公开(公告)号：WO1990015144A1

公开(公告)日：1990-12-13

申请号：PCT/US1990003125

申请日：1990-06-01

Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  TIMBERLAKE, William, E. ,  ADAMS, Thomas, E. ,  MIRABITO, Peter, M.

Inventor： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

IPC: C12N15/80

CPC classification number: C12N15/80

Abstract: The subject methods and compositions are directed to regulating the growth and differentiation of microorganisms. In particular, disclosed is the DNA sequence for a regulatory gene controlling growth and development of the fungus Aspergillus nidulans and the amino acid sequence for the protein encoded by the gene. Also disclosed is an A. nidulans strain that permits inducible transcription of the gene in vegetative cells. A method is presented for the mis-scheduled expression of the gene which induces abortive differentiation.

Abstract translation: 本发明的方法和组合物旨在调节微生物的生长和分化。 特别地，公开了控制真菌构巢曲霉生长发育的调控基因的DNA序列和由该基因编码的蛋白质的氨基酸序列。 还公开了构巢曲霉菌株，其允许基因在营养细胞中的诱导型转录。 提出了诱导流产分化的基因的错排列表达的方法。

公开(公告)号：WO2011035036A1

公开(公告)日：2011-03-24

申请号：PCT/US2010/049136

申请日：2010-09-16

Applicant: ETHICON ENDO-SURGERY, INC. ,  DLUGOS, Daniel, F. ,  ADAMS, Thomas, E. ,  BYRUM, Randal, T. ,  BORK, Toralf ,  CHEN, Christine, H. ,  CONLON, Sean, P. ,  CRIVELLI, Rocco ,  GARNER, Dean, L. ,  GINGGEN, Alec ,  KRUMANAKER, David, T. ,  MARCOTTE, Amy, L. ,  NALAGATLA, Anil, K. ,  SMITH, Bret, W. ,  SWAYZE, Jeffrey, S. ,  TIMM, Richard, W.

Inventor： DLUGOS, Daniel, F. ,  ADAMS, Thomas, E. ,  BYRUM, Randal, T. ,  BORK, Toralf ,  CHEN, Christine, H. ,  CONLON, Sean, P. ,  CRIVELLI, Rocco ,  GARNER, Dean, L. ,  GINGGEN, Alec ,  KRUMANAKER, David, T. ,  MARCOTTE, Amy, L. ,  NALAGATLA, Anil, K. ,  SMITH, Bret, W. ,  SWAYZE, Jeffrey, S. ,  TIMM, Richard, W.

IPC: A61F5/00 ,  A61F2/00

CPC classification number: A61F5/003 ,  A61F2/0036 ,  A61F5/0053 ,  A61F5/0056 ,  A61F5/0059

Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism (312) is provided for the tension element.

Abstract translation: 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 设置张力元件（32）以在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张紧元件控制由细长构件施加的抵抗患者身体器官或管道的张力。 为张力元件提供释放机构（312）。

公开(公告)号：WO2011035023A3

公开(公告)日：2011-07-28

申请号：PCT/US2010049120

申请日：2010-09-16

Applicant: ETHICON ENDO SURGERY INC ,  DLUGOS DANIEL F ,  ADAMS THOMAS E ,  BYRUM RANDAL T ,  CONLON SEAN P ,  CRIVELLI ROCCO ,  GARNER DEAN L ,  GINGGEN ALEC J ,  HABERSTICH WELLS D ,  HUEIL GEOFFREY C ,  KORVICK DONNA L ,  KRUMANAKER DAVID T ,  LESSEK TIMOTHY P ,  MARCOTTE AMY L ,  MESSERLY JEFFREY D ,  MOORE KYLE P ,  MUMAW DANIEL J ,  NALAGATLA ANIL K ,  ORTIZ MARK S ,  SHELTON FREDERICK E IV ,  SMITH BRET W ,  SWAYZE JEFFREY S ,  SWINDON PATRICK J ,  THOMPSON ERIC W ,  TSONTON MARK ,  WEANER LAUREN S ,  WIDENHOUSE CHRISTOPHER W ,  WOODRUFF SCOTT A

Inventor： DLUGOS DANIEL F ,  ADAMS THOMAS E ,  BYRUM RANDAL T ,  CONLON SEAN P ,  CRIVELLI ROCCO ,  GARNER DEAN L ,  GINGGEN ALEC J ,  HABERSTICH WELLS D ,  HUEIL GEOFFREY C ,  KORVICK DONNA L ,  KRUMANAKER DAVID T ,  LESSEK TIMOTHY P ,  MARCOTTE AMY L ,  MESSERLY JEFFREY D ,  MOORE KYLE P ,  MUMAW DANIEL J ,  NALAGATLA ANIL K ,  ORTIZ MARK S ,  SHELTON FREDERICK E IV ,  SMITH BRET W ,  SWAYZE JEFFREY S ,  SWINDON PATRICK J ,  THOMPSON ERIC W ,  TSONTON MARK ,  WEANER LAUREN S ,  WIDENHOUSE CHRISTOPHER W ,  WOODRUFF SCOTT A

IPC: A61F5/00 ,  A61F2/00

CPC classification number: A61F5/0053 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0033 ,  A61F5/0056 ,  A61F5/0059

Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Abstract translation: 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 细长构件具有可压缩的腹侧表面和基本刚性的背侧周边，其中细长构件包括沿腹侧面定位的流体囊。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张力元件控制由细长构件施加的抗张力抵靠患者身体器官或管道的张力。 还公开了替代实施例。

公开(公告)号：WO2011035023A2

公开(公告)日：2011-03-24

申请号：PCT/US2010/049120

申请日：2010-09-16

Applicant: ETHICON ENDO-SURGERY, INC. ,  DLUGOS, Daniel, F. ,  ADAMS, Thomas, E. ,  BYRUM, Randal, T. ,  CONLON, Sean, P. ,  CRIVELLI, Rocco ,  GARNER, Dean, L. ,  GINGGEN, Alec, J. ,  HABERSTICH, Wells, D. ,  HUEIL, Geoffrey, C. ,  KORVICK, Donna, L. ,  KRUMANAKER, David, T. ,  LESSEK, Timothy, P. ,  MARCOTTE, Amy, L. ,  MESSERLY, Jeffrey, D. ,  MOORE, Kyle, P. ,  MUMAW, Daniel, J. ,  NALAGATLA, Anil, K. ,  ORTIZ, Mark, S. ,  SHELTON, Frederick, E., IV. ,  SMITH, Bret, W. ,  SWAYZE, Jeffrey, S. ,  SWINDON, Patrick, J. ,  THOMPSON, Eric, W. ,  TSONTON, Mark ,  WEANER, Lauren, S. ,  WIDENHOUSE, Christopher, W. ,  WOODRUFF, Scott, A.

Inventor： DLUGOS, Daniel, F. ,  ADAMS, Thomas, E. ,  BYRUM, Randal, T. ,  CONLON, Sean, P. ,  CRIVELLI, Rocco ,  GARNER, Dean, L. ,  GINGGEN, Alec, J. ,  HABERSTICH, Wells, D. ,  HUEIL, Geoffrey, C. ,  KORVICK, Donna, L. ,  KRUMANAKER, David, T. ,  LESSEK, Timothy, P. ,  MARCOTTE, Amy, L. ,  MESSERLY, Jeffrey, D. ,  MOORE, Kyle, P. ,  MUMAW, Daniel, J. ,  NALAGATLA, Anil, K. ,  ORTIZ, Mark, S. ,  SHELTON, Frederick, E., IV. ,  SMITH, Bret, W. ,  SWAYZE, Jeffrey, S. ,  SWINDON, Patrick, J. ,  THOMPSON, Eric, W. ,  TSONTON, Mark ,  WEANER, Lauren, S. ,  WIDENHOUSE, Christopher, W. ,  WOODRUFF, Scott, A.

IPC: A61F5/00 ,  A61F2/00

CPC classification number: A61F5/0053 ,  A61F2/0036 ,  A61F5/003 ,  A61F5/0033 ,  A61F5/0056 ,  A61F5/0059

Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Abstract translation: 用于调节患者器官或管道的功能的设备包括具有第一端和第二端的细长构件。 细长构件具有可压缩的腹面和基本上刚性的背面周边，其中细长构件包括沿着腹面定位的流体囊。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件形成围绕器官或导管的环。 张紧元件设置成在细长构件内运动。 驱动元件与张紧元件相关联并且与张紧元件接合，以用于使张紧元件控制由细长构件施加在患者的身体器官或导管上的张力。 还公开了其他实施例。