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    BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS
    82.
    发明申请
    BARRIERS FOR BIOACTIVE AGENT-CONTAINING POLYMERIC COATINGS 审中-公开
    含有活性剂的聚合物涂层的屏障

    公开(公告)号：WO2004052420A3

    公开(公告)日：2004-07-22

    申请号：PCT/US0338788

    申请日：2003-12-05

    Applicant: SURMODICS INC ,  LAWIN LAURIE R ,  BOUCHA-RAYLE MICHELLE C ,  KLOKE TIMOTHY M

    Inventor： LAWIN LAURIE R ,  BOUCHA-RAYLE MICHELLE C ,  KLOKE TIMOTHY M

    IPC: A61K9/22 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

    CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

    Abstract: A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.

    Abstract translation: 适于定位在医疗装置上的含聚合物，含生物活性剂的涂层形式的第一表面和由另一种材料提供的第二表面之间的屏障，所述第二表面由定位在并置位置且优选可移动并置位置的另一材料提供到第一表面。 由嵌段共聚物或光衍生聚合物提供的阻挡层提供对聚合物组合物在制造，储存，递送或展开过程中的机械损伤和/或分层和/或装置在体内滞留的保护。 包括医疗装置（例如支架）和另一装置（例如周围护套或内部可膨胀气囊）的组合，在所述装置之间定位有所述类型的屏障。

    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    84.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 审中-公开
    用于提供表面涂层的试剂和方法

    公开(公告)号：WO2003055611A1

    公开(公告)日：2003-07-10

    申请号：PCT/US2002/041143

    申请日：2002-12-20

    Applicant: SURMODICS, INC. ,  CHAPPA, Ralph A. ,  STUCKE, Sean M. ,  AMOS, Richard A. ,  EVERSON, Terrence P. ,  CHUDZIC, Stephen J. ,  SWAN, Dale G. ,  DUQUETTE, Peter H.

    Inventor： CHAPPA, Ralph A. ,  STUCKE, Sean M. ,  AMOS, Richard A. ,  EVERSON, Terrence P. ,  CHUDZIC, Stephen J. ,  SWAN, Dale G. ,  DUQUETTE, Peter H.

    IPC: B05D1/36

    CPC classification number: B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a performed, and particularly a porous, polymeric substrate. The method includes the steps of a)- providing a porous support surface, b)- providing a nonpolymeric grafting reagent comprising a photoinitator group, c)- providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d)- applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    Abstract translation: 一种接枝试剂和相关方法，其以提供和/或保留所需性质如表面孔隙的方式使用试剂在支撑表面上形成聚合物层，特别是多孔载体表面。 试剂和方法可以用于提供具有所需性质的薄的，顺应的，均匀的未交联的涂层，其在所执行的，特别是多孔的聚合物基材的表面上。 该方法包括以下步骤：a。提供多孔载体表面，b-提供包含光引发剂基团的非聚合接枝试剂，c-在接枝试剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并且在激活光引发剂时聚合，并且以接枝试剂的方式和条件下将接枝试剂和单体施用到表面，并且在适合于用接枝剂涂覆表面的条件下并且在活化时使单体聚合到表面 的接枝试剂。

    METHOD FOR MAKING A SELF-ASSEMBLING MONOLAYER AND COMPOSITION
    86.
    发明申请
    METHOD FOR MAKING A SELF-ASSEMBLING MONOLAYER AND COMPOSITION 审中-公开

    公开(公告)号：WO2003008646A3

    公开(公告)日：2003-01-30

    申请号：PCT/US2001/022400

    申请日：2001-07-17

    Applicant: SURMODICS, INC.

    Inventor： GUIRE, Patrick, E. ,  TATON, Kristin, S.

    IPC: B05D1/18

    Abstract: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.

    SELF ASSEMBLING MONOLAYER COMPOSITIONS
    87.
    发明申请
    SELF ASSEMBLING MONOLAYER COMPOSITIONS 审中-公开
    自组装单层组合物

    公开(公告)号：WO03008646A2

    公开(公告)日：2003-01-30

    申请号：PCT/US0122400

    申请日：2001-07-17

    Applicant: SURMODICS INC

    Inventor： GUIRE PATRICK E ,  TATON KRISTIN S

    IPC: G01N33/53 ,  B05D1/18 ,  B05D3/06 ,  C12M1/40 ,  G01N33/543 ,  C12Q1/68

    CPC classification number: B82Y30/00 ,  B05D1/185 ,  B05D3/06 ,  B82Y40/00

    Abstract: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.

    Abstract translation: 用于在材料表面或合适的界面上提供稳定形式的自组装单层的表面涂料组合物，以及制备这种组合物的方法和使用这种组合物涂覆表面的方法，例如 作为可植入医疗装置的表面，以便为表面提供期望的性质。 该方法以基本上保持或改善SAM和表面本身的特性和/或性能的方式提供SAM到表面的共价附着。 通过使用一种或多种潜在反应性基团来实现共价连接，例如由表面和/或由SAM形成分子本身提供的。

    CROSSLINKABLE MACROMERS
    88.
    发明申请
    CROSSLINKABLE MACROMERS 审中-公开
    可交换MACROMERS

    公开(公告)号：WO2002100453A1

    公开(公告)日：2002-12-19

    申请号：PCT/US2001/018345

    申请日：2001-06-07

    Applicant: SURMODICS, INC.

    Inventor： CHUDZIK, Stephen, J. ,  CLAPPER, David, L.

    IPC: A61L27/34

    CPC classification number: A61L31/10 ,  A61L24/0031 ,  A61L27/34 ,  C08L89/06 ,  C08L5/00

    Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the corsslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

    Abstract translation: 一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。 大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个引发剂基团（例如聚合物 - 侧基引发剂基团）。 当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。 大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。 本发明的大分子单体系统可以以足以允许组织生长通过衔铁基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。 在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

    SOLID PHASE SYNTHESIS METHOD AND REAGENT
    89.
    发明申请
    SOLID PHASE SYNTHESIS METHOD AND REAGENT 审中-公开
    固相合成方法和试剂

    公开(公告)号：WO0166554A3

    公开(公告)日：2002-03-14

    申请号：PCT/US0103780

    申请日：2001-02-06

    Applicant: SURMODICS INC

    Inventor： SWANSON MELVIN J

    IPC: C12N15/09 ,  C07B61/00 ,  C07H15/12 ,  C07H21/00 ,  C07K1/04 ,  C08F20/58 ,  C08F220/54 ,  C08F220/56

    CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07K1/04 ,  C08F220/54 ,  C08F220/56

    Abstract: A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.

    Abstract translation: 适于涂覆在载体表面上的试剂组合物，以便为该表面提供高密度的反应性基团。 如此涂覆的表面可以用于任何合适的目的，并且特别适合用作固相合成载体表面。 合成载体表面又可用于重复和组合合成，例如多核苷酸，多肽和多糖的合成。 聚合物涂层可以用于提供增加的有效表面积，特别是在支撑表面的有效面积本身受到限制的情况下，如在硅晶片的表面上。 在这样做时，聚合物涂层提供了诸如反应性密度和表面积或体积之类的特性的最佳组合。

    ANCHORED DILATOR SYSTEM AND METHODS FOR SAME
    90.
    发明申请
    ANCHORED DILATOR SYSTEM AND METHODS FOR SAME 审中-公开

    公开(公告)号：WO2021126934A1

    公开(公告)日：2021-06-24

    申请号：PCT/US2020/065252

    申请日：2020-12-16

    Applicant: SURMODICS, INC.

    Inventor： SUTTON, Gregg ,  OLSON, Charles ,  GANSKE, Karl, V.

    IPC: A61M25/06 ,  A61M29/02 ,  A61B17/34 ,  A61B17/12 ,  A61B17/22 ,  A61B29/00 ,  A61M2029/025 ,  A61M2210/12

    Abstract: An anchored dilator includes a push tube having proximal and distal push tube portions. A dilator tip is coupled with the distal push tube portion and is configured for selectable coupling with a catheter. The dilator tip includes an anchor cuff having a cuff interface. The anchor cuff is configured to transition between a shuttle configuration having a shuttle profile and an anchored configuration having an anchored profile larger than the shuttle profile. A cuff operator assembly is configured to transition the anchor cuff between the anchored and shuttle configurations. The cuff operator assembly includes a cuff operator movably coupled with the dilator tip, and an operator shaft coupled with the cuff operator. The operator shaft extends toward the proximal push tube portion. Actuation of the cuff operator with the operator shaft transitions the anchor cuff between the shuttle configuration and the anchored configuration.

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