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    MATERIAL RETRIEVAL DEVICE AND METHOD OF USING
    64.
    发明申请
    MATERIAL RETRIEVAL DEVICE AND METHOD OF USING 审中-公开
    材料检索装置和使用方法

    公开(公告)号：WO2007081601A2

    公开(公告)日：2007-07-19

    申请号：PCT/US2006/060483

    申请日：2006-11-02

    Applicant: SOUTHERN ILLINOIS UNIVERSITY ,  SCHWARTZ, Bradley, F . ,  MAHAJAN, Ajay ,  DON, Jarlen

    Inventor： SCHWARTZ, Bradley, F . ,  MAHAJAN, Ajay ,  DON, Jarlen

    IPC: A61B17/26

    CPC classification number: A61B17/221 ,  A61B2017/00287 ,  A61B2017/2212 ,  A61B2090/0454 ,  A61B2090/049

    Abstract: A medical device configured to be inserted into a patient's body to retrieve material from the patient's body includes a basket assembly. The basket assembly is configured to transition between various states including an expanded state and a collapsed state. The basket assembly may be substantially covered in a flexible sheet except for a side-facing opening when the basket assembly is in the expanded state. When the basket assembly is in the collapsed state, the side-facing opening may be substantially closed. The device may be inserted into the patient's body while the basket assembly is in the collapsed state. While in the patient's body, the basket assembly may be transitioned to the expanded state. Then, a physician may maneuver material to be removed from the patient's body into the basket assembly via the side-facing opening. Next, the basket assembly may be transitioned into the collapsed state or a partially collapsed state so that the basket assembly can be removed from the patient's body.

    Abstract translation: 被构造成插入患者体内以从患者身体取回材料的医疗装置包括筐组件。 筐组件被配置成在包括展开状态和折叠状态的各种状态之间转换。 当筐组件处于展开状态时，筐组件可以基本上覆盖在除了侧向开口之外的柔性片中。 当篮筐组件处于折叠状态时，侧向开口可以基本封闭。 当筐组件处于塌陷状态时，装置可以插入患者体内。 当在患者身体中时，篮筐组件可以转换到扩张状态。 然后，医生可以通过侧向开口操纵要从患者身体移除到篮筐组件中的材料。 接下来，筐组件可以转变成塌陷状态或部分塌陷状态，使得筐组件可以从患者身体移除。

    SILICATE DERIVED SOL-GELS SENSITIVE TO WATER CONTENT CHANGE
    66.
    发明申请
    SILICATE DERIVED SOL-GELS SENSITIVE TO WATER CONTENT CHANGE 审中-公开
    硅胶衍生的溶胶对水含量变化敏感

    公开(公告)号：WO2005028603A1

    公开(公告)日：2005-03-31

    申请号：PCT/US2004/030989

    申请日：2004-09-17

    Applicant: GENENCOR INTERNATIONAL, INC. ,  SOUTHERN ILLINOIS UNIVERSITY ,  BECKER, Nathaniel T. ,  BAKUL, Dave C. ,  DESHPANDE, Kiranmayi ,  GEBERT, Mark C. ,  MCAULIFFE, Joseph C. ,  SMITH, Wyatt Charles

    Inventor： BECKER, Nathaniel T. ,  BAKUL, Dave C. ,  DESHPANDE, Kiranmayi ,  GEBERT, Mark C. ,  MCAULIFFE, Joseph C. ,  SMITH, Wyatt Charles

    IPC: C11D3/20

    CPC classification number: C11D3/38672 ,  B01J13/0056

    Abstract: The present invention provides an enzyme-entrapped sol-gel composition wherein one or more enzymes are stably entrapped within the gels and are released from the gels in responsive to an increase in environmental water percentage (by weight). The method for preparing such a composition comprises the steps of : (a) mixing a first aqueous solution with one or more alkali metal silicates or alkyl siliconate salts to reduce the pH to 12 or lower to form a first sol; (b) mixing a second aqueous solution with one or more organofunctional silane precursors to form a second sol; (c) mixing the first sol, the second sol, and a third aqueous solution containing one or more enzymes to form gels. The present invention further provides a liquid detergent, a liquid soap or a shampoo formulation comprising an enzyme-entrapped sol-gel system, wherein the enzymes are released upon dilution of the formulation in water. The silica gel matrices not only improve the thermal stability of enzymes but also prevent the enzyme denaturation due to proteolysis/autolysis or interference from other components of the formulation.

    Abstract translation: 本发明提供一种酶包封的溶胶 - 凝胶组合物，其中一种或多种酶稳定地截留在凝胶内，并响应于环境水百分数（重量）的增加而从凝胶释放。 制备这种组合物的方法包括以下步骤：（a）将第一水溶液与一种或多种碱金属硅酸盐或烷基硅酸盐混合以将pH降低至12或更低以形成第一溶胶; （b）将第二水溶液与一种或多种有机官能硅烷前体混合以形成第二溶胶; （c）混合含有一种或多种酶的第一溶胶，第二溶胶和第三水溶液以形成凝胶。 本发明还提供了一种液体洗涤剂，液体皂或包含酶包被溶胶 - 凝胶系统的洗发剂制剂，其中在将制剂稀释在水中时释放酶。 硅胶基质不仅提高了酶的热稳定性，而且防止了由于蛋白水解/自溶或制剂中其他成分的干扰引起的酶变性。

    NUTRIENT MEDIUM FOR MAINTAINING NEURAL CELLS IN INJURED NERVOUS SYSTEM
    67.
    发明申请
    NUTRIENT MEDIUM FOR MAINTAINING NEURAL CELLS IN INJURED NERVOUS SYSTEM 审中-公开

    公开(公告)号：WO2003029417A3

    公开(公告)日：2003-04-10

    申请号：PCT/US2002/031137

    申请日：2002-10-01

    Applicant: SOUTHERN ILLINOIS UNIVERSITY ,  BREWER, Gregory, J.

    Inventor： BREWER, Gregory, J.

    IPC: C12N5/00

    Abstract: A method to improve neural cell viability in brain or spinal cord tissue after brain or spinal cord injury or surgery is provided. This method comprises applying a sterile liquid medium to the brain or spinal cord tissue, wherein the sterile aqueous liquid medium comprises 0 to about 3000 µM CaCI 2 , about 0.1 to about 1.2 µM Fe(NO 3 ) 3 , about 2500 to about 10000 µM KCI, 0 to about 4000 µM MgCI 2 , about 30000 to about 150000 µM NaCI, about 100 to about 30000 µM NaHCO 3 , about 250 to about 4000 µM NaH 2 PO 4 , about 0.01 to about 0.4 µM sodium selenite, about 0.2 to about 2 µM ZnSO 4 , about 2500 to about 50000 µM D-glucose, about 1 to about 50 µM L-carnitine, about 3 to about 80 µM ethanolamine, about 15 to about 400 µM D(+)-galactose, about 40 to about 800 µM putrescine, about 20 to about 500 µM sodium pyruvate, and growth-promoting essential fatty acids, hormones, amino acids, vitamins and anti-oxidants in amounts effective for neuron growth, and wherein the medium is essentially free of ferrous sulfate, glutamate, and aspartate.

    THERAPEUTIC APPLICATIONS OF ESTROGENIC CARBOXYLIC ACIDS
    68.
    发明申请
    THERAPEUTIC APPLICATIONS OF ESTROGENIC CARBOXYLIC ACIDS 审中-公开
    雌激素羧酸的治疗应用

    公开(公告)号：WO9966915A3

    公开(公告)日：2000-06-15

    申请号：PCT/US9913940

    申请日：1999-06-22

    Applicant: SOUTHERN ILLINOIS UNIVERSITY A ,  ADLER STUART R ,  DANDLIKER WALTER B

    Inventor： ADLER STUART R ,  DANDLIKER WALTER B ,  MEYERS CAL Y ,  BANZ WILLIAM J ,  WINTERS TODD A ,  YUQING HOU

    IPC: A61K31/19

    CPC classification number: A61K31/19

    Abstract: Provided are methods employing estrogenic compounds for: repressing weight gain or reducing weight in male patients; treating or preventing prostate cancer and peri- or post-menopausal symptoms; treating estrogen-responsive conditions that no longer respond to treatment with conventional steroidal estrogens; treating or preventing estrogen-responsive uterine cancer, breast cancer, and ovarian follicle atresia; inducing ovulation to increase fertility; oral contraception; treating or preventing diseases or conditions caused or prolonged by free radicals; treating or preventing cardiovascular disease, hyperlipidemia or hypercholesterolemia, and hyperglycemia; improving body fat distribution; and treating or preventing Alzheimer's disease, osteoporosis, and pattern baldness. Also provided are methods for treating or preventing prostatic diseases including benign prostate hyperplasia and other related conditions, androgen-responsive pathological conditions in males, and methods for male birth control and chemical castration, employing estrogenic carboxylic acids.

    Abstract translation: 提供使用雌激素化合物的方法：抑制男性患者的体重增加或减轻体重; 治疗或预防前列腺癌和绝经后或绝经后症状; 治疗不再响应于常规甾体雌激素治疗的雌激素反应性病症; 治疗或预防雌激素反应性子宫癌，乳腺癌和卵巢卵泡闭锁; 诱导排卵增加生育能力; 口服避孕药 治疗或预防由自由基引起或延长的疾病或病症; 治疗或预防心血管疾病，高脂血症或高胆固醇血症和高血糖症; 改善身体脂肪分布; 以及治疗或预防阿尔茨海默病，骨质疏松症和模式秃发。 还提供了用于治疗或预防前列腺疾病的方法，包括良性前列腺增生和其他相关病症，男性的雄激素反应性病理状况，以及使用雌激素羧酸的男性避孕和化学阉割的方法。

    GaAs SUBSTRATE WITH A PASSIVATING EPITAXIAL GALLIUM SULFIDE FILM AND METHODS FOR FORMING SAME
    69.
    发明申请
    GaAs SUBSTRATE WITH A PASSIVATING EPITAXIAL GALLIUM SULFIDE FILM AND METHODS FOR FORMING SAME 审中-公开
    具有钝化外延型硫酸铝膜的GaAs衬底及其形成方法

    公开(公告)号：WO1997048499A1

    公开(公告)日：1997-12-24

    申请号：PCT/US1997010605

    申请日：1997-06-19

    Applicant: THE BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY

    Inventor： THE BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY ,  ZHU, Xiaoyang

    IPC: B05D03/06

    CPC classification number: C23C16/56 ,  C23C16/28 ,  C30B25/105 ,  C30B29/46

    Abstract: A passivating epitaxial film of Group III-sulfur material is formed on a III-V compound semiconductor substrate (10) based on the interaction of the substrate with sulfur atoms (40). In a preferred and non-limiting embodiment, en epitaxial Ga2(S2)3 film is formed on a GaAs substrate by exposing a surface (12) of the GaAs substrate to a gaseous sulfur-containing molecule (e.g. H2S), photo-irradiating the sulfur-containing molecule to deposit sulfur atoms on the exposed surface and annealing the sulfur-deposited substrate (10).

    Abstract translation: 基于底物与硫原子的相互作用（40），在III-V化合物半导体衬底（10）上形成III族硫材料的钝化外延膜。 在优选和非限制性实施方案中，通过将GaAs衬底的表面（12）暴露于含气体的分子（例如H 2 S），在GaAs衬底上形成外延Ga 2（S 2）3膜， 含硫分子将硫原子沉积在暴露的表面上并使硫沉积的衬底（10）退火。

    PROCESS FOR PRODUCING POLYNUCLEOTIDES
    70.
    发明申请
    PROCESS FOR PRODUCING POLYNUCLEOTIDES 审中-公开
    生产多核苷酸的方法

    公开(公告)号：WO1984002526A1

    公开(公告)日：1984-07-05

    申请号：PCT/US1983002056

    申请日：1983-12-29

    Applicant: SOUTHERN ILLINOIS UNIVERSITY FOUNDATION

    Inventor： SOUTHERN ILLINOIS UNIVERSITY FOUNDATION ,  SUNG, Michael, T. ,  CAO, Tin, M. ,  BINGHAM, Scott, E.

    IPC: C07H15/12

    CPC classification number: C07H21/00

    Abstract: In a transverse phosphite process for preparation of polynucleotides, a 5' reactive resin nucloside is reacted with a bifunctional phosphorus (III) reagent to produce a monofunctional resin nucleosidophosphorus (III) intermediate. This intermediate is condensed with a 3' reactive 5' blocked nucleoside to produce a dinucleosidophosphite. The latter is 5' deblocked and the cycle of reaction with bifunctional intermediate and condensation with 5' blocked 3' reactive nucleoside repeated to build a chain corresponding to the desire polynucleotide. Phosphite is converted to phosphate by oxidation to produce the polynucleotide. Improved structures and processes for linking the nucleotide chain to the resin, and improve techniques for detaching the final nucleotide from the resin are also disclosed.

    Abstract translation: 在用于制备多核苷酸的亚磷酸亚酯方法中，将5'反应性树脂核苷酸与双功能磷（III）试剂反应以制备单官能树脂核苷酸（III）中间体。 该中间体与3'反应性5'封闭核苷缩合以产生二核苷酸亚磷酸酯。 后者为5'解封端，并与双功能中间体反应循环，并与5'封闭的3'反应性核苷缩合，重复构建对应于所需多核苷酸的链。 通过氧化将亚磷酸酯转化成磷酸盐以产生多核苷酸。 还公开了将核苷酸链与树脂连接的改进的结构和方法，以及用于从树脂中分离最终核苷酸的改进技术。

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