公开(公告)号：WO2011103071A1

公开(公告)日：2011-08-25

申请号：PCT/US2011/024845

申请日：2011-02-15

Applicant: CARDIAC PACEMAKERS, INC. ,  LI, Dan ,  SHARMA, Arjun ,  ZHANG, Yi

Inventor： LI, Dan ,  SHARMA, Arjun ,  ZHANG, Yi

IPC: A61N1/365 ,  A61N1/362 ,  A61B5/0464 ,  A61B5/0205 ,  A61B5/08 ,  A61N1/39

CPC classification number: A61N1/36585 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0816 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36578 ,  A61N1/3962

Abstract: Detected changes in respiration parameters, either alone or in conjunction with other physiological signals, can be used to discriminate between hemodynamically stable and hemodynamically unstable tachyarrhythmias. In some examples, this discrimination can be used to help guide therapy decisions. In various examples, a relationship is determined between a characteristic of a respiration signal and a characteristic of an auxiliary signal and uses the relationship to determine a hemodynamic stability characteristic of the tachyarrhythmia.

Abstract translation: 单独或与其他生理信号联合检测的呼吸参数变化可用于区分血液动力学稳定和血液动力学不稳定的快速性心律失常。 在一些例子中，这种歧视可用于帮助指导治疗决策。 在各种示例中，在呼吸信号的特征和辅助信号的特征之间确定关系，并且使用该关系来确定快速性心律失常的血液动力学稳定性特征。

公开(公告)号：WO2011093991A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/000121

申请日：2011-01-21

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  FELDMAN, Marc, D. ,  PORTERFIELD, John ,  RAGHAVAN, Karthik ,  VALVANO, Jonathan, W. ,  PEARCE, John, A.

Inventor： FELDMAN, Marc, D. ,  PORTERFIELD, John ,  RAGHAVAN, Karthik ,  VALVANO, Jonathan, W. ,  PEARCE, John, A.

IPC: A61B5/02

CPC classification number: A61B5/0537 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0452 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1076 ,  A61B5/204 ,  A61B5/441 ,  A61B5/4519 ,  A61B5/4878 ,  A61N1/36521 ,  A61N1/3684 ,  A61N1/3962

Abstract: An apparatus and associated method for determining tissue versus fluid components of an organ includes a detector that generates a detector signal based on electrical signals derived from tissue and fluid and a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. The method includes a piggyback of an admittance system onto an AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. The apparatus and method includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ.

Abstract translation: 用于确定器官的组织与流体成分的装置和相关方法包括：检测器，其基于从组织和流体得到的电信号和与检测器通信的信号处理器产生检测器信号，该信号处理器实时地从 检测器信号并产生流体量信号。 该方法包括对于患者的心脏的AICD /双心室起搏器的导纳系统的背负，特别是具有与充血性心力衰竭一致的特征的弱化心脏。 该装置和方法包括与检测器通信的发射器，其发射指示器官的导纳的无线信号。

公开(公告)号：WO2011017049A1

公开(公告)日：2011-02-10

申请号：PCT/US2010/043228

申请日：2010-07-26

Applicant: CARDIAC PACEMAKERS, INC. ,  AVERINA, Viktoria, A. ,  HAMANN, Jason, J. ,  RUBLE, Stephen ,  SHUROS, Allan, C.

Inventor： AVERINA, Viktoria, A. ,  HAMANN, Jason, J. ,  RUBLE, Stephen ,  SHUROS, Allan, C.

IPC: A61B5/08 ,  A61B5/053

CPC classification number: A61N1/3601 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4035 ,  A61B5/4869 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/36585

Abstract: A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.

Abstract translation: 可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。 此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。

公开(公告)号：WO2010118033A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/030102

申请日：2010-04-06

Applicant: CARDIAC PACEMAKERS, INC. ,  SHUROS, Allan C. ,  STOLEN, Craig ,  ARCOT-KRISHNAMURTHY, Shantha

Inventor： SHUROS, Allan C. ,  STOLEN, Craig ,  ARCOT-KRISHNAMURTHY, Shantha

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/39

CPC classification number: A61N1/36521 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3702

Abstract: A method and device are described for delivering cardiac therapy in which an implantable device for delivering such cardiac therapy is additionally configured to detect the presence of inflammation. Upon detection of inflammation, the device may be configured to modify its delivery of therapy in various ways and/or to communicate the information to an external agent for other types of interventions.

Abstract translation: 描述了用于递送心脏疗法的方法和装置，其中用于递送这种心脏治疗的可植入装置另外配置为检测炎症的存在。 在检测到炎症时，该装置可以被配置为以各种方式修改其治疗递送和/或将信息传达给外部代理以用于其他类型的干预。

公开(公告)号：WO2010062451A1

公开(公告)日：2010-06-03

申请号：PCT/US2009/058127

申请日：2009-09-24

Applicant: MEDTRONIC, INC. ,  WHALSTRAND, John, D. ,  DENISON, Timothy, J. ,  SANTA, Wesley, A.

Inventor： WHALSTRAND, John, D. ,  DENISON, Timothy, J. ,  SANTA, Wesley, A.

IPC: A61B5/053 ,  G01R27/02 ,  H03F3/00 ,  A61B5/026 ,  A61N1/372 ,  A61N1/39 ,  A61N1/365

CPC classification number: A61B5/053 ,  A61B5/026 ,  A61B5/0538 ,  A61B5/6846 ,  A61B5/7217 ,  A61N1/36521

Abstract: A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.

Abstract translation: 公开了一种用于确定复杂心脏间阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调直流信号的信号发生器装置，用于调制可调直流信号以产生调制 至少一个用于在心肌上传播调制信号的电极，至少一个用于检测来自心肌的输出调制信号的传感器，以及至少一个用于减少输出的调制信号中的过程噪声（攻击者）的影响的电路。 该至少一个电路包括放大器，解调器和积分器。 最终输出的调制信号的幅度和相位指示心肌的复阻抗。 心肌复杂阻抗模式的变化提供了向心肌减少的氧气和血流量的指示。 该装置可用于植入式装置，包括心脏起搏器和植入式心脏复律除颤器。

公开(公告)号：WO2010051500A1

公开(公告)日：2010-05-06

申请号：PCT/US2009/062865

申请日：2009-10-30

Applicant: MEDTRONIC, INC. ,  KRAUSE, Paul, G. ,  SCHEINER, Avram

Inventor： KRAUSE, Paul, G. ,  SCHEINER, Avram

IPC: A61N1/365

CPC classification number: A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

Abstract: An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

Abstract translation: 包括心脏治疗模块和神经刺激治疗模块的可植入医疗系统可以识别神经刺激电极何时向患者的心脏移动。 在一些示例中，系统可以基于对通过神经刺激电极递送给患者的电信号的生理反应来确定神经刺激电极是否已经向患者的心脏迁移。 此外，在一些示例中，系统可以基于经由神经刺激电极感测的电心脏信号来确定神经刺激电极是否已经向患者的心脏迁移。

公开(公告)号：WO2010042855A1

公开(公告)日：2010-04-15

申请号：PCT/US2009/060223

申请日：2009-10-09

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  PATTERSON, Robert ,  YANG, Fei

Inventor： PATTERSON, Robert ,  YANG, Fei

IPC: A61B5/02

CPC classification number: A61B5/053 ,  A61B5/0535 ,  A61B5/4878 ,  A61N1/36521

Abstract: In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a third electrode in the superior vena cava, where the voltage potential is created by the electrical current. Pulmonary edema is assessed based on an impedance value calculated from the electrical current and the voltage potential and a stored edema threshold impedance value.

Abstract translation: 在监测人的肺水肿的方法中，在位于心脏中或周围的第一电极和植入胸部区域的医疗装置的壳体之间注入电流。 在上腔静脉中的第二电极和上腔静脉中的第三电极之间测量电压电位，其中电压由电流产生。 基于从电流和电压电位计算的阻抗值以及存储的水肿阈值阻抗值来评估肺水肿。

公开(公告)号：WO2010024733A1

公开(公告)日：2010-03-04

申请号：PCT/SE2008/000483

申请日：2008-08-28

Applicant: ST. JUDE MEDICAL AB ,  BROOMÉ, Michael ,  BLOMQVIST, Andreas

Inventor： BROOMÉ, Michael ,  BLOMQVIST, Andreas

IPC: A61N1/365 ,  A61B5/053

CPC classification number: A61B5/02028 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/7235 ,  A61B5/7239 ,  A61N1/36521 ,  A61N1/3682

Abstract: An implantable medical device (100) applies an electric signal to at least a portion of a heart (10) in a subject (1). A resulting electric signal is collected from the heart (10) and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/ or cardiac therapy adjustment.

Abstract translation: 植入式医疗装置（100）将电信号施加到被检体（1）的心脏（10）的至少一部分。 从心脏（10）收集所得到的电信号，并将其与应用的信号一起用于确定心源性阻抗信号。 处理阻抗信号以估计等体积收缩时间，等体积弛豫时间和心脏周期的排出时间。 这三个时间参数用于计算心脏的Tei指数。 Tei指数可用作心脏诊断和/或心脏治疗调整中的心肌性能参数。

公开(公告)号：WO2009134463A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/030961

申请日：2009-01-14

Applicant: MEDTRONIC, INC. ,  GOETZ, Steven, M. ,  SMITH, Tood, Verlan ,  TORGERSON, Nathan, A. ,  BALL, Warren, W.

Inventor： GOETZ, Steven, M. ,  SMITH, Tood, Verlan ,  TORGERSON, Nathan, A. ,  BALL, Warren, W.

IPC: A61N1/372 ,  A61N1/36 ,  A61N1/08

CPC classification number: A61N1/36521 ,  A61N1/36185 ,  A61N1/37247

Abstract: Method, controller and system for an implantable medical device capable of delivering therapeutic stimulation through a plurality of electrodes. A control module is operable to conduct a plurality of measurements of impedance values creating a plurality of measured impedance values for a plurality of selected sets of individual ones of the plurality of electrodes based on a plurality of active parameters. The control module conducts the plurality of measurements of impedance values in a plurality of stages in which at least one of said plurality of active parameters is varied between individual ones of the plurality of stages.

Abstract translation: 一种能够通过多个电极传递治疗刺激的可植入医疗装置的方法，控制器和系统。 控制模块可操作以基于多个有效参数进行阻抗值的多个测量，从而产生多个选定组的多个电极中的多个测量的阻抗值。 所述控制模块在所述多个级中的各个阶段之间变化所述多个有效参数中的至少一个有效参数的多个级中进行阻抗值的多个测量。

公开(公告)号：WO2009123508A1

公开(公告)日：2009-10-08

申请号：PCT/SE2008/000238

申请日：2008-03-31

Applicant: ST. JUDE MEDICAL AB ,  JÄRVERUD, Karin ,  BLOMQVIST, Andreas ,  WIKEFELDT, Carl

Inventor： JÄRVERUD, Karin ,  BLOMQVIST, Andreas ,  WIKEFELDT, Carl

IPC: A61N1/365 ,  G01N33/49

CPC classification number: A61N1/36521 ,  A61B5/0464 ,  A61B5/053 ,  A61N1/3622 ,  A61N1/36585 ,  A61N1/37258 ,  A61N1/3962

Abstract: An implantable medical device (100) comprises a detector (110) for detecting an arrhythmia event of a subject's (1) heart (10) and generating an arrhythmia signal based on the detected event. An impedance determining unit (120) determines impedance data representative of blood aggregation level of blood present in a cavity, such as heart chamber (12, 14), of the subject (1). An anti-arrhythmia unit (130) of the device (100) is arranged for applying electric anti- arrhythmia treatment to at least a portion of the heart (10). This unit (130) is conditionally operable based on the arrhythmia signal and the impedance data. The risk blood aggregates and clots obstructing blood vessels following anti- arrhythmia treatment is significant reduces by conditioning the treatment based on the aggregation level representing impedance data.

Abstract translation: 可植入医疗装置（100）包括用于检测受试者（1）心脏（10）的心律失常事件的检测器（110），并且基于检测到的事件产生心律失常信号。 阻抗确定单元（120）确定表示存在于诸如对象（1）的心室（12,14）的空腔中的血液的血液聚集水平的阻抗数据。 布置了装置（100）的抗心律失常单元（130），用于向心脏（10）的至少一部分进行电抗心律失常治疗。 该单元（130）基于心律失常信号和阻抗数据有条件地操作。 抗心律失常治疗后阻塞血管的血液凝集和血栓风险显着降低，这是通过根据代表阻抗数据的汇总水平进行治疗来进行治疗。