公开(公告)号：WO2004048523A3

公开(公告)日：2005-02-24

申请号：PCT/US0337346

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS INC ,  MONIA BRETT P ,  DOBIE KENNETH W ,  PANASCI LAWRENCE

Inventor： MONIA BRETT P ,  DOBIE KENNETH W ,  PANASCI LAWRENCE

IPC: C12N5/02 ,  C12N15/113 ,  C12Q1/68 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04 ,  C12N15/88 ,  C12P19/34

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of Ku86. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Ku86. Methods of using these compounds for modulation of Ku86 expression and for diagnosis and treatment of disease associated with expression of Ku86 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节Ku86的表达。 组合物包含针对编码Ku86的核酸的寡核苷酸。 提供了使用这些化合物调节Ku86表达和用于诊断和治疗与Ku86表达相关的疾病的方法。

公开(公告)号：WO2004005461A3

公开(公告)日：2004-11-04

申请号：PCT/US0320309

申请日：2003-06-25

Applicant: ISIS PHARMACEUTICALS INC ,  BHANOT SANJAY ,  DOBIE KENNETH W

Inventor： BHANOT SANJAY ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C07H21/04 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C12N15/86 ,  C12P19/34

CPC classification number: C12N15/1136 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor 2. Methods of using these compounds for modulation of insulin-like growth factor 2 expression and for treatment of diseases associated with expression of insulin-like growth factor 2 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节胰岛素样生长因子2的表达。组合物包含靶向编码胰岛素样生长因子2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节 提供胰岛素样生长因子2表达和用于治疗与胰岛素样生长因子2的表达相关的疾病。

公开(公告)号：WO2004055162A3

公开(公告)日：2004-10-07

申请号：PCT/US0339436

申请日：2003-12-11

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: C07H21/04 ,  C12N15/113 ,  A61K48/00 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C07H21/00 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/01003 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.

Abstract translation: 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。

公开(公告)号：WO2004071407A2

公开(公告)日：2004-08-26

申请号：PCT/US2004002003

申请日：2004-02-06

Applicant: ISIS PHARMACEUTICALS INC ,  BHANOT SANJAY ,  COWSERT LEX M ,  WYATT JACQUELINE R ,  FREIER SUSAN M ,  MONIA BRETT P ,  BUTLER MADELINE M ,  MCKAY ROBERT ,  DOBIE KENNETH W

Inventor： BHANOT SANJAY ,  COWSERT LEX M ,  WYATT JACQUELINE R ,  FREIER SUSAN M ,  MONIA BRETT P ,  BUTLER MADELINE M ,  MCKAY ROBERT ,  DOBIE KENNETH W

IPC: A61K20060101 ,  A61K38/00 ,  A61K48/00 ,  C12N5/02 ,  C12N15/113 ,  A61K

CPC classification number: C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

Abstract translation: 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。

公开(公告)号：WO2004009018A3

公开(公告)日：2004-08-26

申请号：PCT/US0322422

申请日：2003-07-18

Applicant: ISIS PHARMACEUTICALS INC ,  COWSERT LEX M ,  DOBIE KENNETH W

Inventor： COWSERT LEX M ,  DOBIE KENNETH W

IPC: A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  A01N43/04 ,  A61K31/10

CPC classification number: C12N15/1138 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of PTPRM. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPRM. Methods of using these compounds for modulation of PTPRM expression and for treatment of diseases associated with expression of PTPRM are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节PTPRM的表达。 该组合物包含靶向编码PTPRM的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTPRM表达和治疗与PTPRM表达相关的疾病的方法。

公开(公告)号：WO2004046325A3

公开(公告)日：2004-07-15

申请号：PCT/US0336574

申请日：2003-11-14

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/01037 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of serine/threonine kinase 16. The compositions comprise oligonucleotides, targeted to nucleic acid encoding serine/threonine kinase 16. Methods of using these compounds for modulation of serine/threonine kinase 16 expression and for diagnosis and treatment of disease associated with expression of serine/threonine kinase 16 are provided.

Abstract translation: 提供了调节丝氨酸/苏氨酸激酶16表达的化合物，组合物和方法。所述组合物包含靶向编码丝氨酸/苏氨酸激酶16的核酸的寡核苷酸。使用这些化合物调节丝氨酸/苏氨酸激酶16表达的方法和 提供了与丝氨酸/苏氨酸激酶16表达相关的疾病的诊断和治疗。

公开(公告)号：WO2004048531A2

公开(公告)日：2004-06-10

申请号：PCT/US2003/037445

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS, INC. ,  DOBIE, Kenneth, W.

Inventor： DOBIE, Kenneth, W.

IPC: C12N

CPC classification number: C12N9/1205

Abstract: Compounds, compositions and methods are provided for modulating the expression of death-associated protein kinase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding death-associated protein kinase 1. Methods of using these compounds for modulation of death-associated protein kinase 1 expression and for diagnosis and treatment of disease associated with expression of death-associated protein kinase 1 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节死亡相关蛋白激酶1的表达。该组合物包含针对编码死亡相关蛋白激酶的核酸的寡核苷酸1.使用这些化合物调节死亡相关蛋白激酶1的方法 提供了与死亡相关蛋白激酶1表达相关的疾病的表达和诊断和治疗。

公开(公告)号：WO2004048526A3

公开(公告)日：2004-06-10

申请号：PCT/US2003/037383

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS, INC. ,  WARD, Donna, T. ,  DOBIE, Kenneth, W. ,  FREIER, Susan, M. ,  MARCUSSON, Eric, G.

Inventor： WARD, Donna, T. ,  DOBIE, Kenneth, W. ,  FREIER, Susan, M. ,  MARCUSSON, Eric, G.

IPC: C12Q1/68

Abstract: Compounds, compositions and methods are provided for modulating the expression of HIF1a and/or HIF2a. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIFlα and HIF2α. Methods of using these compounds for modulation of HIFlα and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIFlα and/or HIF2α are provided.

公开(公告)号：WO2004047750A2

公开(公告)日：2004-06-10

申请号：PCT/US2003/037405

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS. INC. ,  FREIER, Susan, M. ,  DOBIE, Kenneth, W.

Inventor： FREIER, Susan, M. ,  DOBIE, Kenneth, W.

IPC: A61K

CPC classification number: C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of Notch2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Notch2. Methods of using these compounds for modulation of Notch2 expression and for diagnosis and treatment of disease associated with expression of Notch2 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节Notch2的表达。 组合物包含针对编码Notch2的核酸的寡核苷酸。 提供了使用这些化合物调节Notch2表达和用于诊断和治疗与Notch2表达相关的疾病的方法。

公开(公告)号：WO2004047736A2

公开(公告)日：2004-06-10

申请号：PCT/US2003/037237

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS, INC. ,  BENNETT, Frank, C. ,  DEAN, Nicholas, M. ,  DOBIE, Kenneth, W.

Inventor： BENNETT, Frank, C. ,  DEAN, Nicholas, M. ,  DOBIE, Kenneth, W.

IPC: A61K

CPC classification number: C12N15/113 ,  A61K48/00 ,  C07H21/04 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of BCL2-associated athanogene. The compositions comprise oligonucleotides, targeted to nucleic acid encoding BCL2-associated athanogene. Methods of using these compounds for modulation of BCL2-associated athanogene expression and for diagnosis and treatment of disease associated with expression of BCL2-associated athanogene are provided.

Abstract translation: 提供了化合物，组合物和方法用于调节BCL2相关氨基酸的表达。 该组合物包含寡核苷酸，靶向编码BCL2相关基因的核酸。 提供了使用这些化合物调节与BCL2相关的动脉粥样硬化表达以及诊断和治疗与BCL2相关动脉粥样硬化表达相关的疾病的方法。