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    NEW SYNTHESIS OF FUCOSE
    32.
    发明申请
    NEW SYNTHESIS OF FUCOSE 审中-公开
    FUCOSE的新合成

    公开(公告)号：WO2013046181A1

    公开(公告)日：2013-04-04

    申请号：PCT/IB2012/055211

    申请日：2012-09-28

    Applicant: GLYCOM A/S ,  KHANZHIN, Nikolay ,  BOUTET, Julien ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    Inventor： KHANZHIN, Nikolay ,  BOUTET, Julien ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    IPC: C07H1/00 ,  C07D493/04 ,  C07H3/08

    CPC classification number: C07H1/00 ,  C07D493/04 ,  C07H3/02 ,  C07H3/08 ,  C07H9/02 ,  C07H9/04 ,  C07H11/00

    Abstract: The present invention provides a process for converting D-glucose into L-fucose, where a first aspect of the invention relates to a method of making a compound of formula (1) wherein R is independently H,alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, comprising the step of treating a compound of formula (2) wherein R is defined above and R 1 is a sulphonate leaving group, with a reducing complex metal hydride and, preferably, a base to form the compound of formula (1); a compound of formula (13).

    Abstract translation: 本发明提供了将D-葡萄糖转化为L-岩藻糖的方法，其中本发明的第一方面涉及制备式（1）化合物的方法，其中R独立地为H，烷基或苯基，或优选地，其中 两个生发R基团与它们所连接的碳原子一起形成一个C3-亚环烷基，其包括处理式（2）化合物的步骤，其中R定义如上，R1是磺酸根离去基团， 还原复合金属氢化物，优选碱形成式（1）化合物; 式（13）的化合物。

    HMO PRODUCTION
    38.
    发明申请
    HMO PRODUCTION 审中-公开

    公开(公告)号：WO2021148611A1

    公开(公告)日：2021-07-29

    申请号：PCT/EP2021/051468

    申请日：2021-01-22

    Applicant: GLYCOM A/S

    Inventor： PAPADAKIS, Manos ,  KAMPMANN, Katrine, Bych

    IPC: C12N15/70 ,  C12P19/00 ,  C07H3/06

    Abstract: The present inventive concept relates to a genetically modified cell enabled for the production of an oligosaccharide, preferably, an HMO, comprising a recombinant nucleic acid encoding a protein of the MFS superfamily; and methods using said cell for the production the oligosaccharide, preferably an HMO.

    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES
    39.
    发明申请
    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES 审中-公开

    公开(公告)号：WO2019229711A1

    公开(公告)日：2019-12-05

    申请号：PCT/IB2019/054522

    申请日：2019-05-31

    Applicant: GLYCOM A/S

    Inventor： VIGSNÆS, Louise Kristine ,  MCCONNELL, Bruce ,  ROTHAUS CHRISTENSEN, Kristine

    IPC: A61K31/702 ,  A61K31/715 ,  A61P37/06

    Abstract: The invention relates to a method, compounds and compositions for the secondary prevention, treatment or dietary management of symptomatic and asymptomatic non -intestinal autoimmune diseases in a non-infant human including Sjogren's syndrome and type 1 diabetes. Said method, compounds and compositions for the secondary prevention, treatment or dietary management include human milk oligosaccharide (HMO), preferably mixtures of human milk oligosaccharides selected from the group of 2'-FL, LNnT, LNT, DFL, and 6'-SL.

    NUCLEIC ACID CONSTRUCT FOR IN VITRO AND IN VIVO GENE EXPRESSION
    40.
    发明申请
    NUCLEIC ACID CONSTRUCT FOR IN VITRO AND IN VIVO GENE EXPRESSION 审中-公开

    公开(公告)号：WO2019123324A1

    公开(公告)日：2019-06-27

    申请号：PCT/IB2018/060355

    申请日：2018-12-19

    Applicant: GLYCOM A/S

    Inventor： PEDERSEN, Margit ,  PAPADAKIS, Manos

    IPC: C12N15/113 ,  C12N15/70 ,  C07H3/06

    Abstract: The present invention relates to the field of recombinant production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMO).

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