公开(公告)号：WO2013098833A2

公开(公告)日：2013-07-04

申请号：PCT/IN2012/000599

申请日：2012-09-10

Applicant: CADILA HEALTHCARE LIMITED ,  DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  PAL, Daya, Ram ,  SHARMA, Mukul, Hari, Prasad ,  JAIN, Kuldeep, Natwarlal ,  PATEL, Naitik, Bharatbhai

Inventor： DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  PAL, Daya, Ram ,  SHARMA, Mukul, Hari, Prasad ,  JAIN, Kuldeep, Natwarlal ,  PATEL, Naitik, Bharatbhai

IPC: C07D413/14 ,  C07D413/10

CPC classification number: C07D413/14 ,  C07D265/32 ,  C07D413/10

Abstract: The invention discloses processes for the preparation of rivaroxaban and its pharmaceutically acceptable salts, solvates, and hydrates thereof. The invention also relates to novel intermediates for the preparation of rivaroxaban.

Abstract translation: 本发明公开了制备利伐沙班及其药学上可接受的盐，溶剂化物和水合物的方法。 本发明还涉及制备利伐沙班的新型中间体。

公开(公告)号：WO2012137224A1

公开(公告)日：2012-10-11

申请号：PCT/IN2012/000242

申请日：2012-04-04

Applicant: UNIVERSITY OF DELHI ,  VALLABHBHAI PATEL CHEST INSTIUTE ,  PARMAR, Virinder Singh ,  PRASAD, Ashok Kumar ,  RAJ, Hanumantharao Guru ,  BOSE, Mridula ,  SHARMA, Sunil Kumar ,  TONDON, Rashmi ,  BAGHEL, Anil ,  KATHURIA, Abha ,  GUPTA, Garima ,  AGGARWAL, Neha

Inventor： PARMAR, Virinder Singh ,  PRASAD, Ashok Kumar ,  RAJ, Hanumantharao Guru ,  BOSE, Mridula ,  SHARMA, Sunil Kumar ,  TONDON, Rashmi ,  BAGHEL, Anil ,  KATHURIA, Abha ,  GUPTA, Garima ,  AGGARWAL, Neha

IPC: A01N43/16 ,  A61K31/35

CPC classification number: A61K31/37 ,  A61K31/4704

Abstract: The present invention relates to method for treating mycobacterial infection/disease by administration of a therapeutically effective amount of compound of formula I.

Abstract translation: 本发明涉及通过给予治疗有效量的式I化合物来治疗分枝杆菌感染/疾病的方法。

公开(公告)号：WO2012066565A2

公开(公告)日：2012-05-24

申请号：PCT/IN2011/000783

申请日：2011-11-11

Applicant: CADILA HEALTHCARE LIMITED ,  DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  SHARMA, Piyush, Rajendra

Inventor： DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  SHARMA, Piyush, Rajendra

IPC: C07D491/04 ,  A61K31/407

CPC classification number: C07D491/04 ,  A61K31/407

Abstract: The present invention discloses substantially pure monoclinic form of asenapine maleate having d95 particle size of less than about 100 microns.

Abstract translation: 本发明公开了具有小于约100微米的d95粒度的马来酸阿塞那平的基本上纯的单斜晶形。

公开(公告)号：WO2011121607A3

公开(公告)日：2011-12-15

申请号：PCT/IN2011000213

申请日：2011-03-29

Applicant: CADILA HEALTHCARE LTD ,  DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  PATEL MAYUR RAMNIKBHAI

Inventor： DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  PATEL MAYUR RAMNIKBHAI

IPC: C07C211/42 ,  A61K31/135 ,  A61P25/00

CPC classification number: C07C211/42 ,  C07C2602/08

Abstract: The present invention relates to rasagiline (I) and its pharmaceutically acceptable salts. The invention also relates to improved processes for the preparation of rasagiline and its pharmaceutically acceptable salts. The invention also relates to pharmaceutical compositions that include the pharmaceutically acceptable salts of rasagiline and use of the compositions for treating the signs and symptoms of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.

Abstract translation: 本发明涉及雷沙吉兰（I）及其药学上可接受的盐。 本发明还涉及制备雷沙吉兰及其药学上可接受的盐的改进方法。 本发明还涉及包含雷沙吉兰的药学上可接受的盐的药物组合物以及该组合物用于治疗特发性帕金森病的体征和症状作为初始单一疗法和作为左旋多巴的辅助疗法的用途。

公开(公告)号：WO2010079404A3

公开(公告)日：2011-11-24

申请号：PCT/IB2009055958

申请日：2009-12-28

Applicant: ALEMBIC LTD ,  PONNAIAH RAVI ,  PRASAD ASHOK ,  PATEL KILLOL ,  ACHARYA HITARTH HARSHENDU ,  KATORE VILAS ,  SHAH BHAVIK

Inventor： PONNAIAH RAVI ,  PRASAD ASHOK ,  PATEL KILLOL ,  ACHARYA HITARTH HARSHENDU ,  KATORE VILAS ,  SHAH BHAVIK

IPC: C07D333/20

CPC classification number: C07D333/20

Abstract: The present invention relates to improved process for the preparation of Duloxetine of formula (I) and salts thereof wherein said improvement takes place in step of condensation.

Abstract translation: 本发明涉及制备式（I）的度洛西汀及其盐的改进方法，其中所述改进发生在缩合步骤中。

公开(公告)号：WO2011030353A3

公开(公告)日：2011-11-17

申请号：PCT/IN2010000594

申请日：2010-09-07

Applicant: UNIV DELHI ,  PARMAR VIRINDER SINGH ,  PRASAD ASHOK KUMAR ,  SAXENA RAJENDRA KUMAR ,  SHAKYA GAURAV

Inventor： PARMAR VIRINDER SINGH ,  PRASAD ASHOK KUMAR ,  SAXENA RAJENDRA KUMAR ,  SHAKYA GAURAV

IPC: C12P19/38

CPC classification number: C12P19/38 ,  C12P19/30

Abstract: The present invention provides a process for the regioselective acylation of nucleosides, said process comprising preparing solution of a nucleoside, an acylating agent and a lipase; subjecting said solution to incubation at a predetermined temperature and filtering off the enzyme to obtain the product

Abstract translation: 本发明提供了核苷区域选择性酰化的方法，所述方法包括制备核苷，酰化剂和脂肪酶的溶液; 使所述溶液在预定温度下温育并过滤掉酶以获得产物

公开(公告)号：WO2010070510A2

公开(公告)日：2010-06-24

申请号：PCT/IB2009/055410

申请日：2009-11-30

Applicant: ALEMBIC LIMITED ,  PONNAIAH, Ravi ,  PRASAD, Ashok ,  PANCHASARA, Dineshkumar Ramabhai ,  PATWA, Mitul Bipinchandra ,  PATEL, Ketan, Bharatenduhai

Inventor： PONNAIAH, Ravi ,  PRASAD, Ashok ,  PANCHASARA, Dineshkumar Ramabhai ,  PATWA, Mitul Bipinchandra ,  PATEL, Ketan, Bharatenduhai

IPC: C07D417/04

CPC classification number: C07D281/16

Abstract: The present invention relates to an improved process for preparing Quetiapine fumarate of formula (I).

Abstract translation: 本发明涉及制备式（I）富马酸喹硫平的改进方法。

公开(公告)号：WO2009047699A8

公开(公告)日：2009-05-28

申请号：PCT/IB2008054092

申请日：2008-10-07

Applicant: ALEMBIC LTD ,  DEO KESHAV ,  PRASAD ASHOK

Inventor： DEO KESHAV ,  PRASAD ASHOK

IPC: C08B37/14

CPC classification number: C08B37/0057

Abstract: The present invention relates to provide an improved process for preparation of an amorphous form of Pentosan polysulfate sodium, comprising steps of: i) dissolving crude Pentosan polysulfate sodium having molecular weight of 4000 to 6000 Dalton in water ii) spray drying the solution obtained in step (i) to obtain amorphous form of Pentosan polysulfate sodium

Abstract translation: 本发明涉及提供制备无定形形式的聚硫酸戊聚糖钠的改进方法，其包括以下步骤：i）将分子量为4000至6000道尔顿的粗多硫酸戊多糖钠溶解于水中; ii）将步骤 （i）获得无定形形式的聚硫酸戊聚糖钠

公开(公告)号：WO2009047699A1

公开(公告)日：2009-04-16

申请号：PCT/IB2008/054092

申请日：2008-10-07

Applicant: ALEMBIC LIMITED ,  DEO, Keshav ,  PRASAD, Ashok

Inventor： DEO, Keshav ,  PRASAD, Ashok

IPC: C08B37/14

CPC classification number: C08B37/0057

Abstract: The present invention relates to provide an improved process for preparation of an amorphous form of Pentosan polysulfate sodium, comprising steps of: i) dissolving crude Pentosan polysulfate sodium having molecular weight of 4000 to 6000 Dalton in water ii) spray drying the solution obtained in step (i) to obtain amorphous form of Pentosan polysulfate sodium

Abstract translation: 本发明涉及提供一种制备无定形形式的戊聚糖多硫酸钠的改进方法，包括以下步骤：i）将分子量为4000至6000道尔顿的粗戊聚糖多硫酸钠溶于水中ii）喷雾干燥步骤 （i）获得无定形形式的戊聚糖多硫酸钠

公开(公告)号：WO2009004557A2

公开(公告)日：2009-01-08

申请号：PCT/IB2008052609

申请日：2008-06-28

Applicant: RANBAXY LAB LTD ,  PATIL DATTATRAY B ,  PATEL KILLOL ,  PRASAD ASHOK ,  PRASAD MOHAN

Inventor： PATIL DATTATRAY B ,  PATEL KILLOL ,  PRASAD ASHOK ,  PRASAD MOHAN

IPC: C07D471/04 ,  C07D471/12

CPC classification number: C07D471/14 ,  C07D471/04 ,  C07D471/12

Abstract: The present invention relates to a process for the preparation of cis-intermediates of Formula II, (Formula II) wherein R1 represents hydrogen, (un)substituted alkyl, alkenyl, aryl, and X represents a leaving group, which are useful synthetic intermediates in the preparation of tetracyclic compounds having phosphodiesterase inhibitory activity.

Abstract translation: 本发明涉及制备式II的顺式 - 中间体的方法（式II），其中R 1表示氢，（取代的）取代的烷基，链烯基，芳基，X表示离去基团，它们是有用的合成中间体 制备具有磷酸二酯酶抑制活性的四环化合物。