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    METHOD AND APPARATUS FOR HEAT OR ELECTROMAGNETIC CONTROL OF GENE EXPRESSION
    5.
    发明申请
    METHOD AND APPARATUS FOR HEAT OR ELECTROMAGNETIC CONTROL OF GENE EXPRESSION 审中-公开
    用于基因表达的热或电磁控制的方法和装置

    公开(公告)号：WO2007095264A1

    公开(公告)日：2007-08-23

    申请号：PCT/US2007/003855

    申请日：2007-02-12

    Applicant: CARDIAC PACEMAKERS, INC. ,  QU, Jihong ,  STOLEN, Craig

    Inventor： QU, Jihong ,  STOLEN, Craig

    IPC: C12N15/87 ,  A61N1/32 ,  A61N1/362 ,  A61K48/00

    CPC classification number: A61N1/3627 ,  A61K48/0058 ,  A61N1/326 ,  A61N1/362 ,  A61N1/36514

    Abstract: A gene regulatory system controls biomarker, gene therapy or endogenous gene expression by emitting one or more forms of energy that regulate gene expression. The system may include a sensor to sense a signal indicative of a need for therapy. The regulation of gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with controlling gene therapy or endogenous gene expression.

    Abstract translation: 基因调控系统通过发射调节基因表达的一种或多种形式的能量来控制生物标志物，基因治疗或内源基因表达。 该系统可以包括用于感测指示治疗需要的信号的传感器。 基于感测信号和/或用户命令来控制基因表达的调节。 在一个实施方案中，该系统结合控制基因治疗或内源基因表达递送一种或多种电疗法。

    SYSTEMS AND METHODS FOR SETTING PARAMETERS OF IMPLANTABLE MEDICAL DEVICES USING PREDICTIVE MARKER DATA
    6.
    发明申请
    SYSTEMS AND METHODS FOR SETTING PARAMETERS OF IMPLANTABLE MEDICAL DEVICES USING PREDICTIVE MARKER DATA 审中-公开
    使用预测标记数据设置可植入医疗器械参数的系统和方法

    公开(公告)号：WO2013003604A1

    公开(公告)日：2013-01-03

    申请号：PCT/US2012/044669

    申请日：2012-06-28

    Applicant: CARDIAC PACEMAKERS, INC. ,  STOLEN, Craig M. ,  BOS, Harlan ,  MEYER, Timothy E. ,  SHARMA, Arjun

    Inventor： STOLEN, Craig M. ,  BOS, Harlan ,  MEYER, Timothy E. ,  SHARMA, Arjun

    IPC: A61N1/365 ,  A61B5/145

    CPC classification number: A61N1/36557 ,  G01N33/74 ,  G01N2333/5754 ,  G01N2800/326

    Abstract: Embodiments of the invention are related to systems and methods for setting parameters of implantable medical devices, amongst other things. In an embodiment, the invention includes a method for programming an implantable medical device including sensing concentrations of a predictive marker such as ET-1 in a patient, selecting programming parameter values based on the sensed concentrations of the predictive marker, and implementing the selected programming parameter values. In an embodiment the invention includes a method for detecting arrhythmia in a patient including sensing concentrations of the predictive marker in a patient, selecting a level of stringency to be used in an arrhythmia detection module based on the sensed concentrations of the predictive marker, sensing electrical signals in the patient, and evaluating the sensed electrical signals for indicia of an arrhythmia using the arrhythmia detection module. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例涉及用于设置可植入医疗装置的参数的系统和方法等。 在一个实施例中，本发明包括一种用于编程可植入医疗装置的方法，包括感测患者中诸如ET-1的预测标记的浓度，基于感测到的预测标记的浓度选择编程参数值，以及实施所选择的节目 参数值。 在一个实施例中，本发明包括一种用于在患者中检测心律不齐的方法，包括感测患者中的预测标记的浓度，基于检测到的预测标记的浓度，选择在心律失常检测模块中使用的严格程度，感测电 信号，并使用心律失常检测模块评​​估用于心律失常标记的检测到的电信号。 本文还包括其它实施例。

    SYSTEM FOR PACING AND INTERMITTENT ISCHEMIA
    8.
    发明申请
    SYSTEM FOR PACING AND INTERMITTENT ISCHEMIA 审中-公开
    系统和间歇式ISCHEMIA

    公开(公告)号：WO2009154732A1

    公开(公告)日：2009-12-23

    申请号：PCT/US2009/003594

    申请日：2009-06-16

    Applicant: CARDIAC PACEMAKERS, INC. ,  STOLEN, Craig ,  SHUROS, Allan, C. ,  ARCOT-KRISHNAMURTHY, Shantha ,  MOKELKE, Eric, A.

    Inventor： STOLEN, Craig ,  SHUROS, Allan, C. ,  ARCOT-KRISHNAMURTHY, Shantha ,  MOKELKE, Eric, A.

    IPC: A61N1/05 ,  A61N1/362 ,  A61N1/365 ,  A61M25/10 ,  A61M25/09 ,  A61B5/0215 ,  A61B5/026 ,  A61B17/12

    CPC classification number: A61N1/056 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/026 ,  A61F2/95 ,  A61N1/3625 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/36571

    Abstract: A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.

    Abstract translation: 系统提供多种增强疗法以限制血运重建后的心肌损伤。 该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。 在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。 提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。 使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。 起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。

    SYSTEMS AND METHODS FOR CONTROLLING A CARDIAC RESYNCHRONISATION DEVICE/THERAPY USING BIOMARKER PANEL DATA
    10.
    发明申请
    SYSTEMS AND METHODS FOR CONTROLLING A CARDIAC RESYNCHRONISATION DEVICE/THERAPY USING BIOMARKER PANEL DATA 审中-公开
    用于控制使用生物标记面板数据的心脏再生装置/治疗的系统和方法

    公开(公告)号：WO2013116544A1

    公开(公告)日：2013-08-08

    申请号：PCT/US2013/024185

    申请日：2013-01-31

    Applicant: CARDIAC PACEMAKERS, INC. ,  STOLEN, Craig M. ,  MEDICAL UNIVERSITY OF SOUTH CAROLINA ,  MEYER, Timothy E. ,  SETH, Milan ,  SPINALE, Francis G. ,  WOLD, Nicholas David

    Inventor： STOLEN, Craig M. ,  MEYER, Timothy E. ,  SETH, Milan ,  SPINALE, Francis G. ,  WOLD, Nicholas David

    IPC: A61N1/362 ,  G01N33/68

    CPC classification number: G01N33/6893 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/686 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3956 ,  G01N2800/52 ,  G06F19/00

    Abstract: Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, a medical system is included having an external programmer device; and an implantable medical device, the implantable medical device configured to communicate with the programmer through a telemetry interface. The external programmer device can be configured to receive data regarding levels of one or more of a panel of biomarkers in a biological sample of a patient; the panel of biomarkers including at least one selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-n, IFNg, BNP, sST2, MMP-2, MMP-9, TEVIP-1, TEVIP-2, and TIMP-4. The external programmer device can be configured to process the data regarding the levels of one or more of the panel of biomarkers. In an embodiment, a method of predicting the likelihood of response to CRT therapy in included. Other embodiments are also included herein.

    Abstract translation: 本公开的实施例涉及用于利用关于医疗装置和方法的生物标志物面板数据的系统和方法。 在一个实施例中，包括具有外部编程器装置的医疗系统; 以及可植入医疗装置，所述可植入医疗装置被配置为通过遥测接口与所述编程器进行通信。 外部编程器装置可以被配置为接收关于患者的生物样品中生物标志物组中的一个或多个的水平的数据; 所述生物标志物组包括选自CRP，SGP-130，sIL-2R，sTNFR-n，IFNg，BNP，sST2，MMP-2，MMP-9，TEVIP-1，TEVIP-2， 和TIMP-4。 外部编程器装置可被配置为处理关于生物标志物的一个或多个面板的水平的数据。 在一个实施例中，预测包括对CRT治疗的可能性的预测方法。 本文还包括其它实施例。

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