公开(公告)号：WO2018219916A1

公开(公告)日：2018-12-06

申请号：PCT/EP2018/064016

申请日：2018-05-29

Applicant: BASF SE

Inventor： GRIESER-SCHMITZ, Christof ,  ELLERSIEK, Carsten ,  POPOV, Alex

IPC: B32B1/08 ,  B32B5/18 ,  B32B5/20 ,  B32B7/12 ,  B32B15/04 ,  B32B15/08 ,  B32B15/095 ,  B32B15/18 ,  B32B15/20 ,  B32B27/18 ,  B32B27/40 ,  B32B1/06 ,  F16L11/14 ,  F16L59/14 ,  F16L59/153 ,  B32B5/32

Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von gedämmten Rohren, umfassend das Bereitstellen eines Mediumrohrs und eines aus einer Folie kontinuierlich gebildeten Folienschlauches oder eines Mediumrohrs und eines Mantelrohrs, wobei das Mediumrohr innerhalb des Folienschlauchs oder des Mantelrohres angeordnet ist und zwischen Mediumrohr und Folienschlauch oder Mantelrohr ein Spalt ausgebildet wird, wobei auf der dem Folienschlauch oder Mantelrohr zugewandten Oberfläche des Mediumrohrs ein Haftvermittler aufgetragen ist, das Einfüllen eines Polyurethansystems mindestens umfassend eine Isocyanatkomponente (a) enthaltend mindestens ein Isocyanat, eine Polyolkomponente (b) und mindestens einen Katalysator in den Spalt bevor der Haftvermittler vollständig gehärtet ist und das Aufschäumen und Aushärtenlassen des Polyurethansystems. Weiterhin betrifft die vorliegende Erfindung gedämmte Rohre, erhältlich oder erhalten nach einem erfindungsgemäßen Verfahren.

公开(公告)号：WO2018211093A1

公开(公告)日：2018-11-22

申请号：PCT/EP2018/063159

申请日：2018-05-18

Applicant: BASF SE

Inventor： SCHROEDER, Hartwig ,  HAEFNER, Stefan ,  ZELDER, Oskar ,  WITTMANN, Christoph ,  LANGE, Anna Christine ,  HOFF, Birgit ,  BOEHMER, Nico

IPC: C12N9/12 ,  C12P7/46 ,  C12R1/01

Abstract: The present invention relates to a process of producing an organic compound, the process comprising I) cultivating a genetically modified microorganism in a culture medium comprising sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK -gene, compared to the original microorganism that has not been genetically modified, and wherein the original microorganism belongs to the family Pasteurellaceae . The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

公开(公告)号：WO2018210815A1

公开(公告)日：2018-11-22

申请号：PCT/EP2018/062531

申请日：2018-05-15

Applicant: BASF SE ,  BASF CORPORATION

Inventor： MOINI, Ahmad ,  MCGUIRE, Robert ,  MÜLLER, Ulrich

IPC: C01B39/48 ,  B01J37/03 ,  B01J29/76

Abstract: A process for preparing a zeolitic material comprising a metal M, having framework type AEI, and having a framework structure which comprises a tetravalent element Y, a trivalent element X, and oxygen, said process comprising (i) providing a zeolitic material comprising the metal M, having a framework type other than AEI, and having a framework structure comprising the trivalent element X, and oxygen; (ii) preparing a synthesis mixture comprising the zeolitic material provided in (i), water, a source of the tetravalent element Y, and an AEI framework structure directing agent; (iii) subjecting the synthesis mixture prepared in (ii) to hydrothermal synthesis conditions comprising heating the synthesis mixture to a temperature in the range of from 100 to 200 °C and keeping the synthesis mixture at a temperature in this range under autogenous pressure, obtaining the zeolitic material having framework type AEI; wherein Y is one or more of Si, Ge, Sn, Ti, Zr; wherein X is one or more of Al, B, Ga, In; wherein M is a transition metal of groups 7 to 12 of the periodic table of elements.

公开(公告)号：WO2018206496A1

公开(公告)日：2018-11-15

申请号：PCT/EP2018/061706

申请日：2018-05-07

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Inventor： WEIGERT, Andreas ,  MORA, Javier ,  BRÜNE, Bernhard ,  PUTYRSKI, Mateusz ,  PARNHAM, Michael John ,  ERNST, Andreas

IPC: C07K16/24 ,  A61P35/00 ,  A61K45/00

Abstract: The present invention relates to an inhibitor of IL-38 for use in treating and/or preventing cancer in a subject Also encompassed by the invention are a pharmaceutical composition comprising an inhibitor of IL-38, a method for treating and/or preventing cancer comprising administering an inhibitor of IL-38 in a therapeutically effective amount as well as a method for identifying an inhibitor of IL-38.

公开(公告)号：WO2018202666A1

公开(公告)日：2018-11-08

申请号：PCT/EP2018/061118

申请日：2018-05-02

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM

Inventor： JIA, Min ,  HOFFMEISTER, Michael

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/178

Abstract: The present invention relates to a method for determining a survival probability of a subject suffering from colorectal cancer comprising a) detecting the methylation status of at least two CpG sites selected from the CpG sites of Table 1 in a sample of said subject and, b) based on the methylation status detected in step a), determining the survival probability of said subject. The present invention further relates to a use of the methylation status of genomic DNA or means for the determination thereof in a sample of a subject suffering from colorectal cancer for determining a survival probability of said subject, preferably for predicting the mortality risk of said subject, and to a data collection, a kit, and a device related thereto.

公开(公告)号：WO2018197446A3

公开(公告)日：2018-11-01

申请号：PCT/EP2018/060403

申请日：2018-04-24

Applicant: F. HOFFMANN-LA ROCHE AG

Inventor： BENDEL, Volker ,  LAIKA, Matthias ,  RIEGER, Wolfgang

IPC: A61L2/07

Abstract: Es wird eine Entnahmevorrichtung (112) zur Entnahme mindestens einer keimarmen Flüssigkeit aus einem Leitungssystem (110) vorgeschlagen. Die Entnahmevorrichtung (112) umfasst mindestens einen Entnahmestutzen (146). Weiterhin umfasst die Entnahmevorrichtung (112) mindestens einen Koppelbogen (156), welcher mit dem Entnahmestutzen (146) lösbar verbunden ist. Mindestens ein Rohrende (154) des Entnahmestutzens (146) ragt in einen Innenraum (158) des Koppelbogens (156) und ist in dem Koppelbogen (156) auf seiner Innenseite (180), seiner Außenseite (174) und seiner Stirnseite (178) mit Reindampf sterilisierbar.

公开(公告)号：WO2018153814A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054031

申请日：2018-02-19

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM

Inventor： BICKELHAUPT, Sebastian ,  KÖNIG, Franziska

IPC: A61B5/00 ,  A61B5/055 ,  G01R33/56 ,  G01R33/563

Abstract: A method for non-invasively classifying a tumorous modification of a tissue according to different stages of the tumorous modification comprises the steps of: a) receiving raw magnetic resonance imaging (MRI) data that has been recorded by applying at least one diffusion weighted imaging (DWI) sequence using three to nine different b-values to a tissue being suspicious to a tumorous modification without application of a contrast agent; b) extracting at least two quantification scheme parameters from the raw MRI data by using at least one quantification scheme, wherein each of the quantification scheme parameters is related to a microstructural property of the tissue; c) applying a weight to each quantification scheme parameter, wherein the weight is dependent on a kind of the tissue and on the quantification scheme, whereby a set of weighted quantification scheme parameters is obtained; d) determining a scoring value by combining the weighted quantification scheme parameters within the set, wherein each of the weighted quantification scheme parameters is used only once for determining the scoring value; and e) classifying the tumorous modification of the tissue into one of at least two classes according to the scoring value. The method and a corresponding classification device are capable of performing non-invasive tissue characterization without contrast agent administration in a highly accurate manner while supplementary information related to conventional imaging properties and clinical information can further increase the high diagnostic accuracy. They are used in their entirety for classifying the tumorous modification of the tissue.

公开(公告)号：WO2018146138A1

公开(公告)日：2018-08-16

申请号：PCT/EP2018/053057

申请日：2018-02-07

Applicant: TRINAMIX GMBH

Inventor： VALOUCH, Sebastian ,  HERMES, Wilfried ,  BRUDER, Ingmar ,  SEND, Robert ,  LUNGENSCHMIED, Christoph

IPC: H01L27/30 ,  G01C3/06 ,  G01S17/46 ,  H01L27/146 ,  G01S7/481 ,  H01L31/0224 ,  H01L51/44

Abstract: A detector (110) for an optical detection of at least one object (112) is proposed. The detector (110) comprises: - at least one transversal optical sensor (114), the transversal optical sensor (114) being adapted to determine a transversal position of a light beam (136) traveling from the object (112) to the detector (110), wherein the transversal position is a position in at least one dimension perpendicular to an optical axis (116) of the detector (110), wherein the transversal optical sensor (140) has at least one photosensitive layer (130) embedded between at least two conductive layers (132, 132'), wherein at least one of the conductive layers (132) comprises an at least partially transparent graphene layer (134) on an at least partially transparent substrate (135), thus, allowing the light beam (136) to travel to the photosensitive layer (130), wherein the transversal optical sensor (114) is further adapted to generate at least one transversal sensor signal indicative of the transversal position of the light beam (136) in the photosensitive layer (130); and - at least one evaluation device (140), wherein the evaluation device (140) is designed to generate at least one item of information on a transversal position of the object (112) by evaluating the at least one transversal sensor signal. Thereby, a simple and, still, efficient detector (110) for an accurate determining of a lateral position of at least one object (112) especially in a partition of the visible spectral range and/or infrared spectral range, in particular for wavelengths of 380 nm to 3000 nm, is provided.

公开(公告)号：WO2018138264A2

公开(公告)日：2018-08-02

申请号：PCT/EP2018/051962

申请日：2018-01-26

Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： KURZ, Georg ,  LOPEZ-CALLE, Eloisa ,  HEGEL, Ewelina ,  ROEDL, Josef ,  HOESS, Eva ,  KAUFMANN, Joerg ,  KIRCHENBAUER, Marisa

IPC: G01N33/543

Abstract: The present invention relates to a method for determining an analyte in a sample in an interaction assay, said method comprising contacting said sample with an interaction modulator, wherein said interaction modulator is selected from the list consisting of Poly-(4- styrenesulfonic acid-co-maleic acid) (PSSM), aminodextran, carboxymethyldextran, Poly-(2- acrylamido-2-methyl-1-propanesulfonic acid (PAMPS), triethylamine, triethanolamine, taurine, and dodecylsulfate. The present invention also relates to a method for determining an analyte in a sample in an interaction assay, said method comprising contacting said sample with an interaction modulator, wherein said interaction modulator is an enhancer of said interaction assay at low analyte concentrations and is a retarder of said interaction assay at high analyte concentrations and wherein said interaction modulator is Poly-(4-styrenesulfonic acid-co-maleic acid) (PSSM) and/or Polyacrylic acid (PAA). The present invention further relates to a kit comprising a detection agent specifically detecting an analyte in a sample and at least one interaction modulator of the present invention. Further, the present invention relates to devices and uses relating to the methods and kits of the present invention.

公开(公告)号：WO2018134388A2

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051405

申请日：2018-01-22

Applicant: ROCHE DIABETES CARE GMBH ,  F. HOFFMANN-LA ROCHE AG ,  ROCHE DIABETES CARE, INC.

Inventor： DECK, Frank ,  LIST, Hans ,  PETRICH, Wolfgang ,  HAASE, Katharina ,  KROEGER-LUI, Niels

IPC: A61B5/145 ,  A61B5/1459

Abstract: An implantable sensor element (110) for detecting at least one analyte in a sample of body fluid is disclosed. The sensor element (110) comprises at least one measurement chamber plate (114) adapted to receive the sample of bodily fluid. The sensor element (110) comprises at least one illumination source (118) designed to generate at least one illumination light beam (120) in at least one spectral range and to transmit the illumination light beam (120) to the measurement chamber plate (114) such that the illumination light beam (120) at least partially illuminates the measurement chamber plate(114). The measurement chamber plate (114) is designed to generate at least one reflection light beam (130) in response to the illumination by the illumination light beam (120) such that the reflection light beam (130) at least partially illuminates the sample of body fluid within the measurement chamber plate (114). The sensor element (110) comprises at least one optical detector (132) designed to detect at least one property of the reflection light beam (130) and to generate at least one sensor signal dependent on the presence of the analyte. The sensor element (110) furthermore comprises at least one control unit (126) designed to evaluate the sensor signal.