公开(公告)号：WO2007109760A3

公开(公告)日：2008-07-24

申请号：PCT/US2007064643

申请日：2007-03-22

Applicant: UNIV MISSOURI ,  BASSI CARL J ,  HOWE MICHAEL ,  GARVER WAYNE

Inventor： BASSI CARL J ,  HOWE MICHAEL ,  GARVER WAYNE

IPC: A61B3/08

CPC classification number: A61B3/063 ,  A61B3/02 ,  A61B3/08

Abstract: A device is used to determine the presence of and the amount (depth) of visual suppression in a subject. The device includes a first light source emitting a first light and a second light source emitting a second light. Intensities of the light sources are independently controllable. A first filter disposed over one eye of the subject allows transmission of the first light and prevents transmission of the second light. A second filter disposed over the other eye of the subject allows transmission of the second light and prevents transmission of the first light. In a method of using the device, the intensity of at least one of the first and second lights is independently controlled, wherein the difference in intensities of the first and second lights at which the lights appear to be at equal brightness to the subject determines the amount of visual suppression in the subject.

Abstract translation: 使用装置来确定受试者的视觉抑制的存在和数量（深度）。 该装置包括发射第一光的第一光源和发射第二光的第二光源。 光源的强度是独立可控的。 设置在被摄体的一只眼睛上的第一滤光器允许透射第一光并防止第二光的透射。 设置在被摄体的另一只眼睛上的第二滤光器允许透射第二光并防止第一光的透射。 在使用该装置的方法中，独立地控制第一和第二光中的至少一个的强度，其中，第一和第二光的强度与对象的亮度相似的亮度的差异决定了 受试者的视力抑制量。

公开(公告)号：WO2008070775A2

公开(公告)日：2008-06-12

申请号：PCT/US2007086640

申请日：2007-12-06

Applicant: UNIV MISSOURI ,  XU ZHI

Inventor： XU ZHI

IPC: B05B1/24

CPC classification number: G01N30/74 ,  G01N30/84 ,  G01N2030/847 ,  G01N2030/8494

Abstract: A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector

Abstract translation: 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流

公开(公告)号：WO2007095350A3

公开(公告)日：2008-04-24

申请号：PCT/US2007004109

申请日：2007-02-15

Applicant: UNIV YALE ,  UNIV MISSOURI ,  BARNSTABLE COLIN J ,  TOMBRAN-TINK JOYCE

Inventor： BARNSTABLE COLIN J ,  TOMBRAN-TINK JOYCE

IPC: A61K38/18

CPC classification number: C07K14/811 ,  A61K38/00

Abstract: The invention provides PEDF peptides which retain the biological activity of full-length PEDF. Fusion proteins comprising a PEDF peptide are also provided. The invention further provides a codon-optimized PEDF coding sequence and method of expressing it in bacteria. Compositions, methods of use and kits are also provided.

Abstract translation: 本发明提供保留全长PEDF的生物学活性的PEDF肽。 还提供了包含PEDF肽的融合蛋白。 本发明还提供密码子优化的PEDF编码序列及其在细菌中的表达方法。 还提供了组合物，使用方法和试剂盒。

公开(公告)号：WO2008019182A2

公开(公告)日：2008-02-14

申请号：PCT/US2007069259

申请日：2007-05-18

Applicant: UNIV MISSOURI ,  ZHANG SHI C ,  HILMAS GREGORY E ,  FAHRENHOLTZ WILLIAM G

Inventor： ZHANG SHI C ,  HILMAS GREGORY E ,  FAHRENHOLTZ WILLIAM G

IPC: C04B35/58 ,  C04B35/81

CPC classification number: C04B35/806 ,  C04B35/58078 ,  C04B35/63476 ,  C04B2235/3804 ,  C04B2235/3821 ,  C04B2235/3826 ,  C04B2235/428 ,  C04B2235/5276 ,  C04B2235/96 ,  C04B2235/9607 ,  C04B2235/963

Abstract: A method of sintering a ZrB 2 - SiC composite body at ambient pressures, including blending a first predetermined amount Of ZrB 2 powder with a second predetermined amount of SiC powder, wherein both powders are characterized by the presence of surface oxide impurities. Next the blended powders are mixed to yield a substantially homogeneous powder mixture and a portion of the substantially homogeneous powder mixture is formed into a green body. The body is fired to a first temperature, wherein substantially all surface oxide impurities are reduced and/or volatilized to substantially eliminate oxides from the green body, and the body is heated to a second temperature and sintered to yield a composite body of at least about 99 percent theoretical density and characterized by SiC whisker-like inclusions distributed substantially evenly in a ZrB 2 matrix.

Abstract translation: 一种在环境压力下烧结ZrB 2-SiC复合体的方法，包括将第一预定量的ZrB 2粉末与第二预定量的SiC粉末混合，其中两种 粉末的特征是存在表面氧化物杂质。 接着将混合的粉末混合以产生基本上均匀的粉末混合物，并且将基本上均匀的粉末混合物的一部分形成为生坯。 本体被烧制至第一温度，其中基本上所有表面氧化物杂质被还原和/或挥发以基本上消除生坯体中的氧化物，并且将本体加热至第二温度并烧结以产生至少约 99％理论密度，并且特征在于在ZrB <2>基质中基本均匀分布的SiC晶须状内含物。

公开(公告)号：WO2006119262A3

公开(公告)日：2007-05-10

申请号：PCT/US2006016762

申请日：2006-05-02

Applicant: UNIV MISSOURI ,  DEUTSCHER SUSAN L ,  QUINN THOMAS P ,  SAUTER EDWARD R

Inventor： DEUTSCHER SUSAN L ,  QUINN THOMAS P ,  SAUTER EDWARD R

IPC: G01N33/00 ,  G01N33/53 ,  G01N33/543

CPC classification number: G01N33/57415 ,  G01N33/57488 ,  G01N33/66 ,  G01N2400/50

Abstract: The present invention generally relates to detection of carbohydrate biomarkers in nipple aspirate fluid samples. One aspect of the invention is a method for assaying a nipple aspirate fluid for the presence of TF or Tn carbohydrate biomarker. The assay generally employs an immobilized capture agent specific for TF or Tn and can be further coupled to either direct or indirect detection of bound TF or Tn carbohydrate biomarker through the use of a labeled binding agent.

Abstract translation: 本发明一般涉及乳头抽吸液样品中碳水化合物生物标志物的检测。 本发明的一个方面是用于测定乳头抽吸液用于存在TF或Tn碳水化合物生物标志物的方法。 该测定通常使用对TF或Tn特异性的固定化捕获剂，并且可以通过使用标记的结合剂进一步与结合的TF或Tn碳水化合物生物标志物的直接或间接检测相结合。

公开(公告)号：WO2006076563A3

公开(公告)日：2006-11-09

申请号：PCT/US2006001207

申请日：2006-01-12

Applicant: UNIV MISSOURI ,  SCHNABEL ROBERT D ,  SONSTEGARD TAD S ,  VAN TASSELL CURTIS P ,  ASHWELL MELISSA S ,  TAYLOR JEREMY F

Inventor： SCHNABEL ROBERT D ,  SONSTEGARD TAD S ,  VAN TASSELL CURTIS P ,  ASHWELL MELISSA S ,  TAYLOR JEREMY F

IPC: C12Q1/68

CPC classification number: C12Q1/6888 ,  C12Q1/6876 ,  C12Q2600/156

Abstract: The invention provides methods for identifying a genetic polymorphism associated with altered milk production traits in dairy cattle. Genetic marker-assisted selection methods provided by the invention allow avoidance of potentially costly phenotypic testing and inaccuracies associated with traditional breeding schemes and improvement of dairy cattle herds.

Abstract translation: 本发明提供用于鉴定与奶牛中改变的牛奶生产性状相关的遗传多态性的方法。 本发明提供的遗传标记辅助选择方法允许避免与传统育种方案相关的潜在代价的表型测试和不准确性，以及改进奶牛群。

公开(公告)号：WO2006012177A2

公开(公告)日：2006-02-02

申请号：PCT/US2005022180

申请日：2005-06-23

Applicant: UNIV MISSOURI ,  PRATHER RANDALL S

Inventor： PRATHER RANDALL S

IPC: A01K67/027

CPC classification number: C12N15/873 ,  A01K2227/108 ,  C12N5/0609 ,  C12N5/061 ,  C12N15/8778 ,  C12N2501/11 ,  C12N2501/20 ,  C12N2501/31 ,  C12N2501/58 ,  C12N2501/998 ,  C12N2517/10

Abstract: The field of invention generally relates to increasing the efficiency of in vitro fertilization by decreasing the rate of polyspermy. One aspect of the invention provides a method of reducing polyspermy in in vitro fertilization by forming an in vitro fertilization mixture that contains osteopontin, oocytes, and sperm, and allowing fertilization of the oocyte by sperm. Another aspect of the invention provides an aqueous mixture for in vitro fertilization that contains osteopontin, oocytes, and sperm.

Abstract translation: 本发明的领域通常涉及通过降低多糖的速率来提高体外受精的效率。 本发明的一个方面提供了通过形成含有骨桥蛋白，卵母细胞和精子的体外受精混合物并且允许精子对卵母细胞进行受精来减少体外受精中的多糖的方法。 本发明的另一方面提供了含有骨桥蛋白，卵母细胞和精子的体外受精的含水混合物。

公开(公告)号：WO2005081970A2

公开(公告)日：2005-09-09

申请号：PCT/US2005005735

申请日：2005-02-24

Applicant: UNIV MISSOURI ,  FORGACS GABOR ,  JAKAB KAROLY ,  NEAGU ADREAN ,  MIRONOV VLADIMIR

Inventor： FORGACS GABOR ,  JAKAB KAROLY ,  NEAGU ADREAN ,  MIRONOV VLADIMIR

CPC classification number: C12N5/0062 ,  B29C64/112 ,  B29C64/209 ,  B29C64/386 ,  B29C64/393 ,  B29K2033/26 ,  B29K2105/0035 ,  B29K2105/0061 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/48 ,  C12M47/00 ,  C12M47/02 ,  C12N5/0697

Abstract: A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.

Abstract translation: 一种组合物，其包含用于通过器官印刷生产工程化器官组织的多个细胞聚集体。 制备多个细胞聚集体的方法包括将细胞悬浮液离心以形成颗粒，通过孔口挤出颗粒，并将挤出的颗粒切割成块。 用于制造细胞聚集体的装置包括挤出系统和切割系统。 在器官印刷的方法中，将多个细胞聚集体嵌入聚合物或凝胶基质中并使其融合以形成所需的三维组织结构。 中间产品包含至少一层矩阵和以预定图案嵌入其中的多个细胞聚集体。 建模方法预测用于组合细胞类型，基质和嵌入模式的融合细胞聚集体的结构演变，以便能够选择用于生产具有所需三维结构的工程组织的器官印刷过程参数。

公开(公告)号：WO2005063386A2

公开(公告)日：2005-07-14

申请号：PCT/US2004021966

申请日：2004-07-09

Applicant: UNIV MISSOURI ,  SWITZER JAY A ,  KOTHARI HITEN M ,  NAKANISHI SHUJI ,  BOHANNAN ERIC W

Inventor： SWITZER JAY A ,  KOTHARI HITEN M ,  NAKANISHI SHUJI ,  BOHANNAN ERIC W

IPC: B01J23/06 ,  B01J23/34 ,  B01J23/50 ,  B01J23/72 ,  B01J23/745 ,  B01J23/75 ,  B01J35/10 ,  C25B3/02 ,  C25B11/04 ,  C25D9/06

CPC classification number: C25D9/06 ,  C25B3/02

Abstract: A solid substrate comprising a surface comprising an achiral array of atoms having thereupon a chiral metal oxide surface. Said substrate is produced by electrodeposition of a chiral metal oxide array from a solution of a chiral salt of said metal onto an achiral array of atoms of high symmetry on said surface. A method comprising electrochemically oxidizing an organic molecule comprising at least one chiral centre by oxidizing said organic molecule with an electrode comprising the solid substrate having a surface of the same chirality as said chiral centre under conditions so as to selectively oxidize said organic molecule in the presence of at least one of its enantiomers having opposite chirality at said chiral centre.

Abstract translation: 包含表面的固体基材，所述表面包含在其上具有手性金属氧化物表面的非手性原子排列。 所述衬底通过将手性金属氧化物阵列从所述金属的手性盐溶液电沉积到所述表面上的高对称性非手性阵列上来制备。 一种方法，包括通过在一定条件下用包含具有与所述手性中心具有相同手性的表面的固体基质的电极氧化所述有机分子，以电化学氧化包含至少一个手性中心的有机分子，从而在存在的情况下选择性地氧化所述有机分子 至少一种在所述手性中心具有相反手性的对映异构体。

公开(公告)号：WO2004065497A3

公开(公告)日：2005-01-13

申请号：PCT/US2004001143

申请日：2004-01-16

Applicant: UNIV MISSOURI CURATORS ,  STOFFER JAMES O ,  O'KEEFE THOMAS J ,  MORRIS ERIC ,  YU PU ,  HAYES SCOTT

Inventor： STOFFER JAMES O ,  O'KEEFE THOMAS J ,  MORRIS ERIC ,  YU PU ,  HAYES SCOTT

IPC: C09C1/56 ,  C09D5/08

CPC classification number: C09C1/56 ,  C01P2004/80 ,  C09D5/084

Abstract: A coating composition comprising an effective corrosion-inhibiting amount of a rare earth compound, a neutral to slightly acidic generating extender or an acidic generating extender, or combinations thereof is provided. In one embodiment, the corrosion-inhibiting components are combined with other components such as extenders, amino acids and amino acid derivatives, gelatin and gelatin derivatives, organic-based exchange resins, and combinations thereof, to enhance the corrosion resistance of the resultant coating film. The coating compositions have good adhesion to substrates such as metals, including aluminum and aluminum alloys.

Abstract translation: 提供了包含有效的腐蚀抑制量的稀土化合物，中性至微酸性产生的增量剂或酸性产生的增量剂的涂料组合物或其组合。 在一个实施方案中，将腐蚀抑制成分与其它组分例如增量剂，氨基酸和氨基酸衍生物，明胶和明胶衍生物，有机基交换树脂及其组合组合，以提高所得涂膜的耐腐蚀性 。 涂料组合物对诸如金属的基材（包括铝和铝合金）具有良好的粘合性。