公开(公告)号：WO2008081198A1

公开(公告)日：2008-07-10

申请号：PCT/GB2008/000033

申请日：2008-01-07

Applicant: IMPERIAL INNOVATIONS LTD ,  HANSEL, Trevor, T.

Inventor： HANSEL, Trevor, T.

IPC: G01N33/50

CPC classification number: G01N33/5047 ,  G01N2333/705

Abstract: To provide in vitro assays for modelling the human side effects of drugs, two procedures are disclosed. Firstly, a rapid fixing protocol is provided that can improve the ability to assay cell surface markers of cell activation, allowing them to be quantified while still present at high levels. This fixing protocol is particularly useful when working with whole blood, thereby permitting immune cell responses to be assessed in the presence of endogenous plasma proteins and the like. Secondly, the CD11b cell surface marker can be used as a predictive indicator of undesired inflammatory activity. Substances can thus be tested in vitro against human blood cells, particularly substances that are not known or expected to provoke an inflammatory response, with up regulated expression of CD11b indicating a potential in vivo problem. These two approaches can be used separately or in combination.

Abstract translation: 为了提供用于建模药物的人的副作用的体外测定，公开了两种方法。 首先，提供了一种快速定影方案，其可以提高细胞表面标志物测定细胞活化的能力，允许它们在仍然以高水平存在时进行定量。 这种修复方案在使用全血时特别有用，从而允许在存在内源性血浆蛋白等的情况下评估免疫细胞反应。 其次，CD11b细胞表面标记物可用作不希望的炎症活性的预测指标。 因此，物质可以在体外对人血细胞，特别是未知或预期引起炎症反应的物质进行体外测试，CD11b的上调表达表明潜在的体内问题。 这两种方法可以单独使用或组合使用。

公开(公告)号：WO2008075086A1

公开(公告)日：2008-06-26

申请号：PCT/GB2007/004961

申请日：2007-12-21

Applicant: OXFORD GENE TECHNOLOGY IP LIMITED ,  SOUTHERN, Edwin ,  MILNER, Natalie ,  PATEL, Kaajal

Inventor： SOUTHERN, Edwin ,  MILNER, Natalie ,  PATEL, Kaajal

IPC: B01L3/00 ,  B01L11/00

CPC classification number: G01N1/312 ,  B01L3/0293 ,  B01L3/5085 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0822 ,  B01L2300/16 ,  B01L2400/088 ,  G01N2001/282

Abstract: There are provided processes for analysing a plurality of different samples. The processes comprise the steps of: a) applying the samples to a support, to which an analytical component is immobilised; and b) allowing the samples to interact with the analytical component, thus permitting analysis of the samples. The samples are applied in step a) to different areas of the support to produce a spatial arrangement of samples on the support. The spatial arrangement of the samples is maintained in step b), thus permitting the results of the analysis to be matched to individual samples.

Abstract translation: 提供了用于分析多个不同样本的处理。 该方法包括以下步骤：a）将样品施加到固定有分析组分的载体上; 和b）允许样品与分析组分相互作用，从而允许对样品进行分析。 将样品在步骤a）中应用于载体的不同区域以产生样品在载体上的空间排列。 在步骤b）中保持样品的空间排列，从而允许分析结果与单个样品匹配。

公开(公告)号：WO2008056114A1

公开(公告)日：2008-05-15

申请号：PCT/GB2007/004207

申请日：2007-11-06

Applicant: IMPERIAL INNOVATIONS LTD ,  KROPF, Pascale ,  MULLER, Ingrid

Inventor： KROPF, Pascale ,  MULLER, Ingrid

IPC: A61K38/50 ,  A61P15/00

CPC classification number: A61K45/06 ,  A61K31/07 ,  A61K31/195 ,  A61K31/355 ,  A61K31/375 ,  A61K31/51 ,  A61K31/519 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K2300/00

Abstract: Arginase activity is highly up-regulated in the placenta in pregnant females, but the up-regulation is not seen in their peripheral tissues. Moreover, the up-regulation is not seen in age-matched non-pregnant controls,. Thus arginase in the placenta is believed to induce reversible and local T cell hyporesponsiveness, thereby playing a crucial role in the maintenance of normal pregnancy.

Abstract translation: 精氨酸酶活性在怀孕女性的胎盘中高度上调，但在其外周组织中未观察到上调。 此外，在年龄匹配的非怀孕对照中不能看到上调。 因此，认为胎盘中的精氨酸酶诱导可逆和局部T细胞的低反应性，从而在维持正常妊娠中起关键作用。

公开(公告)号：WO2008032106A2

公开(公告)日：2008-03-20

申请号：PCT/GB2007/003530

申请日：2007-09-14

Applicant: OXFORD GENE TECHNOLOGY IP LIMITED ,  LUEERSSEN, Dietrich, Wilhelm, Karl

Inventor： LUEERSSEN, Dietrich, Wilhelm, Karl

IPC: G02B21/36 ,  G02B21/00

CPC classification number: G02B21/245 ,  G02B21/16

Abstract: A method and an apparatus for imaging of a sample on a sample platform is described. For each area that is imaged, preparation for acquisition of an image must take place before image data are acquired. The image data obtained from a first area of the sample during a particular acquiring step is transferred to memory whilst preparation for acquisition of an image of a second area of the sample is taking place.

Abstract translation: 描述了用于在样本平台上成像样本的方法和设备。 对于每个成像区域，获取图像的准备工作必须在采集图像数据之前进行。 在特定的采集步骤期间从样本的第一区域获得的图像数据被传送到存储器，同时准备采集样本的第二区域的图像。

公开(公告)号：WO2008001221A2

公开(公告)日：2008-01-03

申请号：PCT/IB2007/002778

申请日：2007-06-21

Applicant: NOVARTIS AG ,  BROEKER, Michael

Inventor： BROEKER, Michael

IPC: A61M5/19

CPC classification number: A61M5/19 ,  A61B17/205 ,  A61M5/3134 ,  A61M5/32 ,  A61M2005/3128 ,  A61M2005/3201

Abstract: A vaccine delivery device (10; 10'; 100; 200; 200') comprises a standard dual-chambered delivery device in which one of the chambers (12a; 212a) contains a first vaccine component and the other of the chambers (12b; 212b) contains a second vaccine component. These components can be concurrently delivered to a patient from a syringe device while remaining separate from each other until they leave the device.

Abstract translation: 疫苗递送装置（10; 10'; 100; 200; 200'）包括标准的双室输送装置，其中一个腔室（12a; 212a）包含第一疫苗组件，另一个腔室（12b; 212b）含有第二疫苗组分。 这些组件可以从注射器装置同时输送到患者，同时保持彼此分离直到它们离开装置。

公开(公告)号：WO2007110776A1

公开(公告)日：2007-10-04

申请号：PCT/IB2007/001149

申请日：2007-03-23

Applicant: NOVARTIS VACCINES AND DIAGNOSTICS GMBH & CO KG ,  SCHEFFCZIK, Hanno

Inventor： SCHEFFCZIK, Hanno

IPC: A61K39/145 ,  A61K47/26 ,  A61P31/16 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/55511 ,  A61K2039/70 ,  C07K14/005 ,  C12N2740/16222 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: Antigens from individual influenza virus strains are not refrigerated before being combined to make multivalent influenza virus vaccines. Moreover, influenza vaccines are not refrigerated between packaging and administration. Thus the need for refrigeration is minimized, and the cold-chain does not have to be maintained between vaccine manufacture and administration.

Abstract translation: 来自个别流感病毒株的抗原在组合以制备多价流感病毒疫苗之前不冷藏。 此外，流感疫苗在包装和给药之间不会冷藏。 因此，对制冷的需要被最小化，并且冷链不必在疫苗制造和给药之间保持。

公开(公告)号：WO2007052163A3

公开(公告)日：2007-05-10

申请号：PCT/IB2006/003880

申请日：2006-11-01

Applicant: NOVARTIS VACCINES AND DIAGNOSTICS GMBH & CO KG ,  GREGERSEN, Jens-Peter ,  KOST, Holger

Inventor： GREGERSEN, Jens-Peter ,  KOST, Holger

IPC: A61K39/12 ,  A61K39/145

Abstract: The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as β-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.

公开(公告)号：WO2007026247A1

公开(公告)日：2007-03-08

申请号：PCT/IB2006/002778

申请日：2006-08-31

Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL ,  TELFORD, John

Inventor： TELFORD, John

IPC: A61K39/05 ,  A61K39/02

CPC classification number: A61K39/05 ,  A61K39/0016 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/55544 ,  Y02A50/466

Abstract: Diphtheria toxin may not be the sole antigenic component that gives rise to protective immunity in diphtheria vaccines. C.diphtheriae pilus proteins have been found within diphtheria vaccines. These pilus proteins may contribute towards the ability of a vaccine to protect against C.diphtheriae infection, and so it may be desirable to enrich their presence in the vaccines. Conversely, their presence means that diphtheria vaccines are not homogenous, and so it may be desirable for quality control purposes to remove them from vaccines, enriching the toxin as the main immunogenic component while retaining protective efficacy.

Abstract translation: 白喉毒素可能不是在白喉疫苗中产生保护性免疫的唯一抗原成分。 白喉疫苗中已发现iph ae属的菌丝蛋白。 这些真菌蛋白质可能有助于疫苗保护免受iph螨感染的能力，因此可能需要丰富其在疫苗中的存在。 相反，它们的存在意味着白喉疫苗不是均匀的，因此质量控制目的可能是期望的，以从疫苗中除去它们，将毒素富集为主要的免疫原性成分，同时保持保护功效。

公开(公告)号：WO2006120576A3

公开(公告)日：2006-11-16

申请号：PCT/IB2006/001703

申请日：2006-05-08

Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL ,  STOCKHOLM UNIVERSITY ,  OSCARSON, Stefan ,  TEODOROVIC, Peter ,  COSTANTINO, Paolo

Inventor： OSCARSON, Stefan ,  TEODOROVIC, Peter ,  COSTANTINO, Paolo

IPC: C07H11/04 ,  A61K39/095 ,  A61P31/04 ,  C07H7/00 ,  C07H13/00 ,  C07H15/04 ,  A61K31/702

Abstract: An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.

公开(公告)号：WO2006117541A1

公开(公告)日：2006-11-09

申请号：PCT/GB2006/001593

申请日：2006-05-03

Applicant: OXFORD GENE TECHNOLOGY IP LIMITED ,  SOUTHERN, Edwin ,  MEULEMAN, Wouter ,  LUEERSSEN, Dietrich, Wilhelm, Karl ,  MILNER, Natalie

Inventor： SOUTHERN, Edwin ,  MEULEMAN, Wouter ,  LUEERSSEN, Dietrich, Wilhelm, Karl ,  MILNER, Natalie

IPC: C12M1/33 ,  C12N1/06 ,  C12Q1/68 ,  B01L3/00

CPC classification number: C12Q1/6876 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  C12M47/06 ,  G01N2015/1006

Abstract: A device for individually analysing cells of interest, comprising (a) a channel for receiving the contents of a cell of interest, wherein the channel has an input end and an output end, and (b) a cell trapping site in proximity to the input end of the channel, wherein (i) the input end of the channel is adapted such that an intact cell of interest cannot enter the channel; and (ii) the channel contains one or more analytical components for analysing the contents of the cell of interest. In use, a cell is applied to the device, where it is trapped by the cell trapping means. The cell cannot enter the channel intact, but its contents can be released in situ to enter the channel's input end. The contents can then move down the channel, towards the output end, and they encounter the immobilised reagents, thereby permitting analysis of the cell contents.

Abstract translation: 一种用于单独分析感兴趣的单元的设备，包括：（a）用于接收感兴趣单元的内容的通道，其中所述通道具有输入端和输出端，以及（b）靠近输入端的单元陷阱位置 其中（i）信道的输入端被适配成使得感兴趣的完整小区不能进入信道; 和（ii）该通道包含用于分析感兴趣细胞的内容物的一个或多个分析成分。 在使用中，将细胞施加到装置，在其中被细胞俘获装置捕获。 单元格无法完整进入通道，但其内容可以原位释放进入通道的输入端。 然后，内容物可以向下移动通道，朝向输出端，并且它们遇到固定的试剂，从而允许细胞内容物的分析。