公开(公告)号：WO2012048129A3

公开(公告)日：2012-07-26

申请号：PCT/US2011055134

申请日：2011-10-06

Applicant: ELAN PHARM INC ,  NEITZ R JEFFREY ,  TROUNG ANH P ,  GALEMMO ROBERT A ,  YE XIAOCONG MICHAEL ,  SEALY JENNIFER ,  ADLER MARC ,  BOWERS SIMEON ,  BEROZA PAUL ,  ANDERSON JOHN P ,  AUBELE DANIELLE L ,  ARTIS DEAN RICHARD ,  HOM ROY K ,  ZHU YONG-LIANG

Inventor： NEITZ R JEFFREY ,  TROUNG ANH P ,  GALEMMO ROBERT A ,  YE XIAOCONG MICHAEL ,  SEALY JENNIFER ,  ADLER MARC ,  BOWERS SIMEON ,  BEROZA PAUL ,  ANDERSON JOHN P ,  AUBELE DANIELLE L ,  ARTIS DEAN RICHARD ,  HOM ROY K ,  ZHU YONG-LIANG

IPC: A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  C07D487/14 ,  C07D487/22 ,  C07D498/22

CPC classification number: C07D487/14 ,  C07D487/22 ,  C07D498/22

Abstract: The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Abstract translation: 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，U1，U2，U3，R2，R3和R4如本文所定义。 本发明进一步提供包含本发明化合物的药物组合物，以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。

公开(公告)号：WO2011079114A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061535

申请日：2010-12-21

Applicant: ELAN PHARMACEUTICALS, INC. ,  GALEMMO, Robert, A., Jr. ,  ARTIS, Dean, Richard ,  YE, Xiaocong, Michael ,  AUBELE, Danielle, L. ,  TRUONG, Anh, P. ,  BOWERS, Simeon ,  HOM, Roy, K. ,  ZHU, Yong-Liang ,  NEITZ, R., Jeffrey ,  SEALY, Jennifer ,  ADLER, Marc ,  BEROZA, Paul ,  ANDERSON, John, P.

Inventor： GALEMMO, Robert, A., Jr. ,  ARTIS, Dean, Richard ,  YE, Xiaocong, Michael ,  AUBELE, Danielle, L. ,  TRUONG, Anh, P. ,  BOWERS, Simeon ,  HOM, Roy, K. ,  ZHU, Yong-Liang ,  NEITZ, R., Jeffrey ,  SEALY, Jennifer ,  ADLER, Marc ,  BEROZA, Paul ,  ANDERSON, John, P.

IPC: C07D475/04 ,  C07D475/12 ,  A61K31/4985 ,  A61P25/00

CPC classification number: C07D475/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D475/04 ,  C07D475/12 ,  C07D487/14 ,  C07D498/14 ,  C07D519/00

Abstract: The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Abstract translation: 本发明提供具有式（I）结构或其盐或溶剂合物的化合物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。

公开(公告)号：WO2012048129A2

公开(公告)日：2012-04-12

申请号：PCT/US2011/055134

申请日：2011-10-06

Applicant: ELAN PHARMACEUTICALS, INC. ,  NEITZ, R., Jeffrey ,  TROUNG, Anh, P. ,  GALEMMO, Robert, A. ,  YE, Xiaocong, Michael ,  SEALY, Jennifer ,  ADLER, Marc ,  BOWERS, Simeon ,  BEROZA, Paul ,  ANDERSON, John, P. ,  AUBELE, Danielle, L. ,  ARTIS, Dean, Richard ,  HOM, Roy, K. ,  ZHU, Yong-liang

Inventor： NEITZ, R., Jeffrey ,  TROUNG, Anh, P. ,  GALEMMO, Robert, A. ,  YE, Xiaocong, Michael ,  SEALY, Jennifer ,  ADLER, Marc ,  BOWERS, Simeon ,  BEROZA, Paul ,  ANDERSON, John, P. ,  AUBELE, Danielle, L. ,  ARTIS, Dean, Richard ,  HOM, Roy, K. ,  ZHU, Yong-liang

IPC: A61K31/55 ,  C07D487/14 ,  C07D471/22 ,  C07D487/22 ,  C07D498/22 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/5377 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04 ,  A61P35/02

CPC classification number: C07D487/14 ,  C07D487/22 ,  C07D498/22

Abstract: The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U 1 , U 2 , U 3 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Abstract translation: 本发明提供了具有根据式（I）的结构的化合物或其盐或溶剂合物，其中环A，U 1，U 2， U 3，R 2，R 3和R 4在本文中定义。 本发明进一步提供了包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如用于治疗和预防各种病症，如帕金森病。

公开(公告)号：WO2011079118A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061551

申请日：2010-12-21

Applicant: ELAN PHARMACEUTICALS, INC ,  GALEMMO, Robert, A., Jr. ,  ARTIS, Dean Richard ,  YE, Xiaocong Michael ,  AUBELE, Danielle, L. ,  TRUONG, Anh, P. ,  BOWERS, Simeon ,  HOM, Roy, K. ,  ZHU, Yong-Liang ,  NEITZ, R., Jeffrey ,  SEALY, Jennifer ,  ADLER, Marc ,  BEROZA, Paul ,  ANDERSON, John, P.

Inventor： GALEMMO, Robert, A., Jr. ,  ARTIS, Dean Richard ,  YE, Xiaocong Michael ,  AUBELE, Danielle, L. ,  TRUONG, Anh, P. ,  BOWERS, Simeon ,  HOM, Roy, K. ,  ZHU, Yong-Liang ,  NEITZ, R., Jeffrey ,  SEALY, Jennifer ,  ADLER, Marc ,  BEROZA, Paul ,  ANDERSON, John, P.

IPC: C07D475/04 ,  C07D475/12 ,  A61K31/4985 ,  A61P25/00

CPC classification number: C07D475/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D475/04 ,  C07D475/12 ,  C07D487/14 ,  C07D498/14 ,  C07D519/00

Abstract: The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E 1 , E 2 , R 1 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Abstract translation: 本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。 本发明进一步提供包含本发明化合物的药物组合物，以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。