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    SYSTEM AND METHOD FOR REDUCING POWER LOSS IN SWITCHED-CAPACITOR POWER CONVERTERS
    32.
    发明申请
    SYSTEM AND METHOD FOR REDUCING POWER LOSS IN SWITCHED-CAPACITOR POWER CONVERTERS 审中-公开
    用于降低开关电源功率转换器的功率损耗的系统和方法

    公开(公告)号：WO2015120023A1

    公开(公告)日：2015-08-13

    申请号：PCT/US2015/014422

    申请日：2015-02-04

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： STAUTH, Jason, T. ,  KESARWANI, Kapil

    IPC分类号： H02M3/07

    CPC分类号： H02M3/07 ,  H02M1/08 ,  H02M2001/0058 ,  H02M2003/072 ,  Y02B70/1491

    摘要： A system for reducing power loss in a switched-capacitor converter includes a first and second switched capacitor sub-converter each having a flying capacitor and a first, second, third, and fourth switching device. Each switching device is controlled by one of a first, second, third, and fourth clock signal. The first, second, third and fourth clock signals of the second switched capacitor sub-converter are inverted such that the first switched capacitor sub-converter operates during a first phase and the second switched capacitor converter operates during a second phase that is 1800 degrees out of phase from the first phase. The system also includes a resonant charge sharing portion for coupling a bottom-plate parasitic capacitance of the first switched capacitor sub-converter to a bottom-plate parasitic capacitance of the second switched capacitor converter.

    摘要翻译： 一种用于降低开关电容器转换器中的功率损耗的系统包括具有飞跨电容器和第一，第二，第三和第四开关装置的第一和第二开关电容器子转换器。 每个开关装置由第一，第二，第三和第四时钟信号之一控制。 第二开关电容器子转换器的第一，第二，第三和第四时钟信号被反相，使得第一开关电容器子转换器在第一阶段期间操作，并且第二开关电容器转换器在1800度的第二相位期间操作 的阶段从第一阶段。 该系统还包括谐振电荷共享部分，用于将第一开关电容器子转换器的底板寄生电容耦合到第二开关电容器转换器的底板寄生电容。

    METHOD AND SYSTEM FOR USING CHERENKOV RADIATION TO MONITOR BEAM PROFILES AND RADIATION THERAPY
    34.
    发明申请
    METHOD AND SYSTEM FOR USING CHERENKOV RADIATION TO MONITOR BEAM PROFILES AND RADIATION THERAPY 审中-公开
    使用CHERENKOV辐射对监测光束轮廓和辐射治疗的方法和系统

    公开(公告)号：WO2015077480A1

    公开(公告)日：2015-05-28

    申请号：PCT/US2014/066668

    申请日：2014-11-20

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： POGUE, Brian, William ,  GLADSTONE, David, Joseph ,  JARVIS, Lesley, Ann ,  GLASER, Adam, Kenneth ,  ZHANG, Rongxiao

    IPC分类号： G01T1/16 ,  G01T1/22

    CPC分类号： G01T1/22 ,  A61N5/1048 ,  A61N5/1071 ,  A61N2005/1059 ,  G01T1/29

    摘要： A system for providing monitoring of radiation therapy from a source of pulsed high energy radiation disposed to provide a radiation beam to a treatment zone; a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting by synchronizing the camera to pulses of the radiation beam; and an image processor adapted to determine extent overlap of the beam area from the images. Additionally an image processor adopted to determine cumulative skin dose in the treatment zone from the images. In a particular embodiment, the processor uses a three-dimensional model of a subject to determine a mapping of image intensity in the images of Cherenkov light to radiation intensity in skin of the subject, to apply the mapping to the images of Cherenkov light to verify skin dose delivered, and to accumulate skin dose by summing the maps of skin dose.

    摘要翻译： 一种用于提供从设置用于向处理区提供辐射束的脉冲式高能辐射源的辐射治疗监测系统; 用于对来自治疗区的切伦科夫灯进行成像的照相机; 用于通过将相机同步到辐射束的脉冲来防止室内照明干扰的装置; 以及适于确定来自图像的光束区域的范围重叠的图像处理器。 另外，图像处理器被用于从图像确定处理区域中的累积皮肤剂量。 在特定实施例中，处理器使用对象的三维模型来确定切伦科夫光图像中的图像强度与受试者皮肤中的辐射强度的映射，以将映射应用于切伦科夫光的图像以验证 皮肤剂量递送，并通过总结皮肤剂量图来积累皮肤剂量。

    METHODS FOR PREVENTING TOXICITY OF ADOPTIVE CELL THERAPY
    35.
    发明申请
    METHODS FOR PREVENTING TOXICITY OF ADOPTIVE CELL THERAPY 审中-公开
    预防细胞治疗毒性的方法

    公开(公告)号：WO2015066262A1

    公开(公告)日：2015-05-07

    申请号：PCT/US2014/063037

    申请日：2014-10-30

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： SENTMAN, Charles, L.

    IPC分类号： C12N5/071 ,  C12N5/00

    CPC分类号： C12N5/0636 ,  C12N2501/22 ,  C12N2510/00

    摘要： Methods for preventing or reducing toxicity of adoptive cell therapy using a population of cells deficient in the expression or activity of GM-CSF, GM-CSF receptor or perforin are provided, as are kits for preparing cells deficient in the expression or activity of GM-CSF, GM-CSF receptor or perforin.

    摘要翻译： 提供了使用缺乏GM-CSF，GM-CSF受体或穿孔素的表达或活性的细胞群来预防或减少过继细胞治疗的方法，以及用于制备缺乏GM-CSF表达或活性的细胞的试剂盒， CSF，GM-CSF受体或穿孔素。

    HEARING-AID NOISE REDUCTION CIRCUITRY WITH NEURAL FEEDBACK TO IMPROVE SPEECH COMPREHENSION
    36.
    发明申请
    HEARING-AID NOISE REDUCTION CIRCUITRY WITH NEURAL FEEDBACK TO IMPROVE SPEECH COMPREHENSION 审中-公开
    具有神经反馈的助听器噪声减少电路提高语音综合

    公开(公告)号：WO2014205327A1

    公开(公告)日：2014-12-24

    申请号：PCT/US2014/043369

    申请日：2014-06-20

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

    发明人： ODAME, Kofi ,  HANSON, Valerie

    IPC分类号： H04R25/00

    CPC分类号： H04R25/505 ,  H04R25/407 ,  H04R25/43 ,  H04R25/554 ,  H04R2225/43 ,  H04R2225/67

    摘要： A hearing prosthetic has microphones configured to receive audio with signal processing circuitry for reducing noise; apparatus configured to receive a signal derived from a neural interface, and to determine an interest signal when the user is interested in processed audio; and a transducer for providing processed audio to a user. The signal processing circuitry is controlled by the interest signal. In particular embodiments, the neural interface is electroencephalographic electrodes processed to detect a P300 interest signal, in other embodiments the interest signal is derived from a sensorimotor rhythm signal. In embodiments, the signal processing circuitry reduces noise by receiving sound from along a direction of focus, while rejecting sound from other directions; the direction of focus being set according to timing of the interest signal. In other embodiments, a sensorimotor rhythm signal is determined and binned, with direction of audio focus set according to amplitude.

    摘要翻译： 听觉假肢具有被配置成用信号处理电路接收音频以减少噪声的麦克风; 被配置为接收从神经接口导出的信号的设备，以及当用户对处理的音频感兴趣时确定兴趣信号; 以及用于向用户提供经处理的音频的换能器。 信号处理电路由感兴趣信号控制。 在特定实施例中，神经接口是经处理以检测P300兴趣信号的脑电图电极，在其他实施例中，兴趣信号是从感觉运动节律信号导出的。 在实施例中，信号处理电路通过从焦点的方向接收声音，同时从其他方向排除声音来减少噪声; 根据兴趣信号的定时设定焦点的方向。 在其他实施例中，根据幅度设定音频焦点的方向，确定感兴趣的运动节律信号并进行分组。

    COMPOSITIONS AND METHODS FOR IN VIVO EXCISION OF HIV-1 PROVIRAL DNA
    38.
    发明申请
    COMPOSITIONS AND METHODS FOR IN VIVO EXCISION OF HIV-1 PROVIRAL DNA 审中-公开
    用于HIV-1病毒DNA的体外实验的组合物和方法

    公开(公告)号：WO2014165349A1

    公开(公告)日：2014-10-09

    申请号：PCT/US2014/031674

    申请日：2014-03-25

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： HOWELL, Alexander, L. ,  ESZTERHAS, Susan, K.

    IPC分类号： C12N15/11

    CPC分类号： C12N15/1132 ,  A61K31/7105 ,  A61K38/1709 ,  C12N15/111 ,  C12N2320/30

    摘要： Methods and kits for excising HIV-1 DNA in vivo are provided, which employ Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-Associated (cas) proteins. Vectors harboring nucleic acids encoding one or more guide RNA, wherein said guide RNA hybridizes with a target HIV-1 DNA are also provided.

    摘要翻译： 提供了用于在体内切除HIV-1 DNA的方法和试剂盒，其使用聚集的定期间隔短回归重复（CRISPR）和CRISPR相关（cas）蛋白。 还提供了携带编码一种或多种引导RNA的核酸的载体，其中所述引物RNA与靶HIV-1 DNA杂交。

    METHOD AND APPARATUS FOR MAGNETIC SUSCEPTIBILITY TOMOGRAPHY, MAGNETOENCEPHALOGRAPHY, AND TAGGANT OR CONTRAST AGENT DETECTION
    40.
    发明申请
    METHOD AND APPARATUS FOR MAGNETIC SUSCEPTIBILITY TOMOGRAPHY, MAGNETOENCEPHALOGRAPHY, AND TAGGANT OR CONTRAST AGENT DETECTION 审中-公开
    用于磁性可疑性TOMOGRAPHY，磁共振成像和标记物或对比剂检测的方法和装置

    公开(公告)号：WO2014031985A1

    公开(公告)日：2014-02-27

    申请号：PCT/US2013/056436

    申请日：2013-08-23

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  DIAMOND, Solomon, G. ,  BURKE, Broc, A. ,  FICKO, Bradley, W.

    发明人： DIAMOND, Solomon, G. ,  BURKE, Broc, A. ,  FICKO, Bradley, W.

    IPC分类号： A61B5/055

    CPC分类号： G01R33/16 ,  A61B5/0042 ,  A61B5/04008 ,  A61B5/0522 ,  A61B2562/0223 ,  G01N27/72

    摘要： A magnetic susceptibility tomographic device has sensitive magnetic sensors about a measurement volume and AC bias coils for providing magnetic fields within the volume. Sensing circuitry reads the sensors, and a processor executes magnetic susceptibility tomography (MST) routines from memory to divide the measurement volume into voxels, to determine differences between applied and measured field strengths of magnetic fields at each voxel and thereby determines magnetic susceptibility of each voxel, and to construct tomographic images representative of magnetic susceptibility as MST images. Embodiments with SQUID and fluxgate sensors are described. Applications to direct measurement of tissue magnetic susceptibility, and to locating and quantifying tagged magnetic nanoparticles are disclosed, including antibody- tagged nanoparticles for use in cancer diagnosis and treatments, and the retrieval of taggant identification codes from an object.

    摘要翻译： 磁化物断层摄影装置具有关于测量体积的敏感磁传感器和用于在体积内提供磁场的AC偏置线圈。 感测电路读取传感器，并且处理器执行来自存储器的磁化率层析成像（MST）程序，以将测量体积划分为体素，以确定每个体素上的磁场的施加和测量场强之间的差异，从而确定每个体素的磁化率 并构建代表磁化率的断层图像作为MST图像。 描述具有SQUID和磁通门传感器的实施例。 公开了用于直接测量组织磁化率以及定位和定量标记的磁性纳米颗粒的应用，包括用于癌症诊断和治疗的抗体标记的纳米颗粒，以及从对象检索标记物识别码。