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    TARGETING OF LIGAND BINDING SITES IN CLFA
    51.
    发明申请
    TARGETING OF LIGAND BINDING SITES IN CLFA 审中-公开
    在CLFA中定位配体结合位点

    公开(公告)号：WO2017079681A1

    公开(公告)日：2017-05-11

    申请号：PCT/US2016/060709

    申请日：2016-11-04

    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： GANESH, Vannakambadi, K. ,  HOOK, Magnus

    IPC: A61K39/085 ,  A61K39/40 ,  A61P31/04 ,  C07K16/12 ,  C12N15/13

    CPC classification number: C07K16/1271 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/92

    Abstract: The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal antibody, a polyclonal antibody, an antigen-binding antibody fragment or a composition that specifically binds to a portion of ClfA with the sequence of SEQ ID No: 15, SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18.

    Abstract translation: 本发明提供了使用单克隆抗体，多克隆抗体，抗原结合抗体片段或特异性结合至抗体结合抗体片段的组合物减少纤维蛋白原在格兰氏阳性细菌感染中与ClfA结合的方法和组合物 具有序列SEQ ID No：15，SEQ ID NO：16，SEQ ID NO：17和SEQ ID NO：18的部分ClfA。

    SOLVENT DEPRESSION OF TRANSITION TEMPERATURE TO SELECTIVELY STIMULATE ACTUATION OF SHAPE MEMORY POLYMER FOAMS
    53.
    发明申请
    SOLVENT DEPRESSION OF TRANSITION TEMPERATURE TO SELECTIVELY STIMULATE ACTUATION OF SHAPE MEMORY POLYMER FOAMS 审中-公开
    过渡温度的溶剂渗透选择性刺激形状记忆聚合物活性物质的激活

    公开(公告)号：WO2016200829A1

    公开(公告)日：2016-12-15

    申请号：PCT/US2016/036245

    申请日：2016-06-07

    Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC ,  THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： BOYLE, Anthony J. ,  HEARON, Keith ,  MAITLAND, Duncan J. ,  NASH, Landon D. ,  WILSON, Thomas S.

    IPC: A61L31/14 ,  A61L31/06 ,  A61B17/12 ,  A61B17/00

    CPC classification number: A61B17/12181 ,  A61B17/12031 ,  A61B17/12113 ,  A61B17/1219 ,  A61B2017/00871 ,  A61B2017/00938 ,  A61B2017/00964 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L2400/16 ,  A61L2430/36 ,  C08L75/04

    Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.

    Abstract translation: 本发明的一个实施方案是设计成通过暴露于溶剂来恢复其原始形状的形状记忆聚合物（SMP）泡沫。 热响应SMP是设计成保持程序化次级形状直到加热到其转变温度以上的聚合物，聚合物在其上恢复其原始或初级形状。 热敏响应的SMP泡沫在使用之前被编程为其次级形状，通常将泡沫压缩至小体积，并保持该程序形状，直到暴露于选定的溶剂如二甲基亚砜或乙醇。 当暴露于溶剂时，SMP泡沫的转变温度降低到环境温度以下，并且SMP泡沫致动至其主要形状。 SMP泡沫被定制为在暴露于特定溶剂时致动，同时在暴露于水或其它溶剂时最小化或防止致动。 这种选择性溶剂致动可以用于增加SMP泡沫装置的工作时间，即在不需要不必要的致动的情况下允许使用装置的时间，同时保持功能性SMP致动。 溶剂致动的SMP泡沫可用于各种应用，包括但不限于治疗动脉瘤和动静脉畸形，组织工程和伤口愈合。

    REACTIVE COATING METHOD FOR DEPOSITION OF INSOLUBLE FLAME RETARDANT USING A WATER-BORNE COATING PROCEDURE
    55.
    发明申请
    REACTIVE COATING METHOD FOR DEPOSITION OF INSOLUBLE FLAME RETARDANT USING A WATER-BORNE COATING PROCEDURE 审中-公开
    使用水银涂层工艺沉积不溶性阻燃剂的反应涂料方法

    公开(公告)号：WO2016154137A1

    公开(公告)日：2016-09-29

    申请号：PCT/US2016/023464

    申请日：2016-03-21

    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： GRUNLAN, Jaime C. ,  LEISTNER, Marcus

    IPC: C09D5/18 ,  C09D161/28 ,  C09K21/04 ,  C09K21/10

    CPC classification number: C09D5/18 ,  C08K5/34922 ,  C08K5/521 ,  C09D7/63 ,  C09D185/02 ,  D06M15/31 ,  D06M2200/30

    Abstract: A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution comprises cationic materials. The cationic materials comprise a melamine. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a layer comprising the anionic layer and the cationic layer. The anionic solution comprises a phosphated molecule.

    Abstract translation: 一种方法包括涂覆基底以提供阻燃基底。 在一个实施方案中，该方法包括将基底暴露于阳离子溶液以产生沉积在基底上的阳离子层。 阳离子溶液包含阳离子材料。 阳离子材料包含三聚氰胺。 该方法还包括将阳离子层暴露于阴离子溶液以产生沉积在阳离子层上的阴离子层，以产生包含阴离子层和阳离子层的层。 阴离子溶液包含磷酸化分子。

    SELF-CLEANING MEMBRANE FOR MEDICAL DEVICES
    57.
    发明申请
    SELF-CLEANING MEMBRANE FOR MEDICAL DEVICES 审中-公开
    用于医疗器械的自清洁膜

    公开(公告)号：WO2016123197A1

    公开(公告)日：2016-08-04

    申请号：PCT/US2016/015088

    申请日：2016-01-27

    Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： GRUNLAN, Melissa A. ,  COTE, Gerard L. ,  ABRAHAM, Alexander A. ,  FEI, Ruochong ,  LOCKE, Andrea K.

    IPC: A61M5/00

    CPC classification number: A61L31/048 ,  A61B5/14532 ,  A61B5/1473 ,  A61L31/10 ,  A61L31/145 ,  C08F220/56 ,  C08L33/26 ,  C08L2203/02

    Abstract: The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

    Abstract translation: 本公开提供了一种用于清洁植入式医疗装置的方法。 在一个实施例中，该方法包括提供包括膜的医疗装置; 其中所述膜包括包含N-异丙基丙烯酰胺（NIPAAm）或聚（N-异丙基丙烯酰胺）（PNIPAAm）和体积相转变温度（VPTT）的热反应性水凝胶。 该方法还包括将医疗装置植入目标区域; 其中所述膜温度保持在与所述目标区域基本相同的温度; 其中接近，满足和/或超过体积相变温度的目标区域内的温度波动导致膜中的溶解或相对消溶，并且在目标区域内相对较低和/或接近和/或低于体积的温度波动 相变温度导致膜中的溶胀或相对膨胀。

    THIN FILM DIFFUSION BARRIER
    58.
    发明申请
    THIN FILM DIFFUSION BARRIER 审中-公开
    薄膜扩张障碍

    公开(公告)号：WO2016108862A1

    公开(公告)日：2016-07-07

    申请号：PCT/US2014/072856

    申请日：2014-12-30

    Applicant: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN ,  MICHELIN RECHERCHE ET TECHNIQUE S.A. ,  THE TEXAS A&M UNIVERSITY SYSTEM

    Inventor： GRUNLAN, Jaime C. ,  WINSTON, Paul ,  STEVENS, Barton E.

    IPC: B05D5/12 ,  B05D7/02 ,  H01B1/12

    CPC classification number: B65D81/24 ,  B01D71/021 ,  B05D3/0254 ,  B05D3/06 ,  B05D3/101 ,  B05D3/107 ,  B05D7/02 ,  B05D7/58 ,  B05D7/5883

    Abstract: A rubber substrate has a material diffusion barrier, and a method produces the same. In an embodiment, a method for producing a material diffusion barrier on a rubber substrate includes exposing the rubber substrate to a cationic solution to produce a cationic layer on the rubber substrate. The method also includes exposing the cationic layer to an anionic solution 5 to produce an anionic layer on the cationic layer. The anionic layer comprises graphene oxide. The layer includes the cationic layer and the anionic layer. The layer comprises the material diffusion barrier.

    Abstract translation: 橡胶基材具有材料扩散阻挡层，并且其制造方法也是如此。 在一个实施方案中，在橡胶基材上制备材料扩散阻挡层的方法包括将橡胶基材暴露于阳离子溶液以在橡胶基材上产生阳离子层。 该方法还包括将阳离子层暴露于阴离子溶液5以在阳离子层上产生阴离子层。 阴离子层包括氧化石墨烯。 该层包括阳离子层和阴离子层。 该层包括材料扩散阻挡层。

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