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    IMPLANT DEPOTS TO DELIVER GROWTH FACTORS TO TREAT OSTEOPOROTIC BONE
    82.
    发明申请
    IMPLANT DEPOTS TO DELIVER GROWTH FACTORS TO TREAT OSTEOPOROTIC BONE 审中-公开
    植入生长因子以治疗骨质疏松

    公开(公告)号：WO2007130930A2

    公开(公告)日：2007-11-15

    申请号：PCT/US2007/067862

    申请日：2007-05-01

    Applicant: WARSAW ORTHOPEDIC, INC. ,  MCKAY, William F.

    Inventor： MCKAY, William F.

    IPC: A61L27/22 ,  A61K9/00

    CPC classification number: A61L27/227 ,  A61K9/0024 ,  A61L27/24 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/604 ,  C08L89/06

    Abstract: The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

    Abstract translation: 本发明涉及用于最佳递送生长因子以治疗骨质疏松性骨的贮库植入物的设计和组成，因为这样的植入物被构造为圆柱（杆）或球形，并且具有天然或合成的聚合物支架 有或没有浸渍的磷酸钙颗粒。 仓库的密度高于典型的BMP海绵载体，以便于其植入和较慢释放生长因子。 支架使得其具有足够的孔隙度和孔径以促进整个骨结构中的生长因子接种和扩散，导致骨质疏松骨中骨矿物质密度增加。 此外，储库植入物的形状允许通过套管或大孔针进行输送。

    SPINAL CONSTRUCT SYSTEM
    87.
    发明申请
    SPINAL CONSTRUCT SYSTEM 审中-公开
    脊柱结构系统

    公开(公告)号：WO2006119158A3

    公开(公告)日：2006-12-28

    申请号：PCT/US2006016551

    申请日：2006-05-01

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61B17/70

    CPC classification number: A61B17/7044 ,  A61B17/7049 ,  A61B17/7055

    Abstract: Embodiments for a spinal construct system including a spinal fixation plate attachable to fixture element in end-to-end fashion with a coupling mechanism that axially and torsionally constrains the first and second rods to one another. In one form, the end to end attachment arrangement is aligned along a common axis of the rods. In another form, the axes of the rods are offset laterally relative to one another.

    Abstract translation: 用于脊柱构造系统的实施例包括脊柱固定板，所述脊柱固定板通过联接机构以端对端的方式附接到固定元件，所述联接机构轴向地且扭转地约束第一和第二杆彼此。 在一种形式中，端到端连接装置沿着杆的公共轴线对齐。 在另一种形式中，杆的轴线相对于彼此横向偏移。

    SPINAL CONSTRUCT SYSTEM
    88.
    发明申请
    SPINAL CONSTRUCT SYSTEM 审中-公开
    脊柱构造系统

    公开(公告)号：WO2006119158A2

    公开(公告)日：2006-11-09

    申请号：PCT/US2006/016551

    申请日：2006-05-01

    Applicant: SDGI HOLDINGS, INC. ,  MCKAY, William, F.

    Inventor： MCKAY, William, F.

    IPC: A61B17/70

    CPC classification number: A61B17/7044 ,  A61B17/7049 ,  A61B17/7055

    Abstract: Embodiments for a spinal construct system including a spinal fixation plate attachable to fixture element in end-to-end fashion with a coupling mechanism that axially and torsionally constrains the first and second rods to one another. In one form, the end to end attachment arrangement is aligned along a common axis of the rods. In another form, the axes of the rods are offset laterally relative to one another.

    Abstract translation: 一种脊柱构造系统的实施例，其包括一个以固定元件的端对端方式连接的脊柱固定板，该连接机构将第一和第二杆彼此轴向地和扭转地约束。 在一种形式中，端对端连接装置沿着杆的公共轴线对齐。 在另一种形式中，杆的轴线相对于彼此横向偏移。

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