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公开(公告)号:WO2021095210A1
公开(公告)日:2021-05-20
申请号:PCT/JP2019/044766
申请日:2019-11-14
申请人: 株式会社島津製作所
发明人: 山口 真一
摘要: 本発明に係るイメージング分析装置の一態様は、試料上の測定領域内に設定された複数の測定点それぞれに対して所定の分析手法による分析を実行してイメージングデータを収集する分析実行部(1)と、測定領域に対する参照画像を取得する参照画像取得部(2)と、同じ試料について得られたイメージングデータと参照画像とについて、該イメージングデータを説明変数とし、該参照画像を構成するデータを目的変数とする所定の回帰分析の演算を実行して回帰モデルを取得する回帰分析実行部(36)と、回帰分析が実行されたときの試料とは異なる試料に対して分析実行部により得られたイメージングデータを上記回帰モデルに適用することで、擬似的な回帰分析結果に基づく予測画像を作成する予測画像作成部(37)と、を備える。
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公开(公告)号:WO2021014487A1
公开(公告)日:2021-01-28
申请号:PCT/JP2019/028418
申请日:2019-07-19
申请人: 株式会社島津製作所 , 国立研究開発法人産業技術総合研究所
摘要: 試料成分由来のプリカーサイオンに所定の種類のラジカルを照射してプロダクトイオンを生成し分析するイオン分析装置において、反応室(2)と、ラジカルを生成して反応室に供給するラジカル供給部(5、6)と、反応室に供給されるラジカルの温度を取得するラジカル温度取得部(911、912)と、ラジカル付着反応の活性化エネルギーが既知である標準物質から生成した所定のプリカーサイオンを所定量、反応室に供給する標準物質供給部(11)と、ラジカルとの反応によって標準物質由来のプリカーサイオンから生成される所定のプロダクトイオンの量を測定するイオン測定部(92)と、該プロダクトイオンの量に基づいて反応ラジカルの量を求める反応ラジカル量算出部(93)と、ラジカルの温度、活性化エネルギー、及び反応ラジカル量に基づいてラジカル密度を求めるラジカル密度算出部(94)とを備える。
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公开(公告)号:WO2020240510A1
公开(公告)日:2020-12-03
申请号:PCT/IB2020/055145
申请日:2020-05-29
摘要: An electrospray probe for use in an electrospray ion source is disclosed, which comprises a cannula extending from a proximal end having an inlet aperture for receiving a liquid sample containing at least one analyte to a discharge emitter end having an outlet aperture through which charged liquid droplets containing ions of said analyte are discharged, and an electrically conductive coating covering at least a portion of an external surface and at least a portion of an internal surface of said emitter end.
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14.
公开(公告)号:WO2020157736A1
公开(公告)日:2020-08-06
申请号:PCT/IB2020/050851
申请日:2020-02-03
发明人: COVEY, Thomas R. , LIU, Chang , TATE, Stephen A.
摘要: A device that produces charged droplets whose composition is optimized for the creation of ions by electro spray composed of: a transport device that is operative to transfer sample components from a liquid sample to a processing chamber, a flowing stream of liquid through the processing chamber into which the samples are deposited, a controller mechanism operative to control the amount of sample transferred, a transport tube through which the flowing liquid containing the sample is directed to an electro spray emitter with a high electric field at the exit, a flow of expanding gas surrounding the electro spray emitter creating a pressure drop at the exit, and, a mass spectrometer for measuring the number of ions produced from the charged droplets emanating from the emitter; wherein the dilution of the sample in the processing chamber and transport fluid is from 100 to 10,000-fold.
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公开(公告)号:WO2020119282A1
公开(公告)日:2020-06-18
申请号:PCT/CN2019/113186
申请日:2019-10-25
申请人: 深圳大学
摘要: 一种双聚焦微流体芯片,包括:离散相流道(1),用于导流离散相,离散相流道(1)上设置有第一缩孔(11),离散相流道(1)的一端设置有离散相入口(12),另一端设置有第二缩孔(13);第一缩孔(11)的孔径和第二缩孔(13)的孔径均小于离散相流道(1)的宽度;两个第一支流道(21),用于导流第一连续相,两个第一支流道(21)汇聚于第一缩孔(11)处;两个第二支流道(31),用于导流第二连续相,两个第二支流道(31)汇聚于第二缩孔(13)处。
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公开(公告)号:WO2020065312A1
公开(公告)日:2020-04-02
申请号:PCT/GB2019/052706
申请日:2019-09-26
申请人: MICROMASS UK LIMITED
IPC分类号: H01J49/16
摘要: A nozzle for an ionisation source comprises: a light passage having an inlet end and an outlet end; and a gas flow passage in fluid communication with the light passage, wherein the gas flow passage is configured to convey, in use, a flow of gas into the light passage such that the flow of gas travels substantially towards the outlet end of the light passage.
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公开(公告)号:WO2019220296A1
公开(公告)日:2019-11-21
申请号:PCT/IB2019/053905
申请日:2019-05-10
摘要: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.
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公开(公告)号:WO2019200388A1
公开(公告)日:2019-10-17
申请号:PCT/US2019/027499
申请日:2019-04-15
发明人: FOGWILL, Michael, O. , DEVLIN, Curt , DOURDEVILLE, Theodore, A. , FAIRCHILD, Jacob, N. , GERHARDT, Geoff, C. , LEVEILLE, Wade, P. , MICHIENZI, Joseph, D. , MUSACCHIO, Jeffrey
摘要: Techniques and apparatus for ion source devices with minimized post- column volumes are described. In one embodiment, for example, an ion source assembly (330) may include a chromatography column (334) in fluid communication with an ion source device (336), the chromatography column (334) arranged within a minimum distance of the ion source (336), the minimum distance comprising between about 60 mm and about 150 mm.
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公开(公告)号:WO2019160801A8
公开(公告)日:2019-08-22
申请号:PCT/US2019/017469
申请日:2019-02-11
申请人: BIOMERIEUX, INC.
发明人: BULLOCK, Jared , COLLINS, Scott , MACGREGOR, Ian , TALMER, Mark
IPC分类号: H01J49/16
摘要: Slide analysis a gripper with three sensors for controlling a slide grip sequence and at least one rotatable carousel with a slide receiving channel. The systems also include a robot with a robot arm that holds a slide gripper residing inside the housing in communication with the rotatable carousel. The systems also include a load lock chamber and a door sealably coupled to the second end portion and an acquisition vacuum chamber with an X-Y stage and a slide holder with a vacuum seal.
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20.
公开(公告)号:WO2019147748A3
公开(公告)日:2019-08-01
申请号:PCT/US2019/014872
申请日:2019-01-24
摘要: A surface ionizer for a trace detection system includes an extreme ultraviolet light source and an ion transfer line. Activation of the extreme ultraviolet light disrupts a surface of a sample along with residue and ionizes the resulting vapor. The ionized vapor is collected in the ion transfer line and passed into an analysis device for detection of components in the vapor.
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