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    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    1.
    发明申请
    CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS 审中-公开
    某些化学实验，组合物和方法

    公开(公告)号：WO2013023145A1

    公开(公告)日：2013-02-14

    申请号：PCT/US2012/050346

    申请日：2012-08-10

    Applicant: NEUPHARMA, INC. ,  QIAN, Xiangping ,  ZHU, Yong-Liang

    Inventor： QIAN, Xiangping ,  ZHU, Yong-Liang

    IPC: A61K31/535

    CPC classification number: C07D307/33 ,  C07D405/12

    Abstract: Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described. Treatment encompasses administration of at least one compound of Formula I, or a pharmaceutically acceptable salt thereof, to a mammalian subject, particularly a human subject, in need of such an administration and includes (i) arresting the development of clinical symptoms of the disease, such as cancer, (ii) bringing about a regression in the clinical symptoms of the disease, such as cancer, and/or (iii) prophylactic treatment for preventing the onset of the disease, such as cancer. Cancer refers to all types of cancer o neoplasm or malignant tumors found in mammals, including carcinomas and sarcomas. Examples of cancer are cancer of the brain, breast, cervix, colon, head & neck, kidney, lung, non-small cell lung, melanoma, mesothelioma, ovary, sarcoma, stomach, uterus and Medulloblastoma.

    Abstract translation: 描述了作为癌基因的衍生物，药物组合物和癌症治疗方法的化学实体。 治疗包括向需要这种施用的哺乳动物受试者，特别是人类受试者施用至少一种式I化合物或其药学上可接受的盐，并且包括（i）阻止疾病的临床症状的发展， 例如癌症，（ii）使疾病如癌症的临床症状消退，和/或（iii）预防疾病发病例如癌症的预防性治疗。 癌症是指哺乳动物中发现的肿瘤或恶性肿瘤的所有类型的肿瘤，包括癌和肉瘤。 癌症的例子是脑，乳腺，子宫颈，结肠，头颈部，肾，肺，非小细胞肺，黑素瘤，间皮瘤，卵巢，肉瘤，胃，子宫和成神经管细胞瘤的癌症。

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