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    BARREL CLAMPING MECHANISMS, SYSTEMS, AND METHODS FOR 3D PRINTING
    2.
    发明申请
    BARREL CLAMPING MECHANISMS, SYSTEMS, AND METHODS FOR 3D PRINTING 审中-公开

    公开(公告)号：WO2023043867A1

    公开(公告)日：2023-03-23

    申请号：PCT/US2022/043577

    申请日：2022-09-15

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： CAMBRON, Scott

    IPC: B29C64/20 ,  B29C64/209 ,  B33Y30/00

    Abstract: A 3D printing assembly, system, and method for 3D printing a biomaterial may include a robotic arm end effector and a barrel clamp assembly. The robotic arm end effector is configured to move along one or more axes of movement for 3D printing. The barrel clamp assembly is distally coupled to the robotic arm end effector and includes a barrel clamp arm and a barrel clamp. The barrel clamp arm includes a top end coupled to the robotic arm end effector and a bottom end opposite to the top end. The bottom end is angled forward with respect to the top end. The barrel clamp is coupled to the bottom end of the barrel clamp arm and is configured to receive and clamp against a distal end of a printing syringe barrel for 3D printing.

    MODULAR LIGHT SOURCE FOR CURING OF 3D PRINTED BIOLOGICAL AND ENGINEERED MATERIALS
    3.
    发明申请
    MODULAR LIGHT SOURCE FOR CURING OF 3D PRINTED BIOLOGICAL AND ENGINEERED MATERIALS 审中-公开

    公开(公告)号：WO2021158659A1

    公开(公告)日：2021-08-12

    申请号：PCT/US2021/016408

    申请日：2021-02-03

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： CAMBRON, Scott ,  BLUM, Andrew

    IPC: B29C64/112 ,  B29C64/118 ,  B29C64/209 ,  B29C64/264 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/20 ,  B22F10/00 ,  B22F12/00

    Abstract: A modular light for removably attaching to a bio-printer robot end effector (1205), where the light includes: an annular modular light ring housing (118) with an annular opening (108) for receiving the end effector (1205) of the bioprinting robot (1200); the housing (118) substantially surrounding a dispensing tip (315) of the end effector (1205); a power supply interface to receive electrical power from the end effector (1205); a plurality of LEDs (102) positioned annularly around the end effector (1205) within the annular modular light ring housing (118), where the plurality of LEDs (102) are spaced in at least two annular rows (104), where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing (118) with respect to a light output plane of the annular modular light ring housing (118); the LEDs (102) are in electrical communication with the power supply interface; and a controller (1305) communicatively coupled with the LEDs (102) and the power supply interface.

    SYSTEM AND WORKSTATION FOR THE DESIGN, FABRICATION AND ASSEMBLY OF 3-DIMENSIONAL CONSTRUCTS
    4.
    发明申请
    SYSTEM AND WORKSTATION FOR THE DESIGN, FABRICATION AND ASSEMBLY OF 3-DIMENSIONAL CONSTRUCTS 审中-公开

    公开(公告)号：WO2019152769A1

    公开(公告)日：2019-08-08

    申请号：PCT/US2019/016238

    申请日：2019-02-01

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： GOLWAY, Michael W.

    IPC: G06Q10/06 ,  G06Q10/08 ,  G06F17/50 ,  G06T19/20 ,  B33Y50/02

    Abstract: Methods and systems for designing a volumetric model of a construct at a user interface through use of a 3-D design, fabrication and assembly system comprising a modeling component, a robotic assembly workstation component, and a workflow configuration module to generate, through the workflow configuration module, a 3-D print bill of materials for a rendered volumetric model; generate a workflow configuration model based on the 3-D print bill of materials, the model including an automated robot control scheme of a series of assembly order instructions to direct a multi-axis robot of the robotic assembly workstation component to print and/or assemble a construct; transmit the workflow configuration model to the robotic assembly workstation component with a print and/or assembly command in accordance with the automated robot control scheme; and print and/or assemble the construct with the multi-axis robot in accordance with the print and/or assembly command.

    SYSTEM AND METHOD FOR A QUICK-CHANGE MATERIAL TURRET IN A ROBOTIC FABRICATION AND ASSEMBLY PLATFORM
    5.
    发明申请
    SYSTEM AND METHOD FOR A QUICK-CHANGE MATERIAL TURRET IN A ROBOTIC FABRICATION AND ASSEMBLY PLATFORM 审中-公开
    用于机器人制造和组装平台中的快速更换材料转移的系统和方法

    公开(公告)号：WO2018067901A1

    公开(公告)日：2018-04-12

    申请号：PCT/US2017/055483

    申请日：2017-10-06

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： CAMBRON, Scott Douglas

    IPC: B29C64/10 ,  B29C64/106 ,  B29C64/20 ,  B29C64/209 ,  B29C64/227 ,  B29C64/255 ,  B33Y10/00 ,  B33Y30/00

    CPC classification number: B29C64/209 ,  B29C64/106 ,  B29C64/112 ,  B29C64/232 ,  B29C64/236 ,  B29C64/241 ,  B29C64/245 ,  B29C64/393 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  Y10S901/30

    Abstract: Systems and methods for a robotic fabrication and assembly platform providing a plurality of printable materials for fabrication of a three-dimensional object are provided. A method includes activating a pneumatic actuator to extend a quick-change turret from a pneumatic seal. The method may insert a plurality of barrels into the quick-change turret. The method may also align one of the plurality of barrels with a pneumatic seal in the quick-change turret. The method may also disengage the pneumatic actuator to seat the aligned barrel onto the pneumatic seal and print a three-dimensional object. The method may further halt the printing of the three-dimensional object prior to completion and engage the pneumatic actuator to extend the quick-change turret from the pneumatic seal.

    Abstract translation: 提供了用于提供用于制造三维物体的多种可印刷材料的机器人制造和组装平台的系统和方法。 一种方法包括启动气动致动器以从气动密封件延伸快速更换转台。 该方法可以将多个桶插入快速更换转台。 该方法还可以将多个桶中的一个与快速更换转台中的气动密封件对齐。 该方法还可以使气动致动器脱离以将对齐的筒安置到气动密封件上并打印三维物体。 该方法可以在完成之前进一步停止打印三维物体并且接合气动致动器以将快速更换转台从气动密封件延伸。

    VASCULARIZED ORGANOID MODEL INCORPORATING ISOLATED HUMAN MICROVESSEL FRAGMENTS
    7.
    发明申请
    VASCULARIZED ORGANOID MODEL INCORPORATING ISOLATED HUMAN MICROVESSEL FRAGMENTS 审中-公开

    公开(公告)号：WO2022076784A1

    公开(公告)日：2022-04-14

    申请号：PCT/US2021/054117

    申请日：2021-10-08

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： STROBEL, Hannah A. ,  HOYING, James B.

    IPC: A61K35/44 ,  C12N5/071 ,  A61L27/38

    Abstract: A method for producing a functional, vascularized organoid or spheroid is provided, the method including: (a) mixing a suspension of stromal cells with microvessel (MV) fragments isolated from adipose tissue to provide an MV/stromal cell suspension; and (b) culturing the MV/stromal cell suspension in an angiogenic medium to provide the functional, vascularized organoid or spheroid. Also provided is a method for producing a functional, vascularized adipocyte organoid or spheroid and a method of screening compounds for pharmacological or toxicological activity, using the vascularized organoids and/or spheroids provided herein.

    TOOL FOR DISPENSING MULTIPLE MATERIALS WITH DISCRETE POSITIONAL CONTROL WITHOUT NEED FOR SEQUENTIAL TOOL CHANGE
    8.
    发明申请
    TOOL FOR DISPENSING MULTIPLE MATERIALS WITH DISCRETE POSITIONAL CONTROL WITHOUT NEED FOR SEQUENTIAL TOOL CHANGE 审中-公开

    公开(公告)号：WO2020257572A1

    公开(公告)日：2020-12-24

    申请号：PCT/US2020/038623

    申请日：2020-06-19

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： CAMBRON, Scott Douglas ,  ELI, Kyle

    IPC: B29C37/00

    Abstract: A 3D printing tool and assembly for dispensing multiple materials includes a barrel holder assembly having at least two barrel orifices extending from a top end of the barrel holder assembly through to a bottom end of the barrel holder assembly, where at least one of the at least two barrel orifices is oriented at an angle from the vertical. A method for operating the 3D printing tool includes positioning a first material distribution barrel within a first barrel orifice, where a first barrel tip is disposed at a first end of the first material distribution barrel. The method further includes dispensing building material from the first material distribution barrel when the first material distribution barrel is substantially vertically oriented and a second material distribution barrel is oriented at an angle from the vertical.

    VASCULARIZED IN VITRO ARRAYS OF LIVING CELLS
    9.
    发明申请
    VASCULARIZED IN VITRO ARRAYS OF LIVING CELLS 审中-公开

    公开(公告)号：WO2018191636A1

    公开(公告)日：2018-10-18

    申请号：PCT/US2018/027516

    申请日：2018-04-13

    Applicant: ADVANCED SOLUTIONS LIFE SCIENCES, LLC

    Inventor： HOYING, James Beatty

    IPC: C12N5/00 ,  C12N1/00

    Abstract: High-throughput column arrays of vascularized living parenchyma / tissue having pillars dispersed in specialized configurations and arrangements substantially vertically through the column to provide support, passive or active perfusion, and access to internal portions of tissue for analytical sampling needs, along with 3-D printing methods of manufacture and analytical screening methods employing the column arrays.

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