公开(公告)号：WO2005102154A3

公开(公告)日：2007-06-14

申请号：PCT/US2005013031

申请日：2005-04-15

Applicant: BECTON DICKINSON CO ,  DRAUDT GREGG ,  AHLGRIM DIRK ,  SCHMINKE JAN ,  FOLLMAN MARK ,  COLUCCI JOSE JR ,  YAO RAY ,  MCCAFFREY ROBERT ,  CHAN VICTOR

Inventor： DRAUDT GREGG ,  AHLGRIM DIRK ,  SCHMINKE JAN ,  FOLLMAN MARK ,  COLUCCI JOSE JR ,  YAO RAY ,  MCCAFFREY ROBERT ,  CHAN VICTOR

IPC: A61B5/00 ,  A61B5/15 ,  B65D81/00 ,  C12Q1/48 ,  G01N33/52 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150259 ,  A61B5/150358 ,  A61B5/15087 ,  A61B5/15113 ,  A61B5/15115 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/157 ,  A61B2562/0295 ,  G01N33/523 ,  G01N33/526 ,  G01N33/66

Abstract: A blood glucose meter having a test strip port (20) and an adjustable lancet device (30) disposed at the same end of the device body (10) is disclosed. The device body (10) further includes an enclosure (70) at the proximal end of the device body (10) which houses a test strip storage vial (75) and which facilitates one-handed opening and closing of the vial (75) to simplify access to test strips contained therein. The enclosure (70) is further provided with a window (72) which allows the reading of the lot numbers on the label of the test strip vial (75) therein without necessitating removal of the vial (75). A data connector (90) is also provided on the device body (10) for communication access, such as to upload data from other devices or to download data to other devices. By combining these multiple components into a single device body, the blood glucose meter requires fewer steps for sampling and testing, and makes device use easier and more convenient.

Abstract translation: 公开了一种具有测试条端口（20）和设置在装置主体（10）的同一端的可调节刺血针装置（30）的血糖仪。 装置主体（10）还包括位于装置本体（10）的近端处的壳体（70），其容纳测试条存储小瓶（75）并且便于将小瓶（75）单手打开和关闭至 简化对其中包含的测试条的访问。 外壳（70）还设置有窗口（72），其允许在其中读取试纸瓶（75）的标签上的批号，而不需要移除小瓶（75）。 数据连接器（90）还设置在设备主体（10）上用于通信访问，例如从其他设备上传数据或将数据下载到其他设备。 通过将这些多个组件组合到单个设备主体中，血糖仪需要更少的采样和测试步骤，并且使设备使用更容易和更方便。

公开(公告)号：WO2007033079A2

公开(公告)日：2007-03-22

申请号：PCT/US2006/035312

申请日：2006-09-11

Applicant: HOME DIAGNOSTICS, INC. ,  WEGNER, Greta ,  POPOVICH, Natasha ,  SLOMSKI, Dennis

Inventor： WEGNER, Greta ,  POPOVICH, Natasha ,  SLOMSKI, Dennis

IPC: C12Q1/54

CPC classification number: C12Q1/006 ,  C12Q1/001 ,  G01N33/521 ,  G01N33/523 ,  G01N33/525 ,  G01N33/526

Abstract: A method for manufacturing a test strip is provided. The method comprises selecting a test strip substrate material and positioning the test strip substrate material a predetermined distance from a matrix material disposed on a second substrate, wherein at least one enzyme to be deposited on the test strip substrate and having glucose as an enzymatic substrate is held within the matrix material. A laser pulse is directed towards the matrix material to release at least a portion of the at least one enzyme having glucose as an enzymatic substrate from the matrix material and deposit the enzyme on the test strip substrate.

Abstract translation: 提供一种制造测试条的方法。 该方法包括选择测试条基材材料并将测试条基材材料定位在距离设置在第二基底上的基质材料预定距离，其中待沉积在测试条基材上并具有葡萄糖作为酶底物的至少一种酶是 保持在基质材料内。 将激光脉冲引向基质材料以从基质材料释放至少一部分具有作为酶底物的葡萄糖的至少一种酶，并将酶沉积在测试条基材上。

公开(公告)号：WO2007025558A1

公开(公告)日：2007-03-08

申请号：PCT/EP2005/009381

申请日：2005-08-31

Applicant: EGOMEDICAL TECHNOLOGIES AG ,  STIENE, Matthias ,  HORSTKOTTE, Elke ,  KUHLMEIER, Dirk ,  JONES, Eurig, Wyn

Inventor： STIENE, Matthias ,  HORSTKOTTE, Elke ,  KUHLMEIER, Dirk ,  JONES, Eurig, Wyn

IPC: G01N33/52 ,  G01N33/543 ,  G01N33/487 ,  B01L3/00 ,  G01N21/00 ,  G02F1/00

CPC classification number: C12Q1/6834 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2400/0406 ,  B82Y5/00 ,  G01N21/8483 ,  G01N33/526 ,  G01N33/54386 ,  G01N33/54393

Abstract: An analyte test element for the qualitative and/or quantitative determination of at least one analyte in a physiological or aqueous sample fluid having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both sur­faces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface en­ergy (6, 6') create a sample distribution system with at least two detection areas (6a, 6'a), said at least one of the detection areas (6a, 6'a) of the first and second surfaces (2a, 4a) is provided with at least one non-enzymatic recognition element (32). The analyte test ele­ment is suitable for analyte test systems evaluating the affinity reaction between an analyte of interest and a recognition element and therefore provides a suitable test system to per­form immunoassays, receptor-assays, or other affinity assays with a simple test element containing qualitative or quantitative calibration mechanisms suitable for point of care and home settings.

Abstract translation: 一种分析物测试元件，用于定性和/或定量测定具有第一表面（2a）和第二表面（4a）的生理或水性样品流体中至少一种分析物彼此相对的预定距离，所述两个表面 具有两个基本上等效的图案，其形成高度和低表面能的区域，其大体上等同排列，由此高表面能（6,6'）的区域产生具有至少两个检测区域（6a，6'）的样品分布系统， 所述第一和第二表面（2a，4a）的所述检测区域（6a，6'a）中的至少一个设置有至少一个非酶识别元件（32）。 分析物测试元件适用于分析物测试系统，用于评估感兴趣分析物与识别元件之间的亲和力反应，因此提供合适的测试系​​统，以进行免疫测定，受体测定或其他亲和力测定，其中包含定性或 定量校准机制适用于护理点和家庭设置。

公开(公告)号：WO2006134870A1

公开(公告)日：2006-12-21

申请号：PCT/JP2006/311752

申请日：2006-06-12

Applicant: 日本化薬株式会社 ,  梅香家 佳彦 ,  町田 礼子 ,  入江 弥生 ,  田辺 敏雄

Inventor： 梅香家 佳彦 ,  町田 礼子 ,  入江 弥生 ,  田辺 敏雄

IPC: G01N33/66 ,  C12Q1/32 ,  C12Q1/48 ,  C12Q1/54 ,  G01N33/48

CPC classification number: G01N33/66 ,  G01N33/525 ,  G01N33/526

Abstract: ［課題］ベッドサイドあるいは診察室での迅速測定や患者自身による家庭でのグルコース及び／またはその誘導体に起因する干渉を受ける血中成分の測定の際には、遠心分離機等を使用せず、全血をそのまま試料として用いることのできる測定方法が望まれている。 ［解決手段］グルコース及び／またはその誘導体に起因する干渉を受ける血中成分の測定方法において、全血と、グルコース及び／またはその誘導体を該測定に干渉しない物質へ変換する物質を接触させ、同時または引続いて血球の分離を行なうことを特徴とする血中成分の測定方法、該測定方法に使用するデバイス及び該デバイスを含むキットを提供する。

Abstract translation: [问题]在他/她自己的家中快速测定在病床上或诊所中由葡萄糖和/或其衍生物干扰的血液成分或由患者进行测定时，需要一种测定方法，其中全血 可以用作样品，而不需要使用离心机等。 用于解决问题的方法一种测定用于测定受葡萄糖和/或其衍生物干扰的血液成分的血液成分的方法，其特征在于包括使全血与能够转化葡萄糖和/或其衍生物的物质接触 衍生成另一种不干扰测定的物质，同时或随后分离血细胞; 在测定方法中使用的装置; 和一个包含该设备的工具包。

公开(公告)号：WO2005098431A1

公开(公告)日：2005-10-20

申请号：PCT/EP2004/002284

申请日：2004-03-05

Applicant: EGOMEDICAL SWISS AG ,  STIENE, Matthias

Inventor： STIENE, Matthias

IPC: G01N33/52

CPC classification number: G01N33/526 ,  B01L3/502707 ,  B01L3/502792 ,  B01L2300/0803 ,  B01L2300/0812 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2400/0406 ,  G01N33/54366 ,  Y10T156/1039 ,  Y10T156/1051 ,  Y10T156/1052

Abstract: This invention provides a device for determining the concentration of an analyte like glucose, cholesterol, free fatty acids, triglycerides, proteins, ketones, phenylalanine or enzymes, in a physiological fluid like blood, serum, plasma, saliva, urine, interstitial and/or intracellular fluid, the device having an integrated calibration and quality control system suitable for dry reagent test strips with a very small sample volume of about 0.5µL based on to a new sample distribution system. The production of the inventive analyte test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the strips.

Abstract translation: 本发明提供了一种用于在诸如血液，血清，血浆，唾液，尿，间质和/或血液的生理流体中测定分析物如葡萄糖，胆固醇，游离脂肪酸，甘油三酯，蛋白质，酮，苯丙氨酸或酶的浓度的装置。 细胞内液体，该装置具有集成的校准和质量控制系统，其适用于基于新的样品分配系统的具有约0.5μL的非常小的样品体积的干试剂测试条。 本发明的分析物测试元件的生产仅涉及少量不复杂的生产步骤，从而能够廉价地生产条带。

公开(公告)号：WO03056163A9

公开(公告)日：2004-10-21

申请号：PCT/US0241075

申请日：2002-12-23

Applicant: POLYMER TECHNOLOGY SYSTEMS INC ,  SUNIL ANAOKAR

Inventor： SUNIL ANAOKAR

IPC: G01N33/92 ,  C12Q1/60 ,  G01N33/52

CPC classification number: G01N33/526 ,  C12Q1/60 ,  G01N33/92

Abstract: A multilayer test strip [20] and method of using the test strip [20] for determining concentration of HDL cholesterol in a whole blood sample. The inventive test strip [20] includes a two-stage blood separation mechanism, including a first glass fiber matrix [38] which separates most of the blood cells and an adjacent, second matrix [40] preferably also containing glass fibers that separates the remainder of the blood cells. The second layer [40] also precipates and retains non-HDL cholesterol, thereby providing plasma that is substantially free of red blood cells and substantially free of non-HDL cholesterol to a reaction layer [42]. Precipitation and retention on non-HDLs takes place by vertical or dead-end filtration in a single layer [40]. The reaction layer [42] produces a color, the intensity of which is proportional to the concentration of HDL cholesterol in the blood sample which is applied to the test strip. Advantageously, the inventive test strip [20] is a vertical flow device, which can be made more compact and operates more efficiently than a lateral flow device.

Abstract translation: 多层测试条[20]和使用测试条[20]测定全血样品中HDL胆固醇浓度的方法。 本发明的测试条[20]包括两级血液分离机构，其包括分离大多数血细胞的第一玻璃纤维基质[38]和相邻的第二基质[40]，优选还含有分隔剩余部分的玻璃纤维 的血细胞。 第二层[40]还沉淀并保留非HDL胆固醇，从而提供基本上不含红细胞的血浆，并且基本上没有非HDL胆固醇到反应层[42]。 非HDLs的沉淀和保留通过垂直或死端过滤在单层中进行[40]。 反应层[42]产生颜色，其强度与施加到测试条上的血液样品中HDL胆固醇的浓度成比例。 有利地，本发明的测试条[20]是垂直流动装置，其可以制造得比侧流装置更紧凑和更有效地操作。

公开(公告)号：WO2003095969A2

公开(公告)日：2003-11-20

申请号：PCT/GB2003/001912

申请日：2003-05-07

Applicant: YORKTEST LABORATORIES LIMITED ,  RHODES, Christopher, Bruce

Inventor： RHODES, Christopher, Bruce

IPC: G01N

CPC classification number: A61B5/417 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150343 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150824 ,  A61B10/00 ,  G01N33/525 ,  G01N33/526

Abstract: The invention relates to a sample collection device which allows the rapid and volumetric collection of a body fluid sample upon which an assay can be conducted which provides a reliable measurement of a biomolecule.

Abstract translation: 本发明涉及一种样品收集装置，其允许体液样品的快速和体积收集，其上可以进行可以进行生物分子的可靠测量的测定。

公开(公告)号：WO2002063296A1

公开(公告)日：2002-08-15

申请号：PCT/US2001/050229

申请日：2001-12-27

Applicant: FERNANDEZ DE CASTRO, Aurora, L.

Inventor： FERNANDEZ DE CASTRO, Aurora, L.

IPC: G01N33/48

CPC classification number: G01N33/526 ,  Y10T436/144444 ,  Y10T436/147777 ,  Y10T436/25375

Abstract: A device (10) for simultaneously measuring a plurality of analytes in blood or other fluids comprising a plurality of reagent pads (12) containing reagents specific to particular analytes.

Abstract translation: 一种用于同时测量血液或其它流体中的多种分析物的装置（10），其包含多个包含特定分析物特异性试剂的试剂垫（12）。

公开(公告)号：WO1996000897A1

公开(公告)日：1996-01-11

申请号：PCT/US1995008029

申请日：1995-06-23

Applicant: LXN CORPORATION

Inventor： LXN CORPORATION ,  BURD, John, F. ,  HOBLITZELL, Talei ,  NEYER, Gebhard

IPC: G01N33/00

CPC classification number: G01N33/526 ,  Y10S435/805 ,  Y10S436/825 ,  Y10T436/255

Abstract: The present invention is directed to a multi-layer test device (10) and method for analyzing the concentration of fructosamine in a liquid sample. The multi-layer test device (10) has a buffer layer (14) containing a buffer having a pH value of at least 9 which is either superposed above or juxtaposed to an indicator layer (15) containing an indicator capable of being reduced by fructosamine. Supporting the buffer layer (14), the indicator layer (15), and any additional layers in the multi-layer device (10) is at least one support member (16) which optionally has a detection aperture (13) for analyzing the concentration of fructosamine on the indicator layer.

Abstract translation: 本发明涉及一种用于分析液体样品中果糖胺浓度的多层测试装置（10）和方法。 所述多层测试装置（10）具有缓冲层（14），该缓冲层含有pH值至少为9的缓冲液，所述缓冲液叠加在指示剂层（15）上方或并置，所述指示剂层（15）含有能够被果糖胺还原的指示剂 。 支撑缓冲层（14），指示层（15）和多层装置（10）中的任何附加层是至少一个支撑构件（16），其可选地具有用于分析浓度的检测孔（13） 果糖胺在指示剂层上。

公开(公告)号：WO1992001498A2

公开(公告)日：1992-02-06

申请号：PCT/US1991005004

申请日：1991-07-15

Applicant: CHOLESTECH CORPORATION

Inventor： CHOLESTECH CORPORATION ,  JONES, Ronald, M.

IPC: B01D0

CPC classification number: G01N33/92 ,  B01D39/2017 ,  B01D2239/0421 ,  B01D2239/0492 ,  C12Q1/60 ,  C12Q2326/00 ,  C12Q2326/96 ,  G01N33/526 ,  G01N2800/044 ,  Y10T436/104165

Abstract: An assay device (14) for measuring the concentration of a soluble analyte, such as HDL-associated cholesterol, in a fluid sample containing interfering compounds, such as LDL- or VLDL-associated cholesterol, which can be selectively precipitated. The device includes a sieving matrix (26) capable of separating soluble and precipitated material migrating through the matrix, and a reservoir (34) which holds a precipitating agent which is effective, within a given concentration range, to selectively precipitate the interfering compounds. The reservoir is designed to delay the release of agent, on contact with the fluid sample, to maintain the concentration of precipitating agent in contact with the fluid sample within the given concentration range. The device additionally includes an assay pad (64, 66, 68, 70) in which the soluble analyte present in the fluid sample can be assayed. A method of separating high-density lipoproteins (HDL) from low- and very-low-density lipoproteins (LDL and VLDL) employs a coated glass fiber matrix which inhibits binding of HDL as a blood fluid sample containing HDL and precipitated LDL and VLDL passes through the matrix.

Abstract translation: 一种测定装置（14），其用于测量含有可被选择性沉淀的干扰化合物如LDL-或VLDL相关胆固醇的流体样品中的可溶性分析物（例如HDL相关胆固醇）的浓度。 该装置包括能够分离通过基质迁移的可溶性和沉淀物质的筛分基质（26），以及储存器（34），其在给定浓度范围内保持有效的沉淀剂以选择性地沉淀干扰化合物。 储存器旨在延迟试剂在与流体样品接触时的释放，以使沉淀剂的浓度与给定浓度范围内的流体样品接触。 该装置还包括其中可以测定存在于流体样品中的可溶性分析物的测定垫（64,66,68,70）。 从低密度脂蛋白（HDL）和低密度脂蛋白（LDL和VLDL）分离高密度脂蛋白（HDL）的方法采用涂覆的玻璃纤维基质，其抑制HDL作为含有HDL和沉淀LDL和VLDL通过的血液样品的结合 通过矩阵。