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    A TIME VARIANT ANTENNA FOR TRANSMITTING WIDEBAND SIGNALS
    23.
    发明申请
    A TIME VARIANT ANTENNA FOR TRANSMITTING WIDEBAND SIGNALS 审中-公开
    用于发送宽带信号的时变天线

    公开(公告)号：WO2015077483A1

    公开(公告)日：2015-05-28

    申请号：PCT/US2014/066672

    申请日：2014-11-20

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： MANTEGHI, Majid ,  SALEHI, Mohsen

    IPC: H01Q3/34

    CPC classification number: H04L27/12 ,  H01Q3/34 ,  H01Q3/44 ,  H01Q5/00 ,  H01Q5/25 ,  H01Q9/0421 ,  H04B1/006 ,  H04B1/04

    Abstract: A circuit for tuning a resonance frequency of an electrically small antenna. The circuit includes a first source configured for providing a modulation signal, a second source configured for providing a periodic electrical signal, an antenna, and a tuning circuit configured for modulating a resonance frequency of the antenna in response to the modulation signal. The tuning circuit includes first and second capacitors that are alternately coupled to the antenna to change the resonance frequency of the antenna. The capacitor currently coupled to the antenna is decoupled from the antenna and the other capacitor is coupled to the antenna when the voltage across the capacitor currently coupled to the antenna is momentarily zero. In an exemplary embodiment, the tuning circuit comprises first and second inductors rather than capacitors. The inductors are switched into and out of the circuit when the current through the currently coupled inductor is momentarily zero.

    Abstract translation: 用于调谐电小天线的谐振频率的电路。 该电路包括被配置为提供调制信号的第一源，被配置为提供周期性电信号的第二源，天线和配置为响应于调制信号调制天线的谐振频率的调谐电路。 调谐电路包括交替耦合到天线的第一和第二电容器，以改变天线的谐振频率。 当前耦合到天线的电容器当前耦合到天线的电容两端暂时为零时，天线耦合的电容器与天线分离，另一个电容器耦合到天线。 在示例性实施例中，调谐电路包括第一和第二电感器而不是电容器。 当通过当前耦合的电感器的电流瞬时为零时，电感器被切换进出电路。

    TREATMENT OF DISEASES CAUSED BY ABNORMAL LYMPHOCYTE FUNCTION WITH AN HDAC6 INHIBITOR
    25.
    发明申请
    TREATMENT OF DISEASES CAUSED BY ABNORMAL LYMPHOCYTE FUNCTION WITH AN HDAC6 INHIBITOR 审中-公开
    用HDAC6抑制剂治疗由异常淋巴细胞功能引起的疾病

    公开(公告)号：WO2015042418A1

    公开(公告)日：2015-03-26

    申请号：PCT/US2014/056584

    申请日：2014-09-19

    Applicant: ACETYLON PHARMACEUTICALS, INC. ,  EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： REILLY, Christopher, M. ,  GAFOOR, Abdul ,  CAUDELL, David, L. ,  REGNA, Nicole L. ,  JARPE, Matthew

    IPC: A61K31/495 ,  A61P37/00 ,  A61P7/00

    CPC classification number: A61K31/505

    Abstract: An HDAC6 inhibitor (a compound of Formula I) is shown to reduce the pathogenesis associated with the B cell mediated autoimmune disease, systemic lupus erythematosus (SLE). Administration of a compound of Formula I attenuated many of the symptoms characteristic of SLE including splenomegaly, abnormal B cell differentiation, an increase in the number double-negative thymic T cells, an increase in the level of auto-antibodies such as anti-dsDNA, immune complex -mediated glomerulonephritis and an increase in inflammatory cytokine production. Treatment with a compound of Formula I also increased the number of the subject's splenic Treg cells while removing circulating auto-antibodies. Inhibition of HDAC6 altered bone marrow B cell differentiation by increasing the percentage of cells in the early-stage developmental fractions of both pro-and pre-B cells. These results demonstrate HDAC6 inhibition with a compound of Formula I can treat SLE disease by altering aberrant T and B cell differentiation.

    Abstract translation: 显示HDAC6抑制剂（式I的化合物）可以减少与B细胞介导的自身免疫性疾病，系统性红斑狼疮（SLE）有关的发病机制。 式I化合物的给药减轻了SLE特征性症状的许多症状，包括脾肿大，异常B细胞分化，双阴性胸腺T细胞数量的增加，自身抗体水平的提高，如抗dsDNA， 免疫复合物介导的肾小球肾炎和炎症细胞因子产生的增加。 使用式I化合物的治疗也增加受试者的脾Treg细胞的数量，同时除去循环自身抗体。 HDAC6的抑制通过增加前和后B细胞的早期发育部分中细胞的百分比来改变骨髓B细胞分化。 这些结果表明，用式I化合物的HDAC6抑制可以通过改变异常的T和B细胞分化来治疗SLE疾病。

    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS
    26.
    发明申请
    DIELECTROPHORESIS METHODS FOR DETERMINING A PROPERTY OF A PLURALITY OF CANCER CELLS 审中-公开
    用于确定多种癌细胞的性质的电化学方法

    公开(公告)号：WO2015017729A1

    公开(公告)日：2015-02-05

    申请号：PCT/US2014/049296

    申请日：2014-07-31

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ,  SCHMELZ, Eva M. ,  ELVINGTON, Elizabeth S. ,  SALMANZADEH, Alireza ,  SANO, Mike ,  ROBERTS, Paul C. ,  DAVALOS, Rafael V.

    Inventor： SCHMELZ, Eva M. ,  ELVINGTON, Elizabeth S. ,  SALMANZADEH, Alireza ,  SANO, Mike ,  ROBERTS, Paul C. ,  DAVALOS, Rafael V.

    IPC: B01D57/02

    CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

    Abstract: Provided are dielectrophoresis (DEP) devices and methods that allow cell sorting to identify, isolate, and/or separate cells of interest based on electrical and physical properties of the cells. Particularly, provided are systems and methods for manipulating particles suspended in a fluid, e.g., cells, micro- or nano-particles, using their electrical signatures. Such methods can be performed using DEP, iDEP, and/or cDEP (contactless dielectrophoresis, where direct contact between the electrodes and the sample is avoided). Typically, an electric field is induced in a sample comprising the target particles and/or cells, such as cancer cells, and the spatial distribution of cells is measured to identify one or more characteristics or properties of the cancer cells. The identified characteristics of the sorted cells can be used to determine drug efficacy and/or resistance with respect to the cells.

    Abstract translation: 提供的是介电电泳（DEP）装置和方法，其允许细胞分选基于细胞的电学和物理性质鉴定，分离和/或分离感兴趣的细胞。 特别地，提供了使用其电特征来操纵悬浮在流体中的颗粒（例如，细胞，微米或纳米颗粒）的系统和方法。 可以使用DEP，iDEP和/或cDEP（非接触式介电电泳，其中避免了电极和样品之间的直接接触）来执行这些方法。 通常，在包含靶颗粒和/或细胞（例如癌细胞）的样品中诱导电场，并且测量细胞的空间分布以鉴定癌细胞的一个或多个特征或性质。 分选的细胞的鉴定特征可用于确定相对于细胞的药物功效和/或抗性。

    POOL CLEANER WITH LASER RANGE FINDER
    28.
    发明申请
    POOL CLEANER WITH LASER RANGE FINDER 审中-公开

    公开(公告)号：WO2014004929A3

    公开(公告)日：2014-01-03

    申请号：PCT/US2013/048370

    申请日：2013-06-27

    Applicant: PENTAIR WATER POOL AND SPA, INC. ,  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： LEONESSA, Alexander ,  BOOTHE, Brian, J. ,  CAIN, Christopher, H.

    IPC: G01C3/32

    Abstract: Embodiments of the invention provide a pool cleaner control system including a laser range finder with a first laser line generator, a second laser line generator, and a camera. The first laser line generator and the second laser line generator are positioned to emit parallel laser lines and the camera is positioned to capture an image of the laser lines projected on an object. The control system also includes a controller in communication with the laser range finder and configured to control operation of the laser line generators to emit the laser lines and to control the camera to capture the image. The controller is also configured to receive the image from the camera, calculate a pixel distance between the laser lines in the image, and calculate the physical distance between the camera and the object based on the pixel distance.

    LOW-TEMPERATURE CO-FIRING OF MULTILAYER TEXTURED PIEZOELECTRIC CERAMICS WITH INNER ELECTRODES
    30.
    发明申请
    LOW-TEMPERATURE CO-FIRING OF MULTILAYER TEXTURED PIEZOELECTRIC CERAMICS WITH INNER ELECTRODES 审中-公开
    具有内部电极的多层纹理压电陶瓷的低温组合

    公开(公告)号：WO2013116616A1

    公开(公告)日：2013-08-08

    申请号：PCT/US2013/024303

    申请日：2013-02-01

    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

    Inventor： YAN, Yongke ,  PRIYA, Shashank

    IPC: C04B35/46 ,  H01L41/187 ,  C04B35/64

    CPC classification number: H01L41/20 ,  C04B35/26 ,  C04B35/493 ,  C04B35/499 ,  C04B35/64 ,  C04B2235/3234 ,  C04B2235/3236 ,  C04B2235/3249 ,  C04B2235/3279 ,  C04B2235/3281 ,  C04B2235/3284 ,  C04B2235/787 ,  H01L41/0477 ,  H01L41/083 ,  H01L41/16 ,  H01L41/1875 ,  H01L41/273 ,  H01L41/43

    Abstract: Textured PMN-PZT fabricated by templated grain growth (TGG) method has a piezoelectric coefficient ( d ) of 3 to 5 times that of its random counterpart. By combining this TGG method with low-temperature co-firing ceramics (LTCC) techniques, co-fired multilayer textured piezoelectric ceramic materials with inner electrodes were produced at a temperature as low as 925 °C, which silver could be used. Trilayer PMN-PZT ceramics prepared by this method show a strain increase of 2.5 times, a driving voltage decrease of 3 times, and an equivalent piezoelectric coefficient ( d* ) improvement of 10 to 15 times that of conventional random ceramic counterparts. Further, a co-fired magnetostrictive / piezoelectric / magnetostrictive laminate structure with silver inner electrode was also synthesized. The integration of textured piezoelectric microstructure with the cost-effective low-temperature co-fired layered structure achieves strong magnetoelectric coupling. These new materials have promising applications including as actuators, ultrasonic transducers, and use in energy harvesters.

    Abstract translation: 通过模板晶粒生长（TGG）法制备的织构化PMN-PZT的压电系数（d）为其随机对应物的3〜5倍。 通过将该TGG方法与低温共烧陶瓷（LTCC）技术相结合，在低至925℃的温度下制备具有内电极的共烧多层织构压电陶瓷材料，可以使用这种银。 通过该方法制备的三层PMN-PZT陶瓷显示出应变增加2.5倍，驱动电压降低3倍，等效压电系数（d *）提高为常规随机陶瓷对应物的10〜15倍。 此外，还合成了具有银内电极的共烧磁致伸缩/压电/磁致伸缩层压结构。 具有成本效益的低温共烧层叠结构的纹理化压电微结构的集成实现了强大的磁电耦合。 这些新材料具有有希望的应用，包括致动器，超声波换能器和在能量收集器中的应用。

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