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    SYSTEMS AND METHODS FOR SIMULATION OF HEMODIALSIS ACCESS AND OPTIMIZATION
    11.
    发明申请
    SYSTEMS AND METHODS FOR SIMULATION OF HEMODIALSIS ACCESS AND OPTIMIZATION 审中-公开
    HEMODIALSIS访问和优化的模拟系统和方法

    公开(公告)号：WO2016073246A1

    公开(公告)日：2016-05-12

    申请号：PCT/US2015/057731

    申请日：2015-10-28

    Applicant: HEARTFLOW, INC

    Inventor： SANKARAN, Sethuraman ,  GRADY, Leo, J. ,  TAYLOR, Charles, A. ,  ZARINS, Christopher, K.

    IPC: G06F19/00 ,  A61M1/00

    CPC classification number: A61B34/10 ,  A61B2034/104 ,  A61B2034/105 ,  A61M1/00 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3659 ,  A61M1/3661 ,  G06F19/00 ,  G16H50/30 ,  G16H50/50

    Abstract: Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.

    Abstract translation: 公开了用于模拟或优化血液透析通路的系统和方法。 一种方法包括接收患者脉管系统的患者特异性解剖模型; 计算解剖模型的一部分的预处理几何形状的预处理血流动力学特征; 模拟解剖模型部分中的血管通路的后处理几何形状; 计算具有血管通路的解剖模型部分的后处理几何形状的后处理血流动力特性; 并产生预处理血液动力学特征或后处理血液动力学特性的表示。

    SYSTEMS AND METHODS FOR IDENTIFYING AND MODELING UNRESOLVED VESSELS IN IMAGE-BASED PATIENT-SPECIFIC HEMODYNAMIC MODELS
    15.
    发明申请
    SYSTEMS AND METHODS FOR IDENTIFYING AND MODELING UNRESOLVED VESSELS IN IMAGE-BASED PATIENT-SPECIFIC HEMODYNAMIC MODELS 审中-公开
    用于在基于图像的患者特异性血流动力学模型中识别和建模未溶解血管的系统和方法

    公开(公告)号：WO2017147500A1

    公开(公告)日：2017-08-31

    申请号：PCT/US2017/019462

    申请日：2017-02-24

    Applicant: HEARTFLOW, INC.

    Inventor： TAYLOR, Charles, A. ,  JIN KIM, Hyun ,  GRADY, Leo ,  TOMBROPOULOS, Rhea ,  CHOI, Gilwoo ,  XIAO, Nan ,  SPAIN, Buzzy

    IPC: G06F19/00

    CPC classification number: G06F19/3437 ,  G06F19/00 ,  G16H50/50

    Abstract: Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving, in an electronic storage medium, one or more patient-specific anatomical models representing at least a vessel of a patient; determining, using a processor, the values and characteristics of one or more patient-specific morphometric features in the one or more patient-specific anatomical models; modifying the patient-specific anatomical model using the determined patient-specific morphometric features; and outputting, one or more of, a modified patient-specific anatomical model or a patient-specific morphometric feature to an electronic storage medium or display.

    Abstract translation: 公开了用于在基于图像的患者特异性血液动力学模型中识别和建模未分解血管及其效果的系统和方法。 一种方法包括：在电子存储介质中接收代表患者的至少一个血管的一个或多个患者特异性解剖模型; 使用处理器确定所述一个或多个患者特异性解剖模型中的一个或多个患者特异性形态测量特征的值和特性; 使用确定的患者特异性形态测量特征修改患者特异性解剖模型; 并且将修改的患者特异性解剖模型或患者特异性形态特征中的一个或多个输出到电子存储介质或显示器。

    SYSTEMS AND METHODS FOR ASSESSING ORGAN AND/OR TISSUE TRANSPLANTATION BY SIMULATING ONE OR MORE TRANSPLANT CHARACTERISTICS
    16.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING ORGAN AND/OR TISSUE TRANSPLANTATION BY SIMULATING ONE OR MORE TRANSPLANT CHARACTERISTICS 审中-公开
    通过模拟一种或多种移植特征来评估器官和/或组织移植的系统和方法

    公开(公告)号：WO2017091492A1

    公开(公告)日：2017-06-01

    申请号：PCT/US2016/063027

    申请日：2016-11-21

    Applicant: HEARTFLOW, INC.

    Inventor： GRADY, Leo ,  TAYLOR, Charles, A. ,  ZARINS, Christopher

    IPC: G06F19/00

    CPC classification number: A61B34/10 ,  A61B5/0263 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B8/06 ,  A61B2034/104 ,  A61B2034/105 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/0081 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30056 ,  G06T2207/30084 ,  G06T2207/30104 ,  G06T2211/404 ,  G09B9/00 ,  G09B23/303 ,  G16H50/50

    Abstract: Systems and methods are disclosed for assessing organ and/or tissue transplantation by estimating blood flow through a virtual transplant model by receiving a patient-specific anatomical model of the intended transplant recipient; receiving a patient-specific anatomical model of the intended transplant donor, the model including the vasculature of the organ or tissue that is intended to be transplanted to the recipient; constructing a unified model of the connected system post transplantation, the connected system including the transplanted organ or tissue from the intended transplant donor and the vascular system of the intended transplant recipient; receiving one or more blood flow characteristics of the connected system; assessing the suitability for an actual organ or tissue transplantation using the received blood flow characteristics; and outputting the assessment into an electronic storage medium or display.

    Abstract translation: 公开了用于评估器官和/或组织移植的系统和方法，其通过接收预期移植接受者的患者特异性解剖模型来估计通过虚拟移植模型的血流量; 接收预期的移植供体的患者特异性解剖模型，所述模型包括旨在移植到受体的器官或组织的脉管系统; 构建移植后连接系统的统一模型，所述连接系统包括来自预期移植供体的移植器官或组织和预期移植受体的血管系统; 接收连接系统的一个或多个血流特性; 使用所接收的血流特性评估实际器官或组织移植的适用性; 并将评估输出到电子存储介质或显示器中。

    SYSTEMS AND METHODS FOR ANATOMICAL MODELING USING INFORMATION FROM A PROCEDURE
    17.
    发明申请
    SYSTEMS AND METHODS FOR ANATOMICAL MODELING USING INFORMATION FROM A PROCEDURE 审中-公开
    用过程信息进行解剖学建模的系统和方法

    公开(公告)号：WO2017083401A1

    公开(公告)日：2017-05-18

    申请号：PCT/US2016/061155

    申请日：2016-11-09

    Applicant: HEARTFLOW, INC.

    Inventor： GRADY, Leo ,  TAYLOR, Charles, A. ,  ROGERS, Campbell ,  ZARINS, Christopher, K. ,  CHOI, Gilwoo

    IPC: G06F19/00

    CPC classification number: G16H50/50 ,  G06F19/00

    Abstract: Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.

    Abstract translation: 本文公开了使用在医疗过程期间获得的信息进行解剖建模的系统和方法，由此生成或获得初始解剖模型，确定初始模型与附加数据和/或测量值之间的对应关系 如果在初始模型和附加数据之间发现差异，则更新解剖模型以结合附加数据并减少差异。

    SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING RISK
    18.
    发明申请
    SYSTEMS AND METHODS FOR ESTIMATING HEMODYNAMIC FORCES ACTING ON PLAQUE AND MONITORING RISK 审中-公开
    用于评估在肌肉和监测风险上行动的动脉系统和方法

    公开(公告)号：WO2017011555A1

    公开(公告)日：2017-01-19

    申请号：PCT/US2016/042093

    申请日：2016-07-13

    Applicant: HEARTFLOW, INC.

    Inventor： KOO, Bon-kwon ,  CHOI, Gilwoo ,  KIM, Hyun, Jin ,  TAYLOR, Charles, A.

    IPC: G06F19/00 ,  A61B5/026

    CPC classification number: G16H50/50 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/026 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

    Abstract: Computer-implemented methods are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: receiving one or more patient-specific parameters of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion; constructing a patient-specific geometric model of at least a portion of a patient's vasculature that is prone to plaque progression, rupture, or erosion, using the received one or more patient-specific parameters; estimating, using one or more processors, the values of hemodynamic forces at one or more points on the patient-specific geometric model, using the patient-specific parameters and geometric model by measuring, deriving, or obtaining one or more of a pressure gradient and a radius gradient; and outputting the estimated values of hemodynamic forces to an electronic storage medium. Systems and computer readable media for executing these methods are also disclosed.

    Abstract translation: 公开了计算机实现的方法来估计作用于斑块或病变的血液动力学的值。 一种方法包括：接收容易发生斑块进展，破裂或侵蚀的患者脉管系统的至少一部分的一个或多个患者特异性参数; 使用所接收的一个或多个患者特定参数来构建容易发生斑块进展，破裂或侵蚀的患者脉管系统的至少一部分的患者特异性几何模型; 使用患者特异性参数和几何模型，通过测量，推导或获得压力梯度中的一个或多个来估计使用一个或多个处理器的血液动力的值在患者特异性几何模型上的一个或多个点处， 半径梯度; 并将所述估计的血流动力值输出到电子存储介质。 还公开了用于执行这些方法的系统和计算机可读介质。

    SYSTEMS AND METHODS FOR PREDICTING TISSUE VIABILITY DEFICITS FROM PHYSIOLOGICAL, ANATOMICAL, AND PATIENT CHARACTERISTICS
    19.
    发明申请
    SYSTEMS AND METHODS FOR PREDICTING TISSUE VIABILITY DEFICITS FROM PHYSIOLOGICAL, ANATOMICAL, AND PATIENT CHARACTERISTICS 审中-公开
    从生理学，解剖学和患者特征预测组织缺陷的系统和方法

    公开(公告)号：WO2016161356A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/025690

    申请日：2016-04-01

    Applicant: HEARTFLOW, INC.

    Inventor： CHOI, Gilwoo ,  SCHAAP, Michiel ,  TAYLOR, Charles, A. ,  GRADY, Leo

    IPC: G06F19/00

    CPC classification number: A61B5/02007 ,  A61B5/026 ,  A61B5/742 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50

    Abstract: Systems and methods are disclosed for using patient-specific anatomical models and physiological parameters to predict viability of a target tissue or vessel to guide diagnosis or treatment of cardiovascular disease. One method includes: receiving a patient-specific vessel model and a patient-specific tissue model of a patient anatomy; receiving one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, etc.) for one or more physiological states; estimating a viability characteristic of the patient-specific tissue or vessel model (e.g., via a trained machine learning algorithm), using the patient-specific physiological parameters; and outputting the viability characteristic to an electronic storage medium or display.

    Abstract translation: 公开了用于使用患者特异性解剖模型和生理参数来预测目标组织或血管的可行性以指导心血管疾病的诊断或治疗的系统和方法。 一种方法包括：接收患者特异性血管模型和患者解剖结构的患者特异性组织模型; 为一种或多种生理状态接收一种或多种患者特异性生理参数（例如血液流动，解剖特征等）; 使用患者特异性生理参数估计患者特异性组织或血管模型的生存力特征（例如经由训练的机器学习算法）; 并将生存特性输出到电子存储介质或显示器。

    SYSTEMS AND METHODS FOR EMBOLISM PREDICTION USING EMBOLUS SOURCE AND DESTINATION PROBABILITIES
    20.
    发明申请
    SYSTEMS AND METHODS FOR EMBOLISM PREDICTION USING EMBOLUS SOURCE AND DESTINATION PROBABILITIES 审中-公开
    使用EMBOLUS来源和目标概率进行嵌体预测的系统和方法

    公开(公告)号：WO2016115206A1

    公开(公告)日：2016-07-21

    申请号：PCT/US2016/013165

    申请日：2016-01-13

    Applicant: HEARTFLOW, INC.

    Inventor： GRADY, Leo, J. ,  CHOI, Gilwoo ,  TAYLOR, Charles, A. ,  ZARINS, Christopher, K.

    IPC: G06F19/00

    CPC classification number: G16H50/20 ,  G06F17/18 ,  G06F19/00 ,  G06N7/005 ,  G16H50/50

    Abstract: Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient- specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient- specific anatomic model, based on the determined blood flow characteristics.

    Abstract translation: 公开了用于确定基于栓塞移动和目的地的患者风险评估或治疗计划的系统和方法。 一种方法包括接收由病人对患者血管系统的至少一部分的患者特异性成像产生的患者特异性解剖模型; 在患者的脉管系统的患者特异性解剖模型中确定或接收感兴趣的位置; 使用计算处理器来计算通过所述患者特异性解剖模型的血流，以通过所述患者特定解剖模型的患者特定解剖模型的至少部分来自感兴趣位置的下游来确定血流特性; 以及使用计算处理器通过所述模拟血流进行粒子跟踪，以基于所确定的血流特性来确定源自所述患者特异性解剖模型中的感兴趣位置的栓塞的目的地概率。

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