公开(公告)号：WO2012154753A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036962

申请日：2012-05-08

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MORTISEN, Derek ,  MA, Xiao ,  TANG, Fuh-Wei ,  LAMBERT, Byron

Inventor： WANG, Yunbing ,  MORTISEN, Derek ,  MA, Xiao ,  TANG, Fuh-Wei ,  LAMBERT, Byron

IPC: A61L31/04 ,  A61L31/14 ,  B29C71/00 ,  A61F2/82

CPC classification number: A61F2/82 ,  A61F2/0095 ,  A61F2240/001 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  B29C71/009 ,  B29C71/04 ,  B29C2035/0877 ,  B65B55/16

Abstract: Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.

Abstract translation: 公开了电子束灭菌后稳定聚合物支架支架分子量的方法。 照射的支架的聚合物的分子量通过暴露于含氧气体而稳定。

公开(公告)号：WO2007146049A3

公开(公告)日：2009-01-22

申请号：PCT/US2007013396

申请日：2007-06-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  HOSSAINY SYED F A ,  TANG FUH-WEI ,  KLEINER LOTHAR ,  GLAUSER THIERRY ,  TANG YIWEN ,  ROORDA WOUTER ,  PACETTI STEPHEN ,  ZHANG GINA ,  CHEN YUNG-MING ,  MCNIVEN ANDREW F ,  MCNIVEN SEAN A ,  YOE BRANDON J

Inventor： HOSSAINY SYED F A ,  TANG FUH-WEI ,  KLEINER LOTHAR ,  GLAUSER THIERRY ,  TANG YIWEN ,  ROORDA WOUTER ,  PACETTI STEPHEN ,  ZHANG GINA ,  CHEN YUNG-MING ,  MCNIVEN ANDREW F ,  MCNIVEN SEAN A ,  YOE BRANDON J

IPC: A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：WO2007146049A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/013396

申请日：2007-06-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HOSSAINY, Syed, F. A. ,  TANG, Fuh-Wei ,  KLEINER, Lothar ,  GLAUSER, Thierry ,  TANG, Yiwen ,  ROORDA, Wouter ,  PACETTI, Stephen ,  ZHANG, Gina ,  CHEN, Yung-Ming ,  MCNIVEN, Andrew, F. ,  MCNIVEN, Sean, A. ,  YOE, Brandon, J.

Inventor： HOSSAINY, Syed, F. A. ,  TANG, Fuh-Wei ,  KLEINER, Lothar ,  GLAUSER, Thierry ,  TANG, Yiwen ,  ROORDA, Wouter ,  PACETTI, Stephen ,  ZHANG, Gina ,  CHEN, Yung-Ming ,  MCNIVEN, Andrew, F. ,  MCNIVEN, Sean, A. ,  YOE, Brandon, J.

IPC: A61L27/40 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia , that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：WO2012024328A3

公开(公告)日：2012-07-19

申请号：PCT/US2011047974

申请日：2011-08-16

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS ,  KLEINER LOTHAR ,  TANG FUH-WEI

Inventor： KLEINER LOTHAR ,  TANG FUH-WEI

IPC: A61L31/06

CPC classification number: A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L2202/24 ,  A61L2400/18 ,  C08L67/04

Abstract: Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

Abstract translation: 公开了消毒后化学稳定聚合物支架的方法。 辐射灭菌后，支架暴露于环境温度以上一段时间。 暴露减少了辐射产生的自由基浓度。

公开(公告)号：WO2009117398A2

公开(公告)日：2009-09-24

申请号：PCT/US2009/037375

申请日：2009-03-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HSU, Shaw, Ling ,  TANG, Yiwen ,  KLEINER, Lothar, W. ,  TANG, Fuh-Wei ,  DING, Ni ,  HOSSAINY, Syed, Faiyaz Ahmed

Inventor： HSU, Shaw, Ling ,  TANG, Yiwen ,  KLEINER, Lothar, W. ,  TANG, Fuh-Wei ,  DING, Ni ,  HOSSAINY, Syed, Faiyaz Ahmed

IPC: A61L27/34 ,  A61L31/10

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L2420/08 ,  C08L67/04

Abstract: Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.

Abstract translation: 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。

公开(公告)号：WO2006118937A3

公开(公告)日：2007-07-26

申请号：PCT/US2006015998

申请日：2006-04-24

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  HOSSAINY SYED F A ,  TANG FUH-WEI ,  EPPERT JOSEPH J ,  KEVORKIAN GREGORY J ,  MCNIVEN ANDREW F

Inventor： HOSSAINY SYED F A ,  TANG FUH-WEI ,  EPPERT JOSEPH J ,  KEVORKIAN GREGORY J ,  MCNIVEN ANDREW F

IPC: A61L31/16 ,  A61L27/14 ,  A61L27/54 ,  A61L31/10

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/606

Abstract: The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers.

Abstract translation: 本发明通常包括对来自聚合物基质的试剂的释放速率的控制。 这种对药剂释放速率的控制提供了对需要这种治疗的患者实现的治疗，预防，诊断和改善效果的控制。 此外，试剂的释放速率的控制也对聚合物基质的机械完整性以及与受试者吸收聚合物的吸收速率的关系有影响。

公开(公告)号：WO2006118937A2

公开(公告)日：2006-11-09

申请号：PCT/US2006/015998

申请日：2006-04-24

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed F.A. ,  TANG, Fuh-wei ,  EPPERT, Joseph J. ,  KEVORKIAN, Gregory J. ,  MCNIVEN, Andrew F.

Inventor： HOSSAINY, Syed F.A. ,  TANG, Fuh-wei ,  EPPERT, Joseph J. ,  KEVORKIAN, Gregory J. ,  MCNIVEN, Andrew F.

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/606

Abstract: The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers.

Abstract translation: 本发明通常包括对来自聚合物基质的试剂的释放速率的控制。 这种对药剂释放速率的控制提供了对需要这种治疗的患者实现的治疗，预防，诊断和改善效果的控制。 此外，试剂的释放速率的控制也对聚合物基质的机械完整性以及与受试者吸收聚合物的吸收速率的关系有影响。

公开(公告)号：WO2005004945A3

公开(公告)日：2005-03-24

申请号：PCT/US2004017060

申请日：2004-05-28

Applicant: ADVANCED CARDIOVASCULAR SYSTEM ,  HOSSAINY SYED F A ,  TANG FUH-WEI ,  PACETTI STEPHEN D ,  ROYAL JEFF ,  HAPP DORRIE M ,  SCHEINPFLUG KURT ,  HU TY

Inventor： HOSSAINY SYED F A ,  TANG FUH-WEI ,  PACETTI STEPHEN D ,  ROYAL JEFF ,  HAPP DORRIE M ,  SCHEINPFLUG KURT ,  HU TY

IPC: A61F2/06 ,  A61F2/90 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00

CPC classification number: A61L27/34 ,  A61F2/91 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08L29/04

Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition which can result in reduction of the rate of release of an active agent from the coating subsequent to the implantation of the device.

Abstract translation: 公开了一种涂层和一种涂覆诸如支架的可植入医疗装置的方法。 该方法包括使涂层经受热状态，该状态可以导致在植入装置之后活性剂从涂层释放的速率降低。

公开(公告)号：WO2005004945A2

公开(公告)日：2005-01-20

申请号：PCT/US2004/017060

申请日：2004-05-28

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed, F., A. ,  TANG, Fuh-Wei ,  PACETTI, Stephen, D. ,  ROYAL, Jeff ,  HAPP, Dorrie, M. ,  SCHEINPFLUG, Kurt ,  HU, Ty

Inventor： HOSSAINY, Syed, F., A. ,  TANG, Fuh-Wei ,  PACETTI, Stephen, D. ,  ROYAL, Jeff ,  HAPP, Dorrie, M. ,  SCHEINPFLUG, Kurt ,  HU, Ty

IPC: A61L31/16

CPC classification number: A61L27/34 ,  A61F2/91 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08L29/04

Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition which can result in reduction of the rate of release of an active agent from the coating subsequent to the implantation of the device.

Abstract translation: 公开了涂覆和涂覆可植入医疗装置（例如支架）的方法。 该方法包括使涂层经受热状态，其可导致在设备植入之后活性剂从涂层中释放的速率降低。

公开(公告)号：WO2012148452A1

公开(公告)日：2012-11-01

申请号：PCT/US2011/057932

申请日：2011-10-26

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  WANG, Yunbing ,  MA, Xiao ,  TANG, Fuh-Wei ,  DING, Ni

Inventor： WANG, Yunbing ,  MA, Xiao ,  TANG, Fuh-Wei ,  DING, Ni

IPC: B29C71/02 ,  A61F2/82 ,  A61F2/90

CPC classification number: B29C71/02 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2240/001 ,  A61L2/007 ,  A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L31/148 ,  A61L2202/21 ,  A61L2202/24 ,  A61L2400/18 ,  B29C35/02 ,  B29C2035/0877 ,  B29C2071/022 ,  B29L2031/753 ,  C08J7/08 ,  C08J7/123 ,  C08J2367/04 ,  C08L67/04

Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number- average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量在更窄的范围内。