1

公开(公告)日：2009-08-27

申请号：PCT/EP2009/051959

申请日：2009-02-19

Applicant: DSM IP ASSETS B.V. ,  HUG, Hubert ,  RAEDERSTORFF, Daniel ,  MUSSELR, Bernd ,  WANG-SCHMIDT, Ying

Inventor： HUG, Hubert ,  RAEDERSTORFF, Daniel ,  MUSSELR, Bernd ,  WANG-SCHMIDT, Ying

IPC: A61K31/404 ,  A61P27/16 ,  A23L1/29

CPC classification number: A61K31/404 ,  A23L2/52 ,  A23L33/105

Abstract: Use of DIM and/or its derivatives for prevention, treatment and/or delay of age-related hearing loss in mammals.

Abstract translation: 使用DIM和/或其衍生物预防，治疗和/或延缓哺乳动物年龄相关的听力损失。

公开(公告)号：WO2008061755A8

公开(公告)日：2009-07-30

申请号：PCT/EP2007010133

申请日：2007-11-22

Applicant: DSM IP ASSETS BV ,  NESTEC SA ,  FOWLER ANN ,  GORALCZYK REGINA ,  KILPERT CLAUS ,  MOHAJERI HASAN ,  RAEDERSTORFF DANIEL ,  DE SAIZIEU ANTOINE ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WEHRLI CHRISTOF

Inventor： FOWLER ANN ,  GORALCZYK REGINA ,  KILPERT CLAUS ,  MOHAJERI HASAN ,  RAEDERSTORFF DANIEL ,  DE SAIZIEU ANTOINE ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WEHRLI CHRISTOF

IPC: A23L1/30 ,  A23K1/16 ,  A61K36/00

CPC classification number: A61K31/365 ,  A23K20/10 ,  A23K20/111 ,  A23L33/105 ,  A61K2300/00

Abstract: The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.

Abstract translation: 本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途 。