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公开(公告)号：WO2009105682A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034729
申请日：2009-02-20
CPC分类号： H01F27/2847 , H01F27/303 , H01F2027/2861
摘要： A multilayer foil winding in a foil-wound magnetic circuit component (200) has conductors (202, 204, 402, 408) that alternate at various points such that the conductors share current more effectively than multiple non-alternating conductors. AC resistance of the multilayer winding is therefore decreased relative to a single, thicker, layer of foil conductor or a multilayer winding that does not alternate layer positions.
摘要翻译： 箔卷绕磁路部件（200）中的多层箔绕组具有在各个点处交替的导体（202,204,402,408），使得导体比多个非交变导体更有效地共享电流。 因此，多层绕组的交流电阻相对于单层较厚的箔导体或不具有交替层位置的多层绕组而降低。
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公开(公告)号：WO2009097543A3
公开(公告)日：2009-08-06
申请号：PCT/US2009/032663
申请日：2009-01-30
摘要： A heat exchanger (102) for exchanging heat between gasses such as air and a liquid or gaseous coolant has narrow spacing (108) between exchanger surfaces for high efficiency. To avoid undue obstruction of gas flow due to ice buildup on the exchanger surfaces,- the heat exchanger (102) is equipped with sensors (110, 112) to monitor the gas flow and an actuator (116, 118) that widens the spacing (108) between exchanger surfaces such that gas flow remains unimpeded. Embodiments provide for defrosting of the exchanger surfaces when an limit on spacing (108) of exchanger surfaces is reached, and for relaxing the spacing (108) to the original narrow spacing (108) when defrosting is completed.
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公开(公告)号：WO2007136971A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/067954
申请日：2007-05-01
IPC分类号： C12P19/14
CPC分类号： C12P19/14
摘要： Methods of utilizing reduced cellulase loads to hydrolyze cellulosic substrates are disclosed. The methods include determining an amount of purified cellulase necessary to substantially hydrolyze a quantity of cellulosic substrate in a period of time; reducing the amount of purified cellulase by a factor of between 2 and 5 to determine a reduced cellulase load; and introducing to the cellulosic substrate either (1 ) a microorganism expressing cell-bound cellulase in a concentration equal to the reduced cellulase load or (2) a fermentation agent that has been engineered to express cell-bound cellulase in a concentration equal to the reduced cellulase load under suitable conditions and for said period of time sufficient to allow substantial hydrolysis of the cellulosic substrate.
摘要翻译： 公开了利用降低的纤维素酶负载来水解纤维素基质的方法。 所述方法包括确定在一段时间内基本上水解一定量的纤维素基质所需的纯化纤维素酶的量; 将纯化的纤维素酶的量减少2至5倍以确定纤维素酶负荷降低; 并且向纤维素底物引入（1）表达细胞结合的纤维素酶的微生物，其浓度等于降低的纤维素酶负荷，或者（2）发酵剂已经被工程化以表达细胞结合的纤维素酶，其浓度等于还原的 纤维素酶负载在合适的条件下并持续足以允许纤维素底物显着水解的所述时间段。
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64.发明申请THERMOPHILIC ORGANISMS FOR CONVERSION OF LIGNOCELLULOSIC BIOMASS TO ETHANOL 审中-公开用于将肉桂生物质转化成乙醇的热化学有机体
公开(公告)号：WO2007053600A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/042442
申请日：2006-10-31
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , DESAI, Sunil, G. , SHAW, Arthur, Josephus, IV , LYND, Lee, R. , TYURIN, Mikhail, V.
IPC分类号： C12P7/06
CPC分类号： C12N9/1029 , C12N9/0006 , C12N9/1217 , C12P7/10 , C12R1/145 , C12Y203/01008 , C12Y207/02001 , Y02E50/16 , Y02E50/17
摘要： Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALKl has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture involving a substrate concentration challenge lead to evolution of ALKl , and formation of a more robust strain designated ALK2. Both organisms produce near theoretical ethanol yields without expressing pyruvate decarboxylase
摘要翻译： 本文公开了消耗多种生物质衍生底物的突变嗜热生物体。 本文公开了消除了乙酸激酶和磷酸转乙酰酶表达的酿酒酵母属杆菌菌株。 此外，菌株ALK1已经通过位点定向同源重组进行工程化，以敲除乙酸和乳酸生产。 涉及底物浓度挑战的连续培养导致ALK1的进化，以及形成称为ALK2的更强健的菌株。 两种生物体产生近乎理论乙醇产量而不表达丙酮酸脱羧酶
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公开(公告)号：WO2007027421A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/031685
申请日：2006-08-14
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G06F17/30011 , G06F17/30587 , G06F17/30634 , G06F2216/11
摘要： The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC) . A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
摘要翻译： 本发明涉及非小细胞肺癌（NSCLC）中Hedgehog途径的组成性活性。 提供了通过检测Hedgehog途径的组分水平来诊断NSCLC的方法，以及用于鉴定将对Hedgehog途径拮抗剂的治疗有积极响应的对象的方法。 还提供了治疗癌症受试者或抗Hedgehog途径拮抗剂的癌症的方法。
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公开(公告)号：WO2007016263A1
公开(公告)日：2007-02-08
申请号：PCT/US2006/029229
申请日：2006-07-28
CPC分类号： C07K14/4738 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , C12N15/8509 , C12N2830/008
摘要： The present invention is a transgenic non-human animal whose genome contains a transgene containing a nucleic acid encoding a cyclin E protein operably linked to a regulatory element including a lung-specific promoter. The transgenic animals of the present invention have elevated levels cyclin E protein in the lung and have in increased occurrence of lung carcinogenesis. The animals of the instant invention were also found to have increased levels of Gli1 and Shh. Vectors, cells and cell lines are provided, as is a method for identifying a therapeutic agent for the chemoprevention or treatment of lung cancer.
摘要翻译： 本发明是一种转基因非人动物，其基因组含有含有编码可包含肺特异性启动子的调节元件的细胞周期蛋白E蛋白的核酸的转基因。 本发明的转基因动物在肺中具有升高的细胞周期蛋白E蛋白，并且肺癌发生的发生率增加。 本发明的动物也被发现具有增加的Gli1和Shh水平。 提供载体，细胞和细胞系，以及用于鉴定化学预防或治疗肺癌的治疗剂的方法。
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公开(公告)号：WO2006113766A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014660
申请日：2006-04-19
发明人： NORTH, William, G.
摘要： The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
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公开(公告)号：WO2006049777A3
公开(公告)日：2006-05-11
申请号：PCT/US2005/035325
申请日：2005-09-30
申请人： TRUSTEES OF DARTMOUTH COLLEGE , REGENTS OF THE UNIVERSITY OF MINNESOTA , DUNLAP, Jay, C. , LOROS, Jennifer, J. , MEHRA, Arun , GOOCH, Van, D.
摘要： The present invention relates to genetic reporters. Specifically, the present invention is directed to a modified gene encoding a luciferase for high level expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon.
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公开(公告)号：WO2004064723A2
公开(公告)日：2004-08-05
申请号：PCT/US2003/014904
申请日：2003-05-12
申请人： TRUSTEES OF DARTMOUTH COLLEGE , HONDA, Tadashi , HONDA, Yukiko , GRIBBLE, Gordon, W. , SPORN, Michael, B. , SUH, Nanjoo
IPC分类号： A61K
CPC分类号： C07D233/54 , A61K31/275 , A61K31/4172 , A61K31/4184 , A61K31/4196 , A61K31/704 , C07D233/68 , C07D235/06 , C07D249/08 , C07D317/34 , C07H15/24
摘要： New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-2-methylimidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-4-methylimidazole show extremely high inhibitory activity (IC 50 = 0.01-1 pM level) against production of nitric oxide induced by interferon-γ in mouse macrophages. These compounds can be used in the prevention or treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, rheumatoid arthritis, and other inflammatory diseases. All the new triterpenoid derivatives are more potent than previously known CDDO.
摘要翻译： 合成了在2-氰基-3,12-二氧代香豆素-1,9（11） - 二烯-28-酸（CDDO）的C-17位具有各种取代基的新三萜衍生物。 其中，2-氰基-3,12-二氧代香豆素-1,9（11） - 二烯-28-腈（CNDDO），1-（2-氰基-3,12-二氧代香豆-1,9（11） - 二烯 1-（2-氰基-3,12-二氧代香豆素-1,9（11） - 二烯-28-油酰基）-2-甲基咪唑，1-（2-氰基-3,12-二氧代香豆素 -1,9（11） - 二烯-28-油酰基）-4-甲基咪唑显示极高的抑制活性（IC 50 = 0.01-1pM水平）对干扰素-γ诱导的一氧化氮的产生 在小鼠巨噬细胞中。 这些化合物可用于预防或治疗诸如癌症，阿尔茨海默病，帕金森病，多发性硬化症，类风湿性关节炎和其他炎性疾病的疾病。 所有新的三萜类衍生物比以前已知的CDDO更有效。
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公开(公告)号：WO2003040317A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/035149
申请日：2002-11-02
申请人： PFIZER PRODUCTS INC. , TRUSTEES OF DARTMOUTH COLLEGE , BEEBE, Jean, S. , COLEMAN, Kevin, G. , DMITROVSKY, Ethan , TURI, Thomas, G.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C12Q2600/158 , Y02A90/26
摘要： The present invention provides genes that are differentially expressed during neoplasia. These genes and gene products comprise panels for use in screening candidate agents for therapeutic intervention in lung cancers, and for use in therapeutic, prognostic and diagnostic methods and compositions. Therapeutic agents are also provided by the invention. Diagnostic compositions include compositions comprising detection agents for detecting one or more genes that have been shown to be up- or down-regulated in pathogenesis of lung cancer. Exemplary detection agents include nucleic acid probes, which can be in solution or attached to a solid surface, e.g., in the form of a microarray. The invention also provides computer-readable media comprising values of levels of expression of one more genes that are modulated in lung cancer.
摘要翻译： 本发明提供在瘤形成期间差异表达的基因。 这些基因和基因产物包含用于筛选用于肺癌治疗性干预的候选药物的片剂，并且用于治疗，预后和诊断方法和组合物。 治疗剂也由本发明提供。 诊断组合物包括含有检测试剂的组合物，所述检测剂用于检测在肺癌的发病机理中已被证明是上调或下调的一种或多种基因。 示例性的检测剂包括核酸探针，其可以在溶液中或连接到固体表面，例如以微阵列的形式。 本发明还提供了包括在肺癌中调节的另外一个基因的表达水平的值的计算机可读介质。
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