公开(公告)号：WO2014204757A1

公开(公告)日：2014-12-24

申请号：PCT/US2014/041972

申请日：2014-06-11

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： PACETTI, Stephen D. ,  LIU, Annie P. ,  JOHNSON, Mark C.

IPC: A61F2/958 ,  A61F2/97 ,  A61F2/00 ,  A61L31/14

CPC classification number: A61F2/958 ,  A61F2/0095 ,  A61F2/82 ,  A61F2/95 ,  A61F2/962 ,  A61F2/966 ,  A61F2/97 ,  A61F2002/9583 ,  A61F2210/0004 ,  A61F2250/0059 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath is removed by a health professional either by removing the sheath directly or using a tube containing the catheter.

Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在卷曲后，将护套放置在卷曲的支架上方以减少卷曲的聚合物支架的反冲，并且当支架被递送到身体中的目标时，保持脚手架气球接合以将支架保持在气囊上。 卫生专业人员可以通过直接取下护套或使用含有导管的管道去除护套。

公开(公告)号：WO2014172485A1

公开(公告)日：2014-10-23

申请号：PCT/US2014/034407

申请日：2014-04-16

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： RAPOZA, Richard ,  DING, Nadine ,  WANG, Yunbing ,  PACETTI, Stephen D. ,  MORTISEN, Derek

IPC: A61L31/14 ,  A61L31/16

CPC classification number: A61F2/82 ,  A61L29/146 ,  A61L29/148 ,  A61L29/16 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/42

Abstract: Implants for treating insufficient blood flow to a heart muscle with transmyocardial revascularization are disclosed. Methods of treating insufficient blood flow to a heart muscle with the implant are also disclosed. The implant can have a body with an inner lumen that supports a channel in the heart muscle to allow for increased blood flow through the lumen upon implantation. The implant can include active agents to prevent or inhibit thrombotic closure of the channel, to promote vascularization, or both.

Abstract translation: 公开了用于治疗心肌血运重建的心肌不足的植入物。 还公开了用植入物治疗心肌不足的方法。 植入物可以具有内部内腔的主体，其支撑心肌中的通道，以允许在植入时通过内腔增加血流量。 植入物可以包括活性剂以预防或抑制通道的血栓闭塞，促进血管形成，或两者。

公开(公告)号：WO2013187988A1

公开(公告)日：2013-12-19

申请号：PCT/US2013/032849

申请日：2013-03-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： JAYASINGHE, Dudley S. ,  DAVALIAN, Dariush ,  FARNBACH, Ronald A.

IPC: A61L31/06 ,  A61L31/14 ,  C08L67/04

CPC classification number: A61L31/06 ,  A61L31/14 ,  A61L2400/16 ,  C08L67/04 ,  C08L71/02

Abstract: Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed The scaffolds are made from a block copolymer of PLLA and a hydrophilic polymer.

Abstract translation: 公开了具有高压碎可恢复性，高抗断裂性和由于在生理条件下的自膨胀性能而减少或无反冲的生物可吸收支架。支架由PLLA和亲水性聚合物的嵌段共聚物制成。

公开(公告)号：WO2013151576A2

公开(公告)日：2013-10-10

申请号：PCT/US2012/053969

申请日：2012-09-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  PAPP, John E. ,  NGUYEN, Hung T. ,  ELERATH, Justin K. ,  HERABADI, Dion I. ,  MARTINS, Michael T. ,  KING, Kirsten S. ,  MUELLER, Scott H. ,  PELOQUIN, Coeta K. ,  PACETTI, Stephen D.

Inventor： PAPP, John E. ,  NGUYEN, Hung T. ,  ELERATH, Justin K. ,  HERABADI, Dion I. ,  MARTINS, Michael T. ,  KING, Kirsten S. ,  MUELLER, Scott H. ,  PELOQUIN, Coeta K. ,  PACETTI, Stephen D.

IPC: A61F2/84 ,  A61F2/82

CPC classification number: A61F2/958 ,  A61F2/844 ,  A61F2/91 ,  A61F2/915 ,  A61F2/966 ,  A61F2002/826 ,  A61F2002/9583 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0039

Abstract: Segmented scaffolds composed of disconnected scaffold segments are disclosed. System of and methods for delivery of the segmented scaffolds are disclosed.

Abstract translation: 公开了由断开的支架段组成的分段支架。 公开了用于递送分段支架的系统和方法。

公开(公告)号：WO2013148860A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/034139

申请日：2013-03-27

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  GILLICK, Matthew ,  WANG, Yunbing ,  MANN, Justin ,  WILSON, Bruce ,  OBERHAUSER, James

Inventor： GILLICK, Matthew ,  WANG, Yunbing ,  MANN, Justin ,  WILSON, Bruce ,  OBERHAUSER, James

IPC: A61F2/958 ,  A61M25/10

CPC classification number: A61F2/958 ,  A61F2250/0013 ,  A61M25/10181 ,  A61M25/10185

Abstract: A fluid accumulator (130) for controlling inflation pressure and pressurization rate of a stent delivery balloon catheter (120) during deployment of a stent or scaffold (126) are disclosed. The fluid accumulator comprises a chamber (136) connected with an inflation lumen of a balloon (125). A movable wall (138) inside the chamber allows the volume of the chamber to vary in response to pressure of inflation fluid that flows into the chamber. The wall moves against a biasing force that opposes a volume increase of the chamber and thus attenuates the pressure in the chamber.

Abstract translation: 公开了一种用于在展开支架或支架（126）期间控制支架输送球囊导管（120）的充气压力和加压速率的流体蓄积器（130）。 流体蓄积器包括与球囊（125）的充气腔连接的腔室（136）。 室内的可移动壁（138）允许室的体积响应于流入室的充气流体的压力而变化。 壁抵抗与室的体积增加相反的偏压力并因此衰减室中的压力。

公开(公告)号：WO2012154842A2

公开(公告)日：2012-11-15

申请号：PCT/US2012/037104

申请日：2012-05-09

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MA, Xiao

Inventor： WANG, Yunbing ,  MA, Xiao

IPC: A61L31/14

CPC classification number: A61L31/148 ,  A61L31/06 ,  A61L2430/00 ,  A61L2430/22 ,  B29C35/0288 ,  B29C35/0805 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/92 ,  B29C2035/0838 ,  B29C2947/92228 ,  B29C2947/92704 ,  B29K2067/046 ,  B29K2105/0002 ,  B29K2995/0088 ,  B29L2023/22 ,  B29L2031/7532 ,  C08L67/04

Abstract: Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. Disclosed methods include controlling features of the degradation profile including the time to loss of radial strength and the degradation time of the stent.

Abstract translation: 公开了控制可生物降解的支架支架的降解特征的方法。 所公开的方法包括控制降解曲线的特征，包括损失径向强度的时间和支架的降解时间。

公开(公告)号：WO2012154753A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036962

申请日：2012-05-08

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MORTISEN, Derek ,  MA, Xiao ,  TANG, Fuh-Wei ,  LAMBERT, Byron

Inventor： WANG, Yunbing ,  MORTISEN, Derek ,  MA, Xiao ,  TANG, Fuh-Wei ,  LAMBERT, Byron

IPC: A61L31/04 ,  A61L31/14 ,  B29C71/00 ,  A61F2/82

CPC classification number: A61F2/82 ,  A61F2/0095 ,  A61F2240/001 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  B29C71/009 ,  B29C71/04 ,  B29C2035/0877 ,  B65B55/16

Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.

Abstract translation: 公开了电子束灭菌后稳定聚合物支架支架分子量的方法。 照射的支架的聚合物的分子量通过暴露于含氧气体而稳定。

公开(公告)号：WO2012112699A2

公开(公告)日：2012-08-23

申请号：PCT/US2012/025275

申请日：2012-02-15

Applicant: SEROS MEDICAL, LLC ,  HEREKAR, Satish, V. ,  MANCHE, Edward, E. ,  EATON, Donald, J.

Inventor： HEREKAR, Satish, V. ,  MANCHE, Edward, E. ,  EATON, Donald, J.

IPC: A61F9/007 ,  A61M35/00 ,  A61M37/00 ,  A61K31/525 ,  A61P27/02 ,  A61M36/00

CPC classification number: A61F9/0017 ,  A61F9/0079 ,  A61K9/0051 ,  A61K31/525 ,  A61K41/0038 ,  A61K41/0057 ,  A61N5/062

Abstract: Systems and methods for delivering and infusing formulations containing riboflavin or its analogues, or other ophthalmic formulations, into corneal tissue are disclosed. Systems and methods are further disclosed to cross-link the corneal tissue through exposure to UVA irradiation. The systems and methods for formulation delivery employ micro-needle array delivery devices.

Abstract translation: 公开了将含有核黄素或其类似物或其他眼用制剂的制剂递送和注入角膜组织的系统和方法。 进一步公开了系统和方法以通过暴露于UVA照射来交联角膜组织。 制剂交付的系统和方法使用微针阵列递送装置。

公开(公告)号：WO2012112543A2

公开(公告)日：2012-08-23

申请号：PCT/US2012/025039

申请日：2012-02-14

Applicant: SEROS MEDICAL, LLC ,  BLUMENKRANZ, Mark S. ,  MANCHE, Edward E. ,  HEREKAR, Satish V. ,  EATON, Donald J.

Inventor： BLUMENKRANZ, Mark S. ,  MANCHE, Edward E. ,  HEREKAR, Satish V. ,  EATON, Donald J.

IPC: A61F9/01 ,  A61K31/525 ,  A61P27/02

CPC classification number: A61F9/0017 ,  A61F9/0079 ,  A61K9/0051 ,  A61K31/525 ,  A61K41/0038 ,  A61K41/0057 ,  A61N5/062

Abstract: Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.

Abstract translation: 公开了用于递送核黄素（R / F）和UVA辐射至巩膜的递送系统和方法。 通过使用LED或光纤，R / F被传递并随后通过UVA照射而被激活，由此引起胶原蛋白组织的交联。 输送系统包括提供符合巩膜的表面的可植入结构。 输送系统包括用于将R / F输送到巩膜表面上的各种类型的结构。 此外，输送系统还包括在巩膜胶原组织中提供辐射R / F的UVA源。

公开(公告)号：WO2011137449A2

公开(公告)日：2011-11-03

申请号：PCT/US2011/034823

申请日：2011-05-02

Applicant: SEROS MEDICAL, LLC ,  HEREKAR, Satish V. ,  MANCHE, Edward E. ,  EATON, Donald J.

Inventor： HEREKAR, Satish V. ,  MANCHE, Edward E. ,  EATON, Donald J.

IPC: A61F9/008 ,  A61N5/067 ,  A61N5/08 ,  A61F7/00

CPC classification number: A61F9/00821 ,  A61F9/0079 ,  A61F2009/00851 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0659

Abstract: An apparatus and a method are provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/ riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that further enables cross-linking (CXL) therapy to be combined with thermal therapy.

Abstract translation: 提供了一种设备和方法，用于以组织维持方式治疗眼组织的目标区域，包括使用两种或更多种治疗方式，包括热辐射源（例如CW红外光纤激光器），其操作在波长范围 在水中具有高吸收性和光化学胶原蛋白交联（CXL），以及一种或多种特定的系统改进，例如用于定制治疗方式的围手术期反馈测量，眼组织表面热控制/冷却机制和 在紫外线辐射存在下靶向眼组织的输送系统中氘代水/核黄素溶液的来源。 提供了快速交联（RXL）的其他方法，其进一步使交联（CXL）治疗与热疗相结合。