中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

571 records (took 0.016 seconds)

    WATER-SOLUBLE COMPOSITIONS OF BIOACTIVE LIPOPHILIC COMPOUNDS
    81.
    发明申请
    WATER-SOLUBLE COMPOSITIONS OF BIOACTIVE LIPOPHILIC COMPOUNDS 审中-公开
    生物活性化合物的水溶性组合物

    公开(公告)号：WO02062392A3

    公开(公告)日：2002-11-14

    申请号：PCT/CA0200115

    申请日：2002-01-31

    Applicant: CA NAT RESEARCH COUNCIL

    Inventor： BOROWY-BOROWSKI HENRYK ,  SIKORSKA-WALKER MARIANNA ,  WALKER P ROY

    IPC: A61K9/00 ,  A61K9/14 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/122 ,  A61K31/355 ,  A61K31/7048 ,  A61K35/60 ,  A61K36/18 ,  A61K47/12 ,  A61K47/28 ,  A61K47/30 ,  A61P31/10 ,  A61K47/14

    CPC classification number: A61K31/7048 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/146 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/047 ,  A61K31/122 ,  A61K31/355 ,  A61K47/28

    Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X-OOC-[(CH2)n-COO]m}p-Y (I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is alpha (+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

    Abstract translation: 包含亲水性化合物和通式为：（X-OOC - [（CH2）n-COO）m} pY（I）的增溶剂的水溶性组合物，其中：X为疏水部分的残基，Y为 亲水部分的残基，p为1或2，m为0或1，并且n为大于或等于0的整数。 亲脂性化合物优选选自水不溶性泛醌，泛醇，维生素，前维生素，多烯大环内酯抗生素及其混合物。 疏水部分优选为固醇或生育酚，亲水部分优选为聚亚烷基二醇。 在一些实施方案中，甾醇是胆固醇或谷甾醇，生育酚是α（+） - 生育酚，聚亚烷基二醇是平均分子量在400和1000之间的聚乙二醇或其甲基单醚，p等于1或2， m等于0或1，n是2和18之间的整数。

    A SUBSTANCE FOR THE USE IN A DIETARY SUPPLEMENTATION OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME
    90.
    发明申请
    A SUBSTANCE FOR THE USE IN A DIETARY SUPPLEMENTATION OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME 审中-公开
    用于膳食补充或用于制备治疗非胰岛素依赖性糖尿病的药物的物质，高血压和/或代谢综合征

    公开(公告)号：WO01056959A1

    公开(公告)日：2001-08-09

    申请号：PCT/DK2001/000075

    申请日：2001-02-01

    IPC: A61K38/00 ,  A61K31/015 ,  A61K31/045 ,  A61K31/19 ,  A61K31/352 ,  A61K31/7034 ,  A61K31/704 ,  A61K36/00 ,  A61K36/28 ,  A61K36/48 ,  A61K45/06 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  C07C13/64 ,  C07C13/68 ,  C07C61/35 ,  C07H15/24 ,  C07H15/256 ,  C07C61/29 ,  C07C62/32

    CPC classification number: A61K31/19 ,  A61K31/015 ,  A61K31/192 ,  A61K31/352 ,  A61K31/70 ,  A61K31/704 ,  A61K36/00 ,  A61K36/48 ,  A61K38/16 ,  A61K38/168 ,  A61K45/06 ,  C07C13/68 ,  C07C61/35 ,  C07C2603/86 ,  C07H15/256 ,  A61K2300/00

    Abstract: A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.

    Abstract translation: 一种物质，包括双环[3.2.1]辛烷的化学结构或用于膳食补充剂中的kaurene的化学结构或作为用于治疗非胰岛素依赖性糖尿病，高血压和/或 代谢综合征。 双环[3.2.1]辛烷独特的化学结构单独或在凯恩结构中提供了物质， 甜菊醇，异硫脲和甜菊苷，具有以血浆葡萄糖依赖性方式增强或增强胰岛素分泌的能力。 包括这些独特化学结构的物质还具有降低血液中胰高血糖素浓度和/或降低血压的能力，从而为非胰岛素依赖性糖尿病和/或高血压提供自我调节治疗系统。 在还包含大豆蛋白和/或大豆纤维和/或至少一种异黄酮的组合药物中，这些物质协同作用，并且这样的组合药物既预防性地也可直接用于例如治疗。 代谢综合征和肥胖症，并且由于自我调节作用，作为膳食补充剂广泛适用。

Patent Agency Ranking