公开(公告)号：WO2012118675A3

公开(公告)日：2014-04-24

申请号：PCT/US2012026215

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LIU YUWEN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  GE JUNHAO ,  XU YUAN ,  YAO LI ,  BACK ARTHUR ,  ZHENG YING

Inventor： LIU YUWEN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  GE JUNHAO ,  XU YUAN ,  YAO LI ,  BACK ARTHUR ,  ZHENG YING

IPC: C08G77/04 ,  G02C7/04

CPC classification number: G02C7/04 ,  B65B5/04 ,  G02B1/043 ,  C08L83/12 ,  C08L33/08 ,  C08L33/10

Abstract: Ophthalmic ally acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (I): wherein m, n, R1 and R2 are as defined herein, the first siloxane monomer having a number average molecular weight of from 400 daltons to 700 daltons; and a second siloxane monomer having a number average molecular weight greater than 7,000 daltons; wherein a total amount of siloxane monomers present in the polymerizable composition is from 30 unit parts to 50 unit parts; the lenses also include units derived from at least one hydrophilic amide monomer having one N-vinyl group that is present in the polymerizable composition in an amount from 30 to 60 unit parts. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated.

Abstract translation: 描述了眼科盟友可接受的可湿性硅氧水凝胶隐形眼镜。 透镜衍生自包含由式（I）表示的第一硅氧烷单体的可聚合组合物：其中m，n，R 1和R 2如本文所定义，第一硅氧烷单体的数均分子量为400道尔顿至700道尔顿 ; 和数均分子量大于7,000道尔顿的第二硅氧烷单体; 其中存在于聚合性组合物中的硅氧烷单体的总量为30单位份〜50单位份; 透镜还包括衍生自至少一种具有一个N-乙烯基的亲水性酰胺单体的单元，该单体存在于可聚合组合物中的量为30至60单位份。 当完全水合时，镜片具有眼科可接受的可润湿透镜表面。

公开(公告)号：WO2012118674A2

公开(公告)日：2012-09-07

申请号：PCT/US2012026214

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  YAO LI ,  HONG YE ,  LIU YUWEN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  BACK ARTHUR

Inventor： YAO LI ,  HONG YE ,  LIU YUWEN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  BACK ARTHUR

IPC: C08L43/04 ,  B65B55/02

CPC classification number: G02B1/043 ,  C08L83/12 ,  C08L101/14 ,  C08L33/10 ,  C08L33/08

Abstract: Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono- functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate- containing siloxane monomer of at least 30:1, respectively.

Abstract translation: 由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅胶水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该聚合性组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体 重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种含亲水性含乙烯基的单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

公开(公告)号：WO2012118673A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026213

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  FRANCIS, Charles A. ,  ZHENG, Ying ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  HONG, Ye ,  CHEN, Charlie

Inventor： FRANCIS, Charles A. ,  ZHENG, Ying ,  XU, Yuan ,  YAO, Li ,  BACK, Arthur ,  HONG, Ye ,  CHEN, Charlie

IPC: C08F230/08

CPC classification number: C08F230/08 ,  C08F222/1006

Abstract: Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R 1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R 2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer represented by formula (2): wherein R 1 of formula (2) is selected from either hydrogen atom or a methyl group; R 2 of formula (2) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (2) represents an integer of from 0 to 10; n of formula (2) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; the configuration of siloxane units includes a random configuration, the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了尺寸稳定的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元：其中式（2）的R 1选自氢原子或甲基; 式（2）的R2选自氢原子或碳原子数为1〜4的烃基; 式（2）的m表示0〜10的整数， 式（2）的n表示4〜100的整数， a和b表示1以上的整数; a + b等于20-500; b /（a + b）等于0.01-0.22; 硅氧烷单元的构型包括随机构型，第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于可聚合组合物中，其量使得第一硅氧烷单体与第二硅氧烷单体的比率在 至少2：1，单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2011049642A1

公开(公告)日：2011-04-28

申请号：PCT/US2010/033416

申请日：2010-05-03

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  BACK, Arthur ,  TUAN, Ashley

Inventor： BACK, Arthur ,  TUAN, Ashley

IPC: G02C7/04

CPC classification number: G02C7/041 ,  G02C7/042 ,  G02C2202/24

Abstract: Methods for slowing progression of myopia or hyperopia of human patients include a step of providing contact lenses. The contact lenses have two or more refractive powers. A first refractive power provides clear visual acuity and a second refractive power provides a defocused retinal image to the human patient. The methods involve providing first and second sets of the contact lenses, the contact lenses of the second set have a different optical design than the contact lenses of the first set. With the present methods, an eye care practitioner is able to select one or more contact lenses from the second set of contact lenses based on one or more ocular parameters of the patient, one or more responses of the patient to the contact lens of the first set, or both, to provide an improved clinical benefit to the patient compared to the benefit provided by the first set of contact lenses.

Abstract translation: 减慢人类近视或远视进展的方法包括提供隐形眼镜的步骤。 隐形眼镜具有两个或更多个屈光力。 第一屈光力提供清晰的视力，并且第二屈光力提供散焦的视网膜图像给人类患者。 所述方法包括提供第一组和第二组隐形眼镜，第二组的隐形眼镜具有与第一组的隐形眼镜不同的光学设计。 根据本方法，眼科医生能够基于患者的一个或多个眼部参数从第二组隐形眼镜中选择一个或多个隐形眼镜，患者对第一个隐形眼镜的隐形眼镜的一个或多个响应 设置或两者，以与第一组隐形眼镜提供的益处相比，为患者提供改善的临床益处。

公开(公告)号：WO2007140220A3

公开(公告)日：2008-06-19

申请号：PCT/US2007069588

申请日：2007-05-23

Applicant: COOPERVISION INT HOLDING CO LP ,  WEI JIANPING ,  BACK ARTHUR

Inventor： WEI JIANPING ,  BACK ARTHUR

IPC: G02C7/02

CPC classification number: G01B11/2441 ,  G01M11/0242 ,  G01M11/025

Abstract: Optical coherence tomography (OCT) systems are used to measure lenses. The present methods use an OCT system to obtain one or more images of a lens. For example, an OCT system can be used to obtain section images, surface images, or combinations of section images and surface images of vision correcting lenses, such as contact lenses, intraocular lenses, corneal onlay lenses, corneal inlay lenses, and spectacle lenses, or non-vision correcting lenses, such as optical instrument and diagnostic instrument lenses. The images can be used to determine features of the lens, such as surface shapes, thicknesses, curvatures, lens powers, and edge profiles, among others. The present methods include lens metrology methods, lens design methods, and lens manufacturing methods.

Abstract translation: 光学相干断层扫描（OCT）系统用于测量透镜。 本方法使用OCT系统来获得透镜的一个或多个图像。 例如，可以使用OCT系统来获得视觉校正透镜（例如隐形眼镜，人工晶状体，角膜镶嵌透镜，角膜嵌体透镜和眼镜片）的截面图像，表面图像或截面图像和表面图像的组合， 或非视力矫正透镜，例如光学仪器和诊断仪器透镜。 图像可以用于确定透镜的特征，诸如表面形状，厚度，曲率，透镜光焦度和边缘轮廓等。 本发明的方法包括透镜测量方法，透镜设计方法和透镜制造方法。

公开(公告)号：WO2012118670A3

公开(公告)日：2014-02-06

申请号：PCT/US2012026210

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LIU YUWEN ,  CHEN CHARLIE ,  HONG YE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR

Inventor： LIU YUWEN ,  CHEN CHARLIE ,  HONG YE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR

IPC: C08G77/04 ,  G02C7/04

CPC classification number: G02B1/043 ,  B65B55/02 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

Abstract: Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.

Abstract translation: 制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。 如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。 水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

公开(公告)号：WO2012118684A3

公开(公告)日：2013-12-12

申请号：PCT/US2012026228

申请日：2012-02-23

Applicant: COOPERVISION INT HOLDING CO LP ,  LIU YUWEN ,  HONG YE ,  GE JUNHAO ,  XU YUAN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR

Inventor： LIU YUWEN ,  HONG YE ,  GE JUNHAO ,  XU YUAN ,  CHEN CHARLIE ,  FRANCIS CHARLES A ,  YAO LI ,  BACK ARTHUR

IPC: G02C7/04

CPC classification number: G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

Abstract translation: 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118686A3

公开(公告)日：2012-09-07

申请号：PCT/US2012/026231

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  CHEN, Charlie ,  LIU, Yuwen ,  XU, Yuan ,  ZHENG, Ying ,  GE, Junhao ,  YAO, Li ,  BACK, Arthur

Inventor： CHEN, Charlie ,  LIU, Yuwen ,  XU, Yuan ,  ZHENG, Ying ,  GE, Junhao ,  YAO, Li ,  BACK, Arthur

IPC: C08G77/04 ,  G02C7/04

Abstract: Silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including 30-60 unit parts by weight of a hydrophilic monomer(s) having one N-vinyl group, 10 to 50 unit parts by weight of 2-hydroxyethyl methacrylate (HEMA), and a first siloxane monomer component comprising a siloxane monomer of formula (1) as described herein or a siloxane monomer of formula (2) as described herein or a siloxane monomer of formula (3) as described herein or any combination thereof, where the total amount of siloxane monomer(s) present in the polymerizable composition is from 15 to 40 unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

公开(公告)号：WO2012118682A2

公开(公告)日：2012-09-07

申请号：PCT/US2012/026223

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  LEE, Paul, Hungchaung ,  LIU, Ronghua ,  SHI, Xinfeng ,  LIU, Yuwen ,  HONG, Ye ,  CHEN, Charlie ,  YAO, Li ,  BACK, Arthur ,  FRANCIS, Charles, A.

Inventor： LEE, Paul, Hungchaung ,  LIU, Ronghua ,  SHI, Xinfeng ,  LIU, Yuwen ,  HONG, Ye ,  CHEN, Charlie ,  YAO, Li ,  BACK, Arthur ,  FRANCIS, Charles, A.

IPC: B65B63/00 ,  C08L43/04

CPC classification number: B29D11/00038 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04 ,  C08L33/10

Abstract: Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophilic monomer are described. These silicone hydrogel contact lenses have, when fully hydrated, has an equilibrium freezable water content of at least 25% wt/wt as determined by differential scanning calorimetry (DSC). Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

Abstract translation: 描述了衍生自包含至少一种硅氧烷单体和至少一种亲水单体的可聚合组合物的硅氧烷水凝胶隐形眼镜。 当通过差示扫描量热法（DSC）测定时，这些硅氧水凝胶隐形眼镜在完全水合时具有至少25％wt / wt的平衡可冷冻水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制备硅酮水凝胶隐形眼镜的方法。

公开(公告)号：WO2012118672A3

公开(公告)日：2012-09-07

申请号：PCT/US2012/026212

申请日：2012-02-23

Applicant: COOPERVISION INTERNATIONAL HOLDING COMPANY, LP ,  BACK, Arthur ,  MORSLEY, David, Robert ,  ROGERS, Richard ,  ALMOND, Sarah ,  CHEN, Charlie ,  LIU, Yuwen ,  FRANCIS, Charles, A. ,  HONG, Ye

Inventor： BACK, Arthur ,  MORSLEY, David, Robert ,  ROGERS, Richard ,  ALMOND, Sarah ,  CHEN, Charlie ,  LIU, Yuwen ,  FRANCIS, Charles, A. ,  HONG, Ye

IPC: C08G77/04 ,  G02C7/04 ,  B29C39/00

Abstract: Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces such that less than five percent of a batch of twenty or more such silicone hydrogel contact lenses have visually identifiable non-wetting spots when the contact lenses are located on eyes of subjects.