公开(公告)号：WO2018165517A1

公开(公告)日：2018-09-13

申请号：PCT/US2018/021691

申请日：2018-03-09

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： GARVEY, Lucy ,  HASSAN, Lubna ,  NICHOLS, Kyla ,  PAQUIN, Allison ,  DANIELLO, Robert J. ,  ROLLE, Marsha

IPC: A61B5/08 ,  A61B5/091 ,  A61B5/087 ,  A01K29/00 ,  G01F1/68

CPC classification number: A61B5/0878 ,  A61B5/0809 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1135 ,  A61B2503/40 ,  A61B2562/0271 ,  A61B2562/029

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.

公开(公告)号：WO2018009388A1

公开(公告)日：2018-01-11

申请号：PCT/US2017/039702

申请日：2017-06-28

Applicant: GENERAL ELECTRIC COMPANY

Inventor： SARKELA, Mika ,  COFFENG, Rene, Johannes ,  UUTELA, Kimmo ,  JÄRVELÄ, Liisa-Maria

IPC: A61B5/00 ,  G06F19/00 ,  A61B5/0424 ,  A61B5/08 ,  A61B5/053 ,  A61B5/1455 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0205

CPC classification number: A61B5/746 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0424 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/14551 ,  A61B5/4836 ,  A61B5/6843 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7465 ,  A61B5/747 ,  A61B5/7475 ,  A61B5/749 ,  G06F19/3418 ,  G16H40/63

Abstract: In the present invention, a system and associated method is provided for monitoring vital parameters of a patient. The monitoring system includes sensors disposed on the patient and operably connected to a monitor. The parameters that are sensed by the sensors are transmitted to the monitor and compared with alarm thresholds and operational criteria stored within the monitor. When an alarm condition is sensed by the system, the system can actively solicit patient assistance in the confirmation of the alarm condition based on a set of reactive inputs stored within the system to enable medical personnel to appropriately respond to clinically relevant sensed alarm condition(s).

Abstract translation: 在本发明中，提供了一种用于监测患者的生命参数的系统和相关方法。 监视系统包括设置在患者身上并可操作地连接到监视器的传感器。 传感器感应到的参数被传送到监视器，并与存储在监视器内的报警阈值和操作标准进行比较。 当系统检测到警报状况时，系统可以基于存储在系统内的一组反应输入来主动请求患者帮助确认警报状况，以使医务人员能够适当地响应临床相关的感测警报状况 ）。

公开(公告)号：WO2017087888A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062920

申请日：2016-11-18

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  LEVINE, Andy H. ,  KANZLER, Christoph, Matthias ,  GUY, Aymeric ,  MIRANDA, Daniel, Leo ,  MOONEY, Joseph ,  ZAPOTOK, Adam ,  BERRY, Samel ,  LAM, Huy ,  SABATÉ DEL RÍO, Jonathan

Inventor： LEVINE, Andy H. ,  KANZLER, Christoph, Matthias ,  GUY, Aymeric ,  MIRANDA, Daniel, Leo ,  MOONEY, Joseph ,  ZAPOTOK, Adam ,  BERRY, Samel ,  LAM, Huy ,  SABATÉ DEL RÍO, Jonathan ,  OSBORNE, John ,  KARABAS, Mustafa ,  DUNNE, Alan ,  NIEMI, James ,  MATTHEWS, Benjamin ,  INGBER, Donald, E. ,  HENRY, Olivier ,  INDIC, Premananda Pai

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/08 ,  A61B5/145 ,  A61M5/00 ,  A61M5/20 ,  A61M37/00

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0452 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/1135 ,  A61B5/145 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/7264 ,  A61B5/7278 ,  A61K31/137 ,  A61M5/00 ,  A61M5/14248 ,  A61M5/20 ,  A61M5/2053 ,  A61M37/00 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2005/206 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/30 ,  A61M2230/50 ,  A61M2230/63 ,  A61M2230/65

Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

Abstract translation: 生理传感器模块包括至少一个可佩戴传感器，其被配置用于佩戴在人体部位上并用于测量至少一个生物信号。 该模块还包括至少一个控制器，其通信地耦合到可佩戴传感器并且被配置为从可佩戴传感器接收生物信号。 控制器还被配置为实时处理生物信号，从生物信号提取一个或多个临床特征，并基于临床特征确定过敏反应的检测。

公开(公告)号：WO2016207306A1

公开(公告)日：2016-12-29

申请号：PCT/EP2016/064593

申请日：2016-06-23

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： WIJSHOFF, Ralph, Wilhelm, Christianus, Gemma, Rosa ,  MÜHLSTEFF, Jens ,  ORDELMAN, Simone, Cornelia, Maria, Anna ,  PEETERS, Wouter, Herman

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/0205 ,  A61B5/026

CPC classification number: A61H31/005 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/0245 ,  A61B5/0261 ,  A61B5/044 ,  A61B5/0456 ,  A61B5/0809 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/11 ,  A61B5/14551 ,  A61B5/4848 ,  A61B5/7203 ,  A61B5/7253 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/746 ,  A61B2505/01 ,  A61N1/3925 ,  A61N1/3937

Abstract: A device for supporting determination of return of spontaneous circulation, ROSC, during an associated cardiopulmonary resuscitation, CPR, procedure which is being performed on an associated patient. A sensor is used to sense a physiological signal of the patient. Frequency analysis of the signal is carried out to extract dominant fundamental frequency components in the signal. From this analysis it is possible to determine that there has been a potential ROSC.

Abstract translation: 用于支持相关心肺复苏期间自发循环（ROSC）返回的测定装置，CPR，相关患者正在进行的手术。 传感器用于感测患者的生理信号。 进行信号的频率分析，以提取信号中的主要基频分量。 从这个分析可以确定存在潜在的ROSC。

公开(公告)号：WO2016170327A1

公开(公告)日：2016-10-27

申请号：PCT/GB2016/051092

申请日：2016-04-20

Applicant: UCL BUSINESS PLC

Inventor： HOLDER, David ,  ARISTOVICH, Kirill

IPC: A61B5/053

CPC classification number: A61B5/04001 ,  A61B5/0536 ,  A61B5/0809 ,  A61B5/6877 ,  A61B5/6884 ,  A61B5/7278 ,  A61B2503/40 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/164 ,  A61B2576/00

Abstract: There is disclosed a method of determining electrical properties in a peripheral nerve (10) of a human or animal subject using a plurality of electrodes (24) spaced around a perimeter of the nerve, by applying a probe electrical signal to each of a plurality of combinations of the electrodes, and using the resulting electrical responses to determine the electrical properties, for example by carrying out an electrical impedance tomography image reconstruction.

Abstract translation: 公开了一种使用多个围绕神经周边间隔的电极（24）来确定人或动物受试者的外周神经（10）中的电性能的方法，通过将探针电信号施加到多个 电极的组合，并且使用所得的电响应来确定电特性，例如通过进行电阻抗层析成像图像重建。

公开(公告)号：WO2015187424A1

公开(公告)日：2015-12-10

申请号：PCT/US2015/032649

申请日：2015-05-27

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： THAKUR, Pramodsingh Hirasingh ,  WARIAR, Ramesh ,  AN, Qi ,  MASKARA, Barun ,  ZHANG, Yi

IPC: A61B5/0205 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/026 ,  A61B5/053 ,  A61B5/08 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/00 ,  G06F19/00 ,  A61N1/38 ,  A61N1/36 ,  A61B5/145 ,  A61B5/0215

CPC classification number: A61B5/0205 ,  A61B5/0022 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/02438 ,  A61B5/0245 ,  A61B5/026 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0537 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/1107 ,  A61B5/1118 ,  A61B5/14542 ,  A61B5/7264 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/395 ,  A61N1/3987 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

Abstract: Systems and methods for assessing hemodynamic status of a patient experiencing atrial tachyarrhythmia such as an atrial fibrillation (AF) episode are disclosed. A system can comprise an atrial tachyarrhythmia detection circuit configured to detect an AF episode, a hemodynamic sensor circuit configured to sense at least one hemodynamic signal, and a hemodynamic status analyzer circuit that can calculate one or more signal metrics using the sensed hemodynamic signal during the AF episode. The hemodynamic status analyzer circuit can categorize the hemodynamic status of the patient into one of two or more categorical hemodynamic status levels which indicate elevated hemodynamic impact of the detected AF episode. A user interface can provide to an end-user a presentation of the categorized hemodynamic status level during AF.

Abstract translation: 公开了用于评估经历心房颤动（AF）发作的房性快速性心律失常患者的血液动力学状态的系统和方法。 系统可以包括被配置为检测AF发作的心房快速性心律失常检测电路，被配置为感测至少一个血液动力学信号的血流动力学传感器电路，以及血流动力学状态分析器电路，其可以在该期间检测到的血液动力学信号计算一个或多个信号度量 AF事件。 血液动力学状态分析器电路可以将患者的血液动力学状态分为两个或更多个分类血液动力学状态水平之一，其指示检测到的AF发作的血液动力学影响升高。 在AF期间，用户界面可以向最终用户提供分类的血液动力学状态水平的呈现。

公开(公告)号：WO2015187324A1

公开(公告)日：2015-12-10

申请号：PCT/US2015/030514

申请日：2015-05-13

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： AN, Qi ,  THAKUR, Pramodsingh, Hirasingh ,  WARIAR, Ramesh

IPC: A61B5/00 ,  A61B5/053 ,  A61B5/0205 ,  A61N1/362

CPC classification number: A61B5/0535 ,  A61B5/0205 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/6823 ,  A61B5/6852 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/362 ,  A61N1/36521 ,  G06F19/00

Abstract: An apparatus may include a sensing circuit configured to generate a sensed physiological signal representative of thoracic impedance of a subject and a controller circuit. The a controller circuit is electrically coupled to the sensing circuit and includes a measurement circuit that determines a measure of absolute thoracic impedance using the sensed physiological signal, and a risk circuit that quantifies a risk of worsening heart failure (WHF) for the subject using a comparison of the determined measure of absolute thoracic impedance to a specified threshold value of absolute thoracic impedance, and generate an indication of risk of WHF of the subject according to the quantifying of the risk.

Abstract translation: 一种装置可以包括感测电路，其被配置为产生代表对象的胸部阻抗的感测生理信号和控制器电路。 控制器电路电耦合到感测电路并且包括使用感测到的生理信号确定绝对胸部阻抗的量度的测量电路，以及风险电路，其使用以下方法量化对象的心力衰竭（WHF）恶化的风险 将确定的绝对胸阻抗测量与绝对胸阻抗的指定阈值进行比较，并根据风险的量化产生受试者的WHF风险指标。

公开(公告)号：WO2014189770A3

公开(公告)日：2015-01-22

申请号：PCT/US2014038248

申请日：2014-05-15

Applicant: ZEPHYR TECHNOLOGY CORP ,  RUSSELL BRIAN ,  WOODWARD JONATHAN JAMES ,  MUKHERJEE AMIT KUMAR ,  BARTLETT DANIEL WAYNE ,  SOLOMON CHRIS

Inventor： RUSSELL BRIAN ,  WOODWARD JONATHAN JAMES ,  MUKHERJEE AMIT KUMAR ,  BARTLETT DANIEL WAYNE ,  SOLOMON CHRIS

IPC: A61B5/08

CPC classification number: A61B5/0809 ,  A61B5/0002 ,  A61B5/0816 ,  A61B5/6823 ,  A61B5/721 ,  A61B5/7225

Abstract: Methods, apparatuses and systems are described for determining respiration through impedance measurements using only two electrodes. A drive signal may be applied to a person, using only two electrodes. Using the same electrodes, the fluctuations in the voltage of the drive signal are determined. The voltage fluctuations in the drive signal are the result of impedance variations in the person's thoracic cavity due to respiration. Therefore, the voltage fluctuations may be used to determine a respiration rate of the person. In doing so, the voltage fluctuations may be digitized using a sampling rate that is much less than the frequency of the applied drive signal.

Abstract translation: 描述了通过仅使用两个电极的阻抗测量来确定呼吸的方法，装置和系统。 驱动信号可以仅使用两个电极施加到人。 使用相同的电极，确定驱动信号的电压的波动。 驱动信号中的电压波动是由于呼吸引起的人胸腔阻抗变化的结果。 因此，可以使用电压波动来确定人的呼吸速率。 在这样做时，电压波动可以使用比所施加的驱动信号的频率小得多的采样率来数字化。

公开(公告)号：WO2013158331A1

公开(公告)日：2013-10-24

申请号：PCT/US2013/033167

申请日：2013-03-20

Applicant: VITAL CONNECT, INC.

Inventor： NARASIMHAN, Ravi ,  FERDOSI, Nima

IPC: A61B5/08 ,  A61B5/04

CPC classification number: A61B5/725 ,  A61B5/0809 ,  A61B5/0816

Abstract: A method and system for determining a respiratory rate of a user are disclosed. The method comprises measuring a differential voltage across first and second electrodes of a sensor device coupled to the user. The method includes sampling the differential voltage using an analog-to-digital converter to produce an output signal. The method includes processing the output signal to detect a breath of the user based on a positive voltage transition through a midpoint, wherein the breath of the user is utilized to determine the respiratory rate of the user.

Abstract translation: 公开了一种用于确定用户呼吸频率的方法和系统。 该方法包括测量耦合到用户的传感器设备的第一和第二电极之间的差分电压。 该方法包括使用模拟 - 数字转换器对差分电压进行采样以产生输出信号。 该方法包括处理输出信号以基于通过中点的正电压转换来检测用户的呼吸，其中用户的呼吸用于确定用户的呼吸频率。

公开(公告)号：WO2013013153A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/047604

申请日：2012-07-20

Applicant: RESPIRATORY MOTION, INC. ,  FREEMAN, Jenny, E. ,  LALLI, Michael ,  KARCZ, Anita ,  PANASYUK, Alexander ,  BOKHENIK, Roman ,  BOCK, Malcom

Inventor： FREEMAN, Jenny, E. ,  LALLI, Michael ,  KARCZ, Anita ,  PANASYUK, Alexander ,  BOKHENIK, Roman ,  BOCK, Malcom

IPC: A61H31/00

CPC classification number: A61B5/0535 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/091 ,  A61B2505/01 ,  A61H31/005 ,  A61H2201/5012 ,  A61H2201/5015 ,  A61H2201/5048 ,  A61H2201/5084 ,  A61H2230/04 ,  A61H2230/205 ,  A61H2230/207 ,  A61H2230/655 ,  A61N1/046 ,  A61N1/3987

Abstract: Disclosed is a device, method and computer readable media for determining the adequacy of Cardiopulmonary Resuscitation (CPR). The device comprises an electrical source generator, an electrical signal sensor receiving a signal from the electrical source generator and a microprocessor. The microprocessor determines changes in impedance of the patient based on the signal received from the electrical signal sensor. Software executing on the microprocessor determines at least one of intrathoracic volume, change in intrathoracic volume, rate of compression, depth of compression, respiratory volume, and respiratory rate based on the change of impedance of the patient and outputs a signal indicating the adequacy of ventilation and compressions.

Abstract translation: 公开了一种用于确定心肺复苏（CPR）的充分性的装置，方法和计算机可读介质。 该装置包括电源发生器，接收来自电源发生器的信号的电信号传感器和微处理器。 微处理器根据从电信号传感器接收的信号确定患者的阻抗变化。 在微处理器上执行的软件基于患者的阻抗变化来确定胸内体积，胸内体积变化，压缩速率，压缩深度，呼吸量和呼吸频率中的至少一个，并输出指示通气适当性的信号 和压缩。