公开(公告)号：WO2020106776A3

公开(公告)日：2020-05-28

申请号：PCT/US2019/062298

申请日：2019-11-19

Applicant: ARIMA GENOMICS, INC.

Inventor： SCHMITT, Anthony ,  TAN, Catherine ,  REID, Derek ,  DE LA TORRE, Chris ,  SELVARAJ, Siddarth

IPC: C12Q1/6806 ,  C12N15/10

Abstract: Provided herein are methods and compositions for preparing nucleic acids in samples that preserve spatial-proximal contiguity information. Samples include, but are not limited to, formalin-fixed paraffin-embedded (FFPE) samples, deeply formalin-fixed samples and samples that comprise protein: cfDNA complexes.

公开(公告)号：WO2019104034A1

公开(公告)日：2019-05-31

申请号：PCT/US2018/062005

申请日：2018-11-20

Applicant: ARIMA GENOMICS, INC.

Inventor： SELVARAJ, Siddarth ,  SCHMITT, Anthony ,  REID, Bret

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869

CPC classification number: C12N15/1065 ,  C12N15/1075 ,  C12N15/1093 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2535/122 ,  C12Q2563/179 ,  C12Q2563/159 ,  C12Q2565/514 ,  C12Q2523/101 ,  C12Q2563/149

Abstract: Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial- proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.

公开(公告)号：WO2017004612A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/040921

申请日：2016-07-04

Applicant: ARIMA GENOMICS, INC. ,  SELVARAJ, Siddarth ,  HEINTZMAN, Nathaniel ,  LAING, Christian, Edgar

Inventor： SELVARAJ, Siddarth ,  HEINTZMAN, Nathaniel ,  LAING, Christian, Edgar

IPC: C12P19/34 ,  C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/24

Abstract: The present disclosure relates to methods to deconvolute a mixture sample of genetic material from different origins or sources. The disclosed methods can be used in various applications, including, the non-invasive determination of a fetal genome, a fetal -ome (e.g. exome). or other targeted fetal locus from cell-free nucleic acids in maternal plasma or other body fluids; the determination of cancer-associated mutations from cell-free nucleic acids in a body fluid sample that contains a mixture of nucleic acids from normal cells and tumor cells; and quantification of donor cell contamination using a body fluid from a transplantation recipient to monitor and/or predict the outcome of a transplantation procedure.

Abstract translation: 本公开涉及从不同来源或来源对遗传物质的混合样品进行去卷积的方法。 所公开的方法可以用于各种应用，包括胎儿基因组，胎儿（例如外显子）的非侵入性测定。 或来自母体血浆或其他体液中的无细胞核酸的其它目标胎儿基因座; 确定体液样品中含有来自正常细胞和肿瘤细胞的核酸混合物的无细胞核酸的癌症相关突变; 以及使用来自移植接受者的体液来定量供体细胞污染来监测和/或预测移植手术的结果。

公开(公告)号：WO2020106776A2

公开(公告)日：2020-05-28

申请号：PCT/US2019/062298

申请日：2019-11-19

Applicant: ARIMA GENOMICS, INC.

Inventor： SCHMITT, Anthony ,  TAN, Catherine ,  REID, Derek ,  DE LA TORRE, Chris ,  SELVARAJ, Siddarth

IPC: C12Q1/6806 ,  C12N15/10 ,  C07H1/00 ,  C07H21/04 ,  C12N15/1003

Abstract: Provided herein are methods and compositions for preparing nucleic acids in samples that preserve spatial-proximal contiguity information. Samples include, but are not limited to, formalin-fixed paraffin-embedded (FFPE) samples, deeply formalin-fixed samples and samples that comprise protein: cfDNA complexes.

公开(公告)号：WO2020236851A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033666

申请日：2020-05-19

Applicant: ARIMA GENOMICS, INC.

Inventor： SCHMITT, Anthony ,  SELVARAJ, Siddarth ,  REID, Bret ,  MAC, Stephen ,  ZHOU, Xiang

IPC: C12Q1/6806

Abstract: Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information.