摘要:
The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R 1 is hydrogen or C 1-6 -alkyl; R 2 is hydroxy, C 3-5 -acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C 1-6 -alkyl; R 3 and R 4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C 1-5 - acyloxy or C 1 -6 -alkoxy; R 5 is C 1-6 -alkyl, hydroxymethyl, carboxy or methoxycarbonyl; R 9 is hydrogen, hydroxymethyl, methoxy, oxo or C 1-5 -acyloxy; R 10 is hydrogen, or R 5 and R 9 taken together are -CH 2 -O- or -0-CH 2 -; or R 5 and R 10 taken together are -CO-O-, -O-CO-, -CH 2 -O- or -0-CH 2 -; R 6 is hydrogen, or R 5 and R 6 together form a bond; R 7 and R 8 independently from each other are C 1-6 -alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C 1-6 -alkoxycarbonyl with the proviso that at least one of R 7 and R 8 is C 1-6 -alkyl; R 11 and R 12 are both hydrogen or R 11 and R 12 together are oxo, with the further proviso for formula (I) that if R 2 is hydroxy R 1 is C 1-6 -alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译:本发明涉及式(I)和(II)的三环二萜及其衍生物,其中R 1是氢或C 1-6烷基; R 2是羟基,C 3-5酰基氧基,羟甲基,1,3-二羟基丙基或C 1-6烷基; R 3和R 4彼此独立地为氢,羟基,羟甲基,C 1-5酰氧基或C 1-4亚烷基, 6 SUB> - 烷氧基; R 5是C 1-6烷基,羟甲基,羧基或甲氧羰基; R 9是氢,羟甲基,甲氧基,氧代或C 1-5酰氧基; R 10为氢或者R 5和R 9一起为-CH 2 -O-或 - 0-CH 2 SUB> - ; 或R 5和R 10一起为-CO-O - , - O-CO - , - CH 2 -O-或 - 0-CH 2 SUB> - ; R 6是氢,或者R 5和R 6一起形成键; R 7和R 8彼此独立地为C 1-6烷基,羧基,x-羟基-C 1 -C 4烷基(其中x 为1至6的整数)或C 1-6烷氧基羰基,条件是R 7和R 8中的至少一个为氢, 是C 1-6烷基; R 11和R 12都是氢或者R 11和R 12一起是氧代,其他条件是 对于式(I),如果R 2是羟基,R 1是C 1-6烷基,其用作药物用于治疗 与神经传递受损相关的障碍,以及饮食和药物组合物及其用途。
摘要:
La présente invention concerne un nouveau procédé de préparation de l'acide 2- hydroxy-4-méthylsélénobut yrique, à partir du 3-méthylsélénoproprionaldéhyde. L'acide 2-hydroxy-4-méthylsélénobutyrique est obtenu seul ou en mélange avec son analogue soufré. L'invention concerne également les compositions, en particulier nutritionnelles, comprenant un mélange d'acide 2-hydroxy-4-méthylsélénobutyrique et d'acide 2-hydroxy-4-méthylt hio butyrique, et un milieu physiologiquement acceptable, et l'utilisation de ce mélange comme ingrédient alimentaire.
摘要:
Stabilization compositions for cysteamine and its hydrochloride and process method related. The composition comprises the following ingredients on the basis of percent by weight: A, 10~60% of cysteamine and its hydrochloride; B, 1~15% of molecular sieve; C, 1~50% of skeleton material; D, 10~80% of diluent. The method comprises: adsorbing cysteamine and its hydrochloride into molecular sieve selecting from zeolite and silica gel, and adding skeleton material and diluent, to obtain skeleton slow-released granule preparation with high stability.
摘要:
The present invention relates to an animal dietary composition including a dietary acid and further to methods of feeding an animal that include providing a dietary acid as part of the animal's diet, resulting in enhanced feed efficiency and weight gain. According to one embodiment, the present invention further relates to limiting the animal's diet.
摘要:
Die vorliegende Erfindung betrifft Propionsäure-haltige Zusammensetzungen in fester und im Wesentlichen reiner Form, enthaltend wenigstens eine Verbindung gemäß Formel (I) (M n+ )(H + ) x (CH 3 CH 2 C(O)O - ) (n+x) , worin M n+ für ein n-wertiges Alkalimetall- oder Erdalkalimetallkation steht, wobei n gleich 1 oder 2 ist; und x eine Zahl im Bereich von 0,25 bis 5 bedeutet; mit der Maßgabe, dass x nicht im Bereich von 0,75 bis 1,75 liegt, wenn M n+ für Kalium steht; ein Verfahren zur Herstellung solcher Propionsäure-haltigen Zusammensetzungen; sowie die Verwendung solcher Zusammensetzungen als Silierhilfsmittel, Konservierungsmittel, Acidifier, Nahrungsergänzungsmittel, Futtermittel oder Futtermitteladditiv für Tierfutter.
摘要翻译:本发明涉及含有至少一种化合物宝石的含固体和基本上纯的形式的含丙酸组合物。 式(I)(M N + SUP>)(H + SUP>)<子> X 子>(CH <子> 3 子> CH <子> 2 < (O)O - )(n + x),其中M n + n代表n价碱金属或 碱土金属阳离子,其中n为1或2; x是在0.25至5范围内的数字; 条件是当M + n +代表钾时,x不在0.75-1.75的范围内; 制备这种含丙酸组合物的方法; 以及使用这样的组合物作为青贮辅助剂,防腐剂,酸化剂,营养补充剂,动物饲料或动物饲料添加剂。 p>
摘要:
A method for improving the palatability of a livestock feed or companion animal food product comprising a basal composition containing unsaturated fatty acids that oxidize to form aldehydes or ketones by contacting the basal composition with a source of bisulfite anions so that any aldehydes or ketones present form organosulfite salts. Bisulfite-treated livestock feed and companion animal food products, and palatability enhancing composition containing a source of bisulfite anions are also disclosed.
摘要:
The present invention is based on the discovery that moist heat treated ruminant animal feed compositions comprising a fermentation biomass, have increased amounts of proteinaceous matter that escapes fermentation within the rumen. The ruminant animal feed compositions may further comprise, alone or in combination, one or more of an isolated enzyme, an organic acid, a gluten protein, at least one divalent metal ion and at least one plant extract. The proteinaceous matter may then be digested or metabolized in the post-rumen portions of the ruminant digestive system, thereby providing further increased energy and protein levels for ruminant animals during times of increased productivity. Compositions and methods of manufacture of the compositions of the embodiments of the present disclosure are disclosed.
摘要:
An animal feed additive, for aquatic or terrestrial animals, which has a primary composition and a secondary composition, both of which maintain their bioactivity during feed processing and storage. The compounds can be volatile, or non-volatile. A method for feeding an aquatic or terrestrial animal a feed, which includes providing the animal with a feed additive with a primary and secondary composition that maintain their bioactivity. The feed, and the method of feeding, protect the animal from disease.