公开(公告)号：WO2019050963A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/049571

申请日：2018-09-05

申请人： UNIVERSITY OF PITTSBURGH -OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： CHEN, Xucai ,  BIN, Qin ,  FLORDELIZA, Villanueva

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61K41/00 ,  A61K48/00

摘要： The systems and methods disclosed herein relate generally to microbubble-assisted delivery of a therapeutic agent, such as a chemotherapeutic agent, to cells or tissue of interest, either in vitro or in vivo, that can be activated by directed ultrasound irradiation. For example, hydrophobic sonosensitizers can be incorporated in microbubble complexes to provide improved sonodynamic therapies.

公开(公告)号：WO2019018241A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/042162

申请日：2018-07-13

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  XU, Yan ,  TANG, Pei ,  WELLS, Marta, Megan

发明人： XU, Yan ,  TANG, Pei ,  WELLS, Marta, Megan

IPC分类号： A61K31/66 ,  A61K31/445 ,  A61K31/495 ,  A61P25/04 ,  A61P25/36

CPC分类号： A61P25/04 ,  A61K31/166 ,  A61K31/452 ,  A61K31/485 ,  A61K31/495 ,  A61K45/06 ,  A61P25/36 ,  A61K2300/00

摘要： Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

公开(公告)号：WO2019010476A1

公开(公告)日：2019-01-10

申请号：PCT/US2018/041210

申请日：2018-07-09

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： KUMTA, Prashant N. ,  GATTU, Bharat ,  DATTA, Moni Kanchan ,  VELIKOKHATNYI, Oleg ,  SHANTHI, Pavithra Murugavel ,  HANUMANTHA, Prashanth Jampani

IPC分类号： G01N27/30 ,  H01G9/00 ,  H01G9/15 ,  H01M10/0525

CPC分类号： H01M4/0459 ,  H01M4/134 ,  H01M4/136 ,  H01M4/1395 ,  H01M4/1397 ,  H01M4/366 ,  H01M4/382 ,  H01M4/5825

摘要： The invention relates to composite multilayer lithium ion battery anodes that include a porous metal alloy foam, and a lithium ion conductor coating applied to the metal alloy foam. The metal alloy foam can include structurally isomorphous alloys of lithium and, optionally, lithium and magnesium. The lithium ion conductor coating can include ternary lithium silicate, such as, lithium orthosilicate. Lithium ions from the ternary lithium silicate may be deposited within the pores of the metal alloy foam. Optionally, the lithium ion conductor coating may include a dopant. The dopant can include one or more of magnesium, calcium, vanadium, niobium and fluorine, and mixtures and combinations thereof.

公开(公告)号：WO2019005685A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039327

申请日：2018-06-25

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  MALLAMPALLI, Rama, K. ,  CHEN, Beibei ,  CHU, Charleen, T. ,  LIU, Yuan

发明人： MALLAMPALLI, Rama, K. ,  CHEN, Beibei ,  CHU, Charleen, T. ,  LIU, Yuan

IPC分类号： C07D405/12 ,  C07D239/90 ,  C07D239/78 ,  C07D239/88 ,  C07D239/74 ,  C07D239/72 ,  A61K31/517 ,  A61P25/28 ,  A61P29/00 ,  A61P9/00 ,  A61P21/00 ,  A61P43/00

摘要： A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R 3 -R 7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R 8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.

公开(公告)号：WO2018218097A1

公开(公告)日：2018-11-29

申请号：PCT/US2018/034554

申请日：2018-05-25

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： ZENG, Dexing ,  GAO, Di ,  WU, Jiamin

IPC分类号： A61B5/1486 ,  C25D7/00

摘要： Bioconjugates and methods of making bioconjugates are provided, wherein the bioconjugates comprise glucose oxidase and nanoparticles that can kill tumor cells. For example, glucose oxidase-iron oxide bioconjugates can produce reactive oxygen species from blood glucose, causing cell death. The use of superparamagnetic iron oxide nanoparticles can provide magnetic resonance imaging guidance to facilitate imaging- guided drug delivery and combine diagnostics with therapy.

公开(公告)号：WO2018187407A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/025997

申请日：2018-04-04

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  UNIVERSITY OF CINCINNATI

发明人： WAGNER, William R. ,  YE, Sang-Ho ,  CHEN, Yingqi ,  SHANOV, Vesselin

IPC分类号： A61F2/28 ,  A61L27/04 ,  A61L27/54 ,  C22C23/00

CPC分类号： C22C23/02 ,  A61F2/28 ,  A61F2/2846 ,  A61F2002/30971 ,  A61F2310/00041 ,  A61L27/047 ,  A61L27/3608 ,  A61L27/427 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C22C23/00 ,  C08L89/00

摘要： The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

公开(公告)号：WO2018160666A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020179

申请日：2018-02-28

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： KALINSKI, Pawel

IPC分类号： A61K39/00 ,  A61K2039/57 ,  A61P35/00 ,  A61P37/04 ,  C07K14/05

摘要： Provided herein are ST-αDC1 and populations of those cells, methods for making ST-αDC1 and populations of those cells, and methods for using ST-αDC1 and populations of those cells for the treatment of cancer, precancerous conditions and chronic infections.

公开(公告)号：WO2018156856A1

公开(公告)日：2018-08-30

申请号：PCT/US2018/019358

申请日：2018-02-23

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： BADHWAR, Vinay ,  D'AMORE, Antonio ,  MATSUMURA, Yasumoto ,  WAGNER, William, R.

IPC分类号： A61F2/24

摘要： A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

公开(公告)号：WO2018132547A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013282

申请日：2018-01-11

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  UNIVERSITY OF MARYLAND, BALTIMORE

发明人： SLUIS-CREMER, Nicolas, Paul ,  TOMICH, Adam, Daniel ,  DOI, Yohei ,  SUNDBERG, Eric, J. ,  KLONTZ, Erik, H. ,  FLETCHER, Steven

IPC分类号： A61K31/665 ,  A61K31/519 ,  C07D487/04 ,  A61P31/04

摘要： Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.

公开(公告)号：WO2018107143A1

公开(公告)日：2018-06-14

申请号：PCT/US2017/065528

申请日：2017-12-11

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： KUMTA, Prashant ,  PATIL, Mitali ,  OKONKWO, David ,  KORMOS, Robert

IPC分类号： A61B5/053 ,  C07K16/18 ,  G01N33/543 ,  G01N33/68

摘要： The invention relates to ex-situ biosensors that impedimetrically detect one or more target biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of conducting material, such as platinum wires, having immobilized thereon antibody and/or aptamer that is selected to specifically and selectively bind to the one or more target biomarkers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the antibody and/or aptamer binds to the target biomarker(s) of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in the electrochemical impedance is indicative of the presence of the target biomarker(s) of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic and health emergency settings.