公开(公告)号：WO2020198487A1

公开(公告)日：2020-10-01

申请号：PCT/US2020/024982

申请日：2020-03-26

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： HA, Taekjip ,  LEE, Jong-Chan ,  MA, Ye

IPC: G02B21/00 ,  G01N21/64

Abstract: The present invention is directed toward a system and method for STED nanography, which reduces background noise. To remove background noise from a STED image, the polarization of the STED beam is altered from that used to obtain the original image. A polarized image is obtained. This polarized image can then be subtracted from the original image to remove noise inherent to the image.

公开(公告)号：WO2019023193A1

公开(公告)日：2019-01-31

申请号：PCT/US2018/043426

申请日：2018-07-24

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： SINGHALA, Mohit ,  ACHARYA, Soumyadipta

IPC: A61B5/08 ,  A61B5/103 ,  A61B5/113

CPC classification number: A61B5/1135 ,  A61B5/08 ,  A61B5/103 ,  A61B5/113 ,  A61B2503/045 ,  A61B2562/12

Abstract: The present invention is directed to a sensing modality for measurement of vital signs, particularly in neonates, using inkjet-printed sensors in order to create a low cost and computationally less-intensive monitor. The invention incorporates the use of sensors specifically design to measure abdominal flex as a measure of their respiration rate. Neonates in particular exhibit abdominal flex during respiration. The flex sensor can be coupled with other off-the-shelf sensors or sensors made using same principles, connected together to a phone through the AUX port of a cell phone or other device for data collection and processing. The sensor can also be configured to communicate wirelessly with a computing device, such as a smartphone.

公开(公告)号：WO2018132802A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013771

申请日：2018-01-16

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAOUD, Yassine ,  CANTO-SOLER, Maria ,  ETIENNE-CUMMINGS, Ralph ,  SINGH, Mandeep ,  LUTTY, Gerard

IPC: A61F2/14 ,  C12N5/071 ,  C12N5/074

Abstract: An embodiment in accordance with the present invention includes 3D retinal tissue generated in a laboratory. The 3D retinal tissue is coupled to an engineered microelectronic chip. The 3D retinal tissue together with the engineered microelectronic chip enable retinal regeneration and vision restoration for patients with retinal cell damage. The engineered microelectronic chip sends electrical signals to specific parts of the 3D retinal tissue for stimulating and recording both the 3D retinal tissue and the cells in the patient's own retina. The chip may be absorbable or removable once connection is made between the 3D retinal tissue and the patient's own remaining retinal tissue.

公开(公告)号：WO2018067684A1

公开(公告)日：2018-04-12

申请号：PCT/US2017/055108

申请日：2017-10-04

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： SARIA, Suchi ,  JINHUA MA, Andy ,  REITER, Austin

IPC: A61B5/11 ,  G08B21/04 ,  G16H30/00

CPC classification number: A61B5/1128 ,  A61B5/1115 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/1171 ,  G06K9/00348 ,  G06K9/00369 ,  G06T7/0012 ,  G06T7/215 ,  G08B21/04 ,  G08B21/0415 ,  G08B21/043 ,  G08B21/0476 ,  G16H30/20 ,  G16H30/40 ,  G16H40/63

Abstract: An embodiment in accordance with the present invention includes a technology to continuously measure patient mobility automatically, using sensors that capture color and depth images along with algorithms that process the data and analyze the activities of the patients and providers to assess the highest level of mobility of the patient. An algorithm according to the present invention employs the following five steps: 1) analyze individual images to locate the regions containing every person in the scene (Person Localization), 2) for each person region, assign an identity to distinguish 'patient' vs. 'not patient' (Patient Identification), 3) determine the pose of the patient, with the help of contextual information (Patient Pose Classification and Context Detection), 4) measure the degree of motion of the patient (Motion Analysis), and 5) infer the highest mobility level of the patient using the combination of pose and motion characteristics (Mobility Classification).

Abstract translation: 根据本发明的实施例包括一种技术，其使用捕获颜色和深度图像的传感器以及处理数据和分析患者和提供者的活动的算法来自动连续地测量患者移动性 以评估患者的最高流动性。 根据本发明的算法采用以下五个步骤：1）分析各个图像以定位包含场景中每个人的区域（人本地化），2）针对每个人区域，分配身份以区分“患者”与 '不耐心'（患者识别），3）借助上下文信息（患者姿态分类和上下文检测）确定患者的姿势，4）测量患者的运动程度（运动分析），以及5 ）使用姿势和运动特征（移动性分类）的组合来推断患者的最高移动性水平。

公开(公告)号：WO2017209821A2

公开(公告)日：2017-12-07

申请号：PCT/US2017/022005

申请日：2017-03-13

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： GAGNON, Zachary ,  MAVROGIANNIS, Nicholas

CPC classification number: G01N27/026 ,  B01L3/50273 ,  B01L2300/0636 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N27/447

Abstract: An embodiment in accordance with the present invention is directed to a non-optical, label-free microfluidic biosensor utilizing an electrical liquid interface between two co-flowing liquids - one with a higher conductivity and one with a higher dielectric constant. The analyte-of-interest is in one solution while the receptor is in the adjacent stream. The electric interface acts as a substrate, when an alternating current electric field is applied perpendicularly across the interface, liquid displacement occurs which is frequency dependent. When a reaction occurs at the interface, it alters the electrical properties of the electrical interface, altering the frequency dependent liquid motion, which is then monitored by impedance spectroscopy downstream.

Abstract translation: 根据本发明的实施方式涉及利用两种共流液体之间的电液界面的非光学无标记微流体生物传感器，一种具有较高电导率，一种具有 更高的介电常数。 目标分析物处于一种溶液中，而受体位于相邻的物流中。 当交流电场垂直地施加在界面上时，电接口用作衬底，发生取决于频率的液体位移。 当界面处发生反应时，它会改变电气界面的电气特性，改变频率相关的液体运动，然后通过阻抗谱下游进行监测。

公开(公告)号：WO2017143161A1

公开(公告)日：2017-08-24

申请号：PCT/US2017/018330

申请日：2017-02-17

Applicant: LUCIANO, Mark

Inventor： LUCIANO, Mark

IPC: A61M25/00 ,  A61M1/00 ,  A61B5/00

CPC classification number: A61B5/00 ,  A61M1/0058 ,  A61M27/006

Abstract: The present disclosure relates generally to controlling a volume of fluid within a portion of a patient's body. For example, the present disclosure can relate to the addition or removal of cerebral spinal fluid (CSF) from a portion of the patient's brain. The amount of fluid can be controlled by a system that includes a dual chamber probe and a volume control. One channel can include a drain element to drain the fluid from the portion of a patient's body. The other channel can include a volume changing element to facilitate the drainage of the fluid by changing a volume of the portion of the patient's body. The volume changing element can be coupled to a volume control, which can control the change of the volume of the portion of the patient's body (e.g., based on passive oscillation or active oscillation).

Abstract translation: 本公开总体上涉及控制患者身体的一部分内的流体体积。 例如，本公开可涉及从患者脑部的一部分添加或除去脑脊液（CSF）。 流体的数量可以通过包括双室探头和音量控制的系统进行控制。 一个通道可以包括排出元件以从患者身体的一部分排出流体。 另一个通道可以包括体积改变元件，以通过改变患者身体部分的体积来促进流体的排出。 体积改变元件可以耦合到音量控制器，该音量控制器可以控制病人身体部分的体积的改变（例如，基于被动振荡或主动振荡）。

公开(公告)号：WO2016073814A1

公开(公告)日：2016-05-12

申请号：PCT/US2015/059386

申请日：2015-11-06

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： BRUPBACHER, Michael ,  ZHANG, Dajie ,  NAGLE, Dennis

IPC: C23C4/00 ,  C23C4/06 ,  C23C4/08 ,  C23C4/10 ,  C23C24/00 ,  C23C24/08

CPC classification number: C23C4/134 ,  C23C4/08 ,  C23C4/11 ,  C23C4/18 ,  C23C8/02 ,  C23C8/08 ,  C23C8/20 ,  C23C8/24 ,  C23C18/08 ,  C23C24/04

Abstract: The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. Refractory coatings can be formed from refractory metal, metal oxide, or metal/metal oxide composite refractory coating precursor of the 9 refractory metals encompassed by groups 4-6 and periods 4-6 of the periodic table; non-metallic elements (e.g. Si & B) and their oxides (i.e. SiO 2 & B 2 O 3 ) are also pertinent. The conversion of the refractory coating precursor to refractory carbide, nitride or boride is achieved via carburization, nitridization, or boridization in the presence of carbon-containing (e.g. CH 4 ), nitrogen containing (e.g. NH 3 ), and boron-containing (e.g. B 2 H 6 ) gaseous species. Any known technique of applying the refractory coating precursor can be used. The porosity of resultant refractory coatings is controlled through compositional manipulation of composite refractory coating precursors.

Abstract translation: 本发明涉及不使用粘合剂形成难熔碳化物，氮化物和硼化物涂层的方法。 本发明涉及产生受控孔隙度的耐火涂层的方法。 耐火涂层可由难熔金属，金属氧化物或金属/金属氧化物复合材料耐火涂层前体形成，这些前体包括元素周期表第4-6组和第4-6周期的9种难熔金属; 非金属元素（例如Si＆B）及其氧化物（即SiO 2和B 2 O 3）也是相关的。 在含碳（如CH4），含氮（如NH3）和含硼（如B2H6）的存在下，耐火涂层前体转化为难熔碳化物，氮化物或硼化物可以通过渗碳，氮化或硼化来实现， 气态物种。 可以使用施加耐火涂层前体的任何已知技术。 通过复合耐火涂层前体的组合操作来控制所得耐火涂层的孔隙率。

公开(公告)号：WO2016022215A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/036394

申请日：2015-06-18

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： WANG, Aaron ,  AVALLONE, John ,  GUYTON, David

IPC: A61B3/12 ,  A61B3/00 ,  A61B5/00

CPC classification number: A61B3/12 ,  A61B3/0083

Abstract: The present invention is directed to an indirect ophthalmoscopic system for imaging of the ocular fundus including a headband configured to hold a digital imaging device and a plus eyepiece lens in front of an eye of the examiner, with the plus eyepiece lens positioned in between the digital imaging device and the examiner's eye, such that the examiner is focused upon the display of the digital imaging device. The aperture of the digital imaging device receives light reflected from the ocular fundus of the patient's eye, emanating from the patient's pupil. The examiner examines the patient and composes the image of the ocular fundus directly in the display screen. In this way, what the examiner sees is captured by the digital imaging device. Stereoscopic imagery is obtained by optical means that create side-by-side virtual images of the aperture of the digital imaging device within the pupil of the eye.

Abstract translation: 本发明涉及一种用于眼底成像的间接眼底镜检查系统，包括头带，其构造成将数字成像装置和加上目镜透镜保持在检查者的眼睛之前，加目镜透镜位于数字 成像装置和检查者的眼睛，使得检查者集中在数字成像装置的显示器上。 数字成像装置的孔径从患者的瞳孔接收从患者眼睛的眼底反射的光。 检查者检查患者，并直接在显示屏幕上组成眼底的图像。 这样，检查者看到的是数字成像设备。 通过光学手段获得立体图像，其在眼睛的瞳孔内产生数字成像装置的孔径的并排虚拟图像。

公开(公告)号：WO2015161155A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/026301

申请日：2015-04-17

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  KENNEDY KRIEGER INSTITUTE, INC.

Inventor： QIN, Qin ,  VAN ZIJL, Peter

IPC: G01R33/24 ,  G01R33/36

CPC classification number: G01R33/56308 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/14542 ,  G01R33/5635 ,  G01R33/56518 ,  G01R33/56563 ,  G01R33/5659

Abstract: The present invention is directed to a system and method for magnetic resonance imaging including an extended Fourier transform-based velocity-selective pulse train design with a pair of refocusing pulses within each velocity encoding step and accompanying phase cycling between different velocity encoding steps. The present invention is robust to B0/B1 field inhomogeneity and eddy current effects. The utility of this technique, through a velocity-selective inversion pulse, is demonstrated in a 2D velocity-selective arterials spin labeling study, which shows a reasonable agreement in CBF quantification with the standard PCASL method.

Abstract translation: 本发明涉及一种用于磁共振成像的系统和方法，其包括在每个速度编码步骤内具有一对重聚焦脉冲的扩展的基于傅立叶变换的速度选择性脉冲串设计以及不同速度编码步骤之间的相位循环。 本发明对B0 / B1场不均匀性和涡流效应是鲁棒的。 在2D速度选择性动脉旋转标记研究中证明了这种技术通过速度选择反转脉冲的效用，其在标准PCASL方法中显示了CBF定量中的合理一致性。

公开(公告)号：WO2015157485A1

公开(公告)日：2015-10-15

申请号：PCT/US2015/025031

申请日：2015-04-09

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： IBRAHIM, Zuhaib ,  MAO, Hai-Quan ,  KRICK, Kellin ,  MARTIN, Russell ,  BRANDACHER, Gerald

IPC: A61L27/14 ,  A61L27/24 ,  A61L27/50

CPC classification number: A61L27/18 ,  A61L27/26 ,  A61L27/50 ,  A61L27/56 ,  A61L2400/12 ,  A61L2430/32 ,  D01D5/003 ,  D01F8/14 ,  D10B2509/00 ,  C08L67/04 ,  C08L89/06

Abstract: The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 µm thick with pores smaller than 25 µm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

Abstract translation: 本发明涉及纳米纤维包裹物的装置和方法，以最小化神经组织的充气和瘢痕形成并使营养物质的运输最大化。 更具体地，本发明涉及由生物相容性材料制备的新型半渗透纳米纤维结构。 纳米纤维构造物应用于端对端吻合术后的神经修复部位周围。 纳米纤维构造物是多孔的，由使用静电纺丝法制备的随机取向的纳米纤维构成。 纳米纤维结构体具有约50-100μm厚的孔，孔小于25μm。 纳米纤维结构防止炎症细胞迁移到神经分支部位，同时仍然允许生长因子和必需营养素的扩散。 纳米纤维结构允许增强神经再生和最佳功能结果。