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    OLIGOSACCHARIDE PRODUCTION
    1.
    发明申请
    OLIGOSACCHARIDE PRODUCTION 审中-公开
    低聚糖生产

    公开(公告)号：WO2015197082A1

    公开(公告)日：2015-12-30

    申请号：PCT/DK2015/050191

    申请日：2015-06-29

    Applicant: GLYCOM A/S

    Inventor： SAMAIN, Eric ,  PELTIER-PAIN, Pauline ,  BYCH, Katrine ,  JOHANSON, Ted ,  CHAMPION, Elise ,  DEKANY, Gyula

    IPC: C12P19/18 ,  C12N1/21

    CPC classification number: C12P19/18 ,  C07K14/245 ,  C12N9/1029 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/2402 ,  C12N9/2471 ,  C12N15/52 ,  C12Y203/01018 ,  C12Y204/01149 ,  C12Y302/01023 ,  C12Y302/01026

    Abstract: The invention relates to a genetically modified microorganism for making a recombinant oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source. The one or more genes encoding a sucrose utilization system are preferably one or more genes encoding a heterologous PTS-dependent sucrose utilization transport system, such as the scr genes.

    Abstract translation: 本发明涉及用于制备重组寡糖的转基因微生物，优选3-8个单糖单元，更优选3-5个单糖单元，特别是包含编码蔗糖利用系统的一个或多个基因的HMO，因此微生物 可以使用蔗糖作为碳源和能源。 编码蔗糖利用系统的一种或多种基因优选是编码异源PTS依赖性蔗糖利用转运系统（例如scr基因）的一种或多种基因。

    SEPARATION OF 2'-O-FUCOSYLLACTOSE FROM FERMENTATION BROTH
    2.
    发明申请
    SEPARATION OF 2'-O-FUCOSYLLACTOSE FROM FERMENTATION BROTH 审中-公开
    从发酵豆中分离出2'-O-纤维素

    公开(公告)号：WO2015188834A1

    公开(公告)日：2015-12-17

    申请号：PCT/DK2015/050158

    申请日：2015-06-11

    Applicant: GLYCOM A/S

    Inventor： MATWIEJUK, Martin ,  CHASSAGNE, Pierre ,  OSZTROVSZKY, Györgyi ,  HORVÁTH, Ferenc ,  DEKANY, Gyula

    IPC: C07H1/06 ,  C07H3/06

    CPC classification number: C07H1/06 ,  C07H3/06

    Abstract: The invention relates to a method for selective crystallization of 2'-O-fucosyllactose (2'-FL) from an aqueous solution comprising 2'-FL and a fucosylated carbohydrate other than 2'-FL, preferably 2',3-di-O-fucosyllactose (DFL), by adding one or more C 1 -C 4 alcohols, preferably methanol, to the solution.

    Abstract translation: 本发明涉及从包含2'-FL的水溶液和除2'-FL之外的岩藻糖基化碳水化合物优选2'，3-二 - O-岩藻糖基乳糖（DFL），通过向溶液中加入一种或多种C 1 -C 4醇，优选甲醇。

    FERMENTATIVE PRODUCTION OF OLIGOSACCHARIDES
    3.
    发明申请
    FERMENTATIVE PRODUCTION OF OLIGOSACCHARIDES 审中-公开
    低聚糖的生产

    公开(公告)号：WO2015032413A1

    公开(公告)日：2015-03-12

    申请号：PCT/DK2014/050273

    申请日：2014-09-05

    Applicant: GLYCOM A/S

    Inventor： DEKANY, Gyula ,  PELTIER-PAIN, Pauline ,  MOLNÁR-GÁBOR, Dóra ,  HEDEROS, Markus

    IPC: C12P19/26 ,  C12P19/18 ,  C07H3/06

    CPC classification number: C12P19/18 ,  C07H3/06 ,  C08B37/006 ,  C12P19/00 ,  C12P19/26 ,  C12Y204/01065 ,  C12Y204/01087 ,  C12Y204/01099

    Abstract: The application discloses a method for producing an oligosaccharide of at least four monosaccharide units, advantageously an HMO, particularly an HMO of only four monosaccharide units, said method comprising a step of: culturing, in a culture medium containing a fucosylated, sialylated or N-acetyl-glucosaminylated lactose trisaccharide as acceptor, a genetically modified cell having a recombinant gene that encodes an enzyme capable of modifying said acceptor or one of the necessary intermediates in the biosynthetic pathway of the oligosaccharide of at least four monosaccharide units, advantageously an HMO, particularly an HMO of only four monosaccharide units, from said acceptor.

    Abstract translation: 本申请公开了一种生产至少四个单糖单元的寡糖的方法，有利地是HMO，特别是仅四个单糖单元的HMO，所述方法包括以下步骤：在含有岩藻糖基化的唾液酸化或N- 乙酰基 - 葡糖胺化的乳糖三糖作为受体，一种遗传修饰的细胞，其具有编码能够修饰至少四个单糖单元的寡糖的生物合成途径中的所述受体或必需中间体的酶的重组基因，有利地是HMO，特别是 来自所述受体的仅四种单糖单元的HMO。

    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION
    4.
    发明申请
    METHOD FOR PRODUCING OLIGOSACCHARIDES AND OLIGOSACCHARIDE GLYCOSIDES BY FERMENTATION 审中-公开
    通过发酵生产低聚葡萄糖苷和低聚果糖苷的方法

    公开(公告)号：WO2013182206A1

    公开(公告)日：2013-12-12

    申请号：PCT/DK2013/050182

    申请日：2013-06-07

    Applicant: GLYCOM A/S

    Inventor： PELTIER-PAIN, Pauline ,  DEKANY, Gyula ,  DUREAU, Remy ,  RISINGER, Christian ,  HEDEROS, Markus ,  CHAMPION, Elise

    IPC: C12P19/44 ,  C07H3/06 ,  C07H5/04 ,  C07H5/08 ,  C07H15/18 ,  C12P19/28 ,  C12P19/64

    CPC classification number: C07H3/06 ,  C07H5/04 ,  C07H15/10 ,  C07H15/14 ,  C07H15/18 ,  C12P19/28 ,  C12P19/44 ,  C12P19/64 ,  Y02P20/55

    Abstract: The application discloses a method for producing anomerically protected glycosidic oligosaccharide derivatives comprising the step of culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor. The application further discloses a method for producing an oligosaccharide comprising the steps of: (a) culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor to produce an anomerically protected glycosidic oligosaccharide derivative, then (b) removing/deprotecting the anomeric protective group.

    Abstract translation: 本申请公开了一种用于制备异头保护的糖苷寡糖衍生物的方法，其包括在含有异头保护的乳糖受体的培养基中培养具有编码可转移糖基残基的糖基转移酶的重组基因的遗传修饰细胞的步骤 活化的糖核苷酸与所述乳糖受体。 本申请进一步公开了一种生产寡糖的方法，包括以下步骤：（a）在含有异头保护的乳糖受体的培养基中培养具有编码可转移糖基残基的糖基转移酶的重组基因的遗传修饰细胞 的活性糖核苷酸与所述乳糖受体产生异头保护的糖苷寡糖衍生物，然后（b）去除/去保护端基异构保护基。

    NEW SYNTHESIS OF FUCOSE
    6.
    发明申请
    NEW SYNTHESIS OF FUCOSE 审中-公开
    FUCOSE的新合成

    公开(公告)号：WO2013046181A1

    公开(公告)日：2013-04-04

    申请号：PCT/IB2012/055211

    申请日：2012-09-28

    Applicant: GLYCOM A/S ,  KHANZHIN, Nikolay ,  BOUTET, Julien ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    Inventor： KHANZHIN, Nikolay ,  BOUTET, Julien ,  BONACCORSI, Filippo ,  DEKANY, Gyula

    IPC: C07H1/00 ,  C07D493/04 ,  C07H3/08

    CPC classification number: C07H1/00 ,  C07D493/04 ,  C07H3/02 ,  C07H3/08 ,  C07H9/02 ,  C07H9/04 ,  C07H11/00

    Abstract: The present invention provides a process for converting D-glucose into L-fucose, where a first aspect of the invention relates to a method of making a compound of formula (1) wherein R is independently H,alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, comprising the step of treating a compound of formula (2) wherein R is defined above and R 1 is a sulphonate leaving group, with a reducing complex metal hydride and, preferably, a base to form the compound of formula (1); a compound of formula (13).

    Abstract translation: 本发明提供了将D-葡萄糖转化为L-岩藻糖的方法，其中本发明的第一方面涉及制备式（1）化合物的方法，其中R独立地为H，烷基或苯基，或优选地，其中 两个生发R基团与它们所连接的碳原子一起形成一个C3-亚环烷基，其包括处理式（2）化合物的步骤，其中R定义如上，R1是磺酸根离去基团， 还原复合金属氢化物，优选碱形成式（1）化合物; 式（13）的化合物。

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