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    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR
    41.
    发明申请
    RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-公开

    公开(公告)号：WO2018162944A1

    公开(公告)日：2018-09-13

    申请号：PCT/IB2017/051275

    申请日：2017-03-04

    Applicant: SHENZHEN RUNSHIN BIOSCIENCE ,  ZHANG, Ying

    Inventor： ZHANG, Ying

    IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00

    Abstract: Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.

    MICRONEEDLE DEVICES AND METHODS
    42.
    发明申请
    MICRONEEDLE DEVICES AND METHODS 审中-公开
    MICRONEEDLE设备和方法

    公开(公告)号：WO2012122163A1

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/027858

    申请日：2012-03-06

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    Inventor： ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    IPC: A61K9/00 ,  A61M37/00

    CPC classification number: A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

    Abstract translation: 一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述局部麻醉剂和剂量延伸组分为非共晶重量比; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂和剂量延伸组分为非共晶重量比，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

    AUFZUGSKABINE
    43.
    发明申请
    AUFZUGSKABINE 审中-公开
    电梯轿厢

    公开(公告)号：WO2012072636A1

    公开(公告)日：2012-06-07

    申请号：PCT/EP2011/071293

    申请日：2011-11-29

    Applicant: INVENTIO AG ,  ZHANG, Ying Jin

    Inventor： ZHANG, Ying Jin

    IPC: B66B11/02

    CPC classification number: B66B11/0253 ,  B23P17/04 ,  F16B5/0635

    Abstract: Bei dieser Auskleidung für eine Aufzugskabine sind Tragprofile (4) vorgesehen, die an einem Kabinentragrahmen (7) angeordnet sind. Jedes Tragprofil (4) weist einen Fuss (8), einen ersten Schenkel (9) und einen zweiten Schenkel (10) auf. Der Fuss (8) ist mit dem Kabinentragrahmen (7) verbunden, die Schenkel (9, 10) laufen an ihren freien Enden zusammen und bilden eine schlitzförmige Verengung (11), durch die Paneelteile (12, 13) von Wände oder eine Decke bildenden Paneele (3) steckbar sind. Die Schenkel (9, 10) weisen Federeigenschaften auf und können entgegen einer Federkraft an der Verengung (11) auseinander bewegt werden. Die Schenkel (9, 10) halten die Paneelteile (12, 13) im Bereich der Verjüngung (11) fest.

    Abstract translation: 在该衬垫用于其上设置有笼支撑框架（7）上的电梯轿厢的支撑型材提供（4）。 每个支撑轮廓（4）具有足（8），第一支腿（9）和一个第二支腿（10）。 足（8）被连接到从形成墙壁或天花板上的笼支撑框架（7），腿（9,10）在其自由端一起运行，并形成穿过面板部分的狭缝状的缩颈（11）（12，13） 面板（3）是可插入的。 腿部（9，10）具有弹簧特性，并且可以在针对缩颈（11）开的弹簧力而移动。 腿部（9，10）保持在锥形（11）牢固地的区域中的板件（12，13）。

    MICROPOROUS THERMOPLASTIC SHEETS
    44.
    发明申请
    MICROPOROUS THERMOPLASTIC SHEETS 审中-公开

    公开(公告)号：WO2012027687A8

    公开(公告)日：2012-03-01

    申请号：PCT/US2011/049379

    申请日：2011-08-26

    Applicant: CORNING INCORPORATED ,  DEROSA, Michael E ,  UPTON, Todd M ,  ZHANG, Ying

    Inventor： DEROSA, Michael E ,  UPTON, Todd M ,  ZHANG, Ying

    IPC: C08J7/02 ,  C12N5/00

    Abstract: Thermoplastic polymeric sheets are rendered microporous and remain substantially flat by contacting the sheet with a first fluid composition that contains or more solvents for the polymeric sheet to render the sheet microporous and then contacting the microporous sheet with a second fluid composition that is substantially free of solvents for the polymer and that contains a non-solvent that is miscible with the one or more solvents of the first composition. Contacting the microporous sheet with the second fluid composition preferably occurs prior to substantial evaporation of the first fluid compositions, or solvents thereof, from the microporous sheet.

    DRILLING FLUIDS COMPRISING SUB-MICRON PRECIPITATED BARITE AS A COMPONENT OF THE WEIGHTING AGENT AND ASSOCIATED METHODS
    47.
    发明申请
    DRILLING FLUIDS COMPRISING SUB-MICRON PRECIPITATED BARITE AS A COMPONENT OF THE WEIGHTING AGENT AND ASSOCIATED METHODS 审中-公开
    包含作为称重剂的组分和相关方法的亚微米级精制巴比特的钻井液

    公开(公告)号：WO2009090371A1

    公开(公告)日：2009-07-23

    申请号：PCT/GB2009/000030

    申请日：2009-01-07

    Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  TURNER, Craig, Robert ,  ZHANG, Ying

    Inventor： ZHANG, Ying

    IPC: C09K8/03

    CPC classification number: C09K8/032

    Abstract: An embodiment of the present invention includes a method comprising circulating a drilling fluid in a well bore, wherein the drilling fluid comprises a carrier fluid; and a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron and a particle having a specific gravity of greater than about 2.6. Another embodiment of the present invention includes a drilling fluid comprising: a carrier fluid; and a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron, and a particle having a specific gravity of greater than about 2.6. Another embodiment of the present invention includes a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron, and a particle having a specific gravity of greater than about 2.6.

    Abstract translation: 本发明的一个实施例包括一种方法，包括使钻井液在井眼中循环，其中钻井液包括载体流体; 以及包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒的加重剂。 本发明的另一个实施例包括一种钻井液，包括：载体流体; 以及包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒的加重剂。 本发明的另一个实施方案包括加重剂，其包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒。

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