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公开(公告)号：WO2018211093A1
公开(公告)日：2018-11-22
申请号：PCT/EP2018/063159
申请日：2018-05-18
Applicant: BASF SE
Inventor： SCHROEDER, Hartwig , HAEFNER, Stefan , ZELDER, Oskar , WITTMANN, Christoph , LANGE, Anna Christine , HOFF, Birgit , BOEHMER, Nico
Abstract: The present invention relates to a process of producing an organic compound, the process comprising I) cultivating a genetically modified microorganism in a culture medium comprising sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK -gene, compared to the original microorganism that has not been genetically modified, and wherein the original microorganism belongs to the family Pasteurellaceae . The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.
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公开(公告)号：WO2015118111A2
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052523
申请日：2015-02-06
Applicant: BASF SE
Inventor： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith
CPC classification number: C12N15/52 , C12N1/02 , C12N9/0006 , C12N9/1029 , C12N9/1288 , C12N15/74 , C12P7/46 , C12Y101/01 , C12Y203/01054 , C12Y207/08031
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
Abstract translation: 本发明涉及与野生型相比，由wcaJ基因编码的酶的活性降低的修饰的微生物。 本发明还涉及生产有机化合物的方法和改性微生物的用途。
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公开(公告)号：WO2019122144A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086226
申请日：2018-12-20
Applicant: BASF SE
Inventor： HOFF, Birgit , BOEHMER, Nico , HAEFNER, Stefan , SCHROEDER, Hartwig , ZELDER, Oskar , WITTMANN, Christoph , SCHROER, Anna Christine
Abstract: The present invention relates to a process of producing an organic compound, the process comprising I) cultivating a genetically modified microorganism in a culture medium comprising at least one assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, II) recovering the organic compound from the fermentation broth obtained in process step I), wherein the genetically modified microorganism comprises A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the udhA-gene, compared to the original microorganism that has not been genetically modified, and wherein the original microorganism belongs to the family Pasteurellaceae. The present invention also relates to a genetically modified microorganism and to the use thereof for the fermentative production of an organic compound from at least one assimilable carbon source.
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Patent Agency Ranking
公开(公告)号：WO2015169919A1
公开(公告)日：2015-11-12
申请号：PCT/EP2015/060100
申请日：2015-05-07
Applicant: BASF SE
Inventor： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith
CPC classification number: C12N15/102 , C07K14/195 , C12N15/74 , C12N2510/02 , C12P7/46 , C12Y207/11
Abstract: The present invention relates to a modified microorganism. The present invention also relates to a method for producing an organic compount and to the use of modified microorganisms.
Abstract translation: 本发明涉及一种修饰微生物。 本发明还涉及一种生产有机化合物的方法和使用改性微生物。
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公开(公告)号：WO2015117916A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052048
申请日：2015-02-02
Applicant: BASF SE
Inventor： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith , LANGE, Anna , LYONS, Benjamin J. , LYONS, Thomas J. , DE CRECY, Eudes , HUGHES, Ewa
CPC classification number: C12N9/1205 , C12N15/52 , C12P7/46 , C12Y207/0104
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
Abstract translation: 本发明涉及与其野生型相比具有由pykA基因编码的酶的活性降低的修饰微生物。 本发明还涉及一种生产有机化合物的方法和使用改性微生物。
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6.发明申请PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF FINE CHEMICALS 审中-公开用于生产精细化学品的方法和重组微生物
公开(公告)号：WO2013093737A1
公开(公告)日：2013-06-27
申请号：PCT/IB2012/057312
申请日：2012-12-14
Applicant: BASF SE , WITTMANN, Christoph , KIND, Stefanie , BECKER, Judith , BASF (CHINA) COMPANY LIMITED , BASF SCHWEIZ AG
Inventor： WITTMANN, Christoph , KIND, Stefanie , BECKER, Judith
IPC: C12N1/21 , C12N15/31 , C12N15/52 , C12N15/77 , C12P13/08 , C12P1/04 , C12P7/46 , C12P11/00 , C12R1/15
CPC classification number: C12P13/08 , C12N9/93 , C12P13/001 , C12Y602/01004 , C12Y602/01005 , Y02P20/52
Abstract: Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β -lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as β -lysine, cadaverine or N-acetylcadaverine is further provided.
Abstract translation: 提供了具有失控的琥珀酰-CoA合成酶活性的重组微生物，以及用于产生赖氨酸，β-赖氨酸，尸胺或N-乙酰胆碱酯酶的用途。 还提供了包含与SEQ ID NO：51或53至少80％相同的氨基酸序列的重组多肽。 还提供使用所述重组微生物生产精细化学品的方法，特别是生产赖氨酸的方法或其衍生物，例如β-赖氨酸，尸胺或N-乙酰基尸胺。
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7.发明申请PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE 审中-公开用于生产CADAVERINE的工艺和重组微生物
公开(公告)号：WO2012114256A1
公开(公告)日：2012-08-30
申请号：PCT/IB2012/050763
申请日：2012-02-20
Applicant: BASF SE , WITTMANN, Christoph , KIND, Stefanie , BASF (CHINA) COMPANY LIMITED
Inventor： WITTMANN, Christoph , KIND, Stefanie
CPC classification number: C12P13/02 , C07K14/34 , C12N9/88 , C12N15/77 , C12P13/001
Abstract: Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.
Abstract translation: 提供了包含改善卡达司汀或N-乙酰基尸胺的生产的脱调形式的DNA分子以及用于产生微生物的重组DNA分子和多肽的重组微生物。 所述微生物包含细胞内赖氨酸脱羧酶活性和去调节的尸胺出口活性，或包含降低的尸胺出口活性和增强的N-乙酰胆固醇形成活性。 还提供了使用重组微生物生产尸胺N-乙酰基尸胺的方法。
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8.发明申请PRODUCTION PROCESS FOR FINE CHEMICALS USING MICROORGANISMS WITH REDUCED ISOCITRATE DEHYDROGENASE ACTIVITY 审中-公开使用具有降低的异烟肼脱氢酶活性的微生物的精细化学品的生产工艺
公开(公告)号：WO2009133114A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055146
申请日：2009-04-28
Applicant: BASF SE , HEROLD, Andrea , SCHRÖDER, Hartwig , JEONG, Weol Kyu , KLOPPROGGE, Corinna , ZELDER, Oskar , HAEFNER, Stefan , RICHTER, Ulrike , BECKER, Judith , WITTMANN, Christoph
Inventor： HEROLD, Andrea , SCHRÖDER, Hartwig , JEONG, Weol Kyu , KLOPPROGGE, Corinna , ZELDER, Oskar , HAEFNER, Stefan , RICHTER, Ulrike , BECKER, Judith , WITTMANN, Christoph
CPC classification number: C12P13/001 , C12N9/0006 , C12P13/02 , C12P13/08 , C12P13/12 , C12P13/20
Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
Abstract translation: 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。 所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。 此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。
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