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    METHODS AND COMPOSITIONS FOR THE SIMULTANEOUS DETECTION OF MULTIPLE ANALYTES
    23.
    发明申请
    METHODS AND COMPOSITIONS FOR THE SIMULTANEOUS DETECTION OF MULTIPLE ANALYTES 审中-公开
    同时检测多种分析方法和组合物

    公开(公告)号：WO01073443A2

    公开(公告)日：2001-10-04

    申请号：PCT/US2001/009576

    申请日：2001-03-26

    IPC: G01N33/543 ,  G01N33/569 ,  G01N33/58

    CPC classification number: G01N33/54313 ,  G01N33/56927 ,  G01N33/56944 ,  G01N33/582 ,  G01N33/585 ,  Y10S435/971 ,  Y10S435/973 ,  Y10T436/101666 ,  Y10T436/13

    Abstract: Methods and compositions comprising immunoassays for the detection of antigens and antibodies in a sample are described. In particular, the present invention provides assays that are useful for rapid and simultaneous detection of multiple different antigens and antibodies. In preferred embodiments, the assays include fluorescent labels of multiple wavelengths or intensities, which are used to label the antigens and antibodies directly and to label beads coated with molecules specific for the antigen or antibody. The detection of a fluorescence shift indicates the presence or identity of the antigen or antibody in the sample.

    Abstract translation: 描述了包含用于检测样品中抗原和抗体的免疫测定法的方法和组合物。 特别地，本发明提供了可用于快速和同时检测多种不同抗原和抗体的测定法。 在优选实施方案中，测定包括多个波长或强度的荧光标记，其用于直接标记抗原和抗体，并标记用抗原或抗体特异性分子包被的珠子。 荧光偏移的检测表明样品中抗原或抗体的存在或同一性。

    METHOD AND MEANS FOR CARIES PREVENTION AND SUSCEPTIBILITY DETECTION
    24.
    发明申请
    METHOD AND MEANS FOR CARIES PREVENTION AND SUSCEPTIBILITY DETECTION 审中-公开
    防止和防止检测的方法和手段

    公开(公告)号：WO99061918A1

    公开(公告)日：1999-12-02

    申请号：PCT/SE1999/000930

    申请日：1999-05-28

    IPC: G01N33/50 ,  A61K39/395 ,  A61K45/00 ,  A61P1/02 ,  A61P31/04 ,  C07K14/47 ,  C07K16/12 ,  C12N1/20 ,  C12N15/09 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/577 ,  G01N33/60 ,  C07K14/435

    CPC classification number: G01N33/56955 ,  A61K2039/505 ,  G01N33/56944

    Abstract: A method for identifying the susceptibility of a person to dental caries comprises the assay of one or several of: an agent having high binding capacity to Streptococcus mutans but low binding capacity to Actinomyces naeslundii, an agent having high binding capacity to S. mutans-binding agglutinin, an agent having high binding capacity to A. naeslundii. The agent having high binding capacity to Streptococcus mutans but low binding capacity to A. naeslundii comprises an allelic Db type of salivary acidic proline-rich molecules (acidic PRPs), a biologically active fragment or a genetic precursor thereof. A corresponding reagent is also identified. Also disclosed are a method and an agent for the prevention of caries, as well as labelled S. mutans and A. naeslundii and their use.

    Abstract translation: 用于鉴定人对龋齿的易感性的方法包括以下测试中的一种或几种：对变形链球菌具有高结合能力的试剂，但对放线菌放线菌素（对于变形链球菌结合具有高结合能力的试剂）的结合能力低 凝集素，一种具有较高粘合能力的药物。 具有对变形链球菌具有高结合能力但对na und属的低结合能力的试剂包含等位基因Db型唾液酸脯氨酸丰富分子（酸性PRPs），其生物活性片段或其遗传前体。 也鉴定出相应的试剂。 还公开了用于预防龋齿的方法和试剂，以及标记的变形链球菌和A.nesesundundii及其用途。

    LMB GENE OF STREPTOCOCCUS AGALACTIAE
    25.
    发明申请
    LMB GENE OF STREPTOCOCCUS AGALACTIAE 审中-公开
    LMB基因克隆

    公开(公告)号：WO99016882A1

    公开(公告)日：1999-04-08

    申请号：PCT/US1998/020028

    申请日：1998-09-25

    IPC: A61K39/00 ,  C07K14/315 ,  C07K16/12 ,  C12N1/21 ,  C12N15/31 ,  G01N33/569 ,  A61K39/09 ,  C12N15/12

    CPC classification number: C07K14/315 ,  A61K39/00 ,  C07K16/1275 ,  G01N33/56944

    Abstract: The present invention provides polynucleotides coding for the mature Lmb Laminin binding streptococcal adhesion mediator polypeptides. The polynucleotides were obtained from a genomic library obtained from Group B Streptococcus R268. The role of Lmb in virulence of S. agalactiae is discussed.

    Abstract translation: 本发明提供了编码成熟的Lamin Laminin结合链球菌粘附介质多肽的多核苷酸。 多核苷酸从获自B组链球菌R268的基因组文库获得。 讨论了人乳酸杆菌在无乳酸乳杆菌毒力中的作用。

    BROAD SPECTRUM PYROGENIC EXOTOXINS ANTAGONISTS AND VACCINES
    26.
    发明申请
    BROAD SPECTRUM PYROGENIC EXOTOXINS ANTAGONISTS AND VACCINES 审中-公开
    广谱光谱外源毒素拮抗剂和疫苗

    公开(公告)号：WO1998029444A1

    公开(公告)日：1998-07-09

    申请号：PCT/IL1997000438

    申请日：1997-12-30

    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  KAEMPFER, Raymond ,  ARAD, Gila

    Inventor： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

    IPC: C07K14/31

    CPC classification number: C07K14/31 ,  A61K39/00 ,  G01N33/56938 ,  G01N33/56944

    Abstract: The invention relates to peptides comprising an amino acid sequence substantially homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of eliciting protective immunity against toxic shock induced by a pyrogenic exotoxin or by a mixture of pyrogenic exotoxins. Preferred peptides comprise an amino acid sequence substantially homologous to the amino sequence of a fragment of Staphylococcal aureus enterotoxin B (SEB). The invention also relates to broad spectrum pharmaceutical compositions for the treatment or short term prophylaxis of toxin-mediated activation of T cells, comprising as active ingredient at least one peptide according to the invention or derivative thereof, and to broad spectrum vaccines for conferring long term immunity against toxic shock induced by at least one pyrogenic exotoxin are provided. The vaccines comprising as active ingredient at least one peptide according to the invention, or derivative thereof.

    Abstract translation: 本发明涉及包含与热原性外毒素片段的氨基序列基本上同源的氨基酸序列的氨基酸序列和所述肽的功能衍生物的肽，其能够引起针对由致热原外毒素引起的毒性休克的保护性免疫，或由热原性外毒素混合物 外毒素。 优选的肽包含与金黄色葡萄球菌肠毒素B（SEB）的片段的氨基序列基本同源的氨基酸序列。 本发明还涉及用于治疗或短期预防毒素介导的T细胞活化的广谱药物组合物，其包含作为活性成分的至少一种根据本发明的肽或其衍生物，以及用于赋予长期的广谱疫苗 提供了由至少一种致热外毒素引起的毒性休克的免疫力。 包含至少一种根据本发明的肽或其衍生物作为活性成分的疫苗。

    REMOVAL OF SELF-BINDING AND STAPH A CROSS-REACTIVITY OF ANTI-STREP ANTIBODY
    28.
    发明申请
    REMOVAL OF SELF-BINDING AND STAPH A CROSS-REACTIVITY OF ANTI-STREP ANTIBODY 审中-公开
    去除抗结核抗体和抗结核抗体的交叉反应

    公开(公告)号：WO1984004169A1

    公开(公告)日：1984-10-25

    申请号：PCT/US1983001877

    申请日：1983-11-28

    Applicant: QUIDEL

    Inventor： QUIDEL ,  KATZ, David, H. ,  CHANG, Shung-Ho

    IPC: G01N33/54

    CPC classification number: G01N33/531 ,  G01N33/563 ,  G01N33/56944 ,  G01N33/6857

    Abstract: An improved diagnostic method and reagent for the assay of Streptococcus Group A, and other antigen containing organisms, in which the high background resulting from cross-reaction of Anti-Streptococcal Group A or the reaction with Staphylococcus is eliminated.

    Abstract translation: 用于测定链球菌A组和其他含抗原的生物体的改进的诊断方法和试剂，其中消除了抗链球菌A组交叉反应或与葡萄球菌反应产生的高背景。

    METHOD AND DEVICE FOR ACCURATE DIAGNOSIS OF DENTAL DISEASES
    30.
    发明申请
    METHOD AND DEVICE FOR ACCURATE DIAGNOSIS OF DENTAL DISEASES 审中-公开

    公开(公告)号：WO2018183454A1

    公开(公告)日：2018-10-04

    申请号：PCT/US2018/024779

    申请日：2018-03-28

    Applicant: CHIU, Yin, To

    Inventor： CHIU, Yin, To

    IPC: G01N33/53 ,  G01N33/569 ,  G01N33/543

    CPC classification number: G01N33/54386 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/56944 ,  G01N2800/18

    Abstract: The present invention provides a method and device for concentration and detection of a target analyte in a solution using a pre-coated porous material embedded with ATPS components. In one embodiment, the water soluble nanoparticles include, but are not limited to, silicon dioxide, iron oxide, titanium dioxide, silver oxide and any combinations thereof. In one embodiment, the present invention provides a device comprising ATPS as a concentration module linked with a lateral flow immunoassay (LFA) component as a detection module. In one embodiment, as the sample wicks up the device and ATPS components undergo phase separation, the analytes are concentrated substantially in the leading front, the concentrated analytes are then detected by the LFA module generating visual test results. In one embodiment, the present method and device are used to detect Streptococcus mutans and thereby dental caries.

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