Abstract:
A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises an alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide or both, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.
Abstract:
A bone dust collection device includes a bone dust collection structure defining a longitudinal axis and having a proximal end and a distal end. The bone dust collection structure has a transverse plate member connected at or in the vicinity of the proximal end to a cylindrical wall defining an aperture at the distal end for receiving and collecting bone dust. The aperture extends proximally and includes a filtration member disposed therein. The filtration member causes at least partial separation of fluid from the bone dust via the fluid passing proximally through the filtration member. The bone dust collection structure enables removal of bone dust collected therein. A method of collecting an anatomical specimen includes generating an anatomical specimen in particulate form at a surgical site of a subject; collecting the particulate accumulated in the collection device; and packing the collected particulate into a region of interest in the subject.
Abstract:
An adjustable spinal implant device, comprising: a sliding portion provided with a tongue; and, a non-sliding portion provided with a slot adapted for receipt of the tongue; wherein the tongue is slidably and rotatably positioned within the slot.
Abstract:
An adjustable spinal implant device, comprising: a sliding portion provided with a tongue; and, a non-sliding portion provided with a slot adapted for receipt of the tongue; wherein the tongue is slidably and rotatably positioned within the slot.
Abstract:
Masked and controlled ion implants, coupled with annealing or etching are used in CVD formed single crystal diamond to create structures for both optical applications, nanoelectromechanical device formation, and medical device formation. Ion implantation is employed to deliver one or more atomic species into and beneath the diamond growth surface in order to form an implanted layer with a peak concentration of atoms at a predetermined depth beneath the diamond growth surface. The composition is heated in a non-oxidizing environment under suitable conditions to cause separation of the diamond proximate the implanted layer. Further ion implants may be used in released structures to straighten or curve them as desired. Boron doping may also be utilized to create conductive diamond structures.
Abstract:
The present disclosure relates to a method and device for removing solid matter from a brain and controlling bleeding associated with the removal of the matter. The method involves securing a cranial anchor to a region of the skull in which an opening has been created to ex- pose brain matter and introducing through a passage defined by the anchor a channel member that displaces brain tissue and exposes the solid matter. After removing the solid matter, a flowable hemostat is introduced into the cavity created by removal of the matter. A balloon introduced into the working channel is then inflated to compress the hemostat against the wall of the cavity to control bleeding from blood vessels around the cavity. The device includes a cranial anchor (12), a channel member (14) defining a working channel, an optional remov- able trocar, and a catheter (44) for introducing the hemostat and the inflatable balloon into the cavity.
Abstract:
The invention provides a method of treating degenerative disc disease and discogenic pain by disposing a hydrogel tissue sealant within the intervertebral disc, where the hydrogel fills voids and tears in the annulus fibrosus and replaces leaked material from the nucleus pulposus. The hydrogel is formed in situ from a substantially liquid premix, which can be emplaced with a syringe needle or a catheter into the intervertebral disc, where it forms the hydrogel by gelation. The hydrogel can also include a therapeutic or a protective material, or a radiopaque or MRI-active agent to aid in visualization.
Abstract:
The invention provides a method of treating degenerative disc disease and discogenic pain by disposing a hydrogel tissue sealant within the intervertebral disc, where the hydrogel fills voids and tears in the annulus fibrosus and replaces leaked material from the nucleus pulposus. The hydrogel is formed in situ from a substantially liquid premix, which can be emplaced with a syringe needle or a catheter into the intervertebral disc, where it forms the hydrogel by gelation. The hydrogel can also include a therapeutic or a protective material, or a radiopaque or MRI-active agent to aid in visualization.
Abstract:
An electrolytic cell (125) includes a container for holding an electrolyte (123). A conductively doped single crystal diamond anode electrode (110) is positioned to be disposed within the electrolyte (123), as is a conductive cathode electrode (120). Conductors are coupled to the electrodes for coupling to a power supply (130). An electrolyte inlet (150) and an electrolyte outlet (155) are coupled to the container for causing electrolyte (123) to flow past the electrodes. The anode electrode (110) is downstream from the cathode (120) electrode in one embodiment, such that an electrolyte (123) comprising water is purified by generation of oxygen and/or ozone.
Abstract:
A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises an alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide or both, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.