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公开(公告)号：WO2021067761A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/054017
申请日：2020-10-02
Applicant: ATYR PHARMA, INC.
Inventor： BURMAN, Luke , CHONG, Yeeting , GREENE, Leslie Ann , KING, David , XU, Zhiwen , ADAMS, Ryan Andrew
IPC: A61K39/395 , A61K45/00 , A61K45/06
Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
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2.发明申请HISTIDYL-TRNA SYNTHETASES FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES 审中-公开HISTIDYL-TRNA合成用于治疗自身免疫和炎性疾病
公开(公告)号：WO2013123432A3
公开(公告)日：2013-10-17
申请号：PCT/US2013026494
申请日：2013-02-15
Applicant: ATYR PHARMA INC , PANGU BIOPHARMA LTD
Inventor： CHIANG KYLE P , GARDINER ELISABETH , LAU CHING FUN , LO WING-SZE , GREVE JEFFREY , ASHLOCK MELISSA , MENDLEIN JOHN D
CPC classification number: C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52
Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
Abstract translation: 本发明一般涉及包含组氨酰-tRNA合成酶多肽或其他特异性封闭剂的组合物和方法，用于治疗自身免疫性疾病和其他炎性疾病，包括与Jo-1抗体相关的炎性疾病。
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3.发明申请HISTIDYL-TRNA SYNTHETASES FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES 审中-公开用于治疗自身免疫和炎症疾病的HISTIDYL-TRNA合成
公开(公告)号：WO2013123432A2
公开(公告)日：2013-08-22
申请号：PCT/US2013/026494
申请日：2013-02-15
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED
Inventor： CHIANG, Kyle P. , GARDINER, Elisabeth , LAU, Ching Fun , LO, Wing-Sze , GREVE, Jeffrey , ASHLOCK, Melissa , MENDLEIN, John D.
CPC classification number: C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52 , Y02A50/473
Abstract: The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
Abstract translation: 本发明一般涉及包含组氨酰-tRNA合成酶多肽或用于治疗自身免疫性疾病和其它炎性疾病的其它特异性阻断剂的组合物和方法，包括与Jo-1抗体相关的那些。
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公开(公告)号：WO2013086216A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068282
申请日：2012-12-06
Applicant: ATYR PHARMA, INC.
Inventor： BUECHLER, Ying Ji , WU, Chi-Fang , ADAMS, Ryan Andrew , PIEHL, Kristi Helen , GREVE, Jeffrey , MENDLEIN, John D.
CPC classification number: C12N9/93 , A61K38/00 , C07K2319/40 , Y02A50/411
Abstract: The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.
Abstract translation: 本发明提供具有改变的半胱氨酸含量的天冬氨酰-tRNA合成酶衍生蛋白（DRS多肽），包含其的组合物，以及使用这些多肽和组合物治疗或诊断各种病症的方法。 本发明的DRS多肽具有免疫调节特性，并表现出改进的活性和稳定性。
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5.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF HISTIDYL-TRNA SYNTHETASES 审中-公开创新发现与HISTIDYL-TRNA合成酶蛋白片段有关的治疗，诊断和抗体组合物
公开(公告)号：WO2012021249A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/043758
申请日：2011-07-12
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED , GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , QUINN, Cheryl, L. , MENDLEIN, John, D.
Inventor： GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , QUINN, Cheryl, L. , MENDLEIN, John, D.
CPC classification number: C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C12N5/0602 , C12N9/96 , C12Y601/01 , C12Y601/01021 , G01N33/68
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含氨酰基-tRNA合成酶的新鉴定的蛋白片段，编码它们的多核苷酸及其互补物的组合物，相关试剂及其在诊断，药物开发，研究和治疗应用中的使用方法。
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Patent Agency Ranking6.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF LYSYL-TRNA SYNTHETASES 审中-公开与LYSYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现
公开(公告)号：WO2011153277A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/038813
申请日：2011-06-01
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED , GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , QUINN, Cheryl, L. , MENDLEIN, John, D.
Inventor： GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , QUINN, Cheryl, L. , MENDLEIN, John, D.
CPC classification number: C07K16/40 , A61K38/00 , C07K2317/24 , C07K2317/622 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/573 , G01N33/68 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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7.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-BETA-TRNA SYNTHETASES 审中-公开治疗，诊断和抗体组合物与苯丙氨酸-ATNA-TRNA合成蛋白片段相关的创新发现
公开(公告)号：WO2011143482A2
公开(公告)日：2011-11-17
申请号：PCT/US2011036326
申请日：2011-05-12
Applicant: ATYR PHARMA INC , PANGU BIOPHARMA LTD , GREENE LESLIE ANN , CHIANG KYLE P , HONG FEI , VASSEROT ALAIN P , LO WING-SZE , WATKINS JEFFRY D , QUINN CHERYL L , XU ZHIWEN , MENDLEIN JOHN D
Inventor： GREENE LESLIE ANN , CHIANG KYLE P , HONG FEI , VASSEROT ALAIN P , LO WING-SZE , WATKINS JEFFRY D , QUINN CHERYL L , XU ZHIWEN , MENDLEIN JOHN D
CPC classification number: A61K38/53 , A61K38/00 , C07K16/40 , C07K2317/21 , C07K2317/55 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，其编码它们的多核苷酸及其互补物，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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8.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ALANYL TRNA SYNTHETASES 审中-公开与ALANYL TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现
公开(公告)号：WO2011139853A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034387
申请日：2011-04-28
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED , GREENE, Leslie Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
Inventor： GREENE, Leslie Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
CPC classification number: C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，其编码它们的多核苷酸及其互补物，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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9.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF THREONYL TRNA SYNTHETASES 审中-公开与THREONYL TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现
公开(公告)号：WO2011139801A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034207
申请日：2011-04-27
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED , GREENE, Leslie Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
Inventor： GREENE, Leslie Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
CPC classification number: C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C07K2317/76 , C07K2319/00 , C12Y601/01003 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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10.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ISOLEUCYL TRNA SYNTHETASES 审中-公开治疗，诊断和抗体组合物的创新发现与蛋白质TRAAS合成蛋白片段相关
公开(公告)号：WO2011139799A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034205
申请日：2011-04-27
Applicant: ATYR PHARMA, INC. , PANGU BIOPHARMA LIMITED , GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
Inventor： GREENE, Leslie, Ann , CHIANG, Kyle, P. , HONG, Fei , VASSEROT, Alain, P. , LO, Wing-Sze , WATKINS, Jeffry, D. , MENDLEIN, John, D. , QUINN, Cheryl, L.
CPC classification number: C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , C12Y601/01005 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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