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    SECRETION-COMPETENT MUTEINS OF THE HUMAN IL-27 ALPHA-SUBUNIT
    22.
    发明申请
    SECRETION-COMPETENT MUTEINS OF THE HUMAN IL-27 ALPHA-SUBUNIT 审中-公开

    公开(公告)号：WO2018202876A1

    公开(公告)日：2018-11-08

    申请号：PCT/EP2018/061561

    申请日：2018-05-04

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： FEIGE, Matthias ,  MUELLER, Stephanie

    IPC: C07K14/54 ,  A61K38/20

    Abstract: The present invention refers to a secretion-competent mutein of the α-subunit of human Interleukin 27 and to a human heterodimeric Interleukin 27. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a secretion- competent mutein of the α-subunit of human Interleukin 27 or the human heterodimeric Interleukin 27, to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing saidsecretion-competent muteins and to a secretion-incompetent mutein of the α-subunit of mouse Interleukin 27and a secretion-competent mutein of the β-subunit of mouse Interleukin 27.

    COMBINATION OF REVERSIBLE AND IRREVERSIBLE CELL LABELING FOR ANALIZING RECEPTOR-LIGAND KOFF RATE
    23.
    发明申请
    COMBINATION OF REVERSIBLE AND IRREVERSIBLE CELL LABELING FOR ANALIZING RECEPTOR-LIGAND KOFF RATE 审中-公开
    用于分析受体 - 配体KOFF率的可逆和不可逆细胞标记的组合

    公开(公告)号：WO2018001985A1

    公开(公告)日：2018-01-04

    申请号：PCT/EP2017/065755

    申请日：2017-06-27

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： NAUERTH, Magdalena ,  BUSCH, Dirk

    IPC: C12Q1/04 ,  C07K14/36 ,  G01N33/50 ,  G01N33/543 ,  G01N33/566

    Abstract: The invention relates to a method of determining the dissociation rate constant (k off ) of a receptor molecule R on a target cell using a combination of reversible and irreversible cell labeling. The invention further relates to a cell comprising such a receptor molecule R, wherein the cell has bound to it such a combination of cell labeling. The invention further relates to a kit and an apparatus useful in performing the methods of the invention. The invention further relates to a method of isolation a high-avidity T cell.

    Abstract translation: 本发明涉及使用可逆和不可逆细胞标记的组合确定靶细胞上受体分子R的解离速率常数（k off）的方法。 本发明进一步涉及包含这样的受体分子R的细胞，其中细胞已经与之结合了细胞标记的这种组合。 本发明还涉及用于实施本发明方法的试剂盒和装置。 本发明进一步涉及分离高亲合力T细胞的方法。

    FILTER BANKS AND METHODS FOR OPERATING FILTER BANKS
    24.
    发明申请
    FILTER BANKS AND METHODS FOR OPERATING FILTER BANKS 审中-公开
    过滤器银行和操作过滤器银行的方法

    公开(公告)号：WO2017137126A1

    公开(公告)日：2017-08-17

    申请号：PCT/EP2016/081541

    申请日：2016-12-16

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： GOMES BALTAR, Leonardo ,  SLIM, Israa ,  NOSSEK, Josef A.

    IPC: H04L27/26

    CPC classification number: H04L27/264

    Abstract: The disclosure refers to a synthesis filter bank, comprising: a transform module which is configured to receive a plurality of input signals, transform the plurality of input signals, and output a plurality of transformed signals, a plurality of filter modules, which are coupled to the transform module, and wherein each filter module of the plurality of filter modules is configured to receive two transformed signals from the transform module, process the two received transformed signals and output two processed signals, and a parallel-to-serial module which is coupled to the plurality of filter modules and which is configured to receive the processed signals from the plurality of filter modules, combine the received processed signals and output a combined signal. Furthermore, an analysis filter bank, a filter bank and methods for operating a synthesis filter bank and for operating an analysis filter bank are disclosed.

    Abstract translation: 本公开涉及合成滤波器组，其包括：变换模块，其被配置为接收多个输入信号，变换该多个输入信号并输出​​多个变换后的信号，多个 所述滤波器模块耦合到所述变换模块，并且其中所述多个滤波器模块中的每个滤波器模块被配置为从所述变换模块接收两个变换的信号，处理这两个接收到的变换信号并输出​​两个处理后的信号， 串联模块，其耦合到所述多个滤波器模块并且被配置为接收来自所述多个滤波器模块的经处理的信号，组合所接收的经处理的信号并输出​​组合信号。 此外，公开了分析滤波器组，滤波器组和用于操作合成滤波器组和用于操作分析滤波器组的方法。

    MODIFIED SPIDER SILK PROTEINS
    28.
    发明申请
    MODIFIED SPIDER SILK PROTEINS 审中-公开
    改性天蚕丝蛋白

    公开(公告)号：WO2007025719A1

    公开(公告)日：2007-03-08

    申请号：PCT/EP2006/008452

    申请日：2006-08-29

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN ,  SCHEIBEL, Thomas

    Inventor： SCHEIBEL, Thomas

    IPC: C07K14/435 ,  C12N15/12

    CPC classification number: B82Y5/00 ,  B82Y10/00 ,  C07K14/43513

    Abstract: The present invention is directed to a method of modifying a spider silk protein and a spider silk protein obtainable by said method. The invention further pertains to a nucleic acid sequence coding for a modified spider silk protein, a vector containing said sequences and host cells transformed with this vector. The invention furthermore is directed to a pharmaceutical or cosmetical composition containing a modified spider silk protein as defined herein and the use of said modified sequences in various fields, in particular in the fields of medicine, cosmetics and technical applications.

    Abstract translation: 本发明涉及通过所述方法获得的蜘蛛丝蛋白质和蜘蛛丝蛋白质的修饰方法。 本发明还涉及编码改性蜘蛛丝蛋白的核酸序列，含有所述序列的载体和用该载体转化的宿主细胞。 本发明还涉及含有如本文所定义的修饰的蜘蛛丝蛋白的药物或化妆品组合物以及所述修饰的序列在各种领域，特别是在医药，化妆品和技术应用领域中的用途。

    RECOMBINANT SPIDER SILK PROTEINS
    29.
    发明申请
    RECOMBINANT SPIDER SILK PROTEINS 审中-公开
    重组天丝蛋白蛋白

    公开(公告)号：WO2006008163A2

    公开(公告)日：2006-01-26

    申请号：PCT/EP2005/007968

    申请日：2005-07-21

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN ,  SCHEIBEL, Thomas ,  HUEMMERICH, Daniel ,  ACKERSCHOTT, Christian

    Inventor： SCHEIBEL, Thomas ,  HUEMMERICH, Daniel ,  ACKERSCHOTT, Christian

    IPC: C07K14/435

    CPC classification number: A61L27/227 ,  A61L27/52 ,  C07K14/43518 ,  D01F4/02

    Abstract: The present invention is directed to recombinant spider silk proteins, nucleic acids, coding for these recombinant spider silk proteins, as well as hosts suitable for expressing those nucleic acids. Furthermore, the present invention is directed to a method of aggregation of spider silk proteins and the use of the proteins in the field of biotechnology and/or medicine and other industrial fields, in particular in the manufacture of automotive parts, in the aircraft construction, in the processing of textiles and leather, as well as in the manufacture and processing of paper and the like.

    Abstract translation: 本发明涉及编码这些重组蜘蛛丝蛋白的重组蜘蛛丝蛋白，核酸，以及适于表达这些核酸的宿主。 此外，本发明涉及一种聚集蜘蛛丝蛋白的方法以及在生物技术和/或医药领域以及其它工业领域，特别是在制造汽车部件领域中的蛋白质在飞机结构中的应用， 在加工纺织品和皮革以及纸张的制造和加工等方面。

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