公开(公告)号：WO2014078576A3

公开(公告)日：2014-07-10

申请号：PCT/US2013070162

申请日：2013-11-14

Applicant: ABON PHARMACEUTICALS LLC ,  AHMED SALAH U ,  ZU YANMING ,  NEELAM KARUNAKAR ,  MUNTAZIM SAAD ,  CHOWDHURY TAHSEEN A ,  TIAN SHIYING

Inventor： AHMED SALAH U ,  ZU YANMING ,  NEELAM KARUNAKAR ,  MUNTAZIM SAAD ,  CHOWDHURY TAHSEEN A ,  TIAN SHIYING

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30

CPC classification number: A61K31/568 ,  A61J3/06 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/205 ,  A61K31/565 ,  A61K31/566 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  B65D75/36

Abstract: This invention relates to dosage forms for the delivery of drugs across the oral mucosa having improved transmucosal permeability. More specifically, the invention relates to an oral transmucosal dosage form comprising a primary vehicle comprising a crystallization inhibition agent (CIA) system and a drug, and a secondary vehicle. It also relates to methods of designing and making this dosage form, methods of administering this dosage form and methods of packaging the dosage forms.

Abstract translation: 本发明涉及通过具有改善的经粘膜渗透性的口腔粘膜递送药物的剂型。 更具体地，本发明涉及包含含有结晶抑制剂（CIA）系统和药物的主要载体的口腔粘膜剂型，以及二级载体。 它还涉及设计和制备该剂型的方法，给予该剂型的方法和包装剂型的方法。

公开(公告)号：WO2010042930A1

公开(公告)日：2010-04-15

申请号：PCT/US2009/060381

申请日：2009-10-12

Applicant: AHMED, Salah, U. ,  SANDEEP, Sethia ,  REAPE, Kathleen ,  HAIT, Howard ,  BEN-MAIMON, Carole, S.

Inventor： AHMED, Salah, U. ,  SANDEEP, Sethia ,  REAPE, Kathleen ,  HAIT, Howard ,  BEN-MAIMON, Carole, S.

IPC: A61K31/56 ,  A61K31/21

CPC classification number: A61K31/21 ,  A61K31/56

Abstract: The present invention is directed to methods of treating vasomotor symptoms in castrated prostatic cancer patients in need of treatment, comprising administering about 15 mg or less of cyproterone acetate per day to the patients. The present invention is further directed to dosage forms comprising about 1 mg to about 15 mg of cyproterone acetate and a package comprising a plurality of dosage forms comprising about 1 mg to about 15 mg of cyproterone acetate.

Abstract translation: 本发明涉及在需要治疗的去势前列腺癌患者中治疗血管舒缩症状的方法，包括每天向患者施用约15mg或更少的醋酸环丙孕酮。 本发明还涉及包含约1mg至约15mg的醋酸环丙孕酮和包含多个剂型的包含约1mg至约15mg的醋酸环丙孕酮的剂型的剂型。

公开(公告)号：WO2010008569A1

公开(公告)日：2010-01-21

申请号：PCT/US2009/004123

申请日：2009-07-16

Applicant: BARR LABORATORIES, INC. ,  AHMED, Salah U. ,  GORUKANTI, Sudhir, R. ,  NAINI, Venkatesh

Inventor： AHMED, Salah U. ,  GORUKANTI, Sudhir, R. ,  NAINI, Venkatesh

IPC: A01N43/40 ,  A61K31/44

CPC classification number: A61K31/4439 ,  A61K9/0056 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5078

Abstract: The present invention relates to non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising delayed-release lansoprazole, processes for preparing the dosage forms, and methods for treating one or more conditions with the dosage forms.

Abstract translation: 本发明涉及包含延迟释放兰索拉唑的非泡腾口腔崩解固体药物剂型，用于制备剂型的方法以及用该剂型治疗一种或多种病症的方法。

公开(公告)号：WO2009099586A3

公开(公告)日：2010-01-14

申请号：PCT/US2009000672

申请日：2009-02-03

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  TSAO JIAXIANG ,  MAHASHABDE ANU ,  HARRISON DIANE D

Inventor： AHMED SALAH U ,  TSAO JIAXIANG ,  MAHASHABDE ANU ,  HARRISON DIANE D

IPC: A61F6/14

CPC classification number: A61K31/57 ,  A61F6/08 ,  A61K9/0036 ,  A61K47/34 ,  A61K47/44 ,  B29C45/0001 ,  B29C45/7207 ,  B29K2083/00 ,  B29K2105/0035 ,  B29L2031/753

Abstract: The present invention relates to monolithic intravaginal rings comprising progesterone, methods of making, and uses thereof. The intravaginal rings comprise progesterone, a polysiloxane elastomer, and a pharmaceutically acceptable hydrocarbon or glycerol esters of a fatty acid.

Abstract translation: 本发明涉及包含孕酮的整体式阴道环，其制备方法和用途。 阴道内环包含孕酮，聚硅氧烷弹性体和药学上可接受的脂肪酸的烃或甘油酯。

公开(公告)号：WO2009097156A1

公开(公告)日：2009-08-06

申请号：PCT/US2009/000662

申请日：2009-02-02

Applicant: BARR LABORATORIES, INC. ,  AHMED, Salah, U. ,  KATIKANENI, Pruthvipathy, R. ,  ZU, Yanming

Inventor： AHMED, Salah, U. ,  KATIKANENI, Pruthvipathy, R. ,  ZU, Yanming

IPC: A61K9/22

CPC classification number: A61K9/5073 ,  A61K9/5078 ,  A61K31/519 ,  A61K31/616 ,  A61K2300/00

Abstract: The present invention is directed to pharmaceutical capsule comprising extended release formulations of dipyridamole, processes for preparing such dipyridamole extended release formulations and their use treatment of stroke.

Abstract translation: 本发明涉及包含双嘧达莫的缓释制剂，制备这种双嘧达莫延长释放制剂的方法及其中风用途治疗的药物胶囊。

公开(公告)号：WO2007109247A3

公开(公告)日：2008-02-28

申请号：PCT/US2007006850

申请日：2007-03-20

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  CHOWDHURY TAHSEEN A ,  LUO YI

Inventor： AHMED SALAH U ,  CHOWDHURY TAHSEEN A ,  LUO YI

IPC: A61B1/303

CPC classification number: A61K9/0036 ,  A61K31/00 ,  A61K31/20 ,  A61K38/00

Abstract: The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.

Abstract translation: 本发明涉及柔性压缩阴道内环，其包含基本均匀的压缩混合物，其包含聚甲基丙烯酸酯，增塑剂和活性剂，以及制备和使用它们的方法及其制备方法。

公开(公告)号：WO2007035954A3

公开(公告)日：2007-11-22

申请号：PCT/US2006037365

申请日：2006-09-25

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  MAHAJAN RAJ R

Inventor： AHMED SALAH U ,  MAHAJAN RAJ R

IPC: A61K9/20 ,  A61K31/5575 ,  A61P15/04

CPC classification number: A61K9/0034 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K31/5575 ,  A61K31/57

Abstract: The present invention is directed to vaginal tablets comprising misoprostol and a pharmaceutically acceptable pH insensitive, hydrophilic cellulose material, wherein the vaginal tablets do not contain a hydrophobic release controlling agent, and wherein the misoprostol and the pharmaceutically acceptable pH insensitive, hydrophilic cellulose material are in a ratio of about 1:50 to about 1:800, and wherein the vaginal tablets do not substantially change the pH of a vaginal tract.

Abstract translation: 本发明涉及包含米索前列醇和药学上可接受的pH不敏感的亲水性纤维素材料的阴道片剂，其中阴道片剂不含疏水性释放控制剂，并且其中米索前列醇和药学上可接受的pH不敏感的亲水性纤维素材料处于 约1:50至约1:800的比例，并且其中阴道片剂不会实质上改变阴道的pH值。

公开(公告)号：WO2007109247A2

公开(公告)日：2007-09-27

申请号：PCT/US2007/006850

申请日：2007-03-20

Applicant: DURAMED PHARMACEUTICALS, INC. ,  AHMED, Salah, U. ,  CHOWDHURY, Tahseen, A. ,  LUO, Yi

Inventor： AHMED, Salah, U. ,  CHOWDHURY, Tahseen, A. ,  LUO, Yi

IPC: A61K31/20 ,  A61K38/00 ,  A61K38/43 ,  A61K9/02

CPC classification number: A61K9/0036 ,  A61K31/00 ,  A61K31/20 ,  A61K38/00

Abstract: The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.

Abstract translation: 本发明涉及柔性压缩阴道内环，其包含基本均匀的压缩混合物，其包含聚甲基丙烯酸酯，增塑剂和活性剂，以及制备和使用它们的方法及其制备方法。

公开(公告)号：WO2006023496A3

公开(公告)日：2007-03-15

申请号：PCT/US2005029123

申请日：2005-08-16

Applicant: DURAMED PHARMACEUTICALS INC ,  AHMED SALAH U ,  DILIBERTI CHARLES E ,  BEN-MAIMON CAROLE S ,  HAIT HOWARD

Inventor： AHMED SALAH U ,  DILIBERTI CHARLES E ,  BEN-MAIMON CAROLE S ,  HAIT HOWARD

IPC: A61K31/56

CPC classification number: A61K31/56

Abstract: The present invention is directed to pharmaceutical vaginal cream compositions comprising a conjugated estrogen and a stabilizer. The present invention is also directed to a method of treating a menopausal condition in a female in need thereof, said method comprising vaginally administering a pharmaceutical vaginal cream composition comprising a conjugated estrogen twice per week for at least 2 weeks.

Abstract translation: 本发明涉及包含共轭雌激素和稳定剂的药物阴道乳膏组合物。 本发明还涉及一种在有需要的女性中治疗更年期病症的方法，所述方法包括阴道施用包含结合雌激素的药物阴道霜组合物，每周两次至少2周。

公开(公告)号：WO2006127879A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/020203

申请日：2006-05-25

Applicant: DURAMED PHARMACEUTICALS, INC. ,  AHMED, Salah, U. ,  LI, Lianli ,  CHOWDHURY, Tahseen A.

Inventor： AHMED, Salah, U. ,  LI, Lianli ,  CHOWDHURY, Tahseen A.

IPC: A61K9/00 ,  A61K9/20 ,  A23L1/05 ,  A23G3/32 ,  A23G3/36 ,  A23G3/44

CPC classification number: A23G3/36 ,  A23P10/28 ,  A61K9/0034 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2063 ,  A61K9/2095

Abstract: The present invention provides flexible solid dosage forms that include an active agent, gelatin, and a polyol or saccharide. The present invention also provides methods of making flexible solid dosage forms.

Abstract translation: 本发明提供了柔性固体剂型，其包括活性剂，明胶和多元醇或糖。 本发明还提供制备柔性固体剂型的方法。