公开(公告)号：WO1996008569A2

公开(公告)日：1996-03-21

申请号：PCT/US1995011723

申请日：1995-09-13

Applicant: BAYLOR COLLEGE OF MEDICINE ,  MUSSER, James, A. ,  KAPUR, Vivek

Inventor： BAYLOR COLLEGE OF MEDICINE

IPC: C12N15/57

CPC classification number: G01N33/56944 ,  C12N9/52

Abstract: Methods and compositions are provided for identifying a group A Streptococcus in any of a variety of physiological samples, such as blood, saliva, throat swabs, cerebrospinal fluid, brocheolar lavage material, and biopsy material. The compositions used include an extracellular cysteine protease or a fragment thereof, obtainable from S. pyogenes and containing at least one conserved epitope, or nucleic acid encoding the cysteine protease or fragment thereof. The compositions also find use in eliciting a protective immune response against a group A Streptococcus infection.

Abstract translation: 提供了用于在各种生理样品（例如血液，唾液，咽喉拭子，脑脊液，brocheolar灌洗材料和活组织检查材料）中的任一种中鉴定A族链球菌的方法和组合物。 所用的组合物包括可从化脓性链球菌获得并含有至少一种保守表位的细胞外半胱氨酸蛋白酶或其片段，或编码半胱氨酸蛋白酶或其片段的核酸。 该组合物还可用于引发针对A组链球菌感染的保护性免疫应答。

公开(公告)号：WO9608569A3

公开(公告)日：1996-07-18

申请号：PCT/US9511723

申请日：1995-09-13

Applicant: BAYLOR COLLEGE MEDICINE ,  MUSSER JAMES A ,  KAPUR VIVEK

Inventor： MUSSER JAMES A ,  KAPUR VIVEK

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/09 ,  A61P7/00 ,  A61P11/04 ,  A61P13/12 ,  A61P17/00 ,  A61P29/00 ,  A61P31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/315 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/52 ,  C12N15/02 ,  C12N15/57 ,  C12P21/08 ,  C12Q1/14 ,  C12Q1/37 ,  C12Q1/68 ,  C12R1/46 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/573 ,  G01N33/577 ,  C07K16/40 ,  C12N5/02

CPC classification number: G01N33/56944 ,  C12N9/52

Abstract: Methods and compositions are provided for identifying a group A Streptococcus in any of a variety of physiological samples, such as blood, saliva, throat swabs, cerebrospinal fluid, brocheolar lavage material, and biopsy material. The compositions used include an extracellular cysteine protease or a fragment thereof, obtainable from S. pyogenes and containing at least one conserved epitope, or nucleic acid encoding the cysteine protease or fragment thereof. The compositions also find use in eliciting a protective immune response against a group A Streptococcus infection.