公开(公告)号：WO2018093950A1

公开(公告)日：2018-05-24

申请号：PCT/US2017/061871

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  WHITE, Nicole S. ,  ZINGERMAN, Joel P. ,  TEREFE, Hibreniguss ,  GHEBRE-SELLASSIE, Isaac

IPC: A61K31/445 ,  C07D213/55 ,  C07D295/182

Abstract: Provided herein are pharmaceutical formulations comprising a monoacylglycerol lipase (MAGL) inhibitor, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

公开(公告)号：WO2017059135A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/054541

申请日：2016-09-29

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  NIPHAKIS, Micah ,  JONES, Todd K.

IPC: C07D233/72 ,  A61K31/496 ,  A61K31/551 ,  C07D233/00 ,  C07D233/40 ,  C07D241/04

CPC classification number: C07D233/86

Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions of said inhibitors, and methods of their use for the treatment of disease.

Abstract translation: 本文提供的是脂蛋白相关磷脂酶A2（Lp-PLA2）抑制剂，所述抑制剂的药物组合物及其用于治疗疾病的方法。

公开(公告)号：WO2015179563A3

公开(公告)日：2015-11-26

申请号：PCT/US2015/031838

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： CRAVATT, Benjamin, F. ,  COGNETTA, Armand, B. ,  HULCE, Jonathan, J. ,  NIPHAKIS, Micah, J. ,  GRICE, Cheryl, A. ,  JONES, Todd, K.

IPC: C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/4439 ,  A61K31/4985

Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.

公开(公告)号：WO2020056105A9

公开(公告)日：2020-03-19

申请号：PCT/US2019/050771

申请日：2019-09-12

Applicant: CELGENE CORPORATION ,  ABIDE THERAPEUTICS, INC.

Inventor： HUANG, Lianfeng ,  TSOU, Nancy ,  WHITE, Nicole, Suzanne ,  XU, Jun ,  ZHANG, Qun

IPC: C07D401/12 ,  A61K31/496 ,  A61P25/04

Abstract: Provided herein are crystalline forms of ( R )-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of ( R )-5-carbamoylpyridin-3-yl-2-methyl-4-(3- (trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.

公开(公告)号：WO2018217809A1

公开(公告)日：2018-11-29

申请号：PCT/US2018/033964

申请日：2018-05-22

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  WEBER, Olivia D. ,  BUZARD, Daniel J. ,  SHAGHAFI, Michael B. ,  WIENER, John J. M. ,  CISAR, Justin S. ,  DUNCAN, Katharine K.

IPC: A61K31/415 ,  A61K31/4155 ,  A61K31/495 ,  C07D247/00 ,  C07D401/12 ,  C07D403/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：WO2018169880A1

公开(公告)日：2018-09-20

申请号：PCT/US2018/022049

申请日：2018-03-12

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  CISAR, Justin S. ,  DUNCAN, Katharine K. ,  FENG, Yu ,  WIENER, John J. M. ,  WEBER, Olivia D.

IPC: A61K31/497 ,  C07D295/205 ,  C07D401/02 ,  C07D471/10

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.

公开(公告)号：WO2018053447A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/052106

申请日：2017-09-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  BUZARD, Daniel J. ,  SHAGHAFI, Michael B. ,  WEBER, Olivia D.

IPC: C07D295/096 ,  A61K31/495

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Abstract translation: 本文提供哌嗪氨基甲酸酯和包含所述化合物的药物组合物。 主题化合物和组合物可用作MAGL和/或ABHD6的调节剂。 此外，主题化合物和组合物可用于治疗疼痛。

公开(公告)号：WO2017087854A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062862

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： WEBER, Olivia D. ,  SHAGHAFI, Michael B. ,  GRICE, Cheryl A. ,  JONES, Todd K.

IPC: A61K31/4155 ,  A61K35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06

CPC classification number: C07D401/12 ,  A61K35/00 ,  C07D231/38 ,  C07D231/40 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/08 ,  C07D491/107 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

Abstract translation: 本文提供了包含所述化合物的吡唑化合物和药物组合物。 主题化合物和组合物可用作MAGL和/或ABHD6的调节剂。 此外，主题化合物和组合物可用于治疗例如疼痛。

公开(公告)号：WO2015179563A2

公开(公告)日：2015-11-26

申请号：PCT/US2015031838

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS INC ,  SCRIPPS RESEARCH INST

Inventor： CRAVATT BENJAMIN F ,  COGNETTA ARMAND B ,  HULCE JONATHAN J ,  NIPHAKIS MICAH J ,  GRICE CHERYL A ,  JONES TODD K

IPC: C07D401/12 ,  A61K31/4439 ,  A61K31/4985 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D487/04 ,  C12Q1/34

Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.

Abstract translation: 本文提供了N-羟基双环乙内酰脲氨基甲酸酯和包含所述化合物的药物组合物。 主题化合物和组合物可用作丝氨酸水解酶的调节剂。 此外，本发明化合物和组合物可用于治疗癌症，疼痛，糖尿病，肥胖/代谢综合征，癫痫，创伤性脑损伤和炎症中的一种或多种。

公开(公告)号：WO2019046330A1

公开(公告)日：2019-03-07

申请号：PCT/US2018/048388

申请日：2018-08-28

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： GRICE, Cheryl A. ,  WEBER, Olivia D. ,  BUZARD, Daniel J. ,  SHAGHAFI, Michael B.

IPC: A61K31/27 ,  A61K31/435 ,  A61K31/438 ,  C07D295/205 ,  C07D403/04 ,  C07D471/10

Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.